Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 26

1.

Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.

Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D'Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Slukvin I, Ryu BY, Sorrentino BP, Adair JE, Snyder SA, Compton AA, Torbett BE.

Blood. 2019 Aug 15. pii: blood.2019000040. doi: 10.1182/blood.2019000040. [Epub ahead of print]

PMID:
31416800
2.

Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations.

Shahbazi R, Sghia-Hughes G, Reid JL, Kubek S, Haworth KG, Humbert O, Kiem HP, Adair JE.

Nat Mater. 2019 Oct;18(10):1124-1132. doi: 10.1038/s41563-019-0385-5. Epub 2019 May 27.

PMID:
31133730
3.

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells.

Radtke S, Perez AM, Venkataraman R, Reddy S, Haworth KG, Humbert O, Kiem HP, Peterson CW.

J Vis Exp. 2019 Feb 15;(144). doi: 10.3791/58933.

PMID:
30829324
4.

Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice.

Kuhlmann AS, Haworth KG, Barber-Axthelm IM, Ironside C, Giese MA, Peterson CW, Kiem HP.

Mol Ther. 2019 Jan 2;27(1):164-177. doi: 10.1016/j.ymthe.2018.09.017. Epub 2018 Sep 27.

PMID:
30391142
5.

Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2.

Humbert O, Laszlo GS, Sichel S, Ironside C, Haworth KG, Bates OM, Beddoe ME, Carrillo RR, Kiem HP, Walter RB.

Leukemia. 2019 Mar;33(3):762-808. doi: 10.1038/s41375-018-0277-8. Epub 2018 Oct 5. No abstract available.

PMID:
30291334
6.

Minimal conditioning in Fanconi anemia promotes multi-lineage marrow engraftment at 10-fold lower cell doses.

Haworth KG, Ironside C, Ramirez MA, Weitz S, Beard BC, Schwartz JD, Adair JE, Kiem HP.

J Gene Med. 2018 Oct;20(10-11):e3050. doi: 10.1002/jgm.3050. Epub 2018 Oct 1.

PMID:
30129972
7.

HIV infection results in clonal expansions containing integrations within pathogenesis-related biological pathways.

Haworth KG, Schefter LE, Norgaard ZK, Ironside C, Adair JE, Kiem HP.

JCI Insight. 2018 Jul 12;3(13). pii: 99127. doi: 10.1172/jci.insight.99127.

8.

Novel lineage depletion preserves autologous blood stem cells for gene therapy of Fanconi anemia complementation group A.

Adair JE, Chandrasekaran D, Sghia-Hughes G, Haworth KG, Woolfrey AE, Burroughs LM, Choi GY, Becker PS, Kiem HP.

Haematologica. 2018 Nov;103(11):1806-1814. doi: 10.3324/haematol.2018.194571. Epub 2018 Jul 5.

9.

Next-Generation Conditioning for Bone Marrow Transplantation: Paving the Way for CAR-T Cell-Based Conditioning.

Haworth KG, Kiem HP.

Mol Ther. 2018 May 2;26(5):1167-1168. doi: 10.1016/j.ymthe.2018.04.011. No abstract available.

10.

A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice.

Wang H, Richter M, Psatha N, Li C, Kim J, Liu J, Ehrhardt A, Nilsson SK, Cao B, Palmer D, Ng P, Izsvák Z, Haworth KG, Kiem HP, Papayannopoulou T, Lieber A.

Mol Ther Methods Clin Dev. 2017 Nov 10;8:52-64. doi: 10.1016/j.omtm.2017.11.004. eCollection 2018 Mar 16.

11.

A distinct hematopoietic stem cell population for rapid multilineage engraftment in nonhuman primates.

Radtke S, Adair JE, Giese MA, Chan YY, Norgaard ZK, Enstrom M, Haworth KG, Schefter LE, Kiem HP.

Sci Transl Med. 2017 Nov 1;9(414). pii: eaan1145. doi: 10.1126/scitranslmed.aan1145.

12.

CCR5-edited gene therapies for HIV cure: Closing the door to viral entry.

Haworth KG, Peterson CW, Kiem HP.

Cytotherapy. 2017 Nov;19(11):1325-1338. doi: 10.1016/j.jcyt.2017.05.013. Epub 2017 Jul 24. Review.

PMID:
28751153
13.

