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HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.

Suskiewicz MJ, Zobel F, Ogden TEH, Fontana P, Ariza A, Yang JC, Zhu K, Bracken L, Hawthorne WJ, Ahel D, Neuhaus D, Ahel I.

Nature. 2020 Feb 6. doi: 10.1038/s41586-020-2013-6. [Epub ahead of print]


A large-scale species level dated angiosperm phylogeny for evolutionary and ecological analyses.

Janssens SB, Couvreur TLP, Mertens A, Dauby G, Dagallier LMJ, Vanden Abeele S, Vandelook F, Mascarello M, Beeckman H, Sosef M, Droissart V, van der Bank M, Maurin O, Hawthorne W, Marshall C, Réjou-Méchain M, Beina D, Baya F, Merckx V, Verstraete B, Hardy O.

Biodivers Data J. 2020 Jan 21;8:e39677. doi: 10.3897/BDJ.8.e39677. eCollection 2020.


Xenotransplantation literature update, November/December 2019.

Thomas A, Hawthorne WJ, Burlak C.

Xenotransplantation. 2020 Jan;27(1):e12582. doi: 10.1111/xen.12582. Epub 2020 Jan 26. Review.


Brief Normothermic Machine Perfusion Rejuvenates Discarded Human Kidneys.

Hameed AM, Lu DB, Patrick E, Xu B, Hu M, Chew YV, Keung K, P'ng CH, Gaspi R, Zhang C, Robertson P, Alexander S, Thomas G, Laurence J, De Roo R, Wong G, Miraziz R, O'Grady G, Yuen L, Hawthorne WJ, Rogers NM, Pleass HC.

Transplant Direct. 2019 Oct 8;5(11):e502. doi: 10.1097/TXD.0000000000000944. eCollection 2019 Nov.


Xenotransplantation literature update, September/October 2019.

Li X, Hawthorne WJ, Burlak C.

Xenotransplantation. 2019 Nov;26(6):e12573. doi: 10.1111/xen.12573. Epub 2019 Nov 25. No abstract available.


FokI-dCas9 mediates high-fidelity genome editing in pigs.

Fisicaro N, Salvaris EJ, Philip GK, Wakefield MJ, Nottle MB, Hawthorne WJ, Cowan PJ.

Xenotransplantation. 2020 Jan;27(1):e12551. doi: 10.1111/xen.12551. Epub 2019 Aug 12.


The long noncoding RNA MALAT1 predicts human pancreatic islet isolation quality.

Wong WK, Jiang G, Sørensen AE, Chew YV, Lee-Maynard C, Liuwantara D, Williams L, O'Connell PJ, Dalgaard LT, Ma RC, Hawthorne WJ, Joglekar MV, Hardikar AA.

JCI Insight. 2019 Jul 30;5. pii: 129299. doi: 10.1172/jci.insight.129299.


β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes.

Lalwani A, Warren J, Liuwantara D, Hawthorne WJ, O'Connell PJ, Gonzalez FJ, Stokes RA, Chen J, Laybutt DR, Craig ME, Swarbrick MM, King C, Gunton JE.

Cell Rep. 2019 May 21;27(8):2370-2384.e6. doi: 10.1016/j.celrep.2019.04.086.


Standardisation of flow cytometry for whole blood immunophenotyping of islet transplant and transplant clinical trial recipients.

Jimenez Vera E, Chew YV, Nicholson L, Burns H, Anderson P, Chen HT, Williams L, Keung K, Zanjani NT, Dervish S, Patrick E, Wang XM, Yi S, Hawthorne W, Alexander S, O'Connell PJ, Hu M.

PLoS One. 2019 May 22;14(5):e0217163. doi: 10.1371/journal.pone.0217163. eCollection 2019.


Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12-14, 2018: "The 2018 Changsha Communiqué" The 10-Year Anniversary of The International Consultation on Xenotransplantation.

Hawthorne WJ, Cowan PJ, Bühler LH, Yi S, Bottino R, Pierson RN 3rd, Ahn C, Azimzadeh A, Cozzi E, Gianello P, Lakey JRT, Luo M, Miyagawa S, Mohiuddin MM, Park CG, Schuurman HJ, Scobie L, Sykes M, Tector J, Tönjes RR, Wolf E, Nuñez JR, Wang W.

Xenotransplantation. 2019 Mar;26(2):e12513. doi: 10.1111/xen.12513. Epub 2019 Apr 13. No abstract available.


Australia and New Zealand Islet and Pancreas Transplant Registry Annual Report 2018-Islet Donations, Islet Isolations, and Islet Transplants.

