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First-in-Human Intravenous Seprehvir in Young Cancer Patients: A Phase 1 Clinical Trial.

Streby KA, Currier MA, Triplet M, Ott K, Dishman DJ, Vaughan MR, Ranalli MA, Setty B, Skeens MA, Whiteside S, Yeager ND, Haworth KB, Simpson K, Conner J, Cripe TP.

Mol Ther. 2019 Sep 10. pii: S1525-0016(19)30406-X. doi: 10.1016/j.ymthe.2019.08.020. [Epub ahead of print]


Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.

Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D'Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Slukvin I, Ryu BY, Sorrentino BP, Adair JE, Snyder SA, Compton AA, Torbett BE.

Blood. 2019 Aug 15. pii: blood.2019000040. doi: 10.1182/blood.2019000040. [Epub ahead of print]



Huang CX, Burt J, Vanderburg A, Günther MN, Shporer A, Dittmann JA, Winn JN, Wittenmyer R, Sha L, Kane SR, Ricker GR, Vanderspek RK, Latham DW, Seager S, Jenkins JM, Caldwell DA, Collins KA, Guerrero N, Smith JC, Quinn SN, Udry S, Pepe F, Bouchy F, Ségransan D, Lovis C, Ehrenreich D, Marmier M, Mayor M, Wohler B, Haworth K, Morgan EH, Fausnaugh M, Ciardi DR, Christiansen J, Charbonneau D, Dragomir D, Deming D, Glidden A, Levine AM, McCullough PR, Yu L, Narita N, Nguyen T, Morton T, Pepper J, Pál A, Rodriguez JE; TESS team.

Astrophys J Lett. 2018 Dec 1;868(2). doi: 10.3847/2041-8213/aaef91. Epub 2018 Nov 30.


The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy in vitro.

Kleven RT, Karani KB, Salido NG, Shekhar H, Haworth KJ, Mast TD, Tadesse DG, Holland CK.

Phys Med Biol. 2019 Aug 21;64(16):165015. doi: 10.1088/1361-6560/ab293b.


Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations.

Shahbazi R, Sghia-Hughes G, Reid JL, Kubek S, Haworth KG, Humbert O, Kiem HP, Adair JE.

Nat Mater. 2019 Oct;18(10):1124-1132. doi: 10.1038/s41563-019-0385-5. Epub 2019 May 27.


Acoustic droplet vaporization-mediated dissolved oxygen scavenging in blood-mimicking fluids, plasma, and blood.

Mercado-Shekhar KP, Su H, Kalaikadal DS, Lorenz JN, Manglik RM, Holland CK, Redington AN, Haworth KJ.

Ultrason Sonochem. 2019 Sep;56:114-124. doi: 10.1016/j.ultsonch.2019.03.029. Epub 2019 Mar 28.


Erratum to 'Effect of clot stiffness on recombinant tissue plasminogen activator lytic susceptibility in vitro' [Ultrasound Med Biol 44 (2018) 2710-2727].

Mercado-Shekhar KP, Kleven R, Rivera HA, Lewis R, Karani KB, Vos HJ, Abruzzo TA, Haworth KJ, Holland CK.

Ultrasound Med Biol. 2019 Jul;45(7):1860. doi: 10.1016/j.ultrasmedbio.2019.04.013. Epub 2019 Apr 30. No abstract available.


CNS germinoma with extensive calcification: An unusual histologic finding.

Tan GC, Sallapan S, Haworth K, Finlay J, Boue DR, Pierson CR.

Malays J Pathol. 2019 Apr;41(1):71-73.


Characterization and Imaging of Lipid-Shelled Microbubbles for Ultrasound-Triggered Release of Xenon.

Shekhar H, Palaniappan A, Peng T, Lafond M, Moody MR, Haworth KJ, Huang S, McPherson DD, Holland CK.

Neurotherapeutics. 2019 Jul;16(3):878-890. doi: 10.1007/s13311-019-00733-4.


Liver Specification in the Absence of Cardiac Differentiation Revealed by Differential Sensitivity to Wnt/β Catenin Pathway Activation.

Haworth K, Samuel L, Black S, Kirilenko P, Latinkic B.

Front Physiol. 2019 Mar 5;10:155. doi: 10.3389/fphys.2019.00155. eCollection 2019.


Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells.

Radtke S, Perez AM, Venkataraman R, Reddy S, Haworth KG, Humbert O, Kiem HP, Peterson CW.

J Vis Exp. 2019 Feb 15;(144). doi: 10.3791/58933.


Novel genetically-modified chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine safely boosts humoral and cellular immunity in healthy older adults.