In Vivo Murine-Matured Human CD3+ Cells as a Preclinical Model for T Cell-Based Immunotherapies.

Haworth KG, Ironside C, Norgaard ZK, Obenza WM, Adair JE, Kiem HP.

Mol Ther Methods Clin Dev. 2017 May 17;6:17-30. doi: 10.1016/j.omtm.2017.05.004. eCollection 2017 Sep 15.

14.

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.

Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy EE, Singh M, Izsvák Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem HP, Ehrhardt A, Papayannopoulou T, Lieber A.

Blood. 2016 Nov 3;128(18):2206-2217. Epub 2016 Aug 23.

15.

Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.

Adair JE, Waters T, Haworth KG, Kubek SP, Trobridge GD, Hocum JD, Heimfeld S, Kiem HP.

Nat Commun. 2016 Oct 20;7:13173. doi: 10.1038/ncomms13173.

16.

The frequency of multipotent CD133(+)CD45RA(-)CD34(+) hematopoietic stem cells is not increased in fetal liver compared with adult stem cell sources.

Radtke S, Haworth KG, Kiem HP.

Exp Hematol. 2016 Jun;44(6):502-7. doi: 10.1016/j.exphem.2016.02.011. Epub 2016 Mar 22.

17.

Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS.

Peterson CW, Haworth KG, Burke BP, Polacino P, Norman KK, Adair JE, Hu SL, Bartlett JS, Symonds GP, Kiem HP.

Mol Ther Methods Clin Dev. 2016 Feb 24;3:16007. doi: 10.1038/mtm.2016.7. eCollection 2016.

18.

Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation.

Peterson CW, Haworth KG, Polacino P, Huang ML, Sykes C, Obenza WM, Repetto AC, Kashuba A, Bumgarner R, DeRosa SC, Woolfrey AE, Jerome KR, Mullins JI, Hu SL, Kiem HP.

AIDS. 2015 Aug 24;29(13):1597-606. doi: 10.1097/QAD.0000000000000702.

19.

Determinants in HIV-2 Env and tetherin required for functional interaction.

Exline CM, Yang SJ, Haworth KG, Rengarajan S, Lopez LA, Droniou ME, Seclen E, Cannon PM.

Retrovirology. 2015 Aug 7;12:67. doi: 10.1186/s12977-015-0194-0.

20.

Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.

Rathbun JY, Droniou ME, Damoiseaux R, Haworth KG, Henley JE, Exline CM, Choe H, Cannon PM.

J Virol. 2015 Aug;89(16):8428-43. doi: 10.1128/JVI.00997-15. Epub 2015 Jun 3.

21.

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.

Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES Jr, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD, Piatak M Jr, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M.

Nature. 2015 Mar 5;519(7541):87-91. doi: 10.1038/nature14264. Epub 2015 Feb 18.

22.

Anti-tetherin activities of HIV-1 Vpu and Ebola virus glycoprotein do not involve removal of tetherin from lipid rafts.

Lopez LA, Yang SJ, Exline CM, Rengarajan S, Haworth KG, Cannon PM.

J Virol. 2012 May;86(10):5467-80. doi: 10.1128/JVI.06280-11. Epub 2012 Mar 7.

23.

A template RNA entry channel in the fingers domain of the poliovirus polymerase.

Kortus MG, Kempf BJ, Haworth KG, Barton DJ, Peersen OB.

J Mol Biol. 2012 Apr 6;417(4):263-78. doi: 10.1016/j.jmb.2012.01.049. Epub 2012 Feb 1.

24.

Lack of adaptation to human tetherin in HIV-1 group O and P.

Yang SJ, Lopez LA, Exline CM, Haworth KG, Cannon PM.

Retrovirology. 2011 Sep 28;8:78. doi: 10.1186/1742-4690-8-78.

25.

Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removal.

Lopez LA, Yang SJ, Hauser H, Exline CM, Haworth KG, Oldenburg J, Cannon PM.

J Virol. 2010 Jul;84(14):7243-55. doi: 10.1128/JVI.02636-09. Epub 2010 May 5.

26.

Anti-tetherin activities in Vpu-expressing primate lentiviruses.

Yang SJ, Lopez LA, Hauser H, Exline CM, Haworth KG, Cannon PM.

Retrovirology. 2010 Feb 18;7:13. doi: 10.1186/1742-4690-7-13.

Supplemental Content

Loading ...
Support Center