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Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment.

Cudjoe EK Jr, Hassan ZH, Kang L, Reynolds PS, Fisher BJ, McCarter J, Sweeney C, Martin EJ, Middleton P, Ellenberg M, Fowler AA 3rd, Spiess BD, Brophy DF, Hawkridge AM, Natarajan R.

J Thromb Haemost. 2019 Nov;17(11):1827-1837. doi: 10.1111/jth.14580. Epub 2019 Aug 25.


A description and evaluation of an educational programme for North West England GP trainees who have multiple fails in the Clinical Skills Assessment (CSA).

Hawkridge A, Molyneux D.

Educ Prim Care. 2019 May;30(3):167-172. doi: 10.1080/14739879.2019.1570476. Epub 2019 Feb 6.


Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy.

Xu J, Patel NH, Saleh T, Cudjoe EK Jr, Alotaibi M, Wu Y, Lima S, Hawkridge AM, Gewirtz DA.

Radiat Res. 2018 Nov;190(5):538-557. doi: 10.1667/RR15099.1. Epub 2018 Aug 22.


Fatty acid oxidation: An emerging facet of metabolic transformation in cancer.

Ma Y, Temkin SM, Hawkridge AM, Guo C, Wang W, Wang XY, Fang X.

Cancer Lett. 2018 Oct 28;435:92-100. doi: 10.1016/j.canlet.2018.08.006. Epub 2018 Aug 10. Review.


The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals.

Ma Y, Min HK, Oh U, Hawkridge AM, Wang W, Mohsin AA, Chen Q, Sanyal A, Lesnefsky EJ, Fang X.

J Biol Chem. 2017 Dec 22;292(51):20989-20997. doi: 10.1074/jbc.M117.812925. Epub 2017 Oct 18.


Proteomics Insights into Autophagy.

Cudjoe EK Jr, Saleh T, Hawkridge AM, Gewirtz DA.

Proteomics. 2017 Oct;17(20). doi: 10.1002/pmic.201700022. Review.


Comparative analysis of INLIGHT™-labeled enzymatically depolymerized heparin by reverse-phase chromatography and high-performance mass spectrometry.

Mangrum JB, Mehta AY, Alabbas AB, Desai UR, Hawkridge AM.

Anal Bioanal Chem. 2017 Jan;409(2):499-509. doi: 10.1007/s00216-016-0055-2. Epub 2016 Nov 25.


The Cape Town Declaration on Vaccines 2012: Unlocking the full potential of vaccines in Africa.

Wiysonge CS, Waggie Z, Hawkridge A, Schoub BD, Madhi SA, Rees H, Hussey GD; delegates of the first International African Vaccinology Conference.

Vaccine. 2016 Jul 19;34(33):3713-4. doi: 10.1016/j.vaccine.2016.05.072. Epub 2016 Jun 15.


Advocating for efforts to protect African children, families, and communities from the threat of infectious diseases: report of the First International African Vaccinology Conference.

Wiysonge CS, Waggie Z, Hawkridge A, Schoub B, Madhi SA, Rees H, Hussey G.

Pan Afr Med J. 2016 Feb 29;23:53. doi: 10.11604/pamj.2016.23.53.9097. eCollection 2016.


Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study.

Fletcher HA, Filali-Mouhim A, Nemes E, Hawkridge A, Keyser A, Njikan S, Hatherill M, Scriba TJ, Abel B, Kagina BM, Veldsman A, Agudelo NM, Kaplan G, Hussey GD, Sekaly RP, Hanekom WA; BCG study team.

BMC Med. 2016 May 16;14:76. doi: 10.1186/s12916-016-0617-3.


BCG and New Preventive Tuberculosis Vaccines: Implications for Healthcare Workers.

Hatherill M, Scriba TJ, Udwadia ZF, Mullerpattan JB, Hawkridge A, Mahomed H, Dye C.

Clin Infect Dis. 2016 May 15;62 Suppl 3:S262-7. doi: 10.1093/cid/ciw025.


Adenovirus type 35-vectored tuberculosis vaccine has an acceptable safety and tolerability profile in healthy, BCG-vaccinated, QuantiFERON(®)-TB Gold (+) Kenyan adults without evidence of tuberculosis.

Walsh DS, Owira V, Polhemus M, Otieno L, Andagalu B, Ogutu B, Waitumbi J, Hawkridge A, Shepherd B, Pau MG, Sadoff J, Douoguih M, McClain JB; Aeras C-012-402 Study Team.

Vaccine. 2016 May 5;34(21):2430-2436. doi: 10.1016/j.vaccine.2016.03.069. Epub 2016 Mar 26.


In-depth LC-MS/MS analysis of the chicken ovarian cancer proteome reveals conserved and novel differentially regulated proteins in humans.

