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Automated high-throughput light-sheet fluorescence microscopy of larval zebrafish.

Logan SL, Dudley C, Baker RP, Taormina MJ, Hay EA, Parthasarathy R.

PLoS One. 2018 Nov 14;13(11):e0198705. doi: 10.1371/journal.pone.0198705. eCollection 2018.


The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial.

Chesterton LS, Blagojevic-Bucknall M, Burton C, Dziedzic KS, Davenport G, Jowett SM, Myers HL, Oppong R, Rathod-Mistry T, van der Windt DA, Hay EM, Roddy E.

Lancet. 2018 Oct 20;392(10156):1423-1433. doi: 10.1016/S0140-6736(18)31572-1.


Inbreeding depression in line 1 Hereford cattle population using pedigree and genomic information1.

Sumreddee P, Togniani S, Hay EH, Roberts A, Aggrey SE, Rekaya R.

J Anim Sci. 2018 Oct 10. doi: 10.1093/jas/sky385. [Epub ahead of print]


Modernized Tools for Streamlined Genetic Manipulation and Comparative Study of Wild and Diverse Proteobacterial Lineages.

Wiles TJ, Wall ES, Schlomann BH, Hay EA, Parthasarathy R, Guillemin K.

MBio. 2018 Oct 9;9(5). pii: e01877-18. doi: 10.1128/mBio.01877-18.


Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence.

Andrique C, Morardet L, Linares LK, Cissé MY, Merle C, Chibon F, Provot S, Haÿ E, Ea HK, Cohen-Solal M, Modrowski D.

JCI Insight. 2018 Sep 6;3(17). pii: 121225. doi: 10.1172/jci.insight.121225. [Epub ahead of print]


Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain.

Healey EL, Afolabi EK, Lewis M, Edwards JJ, Jordan KP, Finney A, Jinks C, Hay EM, Dziedzic KS.

BMC Musculoskelet Disord. 2018 Aug 17;19(1):295. doi: 10.1186/s12891-018-2196-2.


Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC).

Williams NH, Jenkins A, Goulden N, Hoare Z, Hughes DA, Wood E, Foster NE, Walsh D, Carnes D, Sparkes V, Hay EM, Isaacs J, Konstantinou K, Morrissey D, Karppinen J, Genevay S, Wilkinson C.

Trials. 2018 Jul 31;19(1):408. doi: 10.1186/s13063-018-2801-6.


Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials.

Hay E, Dziedzic K, Foster N, Peat G, van der Windt D, Bartlam B, Blagojevic-Bucknall M, Edwards J, Healey E, Holden M, Hughes R, Jinks C, Jordan K, Jowett S, Lewis M, Mallen C, Morden A, Nicholls E, Ong BN, Porcheret M, Wulff J, Kigozi J, Oppong R, Paskins Z, Croft P.

Southampton (UK): NIHR Journals Library; 2018 Jul.


Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4.

Sergi D, Morris AC, Kahn DE, McLean FH, Hay EA, Kubitz P, MacKenzie A, Martinoli MG, Drew JE, Williams LM.

Nutr Neurosci. 2018 Jul 21:1-14. doi: 10.1080/1028415X.2018.1501533. [Epub ahead of print]


Correction: Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells.

Mansouri R, Jouan Y, Hay E, Blin-Wakkach C, Frain M, Ostertag A, Le Henaff C, Marty C, Geoffroy V, Marie PJ, Cohen-Solal M, Modrowski D.

Cell Death Dis. 2018 Jul 16;9(8):788. doi: 10.1038/s41419-018-0830-4.


Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice.

Lin H, Hay E, Latourte A, Funck-Brentano T, Bouaziz W, Ea HK, Khatib AM, Richette P, Cohen-Solal M.

Sci Rep. 2018 Jul 11;8(1):10488. doi: 10.1038/s41598-018-28713-2.


A multi-modal recruitment strategy using social media and internet-mediated methods to recruit a multidisciplinary, international sample of clinicians to an online research study.

McRobert CJ, Hill JC, Smale T, Hay EM, van der Windt DA.

PLoS One. 2018 Jul 6;13(7):e0200184. doi: 10.1371/journal.pone.0200184. eCollection 2018.


Routine micturating cystourethrogram for multicystic dysplastic kidneys: have we moved on?

Shankar S, Hay E, Ray S.

Arch Dis Child. 2018 Nov;103(11):1094-1095. doi: 10.1136/archdischild-2018-315197. Epub 2018 Jul 2. No abstract available.


Objective detection of chronic stress using physiological parameters.