Green CA, Sande CJ, Scarselli E, Capone S, Vitelli A, Nicosia A, Silva-Reyes L, Thompson AJ, de Lara CM, Taylor KS, Haworth K, Hutchings CL, Cargill T, Angus B, Klenerman P, Pollard AJ.

J Infect. 2019 May;78(5):382-392. doi: 10.1016/j.jinf.2019.02.003. Epub 2019 Feb 8.


Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment.

Nguyen K, Pan HY, Haworth K, Mahoney E, Mercado-Shekhar KP, Lin CY, Zhang Z, C Park Y.

Ultrasound Med Biol. 2019 Jan;45(1):160-169. doi: 10.1016/j.ultrasmedbio.2018.09.014. Epub 2018 Oct 26.


Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice.

Kuhlmann AS, Haworth KG, Barber-Axthelm IM, Ironside C, Giese MA, Peterson CW, Kiem HP.

Mol Ther. 2019 Jan 2;27(1):164-177. doi: 10.1016/j.ymthe.2018.09.017. Epub 2018 Sep 27.


Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2.

Humbert O, Laszlo GS, Sichel S, Ironside C, Haworth KG, Bates OM, Beddoe ME, Carrillo RR, Kiem HP, Walter RB.

Leukemia. 2019 Mar;33(3):762-808. doi: 10.1038/s41375-018-0277-8. Epub 2018 Oct 5. No abstract available.


Effect of Clot Stiffness on Recombinant Tissue Plasminogen Activator Lytic Susceptibility in Vitro.

Mercado-Shekhar KP, Kleven RT, Aponte Rivera H, Lewis R, Karani KB, Vos HJ, Abruzzo TA, Haworth KJ, Holland CK.

Ultrasound Med Biol. 2018 Dec;44(12):2710-2727. doi: 10.1016/j.ultrasmedbio.2018.08.005. Epub 2018 Sep 26. Erratum in: Ultrasound Med Biol. 2019 Jul;45(7):1860.


Minimal conditioning in Fanconi anemia promotes multi-lineage marrow engraftment at 10-fold lower cell doses.

Haworth KG, Ironside C, Ramirez MA, Weitz S, Beard BC, Schwartz JD, Adair JE, Kiem HP.

J Gene Med. 2018 Oct;20(10-11):e3050. doi: 10.1002/jgm.3050. Epub 2018 Oct 1.


Frequency-sum beamforming for passive cavitation imaging.

Abadi SH, Haworth KJ, Mercado-Shekhar KP, Dowling DR.

J Acoust Soc Am. 2018 Jul;144(1):198. doi: 10.1121/1.5045328.


Immune profiles of desmoplastic small round cell tumor and synovial sarcoma suggest different immunotherapeutic susceptibility upfront compared to relapse specimens.

Wedekind MF, Haworth KB, Arnold M, Stanek JR, Lee D, Cripe TP.

Pediatr Blood Cancer. 2018 Nov;65(11):e27313. doi: 10.1002/pbc.27313. Epub 2018 Jul 17.


HIV infection results in clonal expansions containing integrations within pathogenesis-related biological pathways.

Haworth KG, Schefter LE, Norgaard ZK, Ironside C, Adair JE, Kiem HP.

JCI Insight. 2018 Jul 12;3(13). pii: 99127. doi: 10.1172/jci.insight.99127.


Novel lineage depletion preserves autologous blood stem cells for gene therapy of Fanconi anemia complementation group A.

Adair JE, Chandrasekaran D, Sghia-Hughes G, Haworth KG, Woolfrey AE, Burroughs LM, Choi GY, Becker PS, Kiem HP.

Haematologica. 2018 Nov;103(11):1806-1814. doi: 10.3324/haematol.2018.194571. Epub 2018 Jul 5.


Dissolved Oxygen Scavenging by Acoustic Droplet Vaporization using Intravascular Ultrasound.

Haworth KJ, Goldstein BH, Mercado-Shekhar KP, Srivastava R, Arunkumar P, Su H, Privitera EM, Holland CK, Redington AN.

IEEE Int Ultrason Symp. 2017 Sep;2017. doi: 10.1109/ULTSYM.2017.8091704. Epub 2017 Nov 2.


Next-Generation Conditioning for Bone Marrow Transplantation: Paving the Way for CAR-T Cell-Based Conditioning.

Haworth KG, Kiem HP.

Mol Ther. 2018 May 2;26(5):1167-1168. doi: 10.1016/j.ymthe.2018.04.011. No abstract available.


Author Response: Tear Levels of 8-hydroxy-2'-deoxyguanosine.

Haworth K, Chandler H.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1588. doi: 10.1167/iovs.17-23682. No abstract available.


A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice.

