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Items: 1 to 50 of 758

1.

Echocardiographic phenotype and prognosis in transthyretin cardiac amyloidosis.

Chacko L, Martone R, Bandera F, Lane T, Martinez-Naharro A, Boldrini M, Rezk T, Whelan C, Quarta C, Rowczenio D, Gilbertson JA, Wongwarawipat T, Lachmann H, Wechalekar A, Sachchithanantham S, Mahmood S, Marcucci R, Knight D, Hutt D, Moon J, Petrie A, Cappelli F, Guazzi M, Hawkins PN, Gillmore JD, Fontana M.

Eur Heart J. 2020 Jan 17. pii: ehz905. doi: 10.1093/eurheartj/ehz905. [Epub ahead of print]

PMID:
31950987
2.

Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy.

Adams D, Ando Y, Beirão JM, Coelho T, Gertz MA, Gillmore JD, Hawkins PN, Lousada I, Suhr OB, Merlini G.

J Neurol. 2020 Jan 6. doi: 10.1007/s00415-019-09688-0. [Epub ahead of print] Review.

PMID:
31907599
3.

TRAP1 chaperone protein mutations and autoinflammation.

Standing AS, Hong Y, Paisan-Ruiz C, Omoyinmi E, Medlar A, Stanescu H, Kleta R, Rowcenzio D, Hawkins P, Lachmann H, McDermott MF, Eleftheriou D, Klein N, Brogan PA.

Life Sci Alliance. 2019 Dec 27;3(2). pii: e201900376. doi: 10.26508/lsa.201900376. Print 2020 Feb.

4.

Multiparametric Echocardiography Scores for the Diagnosis of Cardiac Amyloidosis.

Boldrini M, Cappelli F, Chacko L, Restrepo-Cordoba MA, Lopez-Sainz A, Giannoni A, Aimo A, Baggiano A, Martinez-Naharro A, Whelan C, Quarta C, Passino C, Castiglione V, Chubuchnyi V, Spini V, Taddei C, Vergaro G, Petrie A, Ruiz-Guerrero L, Moñivas V, Mingo-Santos S, Mirelis JG, Dominguez F, Gonzalez-Lopez E, Perlini S, Pontone G, Gillmore J, Hawkins PN, Garcia-Pavia P, Emdin M, Fontana M.

JACC Cardiovasc Imaging. 2019 Dec 18. pii: S1936-878X(19)31007-1. doi: 10.1016/j.jcmg.2019.10.011. [Epub ahead of print]

PMID:
31864973
5.

Applying the 3Rs: A Case Study on Evidence and Perceptions Relating to Rat Cage Height in the UK.

Mazhary H, Hawkins P.

Animals (Basel). 2019 Dec 9;9(12). pii: E1104. doi: 10.3390/ani9121104.

6.

Predictive Values of MRI and PET Derived Quantitative Parameters for Patterns of Failure in Both p16+ and p16- High Risk Head and Neck Cancer.

Cao Y, Aryal M, Li P, Lee C, Schipper M, Hawkins PG, Chapman C, Owen D, Dragovic AF, Swiecicki P, Casper K, Worden F, Lawrence TS, Eisbruch A, Mierzwa M.

Front Oncol. 2019 Nov 14;9:1118. doi: 10.3389/fonc.2019.01118. eCollection 2019.

7.

A mosaic tetracycline resistance gene tet(S/M) detected in an MDR pneumococcal CC230 lineage that underwent capsular switching in South Africa.

Lo SW, Gladstone RA, van Tonder AJ, Du Plessis M, Cornick JE, Hawkins PA, Madhi SA, Nzenze SA, Kandasamy R, Ravikumar KL, Elmdaghri N, Kwambana-Adams B, Almeida SCG, Skoczynska A, Egorova E, Titov L, Saha SK, Paragi M, Everett DB, Antonio M, Klugman KP, Li Y, Metcalf BJ, Beall B, McGee L, Breiman RF, Bentley SD, von Gottberg A; Global Pneumococcal Sequencing Consortium .