Al Abdi RM, Alhitary AE, Abdul Hay EW, Al-Bashir AK.

Med Biol Eng Comput. 2018 Jun 18. doi: 10.1007/s11517-018-1854-8. [Epub ahead of print]


Genomic predictions combining SNP markers and copy number variations in Nellore cattle.

Hay EHA, Utsunomiya YT, Xu L, Zhou Y, Neves HHR, Carvalheiro R, Bickhart DM, Ma L, Garcia JF, Liu GE.

BMC Genomics. 2018 Jun 5;19(1):441. doi: 10.1186/s12864-018-4787-6.


Clinical diagnostic model for sciatica developed in primary care patients with low back-related leg pain.

Stynes S, Konstantinou K, Ogollah R, Hay EM, Dunn KM.

PLoS One. 2018 Apr 5;13(4):e0191852. doi: 10.1371/journal.pone.0191852. eCollection 2018.


Cost-utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: results from the POST Trial.

Kigozi J, Jowett S, Nicholl BI, Lewis M, Bartlam B, Green D, Belcher J, Clarkson K, Lingard Z, Pope C, Chew-Graham CA, Croft P, Hay EM, Peat G, Mallen CD.

Arthritis Care Res (Hoboken). 2018 Apr 2. doi: 10.1002/acr.23568. [Epub ahead of print]


Cost-effectiveness of a model consultation to support self-management in patients with osteoarthritis.

Oppong R, Jowett S, Lewis M, Clarkson K, Paskins Z, Croft P, Edwards JJ, Healey E, Jordan KP, Morden A, Ong BN, Porcheret M, Finney A, Hay E, Dziedzic K.

Rheumatology (Oxford). 2018 Jun 1;57(6):1056-1063. doi: 10.1093/rheumatology/key037.


Using an internet intervention to support self-management of low back pain in primary care: findings from a randomised controlled feasibility trial (SupportBack).

Geraghty AWA, Stanford R, Stuart B, Little P, Roberts LC, Foster NE, Hill JC, Hay EM, Turner D, Malakan W, Leigh L, Yardley L.

BMJ Open. 2018 Mar 9;8(3):e016768. doi: 10.1136/bmjopen-2017-016768.


Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials.

Green DJ, Lewis M, Mansell G, Artus M, Dziedzic KS, Hay EM, Foster NE, van der Windt DA.

Eur J Pain. 2018 Jul;22(6):1057-1070. doi: 10.1002/ejp.1190. Epub 2018 Feb 22.


Novel approach to characterising individuals with low back-related leg pain: cluster identification with latent class analysis and 12-month follow-up.

Stynes S, Konstantinou K, Ogollah R, Hay EM, Dunn KM.

Pain. 2018 Apr;159(4):728-738. doi: 10.1097/j.pain.0000000000001147.


Fast genomic prediction of breeding values using parallel Markov chain Monte Carlo with convergence diagnosis.

Guo P, Zhu B, Niu H, Wang Z, Liang Y, Chen Y, Zhang L, Ni H, Guo Y, Hay EHA, Gao X, Gao H, Wu X, Xu L, Li J.

BMC Bioinformatics. 2018 Jan 3;19(1):3. doi: 10.1186/s12859-017-2003-3.


Genomic prediction of continuous and binary fertility traits of females in a composite beef cattle breed.

Toghiani S, Hay E, Sumreddee P, Geary TW, Rekaya R, Roberts AJ.

J Anim Sci. 2017 Nov;95(11):4787-4795. doi: 10.2527/jas2017.1944.


The feasibility and acceptability of a physical activity intervention for older people with chronic musculoskeletal pain: The iPOPP pilot trial protocol.

Healey EL, Jinks C, Foster NE, Chew-Graham CA, Pincus T, Hartshorne L, Cooke K, Nicholls E, Proctor J, Lewis M, Dent S, Wathall S, Hay EM, McBeth J.

Musculoskeletal Care. 2018 Mar;16(1):118-132. doi: 10.1002/msc.1222. Epub 2017 Dec 8.


Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort.

Konstantinou K, Dunn KM, Ogollah R, Lewis M, van der Windt D, Hay EM; ATLAS Study Team.

Spine J. 2018 Jun;18(6):1030-1040. doi: 10.1016/j.spinee.2017.10.071. Epub 2017 Nov 21.


Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica.

Williams NH, Jenkins A, Goulden N, Hoare Z, Hughes DA, Wood E, Foster NE, Walsh DA, Carnes D, Sparkes V, Hay EM, Isaacs J, Konstantinou K, Morrissey D, Karppinen J, Genevay S, Wilkinson C.

