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First application of loop-mediated isothermal amplification (LAMP) assays for rapid identification of mating type in the heterothallic fungus Aspergillus fumigatus.

King KM, Hawkins NJ, Atkins S, Dyer PS, West JS, Fraaije BA.

Mycoses. 2019 Jun 18. doi: 10.1111/myc.12959. [Epub ahead of print]


Digest: Plant-pathogen coevolution extends to shifts in plant breeding systems.

Hawkins NJ.

Evolution. 2019 Mar;73(3):628-629. doi: 10.1111/evo.13687. Epub 2019 Jan 24.


Evaluation of the transferability of survival calculators for stage II/III colon cancer across healthcare systems.

Jorissen RN, Croxford M, Jones IT, Ward RL, Hawkins NJ, Gibbs P, Sieber OM.

Int J Cancer. 2019 Jul 1;145(1):132-142. doi: 10.1002/ijc.32100. Epub 2019 Jan 20.


Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.

Domingo E, Camps C, Kaisaki PJ, Parsons MJ, Mouradov D, Pentony MM, Makino S, Palmieri M, Ward RL, Hawkins NJ, Gibbs P, Askautrud H, Oukrif D, Wang H, Wood J, Tomlinson E, Bark Y, Kaur K, Johnstone EC, Palles C, Church DN, Novelli M, Danielsen HE, Sherlock J, Kerr D, Kerr R, Sieber O, Taylor JC, Tomlinson I.

Lancet Gastroenterol Hepatol. 2018 Sep;3(9):635-643. doi: 10.1016/S2468-1253(18)30117-1. Epub 2018 Jul 2.


The evolutionary origins of pesticide resistance.

Hawkins NJ, Bass C, Dixon A, Neve P.

Biol Rev Camb Philos Soc. 2018 Jul 3. doi: 10.1111/brv.12440. [Epub ahead of print]


Fitness Penalties in the Evolution of Fungicide Resistance.

Hawkins NJ, Fraaije BA.

Annu Rev Phytopathol. 2018 Aug 25;56:339-360. doi: 10.1146/annurev-phyto-080417-050012. Epub 2018 Jun 29.


Disruption of a -35 kb Enhancer Impairs CTCF Binding and MLH1 Expression in Colorectal Cells.

Liu Q, Thoms JAI, Nunez AC, Huang Y, Knezevic K, Packham D, Poulos RC, Williams R, Beck D, Hawkins NJ, Ward RL, Wong JWH, Hesson LB, Sloane MA, Pimanda JE.

Clin Cancer Res. 2018 Sep 15;24(18):4602-4611. doi: 10.1158/1078-0432.CCR-17-3678. Epub 2018 Jun 13.


MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.

Sakthianandeswaren A, Parsons MJ, Mouradov D, MacKinnon RN, Catimel B, Liu S, Palmieri M, Love C, Jorissen RN, Li S, Whitehead L, Putoczki TL, Preaudet A, Tsui C, Nowell CJ, Ward RL, Hawkins NJ, Desai J, Gibbs P, Ernst M, Street I, Buchert M, Sieber OM.

Cancer Discov. 2018 Aug;8(8):988-1005. doi: 10.1158/2159-8290.CD-17-0909. Epub 2018 Jun 7.


Worldwide emergence of resistance to antifungal drugs challenges human health and food security.

Fisher MC, Hawkins NJ, Sanglard D, Gurr SJ.

Science. 2018 May 18;360(6390):739-742. doi: 10.1126/science.aap7999. Review.


Digest: Plants adapt under attack: genotypic selection and phenotypic plasticity under herbivore pressure.

Hawkins NJ.

Evolution. 2018 May;72(5):1184-1185. doi: 10.1111/evo.13472. Epub 2018 Apr 25.


Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes.

Williams DS, Mouradov D, Jorissen RN, Newman MR, Amini E, Nickless DK, Teague JA, Fang CG, Palmieri M, Parsons MJ, Sakthianandeswaren A, Li S, Ward RL, Hawkins NJ, Faragher I, Jones IT, Gibbs P, Sieber OM.

Gut. 2018 Jan 30. pii: gutjnl-2017-315664. doi: 10.1136/gutjnl-2017-315664. [Epub ahead of print]


Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase.

Sewell TR, Hawkins NJ, Stotz HU, Huang Y, Kelly SL, Kelly DE, Fraaije B, Fitt BDL.

Sci Rep. 2017 Nov 20;7(1):15849. doi: 10.1038/s41598-017-15545-9.


Dose-dependent selection drives lineage replacement during the experimental evolution of SDHI fungicide resistance in Zymoseptoria tritici.

