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Items: 1 to 50 of 134

1.

Heartfelt sepsis: microvascular injury due to genomic storm.

Hawiger J.

Kardiol Pol. 2018;76(8):1203-1216. doi: 10.5603/KP.a2018.0146. Epub 2018 Jul 5. Review.

2.

Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles.

Veach RA, Liu Y, Zienkiewicz J, Wylezinski LS, Boyd KL, Wynn JL, Hawiger J.

PLoS One. 2017 Jun 19;12(6):e0179468. doi: 10.1371/journal.pone.0179468. eCollection 2017.

3.

Interleukin 2 Activates Brain Microvascular Endothelial Cells Resulting in Destabilization of Adherens Junctions.

Wylezinski LS, Hawiger J.

J Biol Chem. 2016 Oct 28;291(44):22913-22923. Epub 2016 Sep 6.

4.

Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.

Wynn JL, Wilson CS, Hawiger J, Scumpia PO, Marshall AF, Liu JH, Zharkikh I, Wong HR, Lahni P, Benjamin JT, Plosa EJ, Weitkamp JH, Sherwood ER, Moldawer LL, Ungaro R, Baker HV, Lopez MC, McElroy SJ, Colliou N, Mohamadzadeh M, Moore DJ.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2627-35. doi: 10.1073/pnas.1515793113. Epub 2016 Apr 25.

5.

New paradigms in sepsis: from prevention to protection of failing microcirculation.

Hawiger J, Veach RA, Zienkiewicz J.

J Thromb Haemost. 2015 Oct;13(10):1743-56. doi: 10.1111/jth.13061. Epub 2015 Aug 6. Review.

6.

The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation.

DiGiandomenico A, Veach RA, Zienkiewicz J, Moore DJ, Wylezinski LS, Hutchens MA, Hawiger J.

PLoS One. 2014 Oct 20;9(10):e110183. doi: 10.1371/journal.pone.0110183. eCollection 2014.

7.

The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli.

Qiao H, Liu Y, Veach RA, Wylezinski L, Hawiger J.

J Biol Chem. 2014 Aug 8;289(32):21973-83. doi: 10.1074/jbc.M114.588723. Epub 2014 Jun 23.

8.

Targeting nuclear import shuttles, importins/karyopherins alpha by a peptide mimicking the NFκB1/p50 nuclear localization sequence.

Zienkiewicz J, Armitage A, Hawiger J.

J Am Heart Assoc. 2013 Sep 16;2(5):e000386. doi: 10.1161/JAHA.113.000386.

9.
10.

Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver.

Liu Y, Major AS, Zienkiewicz J, Gabriel CL, Veach RA, Moore DJ, Collins RD, Hawiger J.

J Am Heart Assoc. 2013 Apr 5;2(2):e000093. doi: 10.1161/JAHA.113.000093.

11.

Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes.

Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J, Ruley HE.

J Immunol. 2012 Mar 15;188(6):2493-7. doi: 10.4049/jimmunol.1101502. Epub 2012 Feb 8.

12.

Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy.

Veach RA, Zienkiewicz J, Collins RD, Hawiger J.

PLoS One. 2012;7(1):e30527. doi: 10.1371/journal.pone.0030527. Epub 2012 Jan 26.

13.

How to approach genome wars in sepsis?

Hawiger J, Musser JM.

Crit Care. 2011;15(6):1007. doi: 10.1186/cc10482. Epub 2011 Dec 2.

14.

In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes.

Moore DJ, Zienkiewicz J, Kendall PL, Liu D, Liu X, Veach RA, Collins RD, Hawiger J.

PLoS One. 2010 Oct 6;5(10):e13235. doi: 10.1371/journal.pone.0013235.

15.

Extended anti-inflammatory action of a degradation-resistant mutant of cell-penetrating suppressor of cytokine signaling 3.

Fletcher TC, DiGiandomenico A, Hawiger J.

J Biol Chem. 2010 Jun 11;285(24):18727-36. doi: 10.1074/jbc.M109.095216. Epub 2010 Apr 16.

16.

Intracellular delivery of a cell-penetrating SOCS1 that targets IFN-gamma signaling.

DiGiandomenico A, Wylezinski LS, Hawiger J.

Sci Signal. 2009 Jul 21;2(80):ra37. doi: 10.1126/scisignal.1162191.

17.

Suppression of acute lung inflammation by intracellular peptide delivery of a nuclear import inhibitor.

Liu D, Zienkiewicz J, DiGiandomenico A, Hawiger J.

Mol Ther. 2009 May;17(5):796-802. doi: 10.1038/mt.2009.18. Epub 2009 Mar 3.

18.

Fractalkine and CX3CR1 mediate leukocyte capture by endothelium in response to Shiga toxin.

