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Items: 1 to 50 of 204

1.

On demand delivery and analysis of single molecules on a programmable nanopore-optofluidic device.

Rahman M, Stott MA, Harrington M, Li Y, Sampad MJN, Lancaster L, Yuzvinsky TD, Noller HF, Hawkins AR, Schmidt H.

Nat Commun. 2019 Aug 16;10(1):3712. doi: 10.1038/s41467-019-11723-7.

PMID:
31420559
2.

Enhanced Detection of Single Viruses On-Chip via Hydrodynamic Focusing.

Black JA, Hamilton E, Hueros RAR, Parks JW, Hawkins AR, Schmidt H.

IEEE J Sel Top Quantum Electron. 2019 Jan-Feb;25(1). pii: 7201206. doi: 10.1109/JSTQE.2018.2854574. Epub 2018 Jul 9.

PMID:
30686911
3.

Buried Rib SiO2 Multimode Interference Waveguides for Optofluidic Multiplexing.

Stott MA, Ganjalizadeh V, Meena G, McMurray J, Olsen M, Orfila M, Schmidt H, Hawkins AR.

IEEE Photonics Technol Lett. 2018 Oct 15;30(16):1487-1490. doi: 10.1109/LPT.2018.2858258. Epub 2018 Jul 23.

PMID:
30618484
4.

A Microscale Planar Linear Ion Trap Mass Spectrometer.

Decker TK, Zheng Y, Ruben AJ, Wang X, Lammert SA, Austin DE, Hawkins AR.

J Am Soc Mass Spectrom. 2019 Mar;30(3):482-488. doi: 10.1007/s13361-018-2104-x. Epub 2018 Dec 12.

PMID:
30542974
5.

Stainless-Steel Column for Robust, High-Temperature Microchip Gas Chromatography.

Ghosh A, Foster AR, Johnson JC, Vilorio CR, Tolley LT, Iverson BD, Hawkins AR, Tolley HD, Lee ML.

Anal Chem. 2019 Jan 2;91(1):792-796. doi: 10.1021/acs.analchem.8b04174. Epub 2018 Dec 19.

PMID:
30525480
6.

Integration of sample preparation and analysis into an optofluidic chip for multi-target disease detection.

Meena GG, Jain A, Parks JW, Stambaugh A, Patterson JL, Hawkins AR, Schmidt H.

Lab Chip. 2018 Dec 7;18(23):3678-3686. doi: 10.1039/c8lc00966j. Epub 2018 Oct 30.

PMID:
30376021
7.

Optofluidic detection of Zika nucleic acid and protein biomarkers using multimode interference multiplexing.

Stambaugh A, Parks JW, Stott MA, Meena GG, Hawkins AR, Schmidt H.

Biomed Opt Express. 2018 Jul 16;9(8):3725-3730. doi: 10.1364/BOE.9.003725. eCollection 2018 Aug 1.

8.

Double resonance ejection using novel radiofrequency phase tracking circuitry in a miniaturized planar linear ion trap mass spectrometer.

Decker TK, Zheng Y, McClellan JS, Ruben AJ, Lammert SA, Austin DE, Hawkins AR.

Rapid Commun Mass Spectrom. 2018 Dec 15;32(23):2024-2030. doi: 10.1002/rcm.8267.

PMID:
30133876
9.

Microchip gas chromatography columns, interfacing and performance.

Ghosh A, Vilorio CR, Hawkins AR, Lee ML.

Talanta. 2018 Oct 1;188:463-492. doi: 10.1016/j.talanta.2018.04.088. Epub 2018 May 2. Review.

PMID:
30029402
10.

Optimized ARROW-Based MMI Waveguides for High Fidelity Excitation Patterns for Optofluidic Multiplexing.

Stott MA, Ganjalizadeh V, Olsen M, Orfila M, McMurray J, Schmidt H, Hawkins AR.

IEEE J Quantum Electron. 2018 Jun;54(3). pii: 6200107. doi: 10.1109/JQE.2018.2816120. Epub 2018 Mar 15.

11.

Experimental Observation of the Effects of Translational and Rotational Electrode Misalignment on a Planar Linear Ion Trap Mass Spectrometer.

Tian Y, Decker TK, McClellan JS, Wu Q, De la Cruz A, Hawkins AR, Austin DE.

J Am Soc Mass Spectrom. 2018 Jul;29(7):1376-1385. doi: 10.1007/s13361-018-1942-x. Epub 2018 Apr 5.

PMID:
29623663
12.