J Antimicrob Chemother. 2019 Dec 2. pii: dkz477. doi: 10.1093/jac/dkz477. [Epub ahead of print]

PMID:
31789384
8.

3Rs-Related and Objective Indicators to Help Assess the Culture of Care.

Hawkins P, Bertelsen T.

Animals (Basel). 2019 Nov 14;9(11). pii: E969. doi: 10.3390/ani9110969.

9.

Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance.

Chattopadhyay S, Thomsen H, Weinhold N, Meziane I, Huhn S, da Silva Filho MI, Vodicka P, Vodickova L, Hoffmann P, Nöthen MM, Jöckel KH, Schmidt B, Landi S, Hajek R, Hallmans G, Pettersson-Kymmer U, Ohlsson C, Milani P, Merlini G, Rowcieno D, Hawkins P, Hegenbart U, Palladini G, Wechalekar A, Schönland SO, Houlston R, Goldschmidt H, Hemminki K, Försti A.

Leukemia. 2019 Nov 6. doi: 10.1038/s41375-019-0619-1. [Epub ahead of print] No abstract available.

PMID:
31695157
10.

How is the acyl chain composition of phosphoinositides created and does it matter?

Barneda D, Cosulich S, Stephens L, Hawkins P.

Biochem Soc Trans. 2019 Oct 31;47(5):1291-1305. doi: 10.1042/BST20190205.

11.

Recognising and understanding cryopyrin-associated periodic syndrome in adults.

Williams R, Hawkins P, Lane T.

Br J Nurs. 2019 Oct 10;28(18):1180-1186. doi: 10.12968/bjon.2019.28.18.1180.

PMID:
31597069
12.

A prospective observational study of 915 patients with systemic AL amyloidosis treated with upfront bortezomib.

Manwani R, Cohen O, Sharpley F, Mahmood S, Sachchithanantham S, Foard D, Lachmann HJ, Quarta C, Fontana M, Gillmore JD, Whelan C, Hawkins PN, Wechalekar AD.

Blood. 2019 Dec 19;134(25):2271-2280. doi: 10.1182/blood.2019000834.

PMID:
31578202
13.

Using an Interactive Framework to Assess a Cultural Simulation for Learning: Tag Team Patient Safety Simulation.

Greenawalt JA, Hawkins PM.

J Nurs Educ. 2019 Oct 1;58(10):591-594. doi: 10.3928/01484834-20190923-06.

PMID:
31573648
14.

The Parkinson's disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3.

Furlong RM, Lindsay A, Anderson KE, Hawkins PT, Sullivan AM, O'Neill C.

J Cell Sci. 2019 Oct 22;132(20). pii: jcs233221. doi: 10.1242/jcs.233221.

PMID:
31540955
15.

Noninvasive Mapping of the Electrophysiological Substrate in Cardiac Amyloidosis and Its Relationship to Structural Abnormalities.

Orini M, Graham AJ, Martinez-Naharro A, Andrews CM, de Marvao A, Statton B, Cook SA, O'Regan DP, Hawkins PN, Rudy Y, Fontana M, Lambiase PD.

J Am Heart Assoc. 2019 Sep 17;8(18):e012097. doi: 10.1161/JAHA.119.012097. Epub 2019 Sep 8.

16.

Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency.

Grace RF, Rose C, Layton DM, Galactéros F, Barcellini W, Morton DH, van Beers EJ, Yaish H, Ravindranath Y, Kuo KHM, Sheth S, Kwiatkowski JL, Barbier AJ, Bodie S, Silver B, Hua L, Kung C, Hawkins P, Jouvin MH, Bowden C, Glader B.

N Engl J Med. 2019 Sep 5;381(10):933-944. doi: 10.1056/NEJMoa1902678.

PMID:
31483964
17.

A 24-year experience of autologous stem cell transplantation for light chain amyloidosis patients in the United Kingdom.

Sharpley FA, Petrie A, Mahmood S, Sachchithanantham S, Lachmann HJ, Gillmore JD, Whelan CJ, Fontana M, Martinez-Naharro A, Quarta C, Hawkins PN, Wechalekar AD.

Br J Haematol. 2019 Dec;187(5):642-652. doi: 10.1111/bjh.16143. Epub 2019 Aug 13.