Gutiérrez-Alonso O, Hawkins NJ, Cools HJ, Shaw MW, Fraaije BA.

Evol Appl. 2017 Sep 3;10(10):1055-1066. doi: 10.1111/eva.12511. eCollection 2017 Dec.


Predicting Resistance by Mutagenesis: Lessons from 45 Years of MBC Resistance.

Hawkins NJ, Fraaije BA.

Front Microbiol. 2016 Nov 15;7:1814. eCollection 2016.


Pathogenic germline MCM9 variants are rare in Australian Lynch-like syndrome patients.

Liu Q, Hesson LB, Nunez AC, Packham D, Hawkins NJ, Ward RL, Sloane MA.

Cancer Genet. 2016 Nov;209(11):497-500. doi: 10.1016/j.cancergen.2016.10.001. Epub 2016 Oct 11.


Validation of specificity of antibodies for immunohistochemistry: the case of ROR2.

Ma SS, Henry CE, Llamosas E, Higgins R, Daniels B, Hesson LB, Hawkins NJ, Ward RL, Ford CE.

Virchows Arch. 2017 Jan;470(1):99-108. doi: 10.1007/s00428-016-2019-5. Epub 2016 Sep 8. Erratum in: Virchows Arch. 2016 Dec;469(6):717.


Erratum to: Validation of specificity of antibodies for immunohistochemistry: the case of ROR2.

Ma SS, Henry CE, Llamosas E, Higgins R, Daniels B, Hesson LB, Hawkins NJ, Ward RL, Ford CE.

Virchows Arch. 2016 Dec;469(6):717. Epub 2016 Oct 29. No abstract available.


Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors.

Hesson LB, Ng B, Zarzour P, Srivastava S, Kwok CT, Packham D, Nunez AC, Beck D, Ryan R, Dower A, Ford CE, Pimanda JE, Sloane MA, Hawkins NJ, Bourke MJ, Wong JW, Ward RL.

Mol Cancer Res. 2016 Dec;14(12):1217-1228. Epub 2016 Sep 26.


ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration.

Ma SS, Srivastava S, Llamosas E, Hawkins NJ, Hesson LB, Ward RL, Ford CE.

BMC Cancer. 2016 Jul 20;16:508. doi: 10.1186/s12885-016-2576-7.


Integration and Analysis of Heterogeneous Colorectal Cancer Data for Translational Research.

Jonnagaddala J, Croucher JL, Jue TR, Meagher NS, Caruso L, Ward R, Hawkins NJ.

Stud Health Technol Inform. 2016;225:387-91.


SNP rs16906252C>T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer.

Kuroiwa-Trzmielina J, Wang F, Rapkins RW, Ward RL, Buchanan DD, Win AK, Clendenning M, Rosty C, Southey MC, Winship IM, Hopper JL, Jenkins MA, Olivier J, Hawkins NJ, Hitchins MP.

Clin Cancer Res. 2016 Dec 15;22(24):6266-6277. Epub 2016 Jun 7.


Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer.

Suraweera N, Mouradov D, Li S, Jorissen RN, Hampson D, Ghosh A, Sengupta N, Thaha M, Ahmed S, Kirwan M, Aleva F, Propper D, Feakins RM, Vulliamy T, Elwood NJ, Tian P, Ward RL, Hawkins NJ, Xu ZZ, Molloy PL, Jones IT, Croxford M, Gibbs P, Silver A, Sieber OM.

Oncotarget. 2016 Jun 14;7(24):36474-36488. doi: 10.18632/oncotarget.9015.


The Impact of Mismatch Repair Status in Colorectal Cancer on the Decision to Treat With Adjuvant Chemotherapy: An Australian Population-Based Multicenter Study.

He EY, Hawkins NJ, Mak G, Roncolato F, Goldstein D, Liauw W, Clingan P, Chin M, Ward RL.

Oncologist. 2016 May;21(5):618-25. doi: 10.1634/theoncologist.2015-0530. Epub 2016 Mar 23.


Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer.

Jorissen RN, Christie M, Mouradov D, Sakthianandeswaren A, Li S, Love C, Xu ZZ, Molloy PL, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, Moore J, Burgess AW, Busam D, Zhao Q, Strausberg RL, Lipton L, Desai J, Gibbs P, Sieber OM.

Br J Cancer. 2015 Sep 15;113(6):979-88. doi: 10.1038/bjc.2015.296. Epub 2015 Aug 25.


Adaptive Tutorials Versus Web-Based Resources in Radiology: A Mixed Methods Comparison of Efficacy and Student Engagement.

