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Items: 1 to 50 of 216

1.

Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation.

Wang Y, Tatham MH, Schmidt-Heck W, Swann C, Singh-Dolt K, Meseguer-Ripolles J, Lucendo-Villarin B, Kunath T, Rudd TR, Smith AJH, Hengstler JG, Godoy P, Hay RT, Hay DC.

iScience. 2019 May 24;16:206-217. doi: 10.1016/j.isci.2019.05.028. [Epub ahead of print]

2.

Methods to analyze STUbL activity.

Branigan E, Plechanovová A, Hay RT.

Methods Enzymol. 2019;618:257-280. doi: 10.1016/bs.mie.2018.11.005. Epub 2019 Jan 3.

PMID:
30850055
3.

Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM, Rebula CA, Tatham MH, Hendus-Altenburger R, Jourdain I, Hay RT, Kragelund BB, Hartmann-Petersen R.

Cell Rep. 2018 Oct 23;25(4):862-870. doi: 10.1016/j.celrep.2018.09.080.

4.

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.

Bustos F, Segarra-Fas A, Chaugule VK, Brandenburg L, Branigan E, Toth R, Macartney T, Knebel A, Hay RT, Walden H, Findlay GM.

Cell Rep. 2018 May 8;23(6):1599-1611. doi: 10.1016/j.celrep.2018.04.022.

5.

E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression.

Müncheberg S, Hay RT, Ip WH, Meyer T, Weiß C, Brenke J, Masser S, Hadian K, Dobner T, Schreiner S.

J Virol. 2018 Jun 13;92(13). pii: e00164-18. doi: 10.1128/JVI.00164-18. Print 2018 Jul 1.

6.

Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP.

Pawellek A, Ryder U, Tammsalu T, King LJ, Kreinin H, Ly T, Hay RT, Hartley RC, Lamond AI.

Elife. 2017 Sep 8;6. pii: e27402. doi: 10.7554/eLife.27402.

7.

Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.

González AE, Muñoz VC, Cavieres VA, Bustamante HA, Cornejo VH, Januário YC, González I, Hetz C, daSilva LL, Rojas-Fernández A, Hay RT, Mardones GA, Burgos PV.

FASEB J. 2017 Jun;31(6):2446-2459. doi: 10.1096/fj.201600713R. Epub 2017 Mar 2.

PMID:
28254759
8.

A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte Meiosis.

Pelisch F, Tammsalu T, Wang B, Jaffray EG, Gartner A, Hay RT.

Mol Cell. 2017 Jan 5;65(1):66-77. doi: 10.1016/j.molcel.2016.11.001. Epub 2016 Dec 8.

9.

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome.

Tatham MH, Cole C, Scullion P, Wilkie R, Westwood NJ, Stark LA, Hay RT.

Mol Cell Proteomics. 2017 Feb;16(2):310-326. doi: 10.1074/mcp.O116.065219. Epub 2016 Dec 2.

10.

Tools to Study SUMO Conjugation in Caenorhabditis elegans.

Pelisch F, Hay RT.

Methods Mol Biol. 2016;1475:233-56. doi: 10.1007/978-1-4939-6358-4_17.

PMID:
27631810
11.

Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage.

Maure JF, Moser SC, Jaffray EG, F Alpi A, Hay RT.

Sci Rep. 2016 May 17;6:26178. doi: 10.1038/srep26178.

12.

A Generic Platform for Cellular Screening Against Ubiquitin Ligases.

Maculins T, Carter N, Dorval T, Hudson K, Nissink JW, Hay RT, Alwan H.

Sci Rep. 2016 Jan 8;6:18940. doi: 10.1038/srep18940.

13.

Identification of RNF168 as a PML nuclear body regulator.

Shire K, Wong AI, Tatham MH, Anderson OF, Ripsman D, Gulstene S, Moffat J, Hay RT, Frappier L.

J Cell Sci. 2016 Feb 1;129(3):580-91. doi: 10.1242/jcs.176446. Epub 2015 Dec 16.

14.

Global Reprogramming of Host SUMOylation during Influenza Virus Infection.

Domingues P, Golebiowski F, Tatham MH, Lopes AM, Taggart A, Hay RT, Hale BG.

Cell Rep. 2015 Nov 17;13(7):1467-1480. doi: 10.1016/j.celrep.2015.10.001. Epub 2015 Nov 5.

15.

Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB, Tammsalu T, Jørgensen MM, Steen N, Hay RT, Thon G.

Nat Commun. 2015 Nov 5;6:8827. doi: 10.1038/ncomms9827.

16.

Proteome-wide identification of SUMO modification sites by mass spectrometry.

Tammsalu T, Matic I, Jaffray EG, Ibrahim AF, Tatham MH, Hay RT.

Nat Protoc. 2015 Sep;10(9):1374-88. doi: 10.1038/nprot.2015.095. Epub 2015 Aug 20.

PMID:
26292070
17.

Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin.