Nepomuceno AI, Shao H, Jing K, Ma Y, Petitte JN, Idowu MO, Muddiman DC, Fang X, Hawkridge AM.

Anal Bioanal Chem. 2015 Sep;407(22):6851-63. doi: 10.1007/s00216-015-8862-4. Epub 2015 Jul 10.


Intact stable isotope labeled plasma proteins from the SILAC-labeled HepG2 secretome.

Mangrum JB, Martin EJ, Brophy DF, Hawkridge AM.

Proteomics. 2015 Sep;15(18):3104-15. doi: 10.1002/pmic.201400369. Epub 2015 Feb 14.


Performance in the MRCGP CSA by candidates' gender: differences according to curriculum area.

Pope L, Hawkridge A, Simpson R.

Educ Prim Care. 2014 Jul;25(4):186-93.


The chicken model of spontaneous ovarian cancer.

Hawkridge AM.

Proteomics Clin Appl. 2014 Oct;8(9-10):689-99. doi: 10.1002/prca.201300135. Review.


Multi-peptide nLC-PC-IDMS-SRM-based assay for the quantification of biomarkers in the chicken ovarian cancer model.

Andrews Kingon GL, Petitte JN, Muddiman DC, Hawkridge AM.

Methods. 2013 Jun 15;61(3):323-30. doi: 10.1016/j.ymeth.2013.04.004. Epub 2013 Apr 19.


Induction and regulation of T-cell immunity by the novel tuberculosis vaccine M72/AS01 in South African adults.

Day CL, Tameris M, Mansoor N, van Rooyen M, de Kock M, Geldenhuys H, Erasmus M, Makhethe L, Hughes EJ, Gelderbloem S, Bollaerts A, Bourguignon P, Cohen J, Demoitié MA, Mettens P, Moris P, Sadoff JC, Hawkridge A, Hussey GD, Mahomed H, Ofori-Anyinam O, Hanekom WA.

Am J Respir Crit Care Med. 2013 Aug 15;188(4):492-502. doi: 10.1164/rccm.201208-1385OC.


Advances in childhood immunisation in South Africa: where to now? Programme managers' views and evidence from systematic reviews.

Wiysonge CS, Ngcobo NJ, Jeena PM, Madhi SA, Schoub BD, Hawkridge A, Shey MS, Hussey GD.

BMC Public Health. 2012 Jul 31;12:578. doi: 10.1186/1471-2458-12-578. Review.


Key issues in the clinical development and implementation of TB vaccines in South Africa.

Rustomjee R, Mcleod R, Hanekom W, Steel G, Mahomed H, Hawkridge A, Welte A, Sinanovic E, Loots G, Grobler A, Mvusi L, Gray G, Hesseling A, Ginsberg A, Lienhardt C, Shea J, Tong X, Lockhart S, Churchyard GJ.

Tuberculosis (Edinb). 2012 Sep;92(5):359-64. doi: 10.1016/ Epub 2012 Jun 12.


Advances in childhood tuberculosis - contributions from the University of Cape Town.

Zar HJ, Eley B, Nicol MP, Figaji A, Hawkridge A.

S Afr Med J. 2012 Mar 2;102(6):518-21. Review.


SATVI - after 10 years closing in on a new and better vaccine to prevent tuberculosis.

Hanekom WA, Hawkridge A, Mahomed H, Scriba TJ, Tameris M, Hughes J, Hatherill M, Day CL, Hussey GD.

S Afr Med J. 2012 Mar 2;102(6):438-41.


The state and future of research at the University of Cape Town's Faculty of Health Sciences.

Hussey G, Hawkridge A.

S Afr Med J. 2012 Mar 2;102(6):412-4.


Childhood tuberculosis: progress requires an advocacy strategy now.

Sandgren A, Cuevas LE, Dara M, Gie RP, Grzemska M, Hawkridge A, Hesseling AC, Kampmann B, Lienhardt C, Manissero D, Wingfield C, Graham SM.

Eur Respir J. 2012 Aug;40(2):294-7. doi: 10.1183/09031936.00187711. Epub 2012 Feb 15.


A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults.

Scriba TJ, Tameris M, Smit E, van der Merwe L, Hughes EJ, Kadira B, Mauff K, Moyo S, Brittain N, Lawrie A, Mulenga H, de Kock M, Makhethe L, Janse van Rensburg E, Gelderbloem S, Veldsman A, Hatherill M, Geldenhuys H, Hill AV, Hawkridge A, Hussey GD, Hanekom WA, McShane H, Mahomed H.

Am J Respir Crit Care Med. 2012 Apr 1;185(7):769-78. doi: 10.1164/rccm.201108-1548OC. Epub 2012 Jan 26.