Wong V, Smith AJ, Hawkins NJ, Kumar RK, Young N, Kyaw M, Velan GM.

Acad Radiol. 2015 Oct;22(10):1299-307. doi: 10.1016/j.acra.2015.07.002. Epub 2015 Aug 17.


Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas.

Zarzour P, Boelen L, Luciani F, Beck D, Sakthianandeswaren A, Mouradov D, Sieber OM, Hawkins NJ, Hesson LB, Ward RL, Wong JW.

Genes Chromosomes Cancer. 2015 May;54(5):303-14. doi: 10.1002/gcc.22243. Epub 2015 Feb 27.


The evolution of fungicide resistance.

Lucas JA, Hawkins NJ, Fraaije BA.

Adv Appl Microbiol. 2015;90:29-92. doi: 10.1016/bs.aambs.2014.09.001. Epub 2014 Nov 12. Review.


Institutional biobanking: an integral part of contemporary pathology practice.

Scott GM, Hettiaratchi A, Salisbury E, Ward RL, Hawkins NJ.

Pathology. 2015 Jan;47(1):4-6. doi: 10.1097/PAT.0000000000000185. No abstract available.


Cohesin Rad21 mediates loss of heterozygosity and is upregulated via Wnt promoting transcriptional dysregulation in gastrointestinal tumors.

Xu H, Yan Y, Deb S, Rangasamy D, Germann M, Malaterre J, Eder NC, Ward RL, Hawkins NJ, Tothill RW, Chen L, Mortensen NJ, Fox SB, McKay MJ, Ramsay RG.

Cell Rep. 2014 Dec 11;9(5):1781-1797. doi: 10.1016/j.celrep.2014.10.059. Epub 2014 Nov 20.


Altered promoter nucleosome positioning is an early event in gene silencing.

Hesson LB, Sloane MA, Wong JW, Nunez AC, Srivastava S, Ng B, Hawkins NJ, Bourke MJ, Ward RL.

Epigenetics. 2014 Oct;9(10):1422-30. doi: 10.4161/15592294.2014.970077.


Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling.

Henry C, Quadir A, Hawkins NJ, Jary E, Llamosas E, Kumar D, Daniels B, Ward RL, Ford CE.

J Cancer Res Clin Oncol. 2015 Feb;141(2):243-54. doi: 10.1007/s00432-014-1824-y. Epub 2014 Sep 11.


Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.

Sloane MA, Wong JW, Perera D, Nunez AC, Pimanda JE, Hawkins NJ, Sieber OM, Bourke MJ, Hesson LB, Ward RL.

Epigenetics. 2014 Aug;9(8):1092-100. doi: 10.4161/epi.29222. Epub 2014 May 16.


Introducing research initiatives into healthcare: what do doctors think?

Wyld L, Smith S, Hawkins NJ, Long J, Ward RL.

Biopreserv Biobank. 2014 Apr;12(2):91-8. doi: 10.1089/bio.2013.0069.


Paralog re-emergence: a novel, historically contingent mechanism in the evolution of antimicrobial resistance.

Hawkins NJ, Cools HJ, Sierotzki H, Shaw MW, Knogge W, Kelly SL, Kelly DE, Fraaije BA.

Mol Biol Evol. 2014 Jul;31(7):1793-802. doi: 10.1093/molbev/msu134. Epub 2014 Apr 14.


RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas.

Deb S, Xu H, Tuynman J, George J, Yan Y, Li J, Ward RL, Mortensen N, Hawkins NJ, McKay MJ, Ramsay RG, Fox SB.

Br J Cancer. 2014 Mar 18;110(6):1606-13. doi: 10.1038/bjc.2014.31. Epub 2014 Feb 18.


Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

Dewhurst SM, McGranahan N, Burrell RA, Rowan AJ, Grönroos E, Endesfelder D, Joshi T, Mouradov D, Gibbs P, Ward RL, Hawkins NJ, Szallasi Z, Sieber OM, Swanton C.

Cancer Discov. 2014 Feb;4(2):175-185. doi: 10.1158/2159-8290.CD-13-0285. Epub 2014 Jan 19.


Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33.

Webster LR, Provan PJ, Graham DJ, Byth K, Walker RL, Davis S, Salisbury EL, Morey AL, Ward RL, Hawkins NJ, Clarke CL, Meltzer PS, Balleine RL.

Pathology. 2013 Dec;45(7):629-36. doi: 10.1097/PAT.0000000000000004.


Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations.

Mouradov D, Domingo E, Gibbs P, Jorissen RN, Li S, Soo PY, Lipton L, Desai J, Danielsen HE, Oukrif D, Novelli M, Yau C, Holmes CC, Jones IT, McLaughlin S, Molloy P, Hawkins NJ, Ward R, Midgely R, Kerr D, Tomlinson IP, Sieber OM.

