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Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.

Campos G, Schmidt-Heck W, De Smedt J, Widera A, Ghallab A, Pütter L, González D, Edlund K, Cadenas C, Marchan R, Guthke R, Verfaillie C, Hetz C, Sachinidis A, Braeuning A, Schwarz M, Weiß TS, Banhart BK, Hoek J, Vadigepalli R, Willy J, Stevens JL, Hay DC, Hengstler JG, Godoy P.

Arch Toxicol. 2020 Jan 9. doi: 10.1007/s00204-019-02630-3. [Epub ahead of print]


Cord compression defined by MRI is the driving factor behind the decision to operate in Degenerative Cervical Myelopathy despite poor correlation with disease severity.

Hilton B, Tempest-Mitchell J, Davies BM, Francis J, Mannion RJ, Trivedi R, Timofeev I, Crawford JR, Hay D, Laing RJ, Hutchinson PJ, Kotter MRN.

PLoS One. 2019 Dec 26;14(12):e0226020. doi: 10.1371/journal.pone.0226020. eCollection 2019.


Fimbrial dermoid cyst with elevated CA19-9 levels: A case report.

Hay D, Biswas B, Dasgupta J.

Case Rep Womens Health. 2019 Oct 15;24:e00156. doi: 10.1016/j.crwh.2019.e00156. eCollection 2019 Oct.


Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.

Sander KN, Kim DH, Ortori CA, Warren AY, Anyanwagu UC, Hay DP, Broughton Pipkin F, Khan RN, Barrett DA.

Metabolomics. 2019 Nov 27;15(12):157. doi: 10.1007/s11306-019-1600-8.


Laparoscopic management of a migrated intragastric balloon causing mechanical small bowel obstruction: a case report and review of the literature.

Hay D, Ryan G, Somasundaram M, Yip V, Navaratne L.

Ann R Coll Surg Engl. 2019 Nov;101(8):e172-e177. doi: 10.1308/rcsann.2019.0104. Epub 2019 Sep 6. Review.


Pharmacological profile of vascular activity of human stem villous arteries.

Sander KN, Ali TY, Warren AY, Hay DP, Broughton Pipkin F, Barrett DA, Khan RN.

Placenta. 2019 Dec;88:12-19. doi: 10.1016/j.placenta.2019.09.009. Epub 2019 Sep 17.


Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells.

Calabrese D, Roma G, Bergling S, Carbone W, Mele V, Nuciforo S, Fofana I, Campana B, Szkolnicka D, Hay DC, Tchorz J, Bouwmeester T, Wieland S, Heim MH.

PLoS One. 2019 Aug 29;14(8):e0221762. doi: 10.1371/journal.pone.0221762. eCollection 2019.


Serum Free Production of Three-dimensional Human Hepatospheres from Pluripotent Stem Cells.

Lucendo-Villarin B, Rashidi H, Alhaque S, Fischer L, Meseguer-Ripolles J, Wang Y, O'Farrelly C, Themis M, Hay DC.

J Vis Exp. 2019 Jul 20;(149). doi: 10.3791/59965.


A comparison of radiological descriptions of spinal cord compression with quantitative measures, and their role in non-specialist clinical management.

Tempest-Mitchell J, Hilton B, Davies BM, Nouri A, Hutchinson PJ, Scoffings DJ, Mannion RJ, Trivedi R, Timofeev I, Crawford JR, Hay D, Laing RJ, Kotter MRN.

PLoS One. 2019 Jul 22;14(7):e0219380. doi: 10.1371/journal.pone.0219380. eCollection 2019.


Pharmacological Characterization and Investigation of N-Terminal Loop Amino Acids of Adrenomedullin 2 That Are Important for Receptor Activation.

Musa H, Hendrikse ER, Brimble MA, Garelja ML, Watkins HA, Harris PWR, Hay DL.

Biochemistry. 2019 Aug 13;58(32):3468-3474. doi: 10.1021/acs.biochem.9b00571. Epub 2019 Jul 29.


Metabolic control of gene transcription in non-alcoholic fatty liver disease: the role of the epigenome.

Sinton MC, Hay DC, Drake AJ.

