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Items: 1 to 50 of 75

1.

Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive.

Oberhofer G, Ivy T, Hay BA.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6250-6259. doi: 10.1073/pnas.1816928116. Epub 2019 Feb 13.

2.

Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs.

Oberhofer G, Ivy T, Hay BA.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9343-E9352. doi: 10.1073/pnas.1805278115. Epub 2018 Sep 17.

3.

Engineered Reciprocal Chromosome Translocations Drive High Threshold, Reversible Population Replacement in Drosophila.

Buchman AB, Ivy T, Marshall JM, Akbari OS, Hay BA.

ACS Synth Biol. 2018 May 18;7(5):1359-1370. doi: 10.1021/acssynbio.7b00451. Epub 2018 Apr 13.

4.

Vectored gene delivery for lifetime animal contraception: Overview and hurdles to implementation.

Hay BA, Li J, Guo M.

Theriogenology. 2018 May;112:63-74. doi: 10.1016/j.theriogenology.2017.11.003. Epub 2017 Nov 8. Review.

5.

Rules of the road for insect gene drive research and testing.

Adelman Z, Akbari O, Bauer J, Bier E, Bloss C, Carter SR, Callender C, Denis AC, Cowhey P, Dass B, Delborne J, Devereaux M, Ellsworth P, Friedman RM, Gantz V, Gibson C, Hay BA, Hoddle M, James AA, James S, Jorgenson L, Kalichman M, Marshall J, McGinnis W, Newman J, Pearson A, Quemada H, Rudenko L, Shelton A, Vinetz JM, Weisman J, Wong B, Wozniak C.

Nat Biotechnol. 2017 Aug 8;35(8):716-718. doi: 10.1038/nbt.3926. No abstract available.

6.

A positive readout single transcript reporter for site-specific mRNA cleavage.

Kandul N, Guo M, Hay BA.

PeerJ. 2017 Jul 20;5:e3602. doi: 10.7717/peerj.3602. eCollection 2017.

7.

Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants.

Zhang T, Mishra P, Hay BA, Chan D, Guo M.

Elife. 2017 Mar 21;6. pii: e17834. doi: 10.7554/eLife.17834.

8.

Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila.

Kandul NP, Zhang T, Hay BA, Guo M.

Nat Commun. 2016 Nov 14;7:13100. doi: 10.1038/ncomms13100.

9.

Mapping a multiplexed zoo of mRNA expression.

Choi HM, Calvert CR, Husain N, Huss D, Barsi JC, Deverman BE, Hunter RC, Kato M, Lee SM, Abelin AC, Rosenthal AZ, Akbari OS, Li Y, Hay BA, Sternberg PW, Patterson PH, Davidson EH, Mazmanian SK, Prober DA, van de Rijn M, Leadbetter JR, Newman DK, Readhead C, Bronner ME, Wold B, Lansford R, Sauka-Spengler T, Fraser SE, Pierce NA.

Development. 2016 Oct 1;143(19):3632-3637.

10.

Identification of Genes Uniquely Expressed in the Germ-Line Tissues of the Jewel Wasp Nasonia vitripennis.

Ferree PM, Fang C, Mastrodimos M, Hay BA, Amrhein H, Akbari OS.

G3 (Bethesda). 2015 Oct 13;5(12):2647-53. doi: 10.1534/g3.115.021386.

11.

Vectored antibody gene delivery mediates long-term contraception.

Li J, Olvera AI, Akbari OS, Moradian A, Sweredoski MJ, Hess S, Hay BA.

Curr Biol. 2015 Oct 5;25(19):R820-2. doi: 10.1016/j.cub.2015.08.002.

12.

Radiosynthesis and ex vivo evaluation of [(18)F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazolidin-2-one for imaging MAO-B with PET.

Hicks JW, Sadovski O, Parkes J, Houle S, Hay BA, Carter RL, Wilson AA, Vasdev N.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):288-91. doi: 10.1016/j.bmcl.2014.11.048. Epub 2014 Nov 24.

PMID:
25488845
13.

Medusa: a novel gene drive system for confined suppression of insect populations.

Marshall JM, Hay BA.

PLoS One. 2014 Jul 23;9(7):e102694. doi: 10.1371/journal.pone.0102694. eCollection 2014.

14.

Olecranon bursitis: a systematic overview.

Blackwell JR, Hay BA, Bolt AM, Hay SM.

Shoulder Elbow. 2014 Jul;6(3):182-90. doi: 10.1177/1758573214532787. Epub 2014 May 6. Review.

15.

Identification of germline transcriptional regulatory elements in Aedes aegypti.