Health Technol Assess. 2017 Oct;21(60):1-180. doi: 10.3310/hta21600.


Implementing core NICE guidelines for osteoarthritis in primary care with a model consultation (MOSAICS): a cluster randomised controlled trial.

Dziedzic KS, Healey EL, Porcheret M, Afolabi EK, Lewis M, Morden A, Jinks C, McHugh GA, Ryan S, Finney A, Main C, Edwards JJ, Paskins Z, Pushpa-Rajah A, Hay EM.

Osteoarthritis Cartilage. 2018 Jan;26(1):43-53. doi: 10.1016/j.joca.2017.09.010. Epub 2017 Oct 14.


Genotype by environment interaction effects in genetic evaluation of preweaning gain for Line 1 Hereford cattle from Miles City, Montana.

MacNeil MD, Cardoso FF, Hay E.

J Anim Sci. 2017 Sep;95(9):3833-3838. doi: 10.2527/jas2017.1829.


Effectiveness and costs of a vocational advice service to improve work outcomes in patients with musculoskeletal pain in primary care: a cluster randomised trial (SWAP trial ISRCTN 52269669).

Wynne-Jones G, Artus M, Bishop A, Lawton SA, Lewis M, Jowett S, Kigozi J, Main C, Sowden G, Wathall S, Burton AK, van der Windt DA, Hay EM, Foster NE; SWAP Study Team.

Pain. 2018 Jan;159(1):128-138. doi: 10.1097/j.pain.0000000000001075.


Passive and Active Microrheology of the Intestinal Fluid of the Larval Zebrafish.

Taormina MJ, Hay EA, Parthasarathy R.

Biophys J. 2017 Aug 22;113(4):957-965. doi: 10.1016/j.bpj.2017.06.069.


Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells.

Mansouri R, Jouan Y, Hay E, Blin-Wakkach C, Frain M, Ostertag A, Le Henaff C, Marty C, Geoffroy V, Marie PJ, Cohen-Solal M, Modrowski D.

Cell Death Dis. 2017 Jun 29;8(6):e2902. doi: 10.1038/cddis.2017.287. Erratum in: Cell Death Dis. 2018 Jul 16;9(8):788.


CNV Analysis of Host Responses to Porcine Reproductive and Respiratory Syndrome Virus Infection.

Hay EHA, Choi I, Xu L, Zhou Y, Rowland RRR, Lunney JK, Liu GE.

J Genomics. 2017 May 24;5:58-63. doi: 10.7150/jgen.20358. eCollection 2017.


Effect of a model consultation informed by guidelines on recorded quality of care of osteoarthritis (MOSAICS): a cluster randomised controlled trial in primary care.

Jordan KP, Edwards JJ, Porcheret M, Healey EL, Jinks C, Bedson J, Clarkson K, Hay EM, Dziedzic KS.

Osteoarthritis Cartilage. 2017 Oct;25(10):1588-1597. doi: 10.1016/j.joca.2017.05.017. Epub 2017 Jun 4.


The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581).

Foster NE, Konstantinou K, Lewis M, Ogollah R, Dunn KM, van der Windt D, Beardmore R, Artus M, Bartlam B, Hill JC, Jowett S, Kigozi J, Mallen C, Saunders B, Hay EM.

BMC Musculoskelet Disord. 2017 Apr 26;18(1):172. doi: 10.1186/s12891-017-1513-5.


The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care.

Mallen CD, Nicholl BI, Lewis M, Bartlam B, Green D, Jowett S, Kigozi J, Belcher J, Clarkson K, Lingard Z, Pope C, Chew-Graham CA, Croft P, Hay EM, Peat G.

PLoS Med. 2017 Apr 11;14(4):e1002273. doi: 10.1371/journal.pmed.1002273. eCollection 2017 Apr.


STEMS pilot trial: a pilot cluster randomised controlled trial to investigate the addition of patient direct access to physiotherapy to usual GP-led primary care for adults with musculoskeletal pain.

Bishop A, Ogollah RO, Jowett S, Kigozi J, Tooth S, Protheroe J, Hay EM, Salisbury C, Foster NE; STEMS study team.

BMJ Open. 2017 Mar 12;7(3):e012987. doi: 10.1136/bmjopen-2016-012987.


Multiregional integration in the brain during resting-state fMRI activity.

Hay E, Ritter P, Lobaugh NJ, McIntosh AR.