Zanchi C, Zoja C, Morigi M, Valsecchi F, Liu XY, Rottoli D, Locatelli M, Buelli S, Pezzotta A, Mapelli P, Geelen J, Remuzzi G, Hawiger J.

J Immunol. 2008 Jul 15;181(2):1460-9.

19.

Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny.

Bezbradica JS, Gordy LE, Stanic AK, Dragovic S, Hill T, Hawiger J, Unutmaz D, Van Kaer L, Joyce S.

Immunity. 2006 Sep;25(3):487-97. Epub 2006 Aug 31.

20.

Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis.

Jo D, Liu D, Yao S, Collins RD, Hawiger J.

Nat Med. 2005 Aug;11(8):892-8. Epub 2005 Jul 10.

PMID:
16007096
21.

Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway.

Li C, Zienkiewicz J, Hawiger J.

J Biol Chem. 2005 Jul 15;280(28):26152-9. Epub 2005 Apr 22.

22.

Nuclear import of proinflammatory transcription factors is required for massive liver apoptosis induced by bacterial lipopolysaccharide.

Liu D, Li C, Chen Y, Burnett C, Liu XY, Downs S, Collins RD, Hawiger J.

J Biol Chem. 2004 Nov 12;279(46):48434-42. Epub 2004 Sep 1.

23.

Suppression of Staphylococcal Enterotoxin B-induced Toxicity by a Nuclear Import Inhibitor.

Liu D, Liu XY, Robinson D, Burnett C, Jackson C, Seele L, Veach RA, Downs S, Collins RD, Ballard DW, Hawiger J.

J Biol Chem. 2004 Apr 30;279(18):19239-46. Epub 2004 Jan 19.

24.

Receptor/transporter-independent targeting of functional peptides across the plasma membrane.

Veach RA, Liu D, Yao S, Chen Y, Liu XY, Downs S, Hawiger J.

J Biol Chem. 2004 Mar 19;279(12):11425-31. Epub 2003 Dec 29.

25.

Innate immunity and inflammation: a transcriptional paradigm.

Hawiger J.

Immunol Res. 2001;23(2-3):99-109. Review.

PMID:
11444396
26.

Immunology at Vanderbilt University.

Oltz EM, Hawiger J.

Immunol Res. 2001;23(2-3):97-8. No abstract available.

PMID:
11444395
27.

Peptide-directed suppression of a pro-inflammatory cytokine response.

Liu XY, Robinson D, Veach RA, Liu D, Timmons S, Collins RD, Hawiger J.

J Biol Chem. 2000 Jun 2;275(22):16774-8.

29.

IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells.

Hawiger J, Veach RA, Liu XY, Timmons S, Ballard DW.

Blood. 1999 Sep 1;94(5):1711-6.

30.

Noninvasive intracellular delivery of functional peptides and proteins.

Hawiger J.

Curr Opin Chem Biol. 1999 Feb;3(1):89-94. Review.

PMID:
10021415
32.

Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules.

Zhang L, Torgerson TR, Liu XY, Timmons S, Colosia AD, Hawiger J, Tam JP.

Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9184-9.

33.
34.

Cellular import of functional peptides to block intracellular signaling.

Hawiger J.

Curr Opin Immunol. 1997 Apr;9(2):189-94. Review.

PMID:
9099795
35.
36.
37.

Mechanisms involved in platelet vessel wall interaction.

Hawiger J.

Thromb Haemost. 1995 Jul;74(1):369-72. Review.

PMID:
8578487
39.

Adhesive ends of fibrinogen and its antiadhesive peptides: the end of a saga?

Hawiger J.

Semin Hematol. 1995 Apr;32(2):99-109. Review. No abstract available.

PMID:
7652584
40.
41.
42.

The integrin alpha v gene: identification and characterization of the promoter region.

Donahue JP, Sugg N, Hawiger J.

Biochim Biophys Acta. 1994 Sep 13;1219(1):228-32.

PMID:
7522056
43.

Report of the Task Force on Vascular Medicine.

Shepherd JT, Bergan JJ, Cohen RA, Hawiger JJ, Hillis LD, Katzen BT, Mohr JP.

Circulation. 1994 Jan;89(1):532-5. No abstract available.

PMID:
8281694
44.

Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopolysaccharide in human endothelial cells.

Read MA, Cordle SR, Veach RA, Carlisle CD, Hawiger J.

Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):9887-91.

45.
46.
47.

Introduction to platelet structural and functional organization.

Hawiger J.

Methods Enzymol. 1992;215:3-5. Review. No abstract available.

PMID:
1435330
48.

Binding of fibrinogen and von Willebrand factor to platelet glycoprotein IIb-IIIa complex.

Hawiger J, Timmons S.

Methods Enzymol. 1992;215:228-43. No abstract available.

PMID:
1435324
49.

Repertoire of platelet receptors.

Hawiger J.

Methods Enzymol. 1992;215:131-6. Review. No abstract available.

PMID:
1435318

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