Optofluidic bioanalysis: fundamentals and applications.

Ozcelik D, Cai H, Leake KD, Hawkins AR, Schmidt H.

Nanophotonics. 2017 Jul;6(4):647-661. doi: 10.1515/nanoph-2016-0156. Epub 2017 Mar 16.

13.

Optofluidic Lab-on-a-Chip Fluorescence Sensor Using Integrated Buried ARROW (bARROW) Waveguides.

Wall T, McMurray J, Meena G, Ganjalizadeh V, Schmidt H, Hawkins AR.

Micromachines (Basel). 2017 Aug;8(8). pii: 252. doi: 10.3390/mi8080252. Epub 2017 Aug 17.

14.

Mitigating Water Absorption in Waveguides Made From Unannealed PECVD SiO2.

Wall T, Hammon S, Hamilton E, Zacheu G, Orfila M, Schmidt H, Hawkins AR.

IEEE Photonics Technol Lett. 2017 May 15;29(10):806-809. doi: 10.1109/LPT.2017.2686354. Epub 2017 Mar 22.

15.

Crystal structure of NucB, a biofilm-degrading endonuclease.

Baslé A, Hewitt L, Koh A, Lamb HK, Thompson P, Burgess JG, Hall MJ, Hawkins AR, Murray H, Lewis RJ.

Nucleic Acids Res. 2018 Jan 9;46(1):473-484. doi: 10.1093/nar/gkx1170.

16.

Optimal fabrication methods for miniature coplanar ion traps.

Decker TK, Tian Y, McClellan JS, Bennett L, Lammert SA, Austin DE, Hawkins AR.

Rapid Commun Mass Spectrom. 2018 Feb 28;32(4):289-294. doi: 10.1002/rcm.8028.

PMID:
29131427
17.

Extending the upper temperature range of gas chromatography with all-silicon microchip columns using a heater/clamp assembly.

Ghosh A, Johnson JE, Nuss JG, Stark BA, Hawkins AR, Tolley LT, Iverson BD, Tolley HD, Lee ML.

J Chromatogr A. 2017 Sep 29;1517:134-141. doi: 10.1016/j.chroma.2017.08.036. Epub 2017 Aug 18.

PMID:
28855092
18.

Improved Miniaturized Linear Ion Trap Mass Spectrometer Using Lithographically Patterned Plates and Tapered Ejection Slit.

Tian Y, Decker TK, McClellan JS, Bennett L, Li A, De la Cruz A, Andrews D, Lammert SA, Hawkins AR, Austin DE.

J Am Soc Mass Spectrom. 2018 Feb;29(2):213-222. doi: 10.1007/s13361-017-1759-z. Epub 2017 Aug 23.

PMID:
28836122
19.

Reducing the Flexibility of Type II Dehydroquinase for Inhibition: A Fragment-Based Approach and Molecular Dynamics Study.

Peón A, Robles A, Blanco B, Convertino M, Thompson P, Hawkins AR, Caflisch A, González-Bello C.

ChemMedChem. 2017 Sep 21;12(18):1512-1524. doi: 10.1002/cmdc.201700396. Epub 2017 Sep 12.

PMID:
28791799
20.

Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms.

Wilkinson DJ, Wang H, Habgood A, Lamb HK, Thompson P, Hawkins AR, Désilets A, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, Rowan AD.

Arthritis Rheumatol. 2017 Aug;69(8):1601-1611. doi: 10.1002/art.40133. Epub 2017 Jul 5. Erratum in: Arthritis Rheumatol. 2018 Oct;70(10):1596.

21.

Improved environmental stability for plasma enhanced chemical vapor deposition SiO2 waveguides using buried channel designs.

Wall TA, Chu RP, Parks JW, Ozcelik D, Schmidt H, Hawkins AR.

Opt Eng. 2016 Apr;55(4). pii: 040501. doi: 10.1117/1.OE.55.4.040501. Epub 2016 Apr 25.

22.

Optimization of Y-splitting antiresonant reflecting optical waveguides-based rib waveguides.

Stott MA, Black J, Hamilton E, Schmidt H, Hawkins AR.

Opt Eng. 2016 Oct;55(10). pii: 100505. doi: 10.1117/1.OE.55.10.100505. Epub 2016 Oct 31.

23.

A Miniaturized Linear Wire Ion Trap with Electron Ionization and Single Photon Ionization Sources.

Wu Q, Tian Y, Li A, Andrews D, Hawkins AR, Austin DE.