Webster AC, Hedley JA, Anderson PF, Hawthorne WJ, Radford T, Drogemuller C, Rogers N, Goodman D, Lee MH, Loudovaris T, Kelly PJ.

Transplant Direct. 2019 Jan 7;5(2):e421. doi: 10.1097/TXD.0000000000000851. eCollection 2019 Feb.


Techniques to Ameliorate the Impact of Second Warm Ischemic Time on Kidney Transplantation Outcomes.

Hameed AM, Yuen L, Pang T, Rogers N, Hawthorne WJ, Pleass HC.

Transplant Proc. 2018 Dec;50(10):3144-3151. doi: 10.1016/j.transproceed.2018.09.003. Epub 2018 Sep 8. Review.


Xenogeneic transplantation and tolerance in the era of CRISPR-Cas9.

Cowan PJ, Hawthorne WJ, Nottle MB.

Curr Opin Organ Transplant. 2019 Feb;24(1):5-11. doi: 10.1097/MOT.0000000000000589. Review.


Epigenetic and Transcriptome Profiling Identifies a Population of Visceral Adipose-Derived Progenitor Cells with the Potential to Differentiate into an Endocrine Pancreatic Lineage.

Williams MD, Joglekar MV, Satoor SN, Wong W, Keramidaris E, Rixon A, O'Connell P, Hawthorne WJ, Mitchell GM, Hardikar AA.

Cell Transplant. 2019 Jan;28(1):89-104. doi: 10.1177/0963689718808472. Epub 2018 Oct 30.


A novel, customized 3D-printed perfusion chamber for normothermic machine perfusion of the kidney.

Hameed A, Dervish S, Rogers N, Pleass H, Hawthorne W.

Transpl Int. 2019 Jan;32(1):107-109. doi: 10.1111/tri.13361. Epub 2018 Oct 28. No abstract available.


Aortic Versus Dual Perfusion for Retrieval of the Liver After Brain Death: A National Registry Analysis.

Hameed AM, Pang T, Yoon P, Balderson G, De Roo R, Yuen L, Lam V, Laurence J, Crawford M, D M Allen R, Hawthorne WJ, Pleass HC.

Liver Transpl. 2018 Nov;24(11):1536-1544. doi: 10.1002/lt.25331.


Optimal surgical management in kidney and pancreas transplantation to minimise wound complications: A systematic review and meta-analysis.

Shahrestani S, Tran HM, Pleass HC, Hawthorne WJ.

Ann Med Surg (Lond). 2018 Aug 18;33:24-31. doi: 10.1016/j.amsu.2018.08.006. eCollection 2018 Sep. Review.


The Evolution of Kidney Transplantation Surgery Into the Robotic Era and Its Prospects for Obese Recipients.

Hameed AM, Yao J, Allen RDM, Hawthorne WJ, Pleass HC, Lau H.

Transplantation. 2018 Oct;102(10):1650-1665. doi: 10.1097/TP.0000000000002328. Review.


Optimal Culture Methods and Microbial Contamination During Kidney Ex Vivo Normothermic Perfusion.

Shahrestani S, Hameed A, Hitos K, Pleass H, Hawthorne WJ.

Transplantation. 2018 Sep;102(9):e398-e399. doi: 10.1097/TP.0000000000002302. No abstract available.



Hameed AM, Laurence JM, Lam VWT, Pleass HC, Hawthorne WJ.

Liver Transpl. 2018 Aug;24(8):1144-1146. doi: 10.1002/lt.25195. No abstract available.


Xenotransplantation literature update, January/February 2018.

Hawthorne WJ, Burlak C.

Xenotransplantation. 2018 Mar;25(2):e12398. doi: 10.1111/xen.12398. No abstract available.


Extra-corporeal normothermic machine perfusion of the porcine kidney: working towards future utilization in Australasia.

Hameed AM, Miraziz R, Lu DB, Warwick N, El-Ayoubi A, Burns H, Chew YV, Matthews R, O'Grady G, Yuen L, Rogers N, Pleass HC, Hawthorne WJ.

ANZ J Surg. 2018 May;88(5):E429-E434. doi: 10.1111/ans.14321. Epub 2017 Dec 14.


Memory T cells are significantly increased in rejected liver allografts of rhesus monkeys.

Kim H, Kim H, Lee SK, Jin XL, Kim TJ, Park C, Lee JI, Kim HS, Hong SK, Yoon KC, Ahn SW, Lee KB, Yi NJ, Yang J, Lee KW, Hawthorne WJ, Suh KS.