Wang H, Richter M, Psatha N, Li C, Kim J, Liu J, Ehrhardt A, Nilsson SK, Cao B, Palmer D, Ng P, Izsvák Z, Haworth KG, Kiem HP, Papayannopoulou T, Lieber A.

Mol Ther Methods Clin Dev. 2017 Nov 10;8:52-64. doi: 10.1016/j.omtm.2017.11.004. eCollection 2018 Mar 16.


Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy.

Haworth KB, Arnold MA, Pierson CR, Choi K, Yeager ND, Ratner N, Roberts RD, Finlay JL, Cripe TP.

Oncotarget. 2017 May 30;8(47):82037-82048. doi: 10.18632/oncotarget.18301. eCollection 2017 Oct 10.


A distinct hematopoietic stem cell population for rapid multilineage engraftment in nonhuman primates.

Radtke S, Adair JE, Giese MA, Chan YY, Norgaard ZK, Enstrom M, Haworth KG, Schefter LE, Kiem HP.

Sci Transl Med. 2017 Nov 1;9(414). pii: eaan1145. doi: 10.1126/scitranslmed.aan1145.


Post Hoc Analysis of Passive Cavitation Imaging for Classification of Histotripsy-Induced Liquefaction in Vitro.

Bader KB, Haworth KJ, Maxwell AD, Holland CK.

IEEE Trans Med Imaging. 2018 Jan;37(1):106-115. doi: 10.1109/TMI.2017.2735238. Epub 2017 Aug 2.


CCR5-edited gene therapies for HIV cure: Closing the door to viral entry.

Haworth KG, Peterson CW, Kiem HP.

Cytotherapy. 2017 Nov;19(11):1325-1338. doi: 10.1016/j.jcyt.2017.05.013. Epub 2017 Jul 24. Review.


Oxidative Stress Measures of Lipid and DNA Damage in Human Tears.

Haworth KM, Chandler HL.

Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO151-BIO157. doi: 10.1167/iovs.17-21436.


Oncolytic Herpes Virus rRp450 Shows Efficacy in Orthotopic Xenograft Group 3/4 Medulloblastomas and Atypical Teratoid/Rhabdoid Tumors.

Studebaker AW, Hutzen BJ, Pierson CR, Haworth KB, Cripe TP, Jackson EM, Leonard JR.

Mol Ther Oncolytics. 2017 May 25;6:22-30. doi: 10.1016/j.omto.2017.05.005. eCollection 2017 Sep 15.


In Vivo Murine-Matured Human CD3+ Cells as a Preclinical Model for T Cell-Based Immunotherapies.

Haworth KG, Ironside C, Norgaard ZK, Obenza WM, Adair JE, Kiem HP.

Mol Ther Methods Clin Dev. 2017 May 17;6:17-30. doi: 10.1016/j.omtm.2017.05.004. eCollection 2017 Sep 15.


Quantitative Frequency-Domain Passive Cavitation Imaging.

Haworth KJ, Bader KB, Rich KT, Holland CK, Mast TD.

IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Jan;64(1):177-191. doi: 10.1109/TUFFC.2016.2620492. Epub 2016 Oct 25.


Seasonal Effect on Ocular Sun Exposure and Conjunctival UV Autofluorescence.

Haworth KM, Chandler HL.

Optom Vis Sci. 2017 Feb;94(2):219-228. doi: 10.1097/OPX.0000000000001014.


In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.

Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy EE, Singh M, Izsvák Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem HP, Ehrhardt A, Papayannopoulou T, Lieber A.

Blood. 2016 Nov 3;128(18):2206-2217. Epub 2016 Aug 23.


Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.

Adair JE, Waters T, Haworth KG, Kubek SP, Trobridge GD, Hocum JD, Heimfeld S, Kiem HP.

Nat Commun. 2016 Oct 20;7:13173. doi: 10.1038/ncomms13173.


Delivery of bevacizumab to atheromatous porcine carotid tissue using echogenic liposomes.

Sutton JT, Haworth KJ, Shanmukhappa SK, Moody MR, Klegerman ME, Griffin JK, Patton DM, McPherson DD, Holland CK.

Drug Deliv. 2016 Nov;23(9):3594-3605. Epub 2016 Sep 30.


Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.

Darton TC, Jones C, Blohmke CJ, Waddington CS, Zhou L, Peters A, Haworth K, Sie R, Green CA, Jeppesen CA, Moore M, Thompson BA, John T, Kingsley RA, Yu LM, Voysey M, Hindle Z, Lockhart S, Sztein MB, Dougan G, Angus B, Levine MM, Pollard AJ.

PLoS Negl Trop Dis. 2016 Aug 17;10(8):e0004926. doi: 10.1371/journal.pntd.0004926. eCollection 2016 Aug.