Akbari OS, Papathanos PA, Sandler JE, Kennedy K, Hay BA.

Sci Rep. 2014 Feb 4;4:3954. doi: 10.1038/srep03954.

16.

Transcriptome profiling of Nasonia vitripennis testis reveals novel transcripts expressed from the selfish B chromosome, paternal sex ratio.

Akbari OS, Antoshechkin I, Hay BA, Ferree PM.

G3 (Bethesda). 2013 Sep 4;3(9):1597-605. doi: 10.1534/g3.113.007583.

17.

The developmental transcriptome of the mosquito Aedes aegypti, an invasive species and major arbovirus vector.

Akbari OS, Antoshechkin I, Amrhein H, Williams B, Diloreto R, Sandler J, Hay BA.

G3 (Bethesda). 2013 Sep 4;3(9):1493-509. doi: 10.1534/g3.113.006742.

18.

Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila; a theoretical exploration of Medea-dependent population suppression.

Akbari OS, Chen CH, Marshall JM, Huang H, Antoshechkin I, Hay BA.

ACS Synth Biol. 2014 Dec 19;3(12):915-28. doi: 10.1021/sb300079h. Epub 2012 Dec 28.

19.

A synthetic gene drive system for local, reversible modification and suppression of insect populations.

Akbari OS, Matzen KD, Marshall JM, Huang H, Ward CM, Hay BA.

Curr Biol. 2013 Apr 22;23(8):671-7. doi: 10.1016/j.cub.2013.02.059. Epub 2013 Mar 28.

20.

General principles of single-construct chromosomal gene drive.

Marshall JM, Hay BA.

Evolution. 2012 Jul;66(7):2150-66. doi: 10.1111/j.1558-5646.2012.01582.x. Epub 2012 Mar 9.

21.

Molecular insights into Parkinson's disease.

Rochet JC, Hay BA, Guo M.

Prog Mol Biol Transl Sci. 2012;107:125-88. doi: 10.1016/B978-0-12-385883-2.00011-4. Review.

PMID:
22482450
22.

Joint effect of single-nucleotide polymorphisms and smoking exposure in chronic obstructive pulmonary disease risk.

Young RP, Hopkins RJ, Hay BA, Gamble GD.

Am J Respir Crit Care Med. 2012 Mar 15;185(6):683; author reply 683-4. No abstract available.

PMID:
22422905
23.

Confinement of gene drive systems to local populations: a comparative analysis.

Marshall JM, Hay BA.

J Theor Biol. 2012 Feb 7;294:153-71. doi: 10.1016/j.jtbi.2011.10.032. Epub 2011 Nov 9.

24.

Does RAGE protect smokers from COPD?

Young RP, Hay BA, Hopkins RJ.

Eur Respir J. 2011 Sep;38(3):743-4; author reply 744. doi: 10.1183/09031936.00041711. No abstract available.

25.

Inverse Medea as a novel gene drive system for local population replacement: a theoretical analysis.

Marshall JM, Hay BA.

J Hered. 2011 May-Jun;102(3):336-41. doi: 10.1093/jhered/esr019.

26.

Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD.

Young RP, Hopkins RJ, Whittington CF, Hay BA, Epton MJ, Gamble GD.

PLoS One. 2011 Feb 3;6(2):e16476. doi: 10.1371/journal.pone.0016476.

27.

GSTM1 null genotype in COPD and lung cancer: evidence of a modifier or confounding effect?

Young RP, Hopkins RJ, Hay BA, Gamble GD.

Appl Clin Genet. 2011 Sep 13;4:137-44. doi: 10.2147/TACG.S21517. Print 2011.

28.

FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer.

Young RP, Hopkins RJ, Hay BA, Whittington CF, Epton MJ, Gamble GD.

Appl Clin Genet. 2010 Dec 22;4:1-10. doi: 10.2147/TACG.S15758. Print 2011.

29.

Chromosome 4q31 locus in COPD is also associated with lung cancer.

Young RP, Whittington CF, Hopkins RJ, Hay BA, Epton MJ, Black PN, Gamble GD.

Eur Respir J. 2010 Dec;36(6):1375-82. doi: 10.1183/09031936.00033310.

30.

Semele: a killer-male, rescue-female system for suppression and replacement of insect disease vector populations.

Marshall JM, Pittman GW, Buchman AB, Hay BA.

Genetics. 2011 Feb;187(2):535-51. doi: 10.1534/genetics.110.124479. Epub 2010 Nov 15.

31.

Medea selfish genetic elements as tools for altering traits of wild populations: a theoretical analysis.