Liver Transpl. 2018 Feb;24(2):256-268. doi: 10.1002/lt.24983.


Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells.

Augstein P, Loudovaris T, Bandala-Sanchez E, Heinke P, Naselli G, Lee L, Hawthorne WJ, Góñez LJ, Neale AM, Vaillant F, Thomas HE, Kay TW, Banakh I, Harrison LC.

Pancreas. 2018 Jan;47(1):25-34. doi: 10.1097/MPA.0000000000000950.


Ex vivo-expanded baboon CD39 +  regulatory T cells prevent rejection of porcine islet xenografts in NOD-SCID IL-2rγ-/- mice reconstituted with baboon peripheral blood mononuclear cells.

Huang D, Wang Y, Hawthorne WJ, Hu M, Hawkes J, Burns H, Davies S, Gao F, Chew YV, Yi S, O'Connell PJ.

Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12344. Epub 2017 Sep 30.


A systematic review and meta-analysis of cold in situ perfusion and preservation for pancreas transplantation.

Hameed AM, Wong G, Laurence JM, Lam VWT, Pleass HC, Hawthorne WJ.

HPB (Oxford). 2017 Nov;19(11):933-943. doi: 10.1016/j.hpb.2017.07.012. Epub 2017 Aug 24. Review.


Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9.

Nottle MB, Salvaris EJ, Fisicaro N, McIlfatrick S, Vassiliev I, Hawthorne WJ, O'Connell PJ, Brady JL, Lew AM, Cowan PJ.

Sci Rep. 2017 Aug 16;7(1):8383. doi: 10.1038/s41598-017-09030-6.


A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis.

Rouse SL, Hawthorne WJ, Berry JL, Chorev DS, Ionescu SA, Lambert S, Stylianou F, Ewert W, Mackie U, Morgan RML, Otzen D, Herbst FA, Nielsen PH, Dueholm M, Bayley H, Robinson CV, Hare S, Matthews S.

Nat Commun. 2017 Aug 15;8(1):263. doi: 10.1038/s41467-017-00361-6.


Human regulatory macrophages are potent in suppression of the xenoimmune response via indoleamine-2,3-dioxygenase-involved mechanism(s).

Guo F, Hu M, Huang D, Zhao Y, Heng B, Guillemin G, Lim CK, Hawthorne WJ, Yi S.

Xenotransplantation. 2017 Sep;24(5). doi: 10.1111/xen.12326. Epub 2017 Aug 2.


Regulation of Clinical Xenotransplantation-Time for a Reappraisal.

Cooper DKC, Pierson RN 3rd, Hering BJ, Mohiuddin MM, Fishman JA, Denner J, Ahn C, Azimzadeh AM, Buhler LH, Cowan PJ, Hawthorne WJ, Kobayashi T, Sachs DH.

Transplantation. 2017 Aug;101(8):1766-1769. doi: 10.1097/TP.0000000000001683. Review.


Transplantation sites for human and murine islets.

Stokes RA, Cheng K, Lalwani A, Swarbrick MM, Thomas HE, Loudovaris T, Kay TW, Hawthorne WJ, O'Connell PJ, Gunton JE.

Diabetologia. 2017 Oct;60(10):1961-1971. doi: 10.1007/s00125-017-4362-8. Epub 2017 Jul 22.


A systematic review and meta-analysis of cold in situ perfusion and preservation of the hepatic allograft: Working toward a unified approach.

Hameed AM, Laurence JM, Lam VWT, Pleass HC, Hawthorne WJ.

Liver Transpl. 2017 Dec;23(12):1615-1627. doi: 10.1002/lt.24829. Epub 2017 Nov 8. Review.


Transplantation sites for porcine islets.

Stokes RA, Simond DM, Burns H, Patel AT, O'Connell PJ, Gunton JE, Hawthorne WJ.

Diabetologia. 2017 Oct;60(10):1972-1976. doi: 10.1007/s00125-017-4363-7. Epub 2017 Jul 21.


Dual kidney transplant techniques: A systematic review.

Cocco A, Shahrestani S, Cocco N, Hameed A, Yuen L, Ryan B, Hawthorne W, Lam V, Pleass H.

Clin Transplant. 2017 Aug;31(8). doi: 10.1111/ctr.13016. Epub 2017 Jun 23. Review.


Thomas Starzl-Visionary and xenotransplantation pioneer: Commentary from the International Xenotransplant Association Vanguard Committee.

Hawthorne WJ, Cimeno A, Ezzelarab M, Sandhu B, Burlak C.

Xenotransplantation. 2017 Mar;24(2). doi: 10.1111/xen.12310. No abstract available.