PMID:
31410841
18.

Cardiac biomarkers are prognostic in systemic light chain amyloidosis with no cardiac involvement by standard criteria.

Sharpley FA, Fontana M, Martinez-Naharro A, Manwani R, Mahmood S, Sachchithanantham S, Lachmann HJ, Gillmore JD, Whelan CJ, Hawkins PN, Wechalekar AD.

Haematologica. 2019 Aug 8. pii: haematol.2019.217695. doi: 10.3324/haematol.2019.217695. [Epub ahead of print]

19.

Carfilzomib is an effective upfront treatment in AL amyloidosis patients with peripheral and autonomic neuropathy.

Manwani R, Mahmood S, Sachchithanantham S, Lachmann HJ, Gillmore JD, Yong K, Rabin N, Popat R, Kyriakou C, Worthington S, Sharpley F, Smith M, Shah R, Cheesman S, Hawkins PN, Wechalekar AD.

Br J Haematol. 2019 Dec;187(5):638-641. doi: 10.1111/bjh.16122. Epub 2019 Aug 6.

PMID:
31388995
20.

British kindred with dominant FMF associated with high incidence of AA amyloidosis caused by novel MEFV variant, and a review of the literature.

Rowczenio DM, Youngstein T, Trojer H, Omoyinmi E, Baginska A, Brogan P, Papadopoulou C, Rezk T, Hawkins PN, Lachmann HJ.

Rheumatology (Oxford). 2019 Aug 5. pii: kez334. doi: 10.1093/rheumatology/kez334. [Epub ahead of print]

PMID:
31384939
21.

Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis.

Taylor GW, Gilbertson JA, Sayed R, Blanco A, Rendell NB, Rowczenio D, Rezk T, Mangione PP, Canetti D, Bass P, Hawkins PN, Gillmore JD.

Kidney Int Rep. 2019 Apr 15;4(7):977-986. doi: 10.1016/j.ekir.2019.04.007. eCollection 2019 Jul.

22.

Retrospective case series describing the efficacy, safety and cost-effectiveness of a vial-sharing programme for canakinumab treatment for paediatric patients with cryopyrin-associated periodic syndrome.

Elmi AA, Wynne K, Cheng IL, Eleftheriou D, Lachmann HJ, Hawkins PN, Brogan P.

Pediatr Rheumatol Online J. 2019 Jul 8;17(1):36. doi: 10.1186/s12969-019-0335-4.

23.

Exploratory Study of MYD88 L265P, Rare NLRP3 Variants, and Clonal Hematopoiesis Prevalence in Patients With Schnitzler Syndrome.

Pathak S, Rowczenio DM, Owen RG, Doody GM, Newton DJ, Taylor C, Taylor J, Cargo C, Hawkins PN, Krause K, Lachmann HJ, Savic S.

Arthritis Rheumatol. 2019 Dec;71(12):2121-2125. doi: 10.1002/art.41030. Epub 2019 Oct 14.

PMID:
31268627
24.

Pneumothorax and lung cysts: a family affair.

Hawkins P, Logan PM, Reeves EP, McElvaney NG.

Lancet. 2019 Jun 29;393(10191):2635. doi: 10.1016/S0140-6736(19)31283-8. Epub 2019 Jun 27. No abstract available.

PMID:
31258130
25.

Noncontrast Magnetic Resonance for the Diagnosis of Cardiac Amyloidosis.

Baggiano A, Boldrini M, Martinez-Naharro A, Kotecha T, Petrie A, Rezk T, Gritti M, Quarta C, Knight DS, Wechalekar AD, Lachmann HJ, Perlini S, Pontone G, Moon JC, Kellman P, Gillmore JD, Hawkins PN, Fontana M.

JACC Cardiovasc Imaging. 2020 Jan;13(1 Pt 1):69-80. doi: 10.1016/j.jcmg.2019.03.026. Epub 2019 Jun 12.

PMID:
31202744
26.

Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study.