Aguilar-Martinez E, Chen X, Webber A, Mould AP, Seifert A, Hay RT, Sharrocks AD.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4854-63. doi: 10.1073/pnas.1509716112. Epub 2015 Aug 17.

18.

Analysis of the SUMO2 Proteome during HSV-1 Infection.

Sloan E, Tatham MH, Groslambert M, Glass M, Orr A, Hay RT, Everett RD.

PLoS Pathog. 2015 Jul 22;11(7):e1005059. doi: 10.1371/journal.ppat.1005059. eCollection 2015 Jul.

19.

Proteotoxic stress reprograms the chromatin landscape of SUMO modification.

Seifert A, Schofield P, Barton GJ, Hay RT.

Sci Signal. 2015 Jul 7;8(384):rs7. doi: 10.1126/scisignal.aaa2213.

PMID:
26152697
20.

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.

Branigan E, Plechanovová A, Jaffray EG, Naismith JH, Hay RT.

Nat Struct Mol Biol. 2015 Aug;22(8):597-602. doi: 10.1038/nsmb.3052. Epub 2015 Jul 6.

21.

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9.

Rojas-Fernandez A, Herhaus L, Macartney T, Lachaud C, Hay RT, Sapkota GP.

Sci Rep. 2015 Apr 29;5:9811. doi: 10.1038/srep09811.

22.

PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.

Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton PE, Hay RT, Dobner T, Schreiner S.

Oncogene. 2016 Jan 7;35(1):69-82. doi: 10.1038/onc.2015.63. Epub 2015 Mar 16.

PMID:
25772236
23.

Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.

Pelisch F, Sonneville R, Pourkarimi E, Agostinho A, Blow JJ, Gartner A, Hay RT.

Nat Commun. 2015 Feb 12;6:6352. doi: 10.1038/ncomms7352. No abstract available.

24.

Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers.

Bett JS, Ritorto MS, Ewan R, Jaffray EG, Virdee S, Chin JW, Knebel A, Kurz T, Trost M, Tatham MH, Hay RT.

Biochem J. 2015 Mar 15;466(3):489-98. doi: 10.1042/BJ20141349.

25.

Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.

Pelisch F, Sonneville R, Pourkarimi E, Agostinho A, Blow JJ, Gartner A, Hay RT.

Nat Commun. 2014 Dec 5;5:5485. doi: 10.1038/ncomms6485. Erratum in: Nat Commun. 2015;6:6352.

26.

Dss1 is a 26S proteasome ubiquitin receptor.

Paraskevopoulos K, Kriegenburg F, Tatham MH, Rösner HI, Medina B, Larsen IB, Brandstrup R, Hardwick KG, Hay RT, Kragelund BB, Hartmann-Petersen R, Gordon C.

Mol Cell. 2014 Nov 6;56(3):453-61. doi: 10.1016/j.molcel.2014.09.008. Epub 2014 Oct 9.

27.

Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri.

Fritah S, Lhocine N, Golebiowski F, Mounier J, Andrieux A, Jouvion G, Hay RT, Sansonetti P, Dejean A.

EMBO Rep. 2014 Sep;15(9):965-72. doi: 10.15252/embr.201338386. Epub 2014 Aug 5.

28.

Family-wide analysis of poly(ADP-ribose) polymerase activity.

Vyas S, Matic I, Uchima L, Rood J, Zaja R, Hay RT, Ahel I, Chang P.

Nat Commun. 2014 Jul 21;5:4426. doi: 10.1038/ncomms5426.

29.

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4.

Xu Y, Plechanovová A, Simpson P, Marchant J, Leidecker O, Kraatz S, Hay RT, Matthews SJ.

Nat Commun. 2014 Jun 27;5:4217. doi: 10.1038/ncomms5217.

30.

SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells.

Bett JS, Ibrahim AF, Garg AK, Rocha S, Hay RT.

J Vis Exp. 2014 May 24;(87). doi: 10.3791/51572.

31.

Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity.

Lang V, Pallara C, Zabala A, Lobato-Gil S, Lopitz-Otsoa F, Farrás R, Hjerpe R, Torres-Ramos M, Zabaleta L, Blattner C, Hay RT, Barrio R, Carracedo A, Fernandez-Recio J, Rodríguez MS, Aillet F.

Mol Oncol. 2014 Jul;8(5):1026-42. doi: 10.1016/j.molonc.2014.04.002. Epub 2014 Apr 13.

32.

Proteome-wide identification of SUMO2 modification sites.

Tammsalu T, Matic I, Jaffray EG, Ibrahim AFM, Tatham MH, Hay RT.

Sci Signal. 2014 Apr 29;7(323):rs2. doi: 10.1126/scisignal.2005146.

33.

E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin.

MacKay C, Carroll E, Ibrahim AFM, Garg A, Inman GJ, Hay RT, Alpi AF.

Cancer Res. 2014 Apr 15;74(8):2246-2257. doi: 10.1158/0008-5472.CAN-13-2131. Epub 2014 Mar 31.

34.

SUMO chain-induced dimerization activates RNF4.