Tuberculosis case finding for vaccine trials in young children in high-incidence settings: a randomised trial.

Moyo S, Verver S, Hawkridge A, Geiter L, Hatherill M, Workman L, Ontong C, Msemburi W, Tameris M, Geldenhuys H, Mulenga H, Snowden MA, Hanekom WA, Hussey G, Mahomed H; South African Tuberculosis Vaccine Initiative Neonatal Study Team.

Int J Tuberc Lung Dis. 2012 Feb;16(2):185-91. doi: 10.5588/ijtld.11.0348.


Tuberculin skin test and QuantiFERON® assay in young children investigated for tuberculosis in South Africa.

Moyo S, Isaacs F, Gelderbloem S, Verver S, Hawkridge AJ, Hatherill M, Tameris M, Geldenhuys H, Workman L, Pai M, Hussey G, Hanekom WA, Mahomed H.

Int J Tuberc Lung Dis. 2011 Sep;15(9):1176-81, i. doi: 10.5588/ijtld.10.0770.


Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.

Randhawa AK, Shey MS, Keyser A, Peixoto B, Wells RD, de Kock M, Lerumo L, Hughes J, Hussey G, Hawkridge A, Kaplan G, Hanekom WA, Hawn TR; South African Tuberculosis Vaccine Initiative Team.

PLoS Pathog. 2011 Aug;7(8):e1002174. doi: 10.1371/journal.ppat.1002174. Epub 2011 Aug 11.


One-Year Plasma N-linked Glycome Intra-individual and Inter-individual Variability in the Chicken Model of Spontaneous Ovarian Adenocarcinoma.

Dixon RB, Bereman MS, Petitte JN, Hawkridge AM, Muddiman DC.

Int J Mass Spectrom. 2011 Aug 15;305(2-3):79-86.


Developing vaccinology expertise for Africa: six years and counting.

Wiysonge CS, Waggie Z, Mahomed H, Hawkridge A, Hatherill M, Hanekom WA, Hussey GD.

Vaccine. 2011 Aug 11;29(35):5821-3. doi: 10.1016/j.vaccine.2011.06.054. Epub 2011 Jun 28.


Performance characteristics of a new hybrid quadrupole time-of-flight tandem mass spectrometer (TripleTOF 5600).

Andrews GL, Simons BL, Young JB, Hawkridge AM, Muddiman DC.

Anal Chem. 2011 Jul 1;83(13):5442-6. doi: 10.1021/ac200812d. Epub 2011 Jun 14.


Improving proteome coverage on a LTQ-Orbitrap using design of experiments.

Andrews GL, Dean RA, Hawkridge AM, Muddiman DC.

J Am Soc Mass Spectrom. 2011 Apr;22(4):773-83. doi: 10.1007/s13361-011-0075-2. Epub 2011 Feb 15.


Utilizing spectral counting to quantitatively characterize tandem removal of abundant proteins (TRAP) in human plasma.

Shuford CM, Hawkridge AM, Burnett JC Jr, Muddiman DC.

Anal Chem. 2010 Dec 15;82(24):10179-85. doi: 10.1021/ac102248d. Epub 2010 Nov 19.


Review of rotavirus studies in Africa: 1976-2006.

Waggie Z, Hawkridge A, Hussey GD.

J Infect Dis. 2010 Sep 1;202 Suppl:S23-33. doi: 10.1086/653554. Review.


Measuring the intra-individual variability of the plasma proteome in the chicken model of spontaneous ovarian adenocarcinoma.

Hawkridge AM, Wysocky RB, Petitte JN, Anderson KE, Mozdziak PE, Fletcher OJ, Horowitz JM, Muddiman DC.

Anal Bioanal Chem. 2010 Sep;398(2):737-49. doi: 10.1007/s00216-010-3979-y. Epub 2010 Jul 17. Erratum in: Anal Bioanal Chem. 2010 Oct;398(4):1835.


Mass spectrometry-based biomarker discovery: toward a global proteome index of individuality.

Hawkridge AM, Muddiman DC.

Annu Rev Anal Chem (Palo Alto Calif). 2009;2:265-77. doi: 10.1146/annurev.anchem.1.031207.112942. Review.


Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns.

Kagina BM, Abel B, Scriba TJ, Hughes EJ, Keyser A, Soares A, Gamieldien H, Sidibana M, Hatherill M, Gelderbloem S, Mahomed H, Hawkridge A, Hussey G, Kaplan G, Hanekom WA; other members of the South African Tuberculosis Vaccine Initiative.

Am J Respir Crit Care Med. 2010 Oct 15;182(8):1073-9. doi: 10.1164/rccm.201003-0334OC. Epub 2010 Jun 17.