Efficacy of histotripsy combined with rt-PA in vitro.

Bader KB, Haworth KJ, Shekhar H, Maxwell AD, Peng T, McPherson DD, Holland CK.

Phys Med Biol. 2016 Jul 21;61(14):5253-74. doi: 10.1088/0031-9155/61/14/5253. Epub 2016 Jun 29.


Size-isolation of ultrasound-mediated phase change perfluorocarbon droplets using differential centrifugation.

Mercado KP, Radhakrishnan K, Stewart K, Snider L, Ryan D, Haworth KJ.

J Acoust Soc Am. 2016 May;139(5):EL142. doi: 10.1121/1.4946831.


Erratum to: "Trans-stent B-mode Ultrasound and Passive Cavitation Imaging" in Ultrasound Med Biol 2016;42(2):518-527.

Haworth KJ, Raymond JL, Radhakrishnan K, Moody MR, Huang SL, Peng T, Shekhar H, Klegerman ME, Kim H, McPherson DD, Holland CK.

Ultrasound Med Biol. 2016 May;42(5):1244. doi: 10.1016/j.ultrasmedbio.2016.01.016. Epub 2016 Feb 12. No abstract available.


Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.

Wu P, Farrell WE, Haworth KE, Emes RD, Kitchen MO, Glossop JR, Hanna FW, Fryer AA.

Epigenetics. 2018;13(2):122-128. doi: 10.1080/15592294.2016.1166321. Epub 2018 Jan 25.


The frequency of multipotent CD133(+)CD45RA(-)CD34(+) hematopoietic stem cells is not increased in fetal liver compared with adult stem cell sources.

Radtke S, Haworth KG, Kiem HP.

Exp Hematol. 2016 Jun;44(6):502-7. doi: 10.1016/j.exphem.2016.02.011. Epub 2016 Mar 22.


Scavenging dissolved oxygen via acoustic droplet vaporization.

Radhakrishnan K, Holland CK, Haworth KJ.

Ultrason Sonochem. 2016 Jul;31:394-403. doi: 10.1016/j.ultsonch.2016.01.019. Epub 2016 Jan 19.


Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS.

Peterson CW, Haworth KG, Burke BP, Polacino P, Norman KK, Adair JE, Hu SL, Bartlett JS, Symonds GP, Kiem HP.

Mol Ther Methods Clin Dev. 2016 Feb 24;3:16007. doi: 10.1038/mtm.2016.7. eCollection 2016.


To Infection and Beyond: The Multi-Pronged Anti-Cancer Mechanisms of Oncolytic Viruses.

Cassady KA, Haworth KB, Jackson J, Markert JM, Cripe TP.

Viruses. 2016 Feb 4;8(2). pii: E43. doi: 10.3390/v8020043. Review.


Characterization of MHC Class I and β-2-Microglobulin Expression in Pediatric Solid Malignancies to Guide Selection of Immune-Based Therapeutic Trials.

Haworth KB, Arnold MA, Pierson CR, Leddon JL, Kurmashev DK, Swain HM, Hutzen BJ, Roberts RD, Cripe TP.

Pediatr Blood Cancer. 2016 Apr;63(4):618-26. doi: 10.1002/pbc.25842. Epub 2015 Nov 17.


Trans-Stent B-Mode Ultrasound and Passive Cavitation Imaging.

Haworth KJ, Raymond JL, Radhakrishnan K, Moody MR, Huang SL, Peng T, Shekhar H, Klegerman ME, Kim H, McPherson DD, Holland CK.

Ultrasound Med Biol. 2016 Feb;42(2):518-27. doi: 10.1016/j.ultrasmedbio.2015.08.014. Epub 2015 Nov 4. Erratum in: Ultrasound Med Biol. 2016 May;42(5):1244.


Pediatric cancer gone viral. Part I: strategies for utilizing oncolytic herpes simplex virus-1 in children.

Cripe TP, Chen CY, Denton NL, Haworth KB, Hutzen B, Leddon JL, Streby KA, Wang PY, Markert JM, Waters AM, Gillespie GY, Beierle EA, Friedman GK.

Mol Ther Oncolytics. 2015;2. pii: 15015. Epub 2015 Sep 16.


Pediatric cancer gone viral. Part II: potential clinical application of oncolytic herpes simplex virus-1 in children.

Friedman GK, Beierle EA, Gillespie GY, Markert JM, Waters AM, Chen CY, Denton NL, Haworth KB, Hutzen B, Leddon JL, Streby KA, Wang PY, Cripe TP.

Mol Ther Oncolytics. 2015;2. pii: 15016. Epub 2015 Sep 16.

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