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Items: 1 to 50 of 53

1.

Fifteen-minute consultation: Pharmacogenomics: a guide for busy clinicians.

Parry CM, Hawcutt D.

Arch Dis Child Educ Pract Ed. 2019 May 15. pii: edpract-2019-316971. doi: 10.1136/archdischild-2019-316971. [Epub ahead of print]

PMID:
31092398
2.

Assessing the impact of breathing retraining on asthma symptoms and dysfunctional breathing in children.

Hepworth C, Sinha I, Saint GL, Hawcutt DB.

Pediatr Pulmonol. 2019 Jun;54(6):706-712. doi: 10.1002/ppul.24300. Epub 2019 Apr 1.

PMID:
30938089
3.

A systematic review of the effects of implementing clinical pathways supported by health information technologies.

Neame MT, Chacko J, Surace AE, Sinha IP, Hawcutt DB.

J Am Med Inform Assoc. 2019 Apr 1;26(4):356-363. doi: 10.1093/jamia/ocy176.

PMID:
30794311
4.

Working together to deliver stratified medicine research effectively.

Attar SG, Poustie VJ, Smye SW, Beety JM, Hawcutt DB, Littlewood S, Oni L, Pirmohamed M, Beresford MW.

Br Med Bull. 2019 Mar 1;129(1):107-116. doi: 10.1093/bmb/ldz003. Review.

PMID:
30753334
5.

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.

Hernandez-Pacheco N, Farzan N, Francis B, Karimi L, Repnik K, Vijverberg SJ, Soares P, Schieck M, Gorenjak M, Forno E, Eng C, Oh SS, Pérez-Méndez L, Berce V, Tavendale R, Samedy LA, Hunstman S, Hu D, Meade K, Farber HJ, Avila PC, Serebrisky D, Thyne SM, Brigino-Buenaventura E, Rodriguez-Cintron W, Sen S, Kumar R, Lenoir M, Rodriguez-Santana JR, Celedón JC, Mukhopadhyay S, Potočnik U, Pirmohamed M, Verhamme KM, Kabesch M, Palmer CNA, Hawcutt DB, Flores C, Maitland-van der Zee AH, Burchard EG, Pino-Yanes M.

Clin Exp Allergy. 2019 Jun;49(6):789-798. doi: 10.1111/cea.13354. Epub 2019 Feb 15.

PMID:
30697902
6.

What causes pneumonia in children who have had their jabs?

Saint GL, Hawcutt DB, McNamara PS.

Thorax. 2019 Mar;74(3):211-212. doi: 10.1136/thoraxjnl-2018-212625. Epub 2019 Jan 4. No abstract available.

PMID:
30610156
7.

The effect of outdoor air pollution on the risk of hospitalisation for bronchiolitis in infants: a systematic review.

King C, Kirkham J, Hawcutt D, Sinha I.

PeerJ. 2018 Aug 28;6:e5352. doi: 10.7717/peerj.5352. eCollection 2018.

8.

17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use.

Farzan N, Vijverberg SJ, Hernandez-Pacheco N, Bel EHD, Berce V, Bønnelykke K, Bisgaard H, Burchard EG, Canino G, Celedón JC, Chew FT, Chiang WC, Cloutier MM, Forno E, Francis B, Hawcutt DB, Herrera-Luis E, Kabesch M, Karimi L, Melén E, Mukhopadhyay S, Merid SK, Palmer CN, Pino-Yanes M, Pirmohamed M, Potočnik U, Repnik K, Schieck M, Sevelsted A, Sio YY, Smyth RL, Soares P, Söderhäll C, Tantisira KG, Tavendale R, Tse SM, Turner S, Verhamme KM, Maitland-van der Zee AH.

Allergy. 2018 Oct;73(10):2083-2088. doi: 10.1111/all.13499. Epub 2018 Jul 9. No abstract available.

9.

Adrenal suppression with inhaled corticosteroids: the seed and the soil - Authors' reply.

Hawcutt DB, Francis B, Pirmohamed M.

Lancet Respir Med. 2018 Jun;6(6):e20. doi: 10.1016/S2213-2600(18)30149-8. No abstract available.

PMID:
29856322
10.

Protocol for a prospective observational study of adverse drug reactions of anti-epileptic drugs in children in the UK.

Egunsola O, Sammons HM, Ojha S, Whitehouse W, Anderson M, Hawcutt D, Choonara I.

BMJ Paediatr Open. 2017 Aug 4;1(1):e000116. doi: 10.1136/bmjpo-2017-000116. eCollection 2017.

11.

Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

Hawcutt DB, Francis B, Carr DF, Jorgensen AL, Yin P, Wallin N, O'Hara N, Zhang EJ, Bloch KM, Ganguli A, Thompson B, McEvoy L, Peak M, Crawford AA, Walker BR, Blair JC, Couriel J, Smyth RL, Pirmohamed M.

Lancet Respir Med. 2018 Jun;6(6):442-450. doi: 10.1016/S2213-2600(18)30058-4. Epub 2018 Mar 15.

12.

Solving the problem of dose optimization of children's medicines.

McWilliam SJ, Hawcutt DB.

Expert Rev Clin Pharmacol. 2018 Mar;11(3):205-208. doi: 10.1080/17512433.2018.1431528. Epub 2018 Jan 30. No abstract available.