The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults.

Abel B, Tameris M, Mansoor N, Gelderbloem S, Hughes J, Abrahams D, Makhethe L, Erasmus M, de Kock M, van der Merwe L, Hawkridge A, Veldsman A, Hatherill M, Schirru G, Pau MG, Hendriks J, Weverling GJ, Goudsmit J, Sizemore D, McClain JB, Goetz M, Gearhart J, Mahomed H, Hussey GD, Sadoff JC, Hanekom WA.

Am J Respir Crit Care Med. 2010 Jun 15;181(12):1407-17. doi: 10.1164/rccm.200910-1484OC. Epub 2010 Feb 18.


Age-related tuberculosis incidence and severity in children under 5 years of age in Cape Town, South Africa.

Moyo S, Verver S, Mahomed H, Hawkridge A, Kibel M, Hatherill M, Tameris M, Geldenhuys H, Hanekom W, Hussey G.

Int J Tuberc Lung Dis. 2010 Feb;14(2):149-54.


Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells.

Scriba TJ, Tameris M, Mansoor N, Smit E, van der Merwe L, Isaacs F, Keyser A, Moyo S, Brittain N, Lawrie A, Gelderbloem S, Veldsman A, Hatherill M, Hawkridge A, Hill AV, Hussey GD, Mahomed H, McShane H, Hanekom WA.

Eur J Immunol. 2010 Jan;40(1):279-90. doi: 10.1002/eji.200939754. Erratum in: Eur J Immunol. 2011 May;41(5):1501.


Clinical studies of TB vaccines.

Hawkridge A.

Hum Vaccin. 2009 Nov;5(11):773-6. Epub 2009 Nov 22. Review.


Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells.

Alcazar O, Hawkridge AM, Collier TS, Cousins SW, Bhattacharya SK, Muddiman DC, Marin-Castano ME.

Mol Cell Proteomics. 2009 Oct;8(10):2201-11. doi: 10.1074/mcp.M900203-MCP200. Epub 2009 Jun 29.


Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South Africa infants: Randomised trial.

Hawkridge A, Hatherill M, Little F, Goetz MA, Barker L, Mahomed H, Sadoff J, Hanekom W, Gaiter L; South African BCG trial team.

Rev Port Pneumol. 2009 Jul-Aug;15(4):747-9. doi: 10.1016/S0873-2159(15)30174-4. English, Portuguese. No abstract available.


Coupling of a vented column with splitless nanoRPLC-ESI-MS for the improved separation and detection of brain natriuretic peptide-32 and its proteolytic peptides.

Andrews GL, Shuford CM, Burnett JC Jr, Hawkridge AM, Muddiman DC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 1;877(10):948-54. doi: 10.1016/j.jchromb.2009.02.040. Epub 2009 Feb 24.


HIV-1 infection in infants severely impairs the immune response induced by Bacille Calmette-Guérin vaccine.

Mansoor N, Scriba TJ, de Kock M, Tameris M, Abel B, Keyser A, Little F, Soares A, Gelderbloem S, Mlenjeni S, Denation L, Hawkridge A, Boom WH, Kaplan G, Hussey GD, Hanekom WA.

J Infect Dis. 2009 Apr 1;199(7):982-90. doi: 10.1086/597304.


Comparison of T-SPOT.TB assay and tuberculin skin test for the evaluation of young children at high risk for tuberculosis in a community setting.

Nicol MP, Davies MA, Wood K, Hatherill M, Workman L, Hawkridge A, Eley B, Wilkinson KA, Wilkinson RJ, Hanekom WA, Beatty D, Hussey G.

Pediatrics. 2009 Jan;123(1):38-43. doi: 10.1542/peds.2008-0611.


Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: randomised trial.

Hawkridge A, Hatherill M, Little F, Goetz MA, Barker L, Mahomed H, Sadoff J, Hanekom W, Geiter L, Hussey G; South African BCG trial team.

BMJ. 2008 Nov 13;337:a2052. doi: 10.1136/bmj.a2052.


Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life.

Mansoor N, Abel B, Scriba TJ, Hughes J, de Kock M, Tameris M, Mlenjeni S, Denation L, Little F, Gelderbloem S, Hawkridge A, Boom WH, Kaplan G, Hussey GD, Hanekom WA.

Clin Immunol. 2009 Mar;130(3):280-9. doi: 10.1016/j.clim.2008.09.006. Epub 2008 Nov 8.


Construction of a versatile high precision ambient ionization source for direct analysis and imaging.

Sampson JS, Hawkridge AM, Muddiman DC.

J Am Soc Mass Spectrom. 2008 Oct;19(10):1527-34. doi: 10.1016/j.jasms.2008.06.013. Epub 2008 Jun 28.


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