The Authors' Reply.

Shahrestani S, Robertson P, Pleass HC, Hawthorne WJ.

Transplantation. 2017 Feb;101(2):e58. doi: 10.1097/TP.0000000000001561. No abstract available.


Purification, crystallization and characterization of the Pseudomonas outer membrane protein FapF, a functional amyloid transporter.

Rouse SL, Hawthorne WJ, Lambert S, Morgan ML, Hare SA, Matthews S.

Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):892-896. Epub 2016 Nov 30.


Structural insights into functional amyloid inhibition in Gram -ve bacteria.

Hawthorne W, Rouse S, Sewell L, Matthews SJ.

Biochem Soc Trans. 2016 Dec 15;44(6):1643-1649. Review.


Bioquality Hotspots in the Tropical African Flora.

Marshall CAM, Wieringa JJ, Hawthorne WD.

Curr Biol. 2016 Dec 5;26(23):3214-3219. doi: 10.1016/j.cub.2016.09.045. Epub 2016 Nov 10.


In Vivo Costimulation Blockade-Induced Regulatory T Cells Demonstrate Dominant and Specific Tolerance to Porcine Islet Xenografts.

Wu J, Hu M, Qian YW, Hawthorne WJ, Burns H, Liuwantara D, Alexander SI, Yi S, O'Connell PJ.

Transplantation. 2017 Jul;101(7):1587-1599. doi: 10.1097/TP.0000000000001482.


Clinical Islet Isolation.

Hawthorne WJ, Williams L, Chew YV.

Adv Exp Med Biol. 2016;938:89-122. doi: 10.1007/978-3-319-39824-2_7.


Necessities for a Clinical Islet Program.

Hawthorne WJ.

Adv Exp Med Biol. 2016;938:67-88. doi: 10.1007/978-3-319-39824-2_6.


Genetic strategies to bring islet xenotransplantation to the clinic.

Hawthorne WJ, Lew AM, Thomas HE.

Curr Opin Organ Transplant. 2016 Oct;21(5):476-83. doi: 10.1097/MOT.0000000000000353. Review.


Characterizing the Mechanistic Pathways of the Instant Blood-Mediated Inflammatory Reaction in Xenogeneic Neonatal Islet Cell Transplantation.

Liuwantara D, Chew YV, Favaloro EJ, Hawkes JM, Burns HL, O'Connell PJ, Hawthorne WJ.

Transplant Direct. 2016 May 19;2(6):e77. doi: 10.1097/TXD.0000000000000590. eCollection 2016 Jun.


Advances in organ preservation for transplantation.

Hameed AM, Hawthorne WJ, Pleass HC.

ANZ J Surg. 2017 Dec;87(12):976-980. doi: 10.1111/ans.13713. Epub 2016 Aug 4. Review.


Islet Transplantation Provides Superior Glycemic Control With Less Hypoglycemia Compared With Continuous Subcutaneous Insulin Infusion or Multiple Daily Insulin Injections.

Holmes-Walker DJ, Gunton JE, Hawthorne W, Payk M, Anderson P, Donath S, Loudovaris T, Ward GM, Kay TW, OʼConnell PJ.

Transplantation. 2017 Jun;101(6):1268-1275. doi: 10.1097/TP.0000000000001381.


Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.

Taylor JD, Hawthorne WJ, Lo J, Dear A, Jain N, Meisl G, Andreasen M, Fletcher C, Koch M, Darvill N, Scull N, Escalera-Maurer A, Sefer L, Wenman R, Lambert S, Jean J, Xu Y, Turner B, Kazarian SG, Chapman MR, Bubeck D, de Simone A, Knowles TP, Matthews SJ.

Sci Rep. 2016 Apr 21;6:24656. doi: 10.1038/srep24656.


Donation After Circulatory Death for Liver Transplantation: A Meta-Analysis on the Location of Life Support Withdrawal Affecting Outcomes.

Cao Y, Shahrestani S, Chew HC, Crawford M, Macdonald PS, Laurence J, Hawthorne WJ, Dhital K, Pleass H.

Transplantation. 2016 Jul;100(7):1513-24. doi: 10.1097/TP.0000000000001175.


Use of the harmonic scalpel in cold phase recovery of the pancreas for transplantation: the westmead technique.

Hameed A, Yu T, Yuen L, Lam V, Ryan B, Allen R, Laurence J, Hawthorne W, Pleass H.

Transpl Int. 2016 May;29(5):636-8. doi: 10.1111/tri.12777. Epub 2016 Apr 20. No abstract available.

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