Clin Epigenetics. 2019 Jul 18;11(1):104. doi: 10.1186/s13148-019-0702-5. Review.


Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation.

Wang Y, Tatham MH, Schmidt-Heck W, Swann C, Singh-Dolt K, Meseguer-Ripolles J, Lucendo-Villarin B, Kunath T, Rudd TR, Smith AJH, Hengstler JG, Godoy P, Hay RT, Hay DC.

iScience. 2019 Jun 28;16:206-217. doi: 10.1016/j.isci.2019.05.028. Epub 2019 May 24.


Blended electrospinning with human liver extracellular matrix for engineering new hepatic microenvironments.

Grant R, Hallett J, Forbes S, Hay D, Callanan A.

Sci Rep. 2019 Apr 18;9(1):6293. doi: 10.1038/s41598-019-42627-7.


Prevalence of maternal psychiatric disorder in pregnancy: 1986 and 2016.

Pawlby S, Sharp D, Hay DF.

Br J Psychiatry. 2019 Feb;214(2):116. doi: 10.1192/bjp.2018.281. No abstract available.


'H, I, J, K, L, M, N, O, PEE! Get it? Pee!': Siblings' shared humour in childhood.

Paine AL, Howe N, Karajian G, Hay DF, DeHart G.

Br J Dev Psychol. 2019 Sep;37(3):336-353. doi: 10.1111/bjdp.12277. Epub 2019 Jan 9.


The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae.

Rausch V, Bostrom JR, Park J, Bravo IR, Feng Y, Hay DC, Link BA, Hansen CG.

Curr Biol. 2019 Jan 21;29(2):242-255.e6. doi: 10.1016/j.cub.2018.11.066. Epub 2018 Dec 27.


Combining stem cell-derived hepatocytes with impedance sensing to better predict human drug toxicity.

Zhou W, Graham K, Lucendo-Villarin B, Flint O, Hay DC, Bagnaninchi P.

Expert Opin Drug Metab Toxicol. 2019 Jan;15(1):77-83. doi: 10.1080/17425255.2019.1558208. Epub 2018 Dec 20.


New Insights into the Regulation of CGRP-Family Receptors.

Gingell JJ, Hendrikse ER, Hay DL.

Trends Pharmacol Sci. 2019 Jan;40(1):71-83. doi: 10.1016/ Epub 2018 Dec 4. Review.


Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop.

Stacey G, Andrews P, Asante C, Barbaric I, Barry J, Bisset L, Braybrook J, Buckle R, Chandra A, Coffey P, Crouch S, Driver P, Evans A, Gardner J, Ginty P, Goldring C, Hay DC, Healy L, Hows A, Hutchinson C, Jesson H, Kalber T, Kimber S, Leathers R, Moyle S, Murray T, Neale M, Pan D, Park BK, Rebolledo RE, Rees I, Rivolta MN, Ritchie A, Roos EJ, Saeb-Parsy K, Schröder B, Sebastian S, Thomas A, Thomas RJ, Turner M, Vallier L, Vitillo L, Webster A, Williams D.

Regen Med. 2018 Dec;13(8):935-944. doi: 10.2217/rme-2018-0120. Epub 2018 Nov 29. Erratum in: Regen Med. 2019 Oct;14(10):981.


Informants' ratings of activity level in infancy predict ADHD symptoms and diagnoses in childhood.

Meeuwsen M, Perra O, van Goozen SHM, Hay DF.

Dev Psychopathol. 2018 Oct 15:1-15. doi: 10.1017/S0954579418000597. [Epub ahead of print]


Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.

Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM.

Nature. 2018 Sep;561(7724):492-497. doi: 10.1038/s41586-018-0535-y. Epub 2018 Sep 12.


3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.

Rashidi H, Luu NT, Alwahsh SM, Ginai M, Alhaque S, Dong H, Tomaz RA, Vernay B, Vigneswara V, Hallett JM, Chandrashekran A, Dhawan A, Vallier L, Bradley M, Callanan A, Forbes SJ, Newsome PN, Hay DC.

Arch Toxicol. 2018 Oct;92(10):3117-3129. doi: 10.1007/s00204-018-2280-2. Epub 2018 Aug 28.