J Am Soc Mass Spectrom. 2017 May;28(5):859-865. doi: 10.1007/s13361-017-1607-1. Epub 2017 Jan 31.

PMID:
28144897
24.

Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of Ebola virus.

Du K, Cai H, Park M, Wall TA, Stott MA, Alfson KJ, Griffiths A, Carrion R, Patterson JL, Hawkins AR, Schmidt H, Mathies RA.

Biosens Bioelectron. 2017 May 15;91:489-496. doi: 10.1016/j.bios.2016.12.071. Epub 2017 Jan 3.

25.

On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood.

Cai H, Stott MA, Ozcelik D, Parks JW, Hawkins AR, Schmidt H.

Biomicrofluidics. 2016 Dec 15;10(6):064116. doi: 10.1063/1.4968033. eCollection 2016 Nov.

26.

A Critical Role for Extracellular DNA in Dental Plaque Formation.

Rostami N, Shields RC, Yassin SA, Hawkins AR, Bowen L, Luo TL, Rickard AH, Holliday R, Preshaw PM, Jakubovics NS.

J Dent Res. 2017 Feb;96(2):208-216. doi: 10.1177/0022034516675849. Epub 2016 Oct 23.

PMID:
27770039
27.

Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme.

Prado V, Lence E, Thompson P, Hawkins AR, González-Bello C.

Chemistry. 2016 Dec 12;22(50):17988-18000. doi: 10.1002/chem.201602923. Epub 2016 Oct 4.

PMID:
27699905
28.

Enhancement of ARROW Photonic Device Performance via Thermal Annealing of PECVD-based SiO2 Waveguides.

Parks JW, Wall TA, Cai H, Hawkins AR, Schmidt H.

IEEE J Sel Top Quantum Electron. 2016 Nov-Dec;22(6). doi: 10.1109/JSTQE.2016.2549801. Epub 2016 Apr 21.

29.

Signal-to-noise Enhancement in Optical Detection of Single Viruses with Multi-spot Excitation.

Ozcelik D, Stott MA, Parks JW, Black JA, Wall TA, Hawkins AR, Schmidt H.

IEEE J Sel Top Quantum Electron. 2016 Jul-Aug;22(4). pii: 4402406. Epub 2016 Mar 21.

30.

Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme.

Prado V, Lence E, Maneiro M, Vázquez-Ucha JC, Beceiro A, Thompson P, Hawkins AR, González-Bello C.

J Med Chem. 2016 Jun 9;59(11):5471-87. doi: 10.1021/acs.jmedchem.6b00483. Epub 2016 May 18.

PMID:
27191386
31.

Single-virus analysis through chip-based optical detection.

Schmidt H, Hawkins AR.

Bioanalysis. 2016 May;8(9):867-70. doi: 10.4155/bio-2016-0004. Epub 2016 Apr 20. No abstract available. Erratum in: Bioanalysis. 2017 Apr;9(8):670.

32.

Optofluidic devices with integrated solid-state nanopores.

Liu S, Hawkins AR, Schmidt H.

Mikrochim Acta. 2016 Apr;183(4):1275-1287. Epub 2016 Jan 27.

33.

Corrigendum: Glycan complexity dictates microbial resource allocation in the large intestine.

Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Baslé A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, Bolam DN.

Nat Commun. 2016 Feb 5;7:10705. doi: 10.1038/ncomms10705. No abstract available.

34.

Study of the Phosphoryl-Transfer Mechanism of Shikimate Kinase by NMR Spectroscopy.

Prado V, Lence E, Vallejo JA, Beceiro A, Thompson P, Hawkins AR, González-Bello C.

Chemistry. 2016 Feb 18;22(8):2758-68. doi: 10.1002/chem.201504438. Epub 2016 Jan 21.

PMID:
26797764
35.

Spectrally reconfigurable integrated multi-spot particle trap.

Leake KD, Olson MA, Ozcelik D, Hawkins AR, Schmidt H.

Opt Lett. 2015 Dec 1;40(23):5435-8. doi: 10.1364/OL.40.005435.

36.

Optofluidic wavelength division multiplexing for single-virus detection.

Ozcelik D, Parks JW, Wall TA, Stott MA, Cai H, Parks JW, Hawkins AR, Schmidt H.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12933-7. doi: 10.1073/pnas.1511921112. Epub 2015 Oct 5.

37.

Optofluidic analysis system for amplification-free, direct detection of Ebola infection.

Cai H, Parks JW, Wall TA, Stott MA, Stambaugh A, Alfson K, Griffiths A, Mathies RA, Carrion R, Patterson JL, Hawkins AR, Schmidt H.

