Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 51

1.

In vitro pharmacological characterization of vorapaxar, a novel platelet thrombin receptor antagonist.

Hawes BE, Zhai Y, Hesk D, Wirth M, Wei H, Chintala M, Seiffert D.

Eur J Pharmacol. 2015 Sep 5;762:221-8. doi: 10.1016/j.ejphar.2015.05.046. Epub 2015 May 27.

PMID:
26022529
2.

Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells.

Ning Y, O'Neill K, Lan H, Pang L, Shan LX, Hawes BE, Hedrick JA.

Br J Pharmacol. 2008 Dec;155(7):1056-65. doi: 10.1038/bjp.2008.337. Epub 2008 Aug 25.

3.

Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.

Cavasotto CN, Orry AJ, Murgolo NJ, Czarniecki MF, Kocsi SA, Hawes BE, O'Neill KA, Hine H, Burton MS, Voigt JH, Abagyan RA, Bayne ML, Monsma FJ Jr.

J Med Chem. 2008 Feb 14;51(3):581-8. doi: 10.1021/jm070759m. Epub 2008 Jan 17.

PMID:
18198821
4.

Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists.

Su J, Tang H, McKittrick BA, Gu H, Guo T, Qian G, Burnett DA, Clader JW, Greenlee WJ, Hawes BE, O'neill K, Spar B, Weig B, Kowalski T, Sorota S.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4845-50. Epub 2007 Jun 17.

PMID:
17604169
5.

SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERG.

Su J, McKittrick BA, Tang H, Burnett DA, Clader JW, Greenlee WJ, Hawes BE, O'Neill K, Spar B, Weig B, Kowalski T, Sorota S, Li C, Liu T.

Bioorg Med Chem. 2007 Aug 15;15(16):5369-85. Epub 2007 Jun 2.

PMID:
17572094
6.

In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs.

Hawes BE, O'neill KA, Yao X, Crona JH, Davis HR Jr, Graziano MP, Altmann SW.

Mol Pharmacol. 2007 Jan;71(1):19-29. Epub 2006 Sep 27.

PMID:
17005902
7.

Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.

Sasikumar TK, Qiang L, Burnett DA, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar BD, Weig B.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5427-31. Epub 2006 Aug 2.

PMID:
16889961
8.

Tetrahydroisoquinolines as MCH-R1 antagonists.

Sasikumar TK, Qiang L, Wu WL, Burnett DA, Greenlee WJ, O'Neill K, Hawes BE, van Heek M, Graziano M.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4917-21. Epub 2006 Jul 7.

PMID:
16824753
9.

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.

Wu WL, Burnett DA, Caplen MA, Domalski MS, Bennett C, Greenlee WJ, Hawes BE, O'Neill K, Weig B, Weston D, Spar B, Kowalski T.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3674-8. Epub 2006 May 11.

PMID:
16690315
10.

Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists.

Wu WL, Burnett DA, Spring R, Qiang L, Sasikumar TK, Domalski MS, Greenlee WJ, O'Neill K, Hawes BE.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3668-73. Epub 2006 May 11.

PMID:
16690312
11.

Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.

McBriar MD, Guzik H, Shapiro S, Paruchova J, Xu R, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'neill K, Spar BD, Weig B, Weston DJ, Farley C, Cook J.

J Med Chem. 2006 Apr 6;49(7):2294-310.

PMID:
16570926
12.

Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice.

Kowalski TJ, Spar BD, Weig B, Farley C, Cook J, Ghibaudi L, Fried S, O'Neill K, Del Vecchio RA, McBriar M, Guzik H, Clader J, Hawes BE, Hwa J.

Eur J Pharmacol. 2006 Mar 27;535(1-3):182-91. Epub 2006 Mar 13.

PMID:
16540104
13.

Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists.

Xu R, Li S, Paruchova J, McBriar MD, Guzik H, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar BD, Weig B, Weston DJ.

Bioorg Med Chem. 2006 May 15;14(10):3285-99. Epub 2006 Jan 26.

PMID:
16442800
14.

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. Epub 2005 May 31.

15.

Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.

McBriar MD, Guzik H, Xu R, Paruchova J, Li S, Palani A, Clader JW, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar B, Weig B.

J Med Chem. 2005 Apr 7;48(7):2274-7.

PMID:
15801820
16.

Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis.

Su J, McKittrick BA, Tang H, Czarniecki M, Greenlee WJ, Hawes BE, O'Neill K.