PLoS Comput Biol. 2017 Mar 1;13(3):e1005410. doi: 10.1371/journal.pcbi.1005410. eCollection 2017 Mar.


Using the CRISPR/Cas9 system to understand neuropeptide biology and regulation.

Hay EA, Knowles C, Kolb A, MacKenzie A.

Neuropeptides. 2017 Aug;64:19-25. doi: 10.1016/j.npep.2016.11.010. Epub 2016 Dec 3. Review.


Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues.

Al-Jazzar A, Javaheri B, Prideaux M, Boyde A, Scudamore CL, Cherifi C, Hay E, Hopkinson M, Boyd M, Cohen-Solal M, Farquharson C, Pitsillides AA.

Int J Mol Sci. 2016 Dec 26;18(1). pii: E29. doi: 10.3390/ijms18010029.


A seasonal switch in histone deacetylase gene expression in the hypothalamus and their capacity to modulate nuclear signaling pathways.

Stoney PN, Rodrigues D, Helfer G, Khatib T, Ashton A, Hay EA, Starr R, Kociszewska D, Morgan P, McCaffery P.

Brain Behav Immun. 2017 Mar;61:340-352. doi: 10.1016/j.bbi.2016.12.013. Epub 2016 Dec 18.


Analysis of binary responses with outcome-specific misclassification probability in genome-wide association studies.

Rekaya R, Smith S, Hay EH, Farhat N, Aggrey SE.

Appl Clin Genet. 2016 Nov 30;9:169-177. eCollection 2016.


An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome.

Hay EA, Khalaf AR, Marini P, Brown A, Heath K, Sheppard D, MacKenzie A.

Neuropeptides. 2017 Aug;64:101-107. doi: 10.1016/j.npep.2016.11.003. Epub 2016 Nov 4.


Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis.

Latourte A, Cherifi C, Maillet J, Ea HK, Bouaziz W, Funck-Brentano T, Cohen-Solal M, Hay E, Richette P.

Ann Rheum Dis. 2017 Apr;76(4):748-755. doi: 10.1136/annrheumdis-2016-209757. Epub 2016 Oct 27.


Keele Aches and Pains Study protocol: validity, acceptability, and feasibility of the Keele STarT MSK tool for subgrouping musculoskeletal patients in primary care.

Campbell P, Hill JC, Protheroe J, Afolabi EK, Lewis M, Beardmore R, Hay EM, Mallen CD, Bartlam B, Saunders B, van der Windt DA, Jowett S, Foster NE, Dunn KM.

J Pain Res. 2016 Oct 14;9:807-818. eCollection 2016.


Intradermal grass pollen immunotherapy increases TH2 and IgE responses and worsens respiratory allergic symptoms.

Slovick A, Douiri A, Muir R, Guerra A, Tsioulos K, Hay E, Lam EPS, Kelly J, Peacock JL, Ying S, Shamji MH, Cousins DJ, Durham SR, Till SJ.

J Allergy Clin Immunol. 2017 Jun;139(6):1830-1839.e13. doi: 10.1016/j.jaci.2016.09.024. Epub 2016 Oct 20.


Sclerostin and Bone Aging: A Mini-Review.

Hay E, Bouaziz W, Funck-Brentano T, Cohen-Solal M.

Gerontology. 2016;62(6):618-623. Epub 2016 May 14. Review.


Reconsultation, self-reported health status and costs following treatment at a musculoskeletal Clinical Assessment and Treatment Service (CATS): a 12-month prospective cohort study.

Roddy E, Jordan KP, Oppong R, Chen Y, Jowett S, Dawes P, Hider SL, Packham J, Stevenson K, Zwierska I, Hay EM.

BMJ Open. 2016 Oct 12;6(10):e011735. doi: 10.1136/bmjopen-2016-011735.


The clinical and cost effectiveness of steroid injection compared with night splints for carpal tunnel syndrome: the INSTINCTS randomised clinical trial study protocol.

Chesterton LS, Dziedzic KS, van der Windt DA, Davenport G, Myers HL, Rathod T, Blagojevic-Bucknall M, Jowet SM, Burton C, Roddy E, Hay EM.

BMC Musculoskelet Disord. 2016 Oct 6;17(1):415.


Reduced representation bisulphite sequencing of ten bovine somatic tissues reveals DNA methylation patterns and their impacts on gene expression.

Zhou Y, Xu L, Bickhart DM, Abdel Hay EH, Schroeder SG, Connor EE, Alexander LJ, Sonstegard TS, Van Tassell CP, Chen H, Liu GE.

BMC Genomics. 2016 Oct 6;17(1):779.

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