Evaluation of extraction and normalisation strategies for the analysis of lipids in placental vessels.

Sander KN, Hay DP, Broughton Pipkin F, Khan RN, Barrett DA.

J Pharm Biomed Anal. 2018 Oct 25;160:297-300. doi: 10.1016/j.jpba.2018.08.012. Epub 2018 Aug 7.


Semi-automated Production of Hepatocyte Like Cells from Pluripotent Stem Cells.

Meseguer-Ripolles J, Lucendo-Villarin B, Wang Y, Hay DC.

J Vis Exp. 2018 Jul 27;(137). doi: 10.3791/57995.


Amyloidogenicity, Cytotoxicity, and Receptor Activity of Bovine Amylin: Implications for Xenobiotic Transplantation and the Design of Nontoxic Amylin Variants.

Akter R, Bower RL, Abedini A, Schmidt AM, Hay DL, Raleigh DP.

ACS Chem Biol. 2018 Sep 21;13(9):2747-2757. doi: 10.1021/acschembio.8b00690. Epub 2018 Aug 22.


Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex.

Simms J, Uddin R, Sakmar TP, Gingell JJ, Garelja ML, Hay DL, Brimble MA, Harris PW, Reynolds CA, Poyner DR.

Biochemistry. 2018 Aug 14;57(32):4915-4922. doi: 10.1021/acs.biochem.8b00502. Epub 2018 Jul 25.


Quantitative feature analysis of continuous analytic wavelet transforms of electrocardiography and electromyography.

Wachowiak MP, Wachowiak-Smolíková R, Johnson MJ, Hay DC, Power KE, Williams-Bell FM.

Philos Trans A Math Phys Eng Sci. 2018 Aug 13;376(2126). pii: 20170250. doi: 10.1098/rsta.2017.0250.


Solid-Phase Thiol-Ene Lipidation of Peptides for the Synthesis of a Potent CGRP Receptor Antagonist.

Williams ET, Harris PWR, Jamaluddin MA, Loomes KM, Hay DL, Brimble MA.

Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11640-11643. doi: 10.1002/anie.201805208. Epub 2018 Aug 6.


CGRP Receptor Biology: Is There More Than One Receptor?

Hay DL.

Handb Exp Pharmacol. 2019;255:13-22. doi: 10.1007/164_2018_131.


Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells.

Lyall MJ, Cartier J, Thomson JP, Cameron K, Meseguer-Ripolles J, O'Duibhir E, Szkolnicka D, Villarin BL, Wang Y, Blanco GR, Dunn WB, Meehan RR, Hay DC, Drake AJ.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170362. doi: 10.1098/rstb.2017.0362.


Developing defined substrates for stem cell culture and differentiation.

Hagbard L, Cameron K, August P, Penton C, Parmar M, Hay DC, Kallur T.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170230. doi: 10.1098/rstb.2017.0230. Review.


Innate immunity in stem cell-derived hepatocytes.

Fischer L, Hay DC, O'Farrelly C.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170220. doi: 10.1098/rstb.2017.0220. Review.


A human iPSC line capable of differentiating into functional macrophages expressing ZsGreen: a tool for the study and in vivo tracking of therapeutic cells.

Lopez-Yrigoyen M, Fidanza A, Cassetta L, Axton RA, Taylor AH, Meseguer-Ripolles J, Tsakiridis A, Wilson V, Hay DC, Pollard JW, Forrester LM.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170219. doi: 10.1098/rstb.2017.0219.


Designer human tissue: coming to a lab near you.

Hay DC, O'Farrelly C.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170212. doi: 10.1098/rstb.2017.0212.


Molecular studies of CGRP and the CGRP family of peptides in the central nervous system.

Hendrikse ER, Bower RL, Hay DL, Walker CS.

Cephalalgia. 2019 Mar;39(3):403-419. doi: 10.1177/0333102418765787. Epub 2018 Mar 22.


Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.

Dal Maso E, Zhu Y, Pham V, Reynolds CA, Deganutti G, Hick CA, Yang D, Christopoulos A, Hay DL, Wang MW, Sexton PM, Furness SGB, Wootten D.