Am J Gastroenterol. 2013 Nov;108(11):1785-93. doi: 10.1038/ajg.2013.292. Epub 2013 Sep 17.


Population-based molecular screening for Lynch syndrome: implications for personalized medicine.

Ward RL, Hicks S, Hawkins NJ.

J Clin Oncol. 2013 Jul 10;31(20):2554-62. doi: 10.1200/JCO.2012.46.8454. Epub 2013 Jun 3. Erratum in: J Clin Oncol. 2013 Nov 10;31(32):4167.


PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer.

Day FL, Jorissen RN, Lipton L, Mouradov D, Sakthianandeswaren A, Christie M, Li S, Tsui C, Tie J, Desai J, Xu ZZ, Molloy P, Whitehall V, Leggett BA, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, Moore J, Busam D, Zhao Q, Strausberg RL, Gibbs P, Sieber OM.

Clin Cancer Res. 2013 Jun 15;19(12):3285-96. doi: 10.1158/1078-0432.CCR-12-3614. Epub 2013 Apr 30.


A correlation of the endoscopic characteristics of colonic laterally spreading tumours with genetic alterations.

Metz AJ, Bourke MJ, Moss A, Dower A, Zarzour P, Hawkins NJ, Ward RL, Hesson LB.

Eur J Gastroenterol Hepatol. 2013 Mar;25(3):319-26. doi: 10.1097/MEG.0b013e32835b57e7.


SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.

Fleming NI, Jorissen RN, Mouradov D, Christie M, Sakthianandeswaren A, Palmieri M, Day F, Li S, Tsui C, Lipton L, Desai J, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, Moore J, Zhu HJ, Mariadason JM, Burgess AW, Busam D, Zhao Q, Strausberg RL, Gibbs P, Sieber OM.

Cancer Res. 2013 Jan 15;73(2):725-35. doi: 10.1158/0008-5472.CAN-12-2706. Epub 2012 Nov 8.


Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.

Christie M, Jorissen RN, Mouradov D, Sakthianandeswaren A, Li S, Day F, Tsui C, Lipton L, Desai J, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, Moore J, Burgess AW, Busam D, Zhao Q, Strausberg RL, Simpson AJ, Tomlinson IP, Gibbs P, Sieber OM.

Oncogene. 2013 Sep 26;32(39):4675-82. doi: 10.1038/onc.2012.486. Epub 2012 Oct 22.


Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa.

Liu J, Hesson LB, Meagher AP, Bourke MJ, Hawkins NJ, Rand KN, Molloy PL, Pimanda JE, Ward RL.

Cancer Prev Res (Phila). 2012 Jul;5(7):921-9. doi: 10.1158/1940-6207.CAPR-11-0577. Epub 2012 May 18.


Mutated in colorectal cancer protein modulates the NFκB pathway.

Sigglekow ND, Pangon L, Brummer T, Molloy M, Hawkins NJ, Ward RL, Musgrove EA, Kohonen-Corish MR.

Anticancer Res. 2012 Jan;32(1):73-9.


Immunohistochemistry for PMS2 and MSH6 alone can replace a four antibody panel for mismatch repair deficiency screening in colorectal adenocarcinoma.

Hicks SC, Ward RL, Hawkins NJ.

Pathology. 2011 Jan;43(1):84-5; author reply 85-6. doi: 10.1097/PAT.0b013e3283410b26. No abstract available.


Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer.

Wong JJ, Hawkins NJ, Ward RL, Hitchins MP.

Mod Pathol. 2011 Mar;24(3):396-411. doi: 10.1038/modpathol.2010.212. Epub 2010 Nov 19.


Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome.

Kwok CT, Ward RL, Hawkins NJ, Hitchins MP.

Fam Cancer. 2010 Sep;9(3):345-56. doi: 10.1007/s10689-009-9314-0.


MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa.

Hawkins NJ, Lee JH, Wong JJ, Kwok CT, Ward RL, Hitchins MP.

Mod Pathol. 2009 Dec;22(12):1588-99. doi: 10.1038/modpathol.2009.130. Epub 2009 Sep 4.


Implementation of novel pyrosequencing assays to screen for common mutations of BRAF and KRAS in a cohort of sporadic colorectal cancers.

Packham D, Ward RL, Ap Lin V, Hawkins NJ, Hitchins MP.

Diagn Mol Pathol. 2009 Jun;18(2):62-71. doi: 10.1097/PDM.0b013e318182af52.


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