Lo SW, Gladstone RA, van Tonder AJ, Lees JA, du Plessis M, Benisty R, Givon-Lavi N, Hawkins PA, Cornick JE, Kwambana-Adams B, Law PY, Ho PL, Antonio M, Everett DB, Dagan R, von Gottberg A, Klugman KP, McGee L, Breiman RF, Bentley SD; Global Pneumococcal Sequencing Consortium.

Lancet Infect Dis. 2019 Jul;19(7):759-769. doi: 10.1016/S1473-3099(19)30297-X. Epub 2019 Jun 10.

27.

Putative novel cps loci in a large global collection of pneumococci.

van Tonder AJ, Gladstone RA, Lo SW, Nahm MH, du Plessis M, Cornick J, Kwambana-Adams B, Madhi SA, Hawkins PA, Benisty R, Dagan R, Everett D, Antonio M, Klugman KP, von Gottberg A, Breiman RF, McGee L, Bentley SD; The Global Pneumococcal Sequencing Consortium.

Microb Genom. 2019 Jul;5(7). doi: 10.1099/mgen.0.000274. Epub 2019 Jun 11.

28.

The UK National Amyloidosis Centre.

Hawkins PN, Fontana M, Gillmore JD.

Eur Heart J. 2019 Jun 1;40(21):1661-1664. doi: 10.1093/eurheartj/ehz346. No abstract available.

PMID:
31152551
29.

Cardiorenal AL amyloidosis: risk stratification and outcomes based upon cardiac and renal biomarkers.

Rezk T, Lachmann HJ, Fontana M, Naharro AM, Sachchithanantham S, Mahmood S, Petrie A, Whelan CJ, Pinney JH, Foard D, Lane T, Youngstein T, Wechalekar AD, Hawkins PN, Gillmore JD.

Br J Haematol. 2019 Aug;186(3):460-470. doi: 10.1111/bjh.15955. Epub 2019 May 24.

PMID:
31124579
30.

Natural History, Quality of Life, and Outcome in Cardiac Transthyretin Amyloidosis.

Lane T, Fontana M, Martinez-Naharro A, Quarta CC, Whelan CJ, Petrie A, Rowczenio DM, Gilbertson JA, Hutt DF, Rezk T, Strehina SG, Caringal-Galima J, Manwani R, Sharpley FA, Wechalekar AD, Lachmann HJ, Mahmood S, Sachchithanantham S, Drage EPS, Jenner HD, McDonald R, Bertolli O, Calleja A, Hawkins PN, Gillmore JD.

Circulation. 2019 Jul 2;140(1):16-26. doi: 10.1161/CIRCULATIONAHA.118.038169. Epub 2019 May 21. Erratum in: Circulation. 2019 Jul 30;140(5):e185.

PMID:
31109193
31.

International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact.

Gladstone RA, Lo SW, Lees JA, Croucher NJ, van Tonder AJ, Corander J, Page AJ, Marttinen P, Bentley LJ, Ochoa TJ, Ho PL, du Plessis M, Cornick JE, Kwambana-Adams B, Benisty R, Nzenze SA, Madhi SA, Hawkins PA, Everett DB, Antonio M, Dagan R, Klugman KP, von Gottberg A, McGee L, Breiman RF, Bentley SD; Global Pneumococcal Sequencing Consortium.

EBioMedicine. 2019 May;43:338-346. doi: 10.1016/j.ebiom.2019.04.021. Epub 2019 Apr 16.

32.

High Prevalence of Intracardiac Thrombi in Cardiac Amyloidosis.

Martinez-Naharro A, Gonzalez-Lopez E, Corovic A, Mirelis JG, Baksi AJ, Moon JC, Garcia-Pavia P, Gillmore JD, Hawkins PN, Fontana M.

J Am Coll Cardiol. 2019 Apr 9;73(13):1733-1734. doi: 10.1016/j.jacc.2019.01.035. No abstract available.

PMID:
30947929
33.

Circulating microRNAs as biomarkers of radiation-induced cardiac toxicity in non-small-cell lung cancer.

Hawkins PG, Sun Y, Dess RT, Jackson WC, Sun G, Bi N, Tewari M, Hayman JA, Kalemkerian GP, Gadgeel SM, Lawrence TS, Haken RKT, Matuszak MM, Kong FS, Schipper MJ, Jolly S.