Rojas-Fernandez A, Plechanovová A, Hattersley N, Jaffray E, Tatham MH, Hay RT.

Mol Cell. 2014 Mar 20;53(6):880-92. doi: 10.1016/j.molcel.2014.02.031.

35.

Sp100 isoform-specific regulation of human adenovirus 5 gene expression.

Berscheminski J, Wimmer P, Brun J, Ip WH, Groitl P, Horlacher T, Jaffray E, Hay RT, Dobner T, Schreiner S.

J Virol. 2014 Jun;88(11):6076-92. doi: 10.1128/JVI.00469-14. Epub 2014 Mar 12.

36.

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation.

Hands KJ, Cuchet-Lourenco D, Everett RD, Hay RT.

J Cell Sci. 2014 Jan 15;127(Pt 2):365-75. doi: 10.1242/jcs.132290. Epub 2013 Nov 4.

37.

BC-box protein domain-related mechanism for VHL protein degradation.

Pozzebon ME, Varadaraj A, Mattoscio D, Jaffray EG, Miccolo C, Galimberti V, Tommasino M, Hay RT, Chiocca S.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18168-73. doi: 10.1073/pnas.1311382110. Epub 2013 Oct 21.

38.

A role for paralog-specific sumoylation in histone deacetylase 1 stability.

Citro S, Jaffray E, Hay RT, Seiser C, Chiocca S.

J Mol Cell Biol. 2013 Dec;5(6):416-27. doi: 10.1093/jmcb/mjt032. Epub 2013 Sep 25.

PMID:
24068740
39.

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.

Tatham MH, Plechanovová A, Jaffray EG, Salmen H, Hay RT.

Biochem J. 2013 Jul 1;453(1):137-45. doi: 10.1042/BJ20130244.

40.

Decoding the SUMO signal.

Hay RT.

Biochem Soc Trans. 2013 Apr;41(2):463-73. doi: 10.1042/BST20130015. Review.

PMID:
23514139
41.

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.

Bett JS, Ibrahim AF, Garg AK, Kelly V, Pedrioli P, Rocha S, Hay RT.

Biochem J. 2013 Apr 15;451(2):185-94. doi: 10.1042/BJ20130026.

42.

Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity.

Aillet F, Lopitz-Otsoa F, Egaña I, Hjerpe R, Fraser P, Hay RT, Rodriguez MS, Lang V.

PLoS One. 2012;7(12):e51672. doi: 10.1371/journal.pone.0051672. Epub 2012 Dec 20.

43.

Reanalysis of phosphoproteomics data uncovers ADP-ribosylation sites.

Matic I, Ahel I, Hay RT.

Nat Methods. 2012 Jul 30;9(8):771-2. doi: 10.1038/nmeth.2106. No abstract available.

44.

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis.

Plechanovová A, Jaffray EG, Tatham MH, Naismith JH, Hay RT.

Nature. 2012 Sep 6;489(7414):115-20. doi: 10.1038/nature11376.

45.

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage.

Yin Y, Seifert A, Chua JS, Maure JF, Golebiowski F, Hay RT.

Genes Dev. 2012 Jun 1;26(11):1196-208. doi: 10.1101/gad.189274.112.

46.

SUMOylation of HNF4α regulates protein stability and hepatocyte function.

Zhou W, Hannoun Z, Jaffray E, Medine CN, Black JR, Greenhough S, Zhu L, Ross JA, Forbes S, Wilmut I, Iredale JP, Hay RT, Hay DC.

J Cell Sci. 2012 Aug 1;125(Pt 15):3630-5. Epub 2012 Apr 14.

47.

OMERO: flexible, model-driven data management for experimental biology.

Allan C, Burel JM, Moore J, Blackburn C, Linkert M, Loynton S, Macdonald D, Moore WJ, Neves C, Patterson A, Porter M, Tarkowska A, Loranger B, Avondo J, Lagerstedt I, Lianas L, Leo S, Hands K, Hay RT, Patwardhan A, Best C, Kleywegt GJ, Zanetti G, Swedlow JR.

Nat Methods. 2012 Feb 28;9(3):245-53. doi: 10.1038/nmeth.1896.

48.

Detection and quantitation of SUMO chains by mass spectrometry.

Matic I, Hay RT.

Methods Mol Biol. 2012;832:239-47. doi: 10.1007/978-1-61779-474-2_17.

PMID:
22350890
49.

Stable-isotope labeling with amino acids in nematodes.

Larance M, Bailly AP, Pourkarimi E, Hay RT, Buchanan G, Coulthurst S, Xirodimas DP, Gartner A, Lamond AI.

Nat Methods. 2011 Aug 28;8(10):849-51. doi: 10.1038/nmeth.1679.

50.

Mechanism of ubiquitylation by dimeric RING ligase RNF4.

Plechanovová A, Jaffray EG, McMahon SA, Johnson KA, Navrátilová I, Naismith JH, Hay RT.

Nat Struct Mol Biol. 2011 Aug 21;18(9):1052-9. doi: 10.1038/nsmb.2108.

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