Ward CM, Su JT, Huang Y, Lloyd AL, Gould F, Hay BA.

Evolution. 2011 Apr;65(4):1149-62. doi: 10.1111/j.1558-5646.2010.01186.x. Epub 2010 Dec 22.

32.

Engineering the genomes of wild insect populations: challenges, and opportunities provided by synthetic Medea selfish genetic elements.

Hay BA, Chen CH, Ward CM, Huang H, Su JT, Guo M.

J Insect Physiol. 2010 Oct;56(10):1402-13. doi: 10.1016/j.jinsphys.2010.05.022. Epub 2010 Jun 9. Review.

33.

Inactivation of both Foxo and reaper promotes long-term adult neurogenesis in Drosophila.

Siegrist SE, Haque NS, Chen CH, Hay BA, Hariharan IK.

Curr Biol. 2010 Apr 13;20(7):643-8. doi: 10.1016/j.cub.2010.01.060. Epub 2010 Mar 25.

34.

A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.

Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD.

Postgrad Med J. 2009 Oct;85(1008):515-24. doi: 10.1136/pgmj.2008.077107.

PMID:
19789190
35.

Lung cancer susceptibility model based on age, family history and genetic variants.

Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD.

PLoS One. 2009;4(4):e5302. doi: 10.1371/journal.pone.0005302. Epub 2009 Apr 23.

36.

Lung cancer gene associated with COPD: triple whammy or possible confounding effect?

Young RP, Hopkins RJ, Hay BA, Epton MJ, Black PN, Gamble GD.

Eur Respir J. 2008 Nov;32(5):1158-64. doi: 10.1183/09031936.00093908.

37.

Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals.

Hawkins JL, Robbins MD, Warren LC, Xia D, Petras SF, Valentine JJ, Varghese AH, Wang IK, Subashi TA, Shelly LD, Hay BA, Landschulz KT, Geoghegan KF, Harwood HJ Jr.

J Pharmacol Exp Ther. 2008 Sep;326(3):801-8. doi: 10.1124/jpet.108.139626. Epub 2008 Jun 24.

PMID:
18577702
38.

Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary.

Shcherbata HR, Ward EJ, Fischer KA, Yu JY, Reynolds SH, Chen CH, Xu P, Hay BA, Ruohola-Baker H.

Cell Stem Cell. 2007 Dec 13;1(6):698-709. doi: 10.1016/j.stem.2007.11.007.

40.

Aminopyrrolidineamide inhibitors of site-1 protease.

Hay BA, Abrams B, Zumbrunn AY, Valentine JJ, Warren LC, Petras SF, Shelly LD, Xia A, Varghese AH, Hawkins JL, Van Camp JA, Robbins MD, Landschulz K, Harwood HJ Jr.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4411-4. Epub 2007 Jun 10.

PMID:
17583500
41.

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila.

Chen CH, Huang H, Ward CM, Su JT, Schaeffer LV, Guo M, Hay BA.

Science. 2007 Apr 27;316(5824):597-600. Epub 2007 Mar 29.

43.

Identifying microRNA regulators of cell death in Drosophila.

Chen CH, Guo M, Hay BA.

Methods Mol Biol. 2006;342:229-40. Review.

PMID:
16957378
44.

The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process.

Muro I, Berry DL, Huh JR, Chen CH, Huang H, Yoo SJ, Guo M, Baehrecke EH, Hay BA.

Development. 2006 Sep;133(17):3305-15. Epub 2006 Aug 3.

45.

Caspase-dependent cell death in Drosophila.

Hay BA, Guo M.

Annu Rev Cell Dev Biol. 2006;22:623-50. Review.

PMID:
16842034
46.

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin.

Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH, Yoo SJ, Hay BA, Guo M.

Nature. 2006 Jun 29;441(7097):1162-6. Epub 2006 May 3.

PMID:
16672981
47.

Structure and activation mechanism of the Drosophila initiator caspase Dronc.

Yan N, Huh JR, Schirf V, Demeler B, Hay BA, Shi Y.

J Biol Chem. 2006 Mar 31;281(13):8667-74. Epub 2006 Jan 30.

48.

The genetics of cell death: approaches, insights and opportunities in Drosophila.

Hay BA, Huh JR, Guo M.

Nat Rev Genet. 2004 Dec;5(12):911-22. Review.

PMID:
15573123
49.

MicroRNAs and the regulation of cell death.

Xu P, Guo M, Hay BA.

Trends Genet. 2004 Dec;20(12):617-24. Review.

PMID:
15522457

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