J Cancer Res Clin Oncol. 2019 Jun;145(6):1635-1643. doi: 10.1007/s00432-019-02903-5. Epub 2019 Mar 28.

PMID:
30923943
34.

Spinal Stenosis in Familial Transthyretin Amyloidosis.

Carr AS, Shah S, Choi D, Blake J, Phadke R, Gilbertson J, Whelan CJ, Wechalekar AD, Gillmore JD, Hawkins PN, Reilly MM.

J Neuromuscul Dis. 2019;6(2):267-270. doi: 10.3233/JND-180348.

PMID:
30856118
35.

Real-Time Quantitative Assessment of Accuracy and Precision of Blood Volume Derived from DCE-MRI in Individual Patients During a Clinical Trial.

Aryal MP, Lee C, Hawkins PG, Chapman C, Eisbruch A, Mierzwa M, Cao Y.

Tomography. 2019 Mar;5(1):61-67. doi: 10.18383/j.tom.2018.00029.

36.

Predictive Models to Determine Clinically Relevant Deviations in Delivered Dose for Head and Neck Cancer.

McCulloch MM, Lee C, Rosen BS, Kamp JD, Lockhart CM, Lee JY, Polan DF, Hawkins PG, Anderson CJR, Heukelom J, Sonke JJ, Fuller CD, Balter JM, Ten Haken RK, Eisbruch A, Brock KK.

Pract Radiat Oncol. 2019 Jul - Aug;9(4):e422-e431. doi: 10.1016/j.prro.2019.02.014. Epub 2019 Mar 2.

PMID:
30836190
37.

Impact of American Joint Committee on Cancer Eighth Edition clinical stage and smoking history on oncologic outcomes in human papillomavirus-associated oropharyngeal squamous cell carcinoma.

Hawkins PG, Mierzwa ML, Bellile E, Jackson WC, Malloy KM, Chinn SB, Spector ME, Shuman AG, Stucken CL, McLean SA, Bradford CR, Prince ME, Carey TE, Worden FP, Swiecicki PL, Taylor JMG, Wolf GT, Eisbruch A, Casper KA.

Head Neck. 2019 Apr;41(4):857-864. doi: 10.1002/hed.25336. Epub 2019 Feb 18.

PMID:
30775826
38.

Automated Pixel-Wise Quantitative Myocardial Perfusion Mapping by CMR to Detect Obstructive Coronary Artery Disease and Coronary Microvascular Dysfunction: Validation Against Invasive Coronary Physiology.

Kotecha T, Martinez-Naharro A, Boldrini M, Knight D, Hawkins P, Kalra S, Patel D, Coghlan G, Moon J, Plein S, Lockie T, Rakhit R, Patel N, Xue H, Kellman P, Fontana M.

JACC Cardiovasc Imaging. 2019 Oct;12(10):1958-1969. doi: 10.1016/j.jcmg.2018.12.022. Epub 2019 Feb 13.

PMID:
30772231
39.

The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis.

Rezk T, Gilbertson JA, Mangione PP, Rowczenio D, Rendell NB, Canetti D, Lachmann HJ, Wechalekar AD, Bass P, Hawkins PN, Bellotti V, Taylor GW, Gillmore JD.

J Pathol Clin Res. 2019 Jul;5(3):145-153. doi: 10.1002/cjp2.126. Epub 2019 Apr 2.

40.

Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.

Suire S, Baltanas FC, Segonds-Pichon A, Davidson K, Santos E, Hawkins PT, Stephens LR.

J Leukoc Biol. 2019 Oct;106(4):815-822. doi: 10.1002/JLB.2HI0918-359RR. Epub 2019 Feb 5.

PMID:
30720883
41.

Acute changes in cardiac structural and tissue characterisation parameters following haemodialysis measured using cardiovascular magnetic resonance.

Kotecha T, Martinez-Naharro A, Yoowannakul S, Lambe T, Rezk T, Knight DS, Hawkins PN, Moon JC, Muthurangu V, Kellman P, Rakhit RD, Gillmore JD, Jeetley P, Davenport A, Fontana M.