Bioorg Med Chem. 2005 Mar 1;13(5):1829-36.

PMID:
15698800
17.

Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.

Hawes BE, Green B, O'Neill K, Fried S, Arreaza MG, Qiu P, Simon JS.

Obes Res. 2004 Aug;12(8):1327-34.

18.

Cloning and characterization of rhesus monkey MCH-R1 and MCH-R2.

Fried S, O'Neill K, Hawes BE.

Peptides. 2002 Aug;23(8):1401-8.

PMID:
12182940
19.

The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo.

Kemp EH, Waterman EA, Hawes BE, O'Neill K, Gottumukkala RV, Gawkrodger DJ, Weetman AP, Watson PF.

J Clin Invest. 2002 Apr;109(7):923-30.

21.

Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.

Wang S, Behan J, O'Neill K, Weig B, Fried S, Laz T, Bayne M, Gustafson E, Hawes BE.

J Biol Chem. 2001 Sep 14;276(37):34664-70. Epub 2001 Jul 17.

22.

Protein tyrosine kinase activity assays.

Hawes BE, van Biesen T.

Curr Protoc Pharmacol. 2001 May;Chapter 3:Unit3.5. doi: 10.1002/0471141755.ph0305s05.

PMID:
21965067
23.

The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways.

Hawes BE, Kil E, Green B, O'Neill K, Fried S, Graziano MP.

Endocrinology. 2000 Dec;141(12):4524-32.

PMID:
11108264
24.

Cellular actions of nociceptin: transduction mechanisms.

Hawes BE, Graziano MP, Lambert DG.

Peptides. 2000 Jul;21(7):961-7. Review.

PMID:
10998529
26.

Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes.

Wang S, Hashemi T, Fried S, Clemmons AL, Hawes BE.

Biochemistry. 1998 May 12;37(19):6711-7.

PMID:
9578554
27.

Regulation of mitogen-activated protein kinase pathways by catecholamine receptors.

Luttrell LM, van Biesen T, Hawes BE, Della Rocca GJ, Luttrell DK, Lefkowitz RJ.

Adv Pharmacol. 1998;42:466-70. No abstract available.

PMID:
9327940
28.

G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors.

Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Krueger KM, Touhara K, Lefkowitz RJ.

Adv Second Messenger Phosphoprotein Res. 1997;31:263-77. Review.

PMID:
9344257
29.

Mitogenic signaling via G protein-coupled receptors.

van Biesen T, Luttrell LM, Hawes BE, Lefkowitz RJ.

Endocr Rev. 1996 Dec;17(6):698-714. Review. No abstract available.

PMID:
8969974
30.

Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.

Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ.

J Biol Chem. 1996 Aug 9;271(32):19443-50.

31.
32.

G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.

van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefkowitz RJ.

J Biol Chem. 1996 Jan 19;271(3):1266-9.

33.

G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.

Touhara K, Hawes BE, van Biesen T, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9284-7.

34.

Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway.

van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ.

Nature. 1995 Aug 31;376(6543):781-4.

PMID:
7651538
35.

Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation.

Hawes BE, van Biesen T, Koch WJ, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 1995 Jul 21;270(29):17148-53.

37.

G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.

Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Touhara K, Lefkowitz RJ.

J Biol Chem. 1995 Jul 14;270(28):16495-8.

38.

Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.

Luttrell LM, Hawes BE, Touhara K, van Biesen T, Koch WJ, Lefkowitz RJ.

J Biol Chem. 1995 Jun 2;270(22):12984-9.

39.
40.

Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling.

Hawes BE, Touhara K, Kurose H, Lefkowitz RJ, Inglese J.

J Biol Chem. 1994 Nov 25;269(47):29825-30.

41.

Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor.

Hawes BE, Luttrell LM, Exum ST, Lefkowitz RJ.

J Biol Chem. 1994 Jun 3;269(22):15776-85.

42.

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

Koch WJ, Hawes BE, Inglese J, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 1994 Feb 25;269(8):6193-7.

46.
48.

Selection of models for the study of GnRH stimulated gonadotropin release prejudices the assignment of roles for mediators and modulators of hormone action.

Conn PM, Hawes BE, Janovick JA.

Mol Cell Endocrinol. 1992 Apr;84(3):C33-7. Review. No abstract available.

PMID:
1316852

Supplemental Content

Loading ...
Support Center