Biochem Pharmacol. 2018 Apr;150:214-244. doi: 10.1016/j.bcp.2018.02.005. Epub 2018 Feb 16.


Correction to: Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety.

Meseguer-Ripolles J, Khetani SR, Blanco JG, Iredale M, Hay DC.

AAPS J. 2018 Feb 12;20(2):30. doi: 10.1208/s12248-018-0191-z.


Receptor Activity Modifying Proteins Have Limited Effects on the Class B G Protein-Coupled Receptor Calcitonin Receptor-Like Receptor Stalk.

Garelja ML, Walker CA, Siow A, Yang SH, Harris PWR, Brimble MA, Watkins HA, Gingell JJ, Hay DL.

Biochemistry. 2018 Feb 27;57(8):1410-1422. doi: 10.1021/acs.biochem.7b01180. Epub 2018 Feb 7.


Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists.

Booe JM, Warner ML, Roehrkasse AM, Hay DL, Pioszak AA.

Mol Pharmacol. 2018 Apr;93(4):355-367. doi: 10.1124/mol.117.110916. Epub 2018 Jan 23.


Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety.

Meseguer-Ripolles J, Khetani SR, Blanco JG, Iredale M, Hay DC.

AAPS J. 2017 Dec 21;20(1):20. doi: 10.1208/s12248-017-0171-8. Review. Erratum in: AAPS J. 2018 Feb 12;20(2):30.


Assessment of Three-Dimensional Trunk Kinematics and Muscle Activation during Cycling with Independent Cranks.

Bourdon E, Mavor M, Hay DC.

J Sports Sci Med. 2017 Dec 1;16(4):536-542. eCollection 2017 Dec.


Liver cell therapy: is this the end of the beginning?

Alwahsh SM, Rashidi H, Hay DC.

Cell Mol Life Sci. 2018 Apr;75(8):1307-1324. doi: 10.1007/s00018-017-2713-8. Epub 2017 Nov 27. Review.


Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor.

Gao Y, Zhang X, Zhang L, Cen J, Ni X, Liao X, Yang C, Li Y, Chen X, Zhang Z, Shu Y, Cheng X, Hay DC, Lai D, Pan G, Wei G, Hui L.

Stem Cell Reports. 2017 Dec 12;9(6):1813-1824. doi: 10.1016/j.stemcr.2017.10.019. Epub 2017 Nov 22.


Chemical probes and inhibitors of bromodomains outside the BET family.

Moustakim M, Clark PGK, Hay DA, Dixon DJ, Brennan PE.

Medchemcomm. 2016 Dec 7;7(12):2246-2264. doi: 10.1039/c6md00373g. Epub 2016 Sep 7. Review.


The effects of weighted skates on ice-skating kinematics, kinetics and muscular activity.

Mavor MP, Hay DC, Graham RB.

J Sports Sci. 2018 Jul;36(14):1623-1629. doi: 10.1080/02640414.2017.1407033. Epub 2017 Nov 21.


Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25.

Hay DL, Garelja ML, Poyner DR, Walker CS.

Br J Pharmacol. 2018 Jan;175(1):3-17. doi: 10.1111/bph.14075. Epub 2017 Nov 28. Review.


Erratum to: Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells.

Lucendo-Villarin B, Filis P, Swortwood MJ, Huestis MA, Meseguer-Ripolles J, Cameron K, Iredale JP, O'Shaughnessy PJ, Fowler PA, Hay DC.

Arch Toxicol. 2017 Nov;91(11):3645. doi: 10.1007/s00204-017-2075-x.


The evaluation of anaemia in an older primary care population: retrospective population-based study.

McCartney D, Shine B, Hay D, Lasserson DS.

BJGP Open. 2017 Oct 4;1(4):bjgpopen17X101157. doi: 10.3399/bjgpopen17X101157. eCollection 2018 Jan.


Late, but not early, arriving younger siblings foster firstborns' understanding of second-order false belief.

Paine AL, Pearce H, van Goozen SHM, de Sonneville LMJ, Hay DF.

J Exp Child Psychol. 2018 Feb;166:251-265. doi: 10.1016/j.jecp.2017.08.007. Epub 2017 Sep 22.


Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.

Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR.

Nat Commun. 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7.

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