Sci Rep. 2015 Sep 25;5:14494. doi: 10.1038/srep14494.

38.

Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct.

González-Bello C, Tizón L, Lence E, Otero JM, van Raaij MJ, Martinez-Guitian M, Beceiro A, Thompson P, Hawkins AR.

J Am Chem Soc. 2015 Jul 29;137(29):9333-43. doi: 10.1021/jacs.5b04080. Epub 2015 Jul 16.

PMID:
26148116
39.

Glycan complexity dictates microbial resource allocation in the large intestine.

Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Baslé A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, Bolam DN.

Nat Commun. 2015 Jun 26;6:7481. doi: 10.1038/ncomms8481. Erratum in: Nat Commun. 2016;7:10705.

40.

Integration of programmable microfluidics and on-chip fluorescence detection for biosensing applications.

Parks JW, Olson MA, Kim J, Ozcelik D, Cai H, Carrion R Jr, Patterson JL, Mathies RA, Hawkins AR, Schmidt H.

Biomicrofluidics. 2014 Sep 30;8(5):054111. doi: 10.1063/1.4897226. eCollection 2014 Sep.

41.

Electro-optical detection of single λ-DNA.

Liu S, Wall TA, Ozcelik D, Parks JW, Hawkins AR, Schmidt H.

Chem Commun (Camb). 2015 Feb 7;51(11):2084-7. doi: 10.1039/c4cc07591a.

42.

Axial thermal gradients in microchip gas chromatography.

Wang A, Hynynen S, Hawkins AR, Tolley SE, Tolley HD, Lee ML.

J Chromatogr A. 2014 Dec 29;1374:216-223. doi: 10.1016/j.chroma.2014.11.035. Epub 2014 Nov 18.

PMID:
25476685
43.

Irreversible covalent modification of type I dehydroquinase with a stable Schiff base.

Tizón L, Maneiro M, Peón A, Otero JM, Lence E, Poza S, van Raaij MJ, Thompson P, Hawkins AR, González-Bello C.

Org Biomol Chem. 2015 Jan 21;13(3):706-16. doi: 10.1039/c4ob01782j.

PMID:
25370445
44.

Correlated electrical and optical analysis of single nanoparticles and biomolecules on a nanopore-gated optofluidic chip.

Liu S, Zhao Y, Parks JW, Deamer DW, Hawkins AR, Schmidt H.

Nano Lett. 2014 Aug 13;14(8):4816-20. doi: 10.1021/nl502400x. Epub 2014 Jul 11.

45.

Ion trap electric field characterization using slab coupled optical fiber sensors.

Chadderdon S, Shumway L, Powell A, Li A, Austin DE, Hawkins AR, Selfridge RH, Schultz SM.

J Am Soc Mass Spectrom. 2014 Sep;25(9):1622-7. doi: 10.1007/s13361-014-0938-4. Epub 2014 Jul 1.

PMID:
24981735
46.

Insights into substrate binding and catalysis in bacterial type I dehydroquinase.

Maneiro M, Peón A, Lence E, Otero JM, Van Raaij MJ, Thompson P, Hawkins AR, González-Bello C.

Biochem J. 2014 Sep 15;462(3):415-24. doi: 10.1042/BJ20140614.

PMID:
24957267
47.

Miniaturization of a planar-electrode linear ion trap mass spectrometer.

Li A, Hansen BJ, Powell AT, Hawkins AR, Austin DE.

Rapid Commun Mass Spectrom. 2014 Jun 30;28(12):1338-44. doi: 10.1002/rcm.6906.

PMID:
24797944
48.

Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors.

Blanco B, Sedes A, Peón A, Otero JM, van Raaij MJ, Thompson P, Hawkins AR, González-Bello C.

J Med Chem. 2014 Apr 24;57(8):3494-510. doi: 10.1021/jm500175z. Epub 2014 Apr 15.

PMID:
24689821
49.

Optical particle sorting on an optofluidic chip.

Leake KD, Phillips BS, Yuzvinsky TD, Hawkins AR, Schmidt H.

Opt Express. 2013 Dec 30;21(26):32605-10. doi: 10.1364/OE.21.032605.

50.

Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases.

Coderch C, Lence E, Peón A, Lamb H, Hawkins AR, Gago F, González-Bello C.

Biochem J. 2014 Mar 15;458(3):547-57. doi: 10.1042/BJ20131103.

PMID:
24392963

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