Sci Rep. 2019 Feb 4;9(1):1388. doi: 10.1038/s41598-018-37845-4.

42.

A novel mass spectrometry method to identify the serum monoclonal light chain component in systemic light chain amyloidosis.

Sharpley FA, Manwani R, Mahmood S, Sachchithanantham S, Lachmann HJ, Gillmore JD, Whelan CJ, Fontana M, Hawkins PN, Wechalekar AD.

Blood Cancer J. 2019 Feb 4;9(2):16. doi: 10.1038/s41408-019-0180-1. No abstract available.

43.

A pilot study demonstrating cardiac uptake with 18F-florbetapir PET in AL amyloidosis patients with cardiac involvement.

Manwani R, Page J, Lane T, Burniston M, Skillen A, Lachmann HJ, Gillmore JD, Fontana M, Whelan C, Hawkins PN, Wagner T, Wechalekar AD.

Amyloid. 2018 Dec;25(4):247-252. doi: 10.1080/13506129.2018.1552852. Epub 2019 Jan 19.

PMID:
30661419
44.

Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis.

Li Y, Metcalf BJ, Chochua S, Li Z, Walker H, Tran T, Hawkins PA, Gierke R, Pilishvili T, McGee L, Beall BW.

Nat Commun. 2019 Jan 14;10(1):178. doi: 10.1038/s41467-018-07997-y.

45.

Increased cerebral blood flow after single dose of antipsychotics in healthy volunteers depends on dopamine D2 receptor density profiles.

Selvaggi P, Hawkins PCT, Dipasquale O, Rizzo G, Bertolino A, Dukart J, Sambataro F, Pergola G, Williams SCR, Turkheimer F, Zelaya F, Veronese M, Mehta MA.

Neuroimage. 2019 Mar;188:774-784. doi: 10.1016/j.neuroimage.2018.12.028. Epub 2018 Dec 13.

PMID:
30553916
46.

Volumetric 18 F-FDG-PET parameters as predictors of locoregional failure in low-risk HPV-related oropharyngeal cancer after definitive chemoradiation therapy.

Chotchutipan T, Rosen BS, Hawkins PG, Lee JY, Saripalli AL, Thakkar D, Eisbruch A, El Naqa I, Mierzwa ML.

Head Neck. 2019 Feb;41(2):366-373. doi: 10.1002/hed.25505. Epub 2018 Dec 12.

PMID:
30548704
47.

Quantitation of 99mTc-DPD uptake in patients with transthyretin-related cardiac amyloidosis.

Ross JC, Hutt DF, Burniston M, Page J, Steeden JA, Gillmore JD, Wechalekar AD, Hawkins PN, Fontana M.

Amyloid. 2018 Sep;25(3):203-210. doi: 10.1080/13506129.2018.1520087.

PMID:
30486686
48.

Oligonucleotide Drugs for Transthyretin Amyloidosis.

Adams D, Hawkins PN, Polydefkis M.

N Engl J Med. 2018 Nov 22;379(21):2086. doi: 10.1056/NEJMc1810994. No abstract available.

PMID:
30484624
49.

Bioimpedance vector analysis for the detection of extracellular volume overload and sarcopenia in systemic AL amyloidosis.

Rezk T, Davenport A, Gan JJ, Lachmann HJ, Fontana M, Martinez-Naharro A, Sachchithanantham S, Guillotte C, Mahmood S, Petrie A, Whelan CJ, Pinney JH, Foard D, Lane T, Youngstein T, Wechalekar AD, Hawkins PN, Gillmore JD.

Br J Haematol. 2019 Jun;185(5):977-980. doi: 10.1111/bjh.15675. Epub 2018 Nov 18. No abstract available.

PMID:
30450572
50.

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.

Tsolakos N, Durrant TN, Chessa T, Suire SM, Oxley D, Kulkarni S, Downward J, Perisic O, Williams RL, Stephens L, Hawkins PT.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12176-12181. doi: 10.1073/pnas.1803446115. Epub 2018 Nov 15.

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