PMID:
29355041
13.

Optimizing the Dosing of Intravenous Theophylline in Acute Severe Asthma in Children.

Saint GL, Semple MG, Sinha I, Hawcutt DB.

Paediatr Drugs. 2018 Jun;20(3):209-214. doi: 10.1007/s40272-017-0281-x.

14.

Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma.

Cordell RL, Valkenburg TSE, Pandya HC, Hawcutt DB, Semple MG, Monks PS.

J Asthma. 2018 Nov;55(11):1205-1213. doi: 10.1080/02770903.2017.1402341. Epub 2017 Dec 6.

PMID:
29211599
15.

Identifying cisplatin-induced kidney damage in paediatric oncology patients.

Barton CD, Pizer B, Jones C, Oni L, Pirmohamed M, Hawcutt DB.

Pediatr Nephrol. 2018 Sep;33(9):1467-1474. doi: 10.1007/s00467-017-3765-6. Epub 2017 Aug 18. Review.

16.

Growth hormone prescribing and initial BMI SDS: Increased biochemical adverse effects and costs in obese children without additional gain in height.

Hawcutt DB, Bellis J, Price V, Povall A, Newland P, Richardson P, Peak M, Blair J.

PLoS One. 2017 Jul 17;12(7):e0181567. doi: 10.1371/journal.pone.0181567. eCollection 2017.

17.

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.

Farzan N, Vijverberg SJ, Andiappan AK, Arianto L, Berce V, Blanca-López N, Bisgaard H, Bønnelykke K, Burchard EG, Campo P, Canino G, Carleton B, Celedón JC, Chew FT, Chiang WC, Cloutier MM, Daley D, Den Dekker HT, Dijk FN, Duijts L, Flores C, Forno E, Hawcutt DB, Hernandez-Pacheco N, de Jongste JC, Kabesch M, Koppelman GH, Manolopoulos VG, Melén E, Mukhopadhyay S, Nilsson S, Palmer CN, Pino-Yanes M, Pirmohamed M, Potočnik U, Raaijmakers JA, Repnik K, Schieck M, Sio YY, Smyth RL, Szalai C, Tantisira KG, Turner S, van der Schee MP, Verhamme KM, Maitland-van der Zee AH.

Pharmacogenomics. 2017 Jul;18(10):931-943. doi: 10.2217/pgs-2017-0035. Epub 2017 Jun 22.

18.

Overview of systematic reviews of therapeutic ranges: methodologies and recommendations for practice.

Cooney L, Loke YK, Golder S, Kirkham J, Jorgensen A, Sinha I, Hawcutt D.

BMC Med Res Methodol. 2017 Jun 2;17(1):84. doi: 10.1186/s12874-017-0363-z. Review.

19.

TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.

Thiesen S, Yin P, Jorgensen AL, Zhang JE, Manzo V, McEvoy L, Barton C, Picton S, Bailey S, Brock P, Vyas H, Walker D, Makin G, Bandi S, Pizer B, Hawcutt DB, Pirmohamed M.

Pharmacogenet Genomics. 2017 Jun;27(6):213-222. doi: 10.1097/FPC.0000000000000281. Review.

20.

Optimising the use of medicines to reduce acute kidney injury in children and babies.

Oni L, Hawcutt DB, Turner MA, Beresford MW, McWilliam S, Barton C, Park BK, Murray P, Wilm B, Copple I, Floyd R, Peak M, Sharma A, Antoine DJ.

Pharmacol Ther. 2017 Jun;174:55-62. doi: 10.1016/j.pharmthera.2017.02.018. Epub 2017 Feb 12. Review.

PMID:
28202365
21.

Using pharmacokinetic modelling to improve prescribing practices of intravenous aminophylline in childhood asthma exacerbations.

Cooney L, McBride A, Lilley A, Sinha I, Johnson TN, Hawcutt DB.

Pulm Pharmacol Ther. 2017 Apr;43:6-11. doi: 10.1016/j.pupt.2017.01.007. Epub 2017 Jan 18.

PMID:
28108402
22.

NIHR Clinical Research Networks: what they do and how they help paediatric research.

Lythgoe H, Price V, Poustie V, Attar S, Hawcutt D, Preston J, Beresford MW.

Arch Dis Child. 2017 Aug;102(8):755-759. doi: 10.1136/archdischild-2016-311057. Epub 2017 Jan 17. Review.

PMID:
28096102
23.

Spontaneous adverse drug reaction reports for neonates and infants in the UK 2001-2010: content and utility analysis.

Hawcutt DB, Russell NJ, Maqsood H, Kouranloo K, Gomberg S, Waitt C, Sharp A, Riordan A, Turner MA.

Br J Clin Pharmacol. 2016 Dec;82(6):1601-1612. doi: 10.1111/bcp.13067. Epub 2016 Sep 12.

24.

Aminophylline Dosage In Asthma Exacerbations in Children: A Systematic Review.

Cooney L, Sinha I, Hawcutt D.

PLoS One. 2016 Aug 2;11(8):e0159965. doi: 10.1371/journal.pone.0159965. eCollection 2016. Review.

25.

Design and conduct of early phase drug studies in children: challenges and opportunities.

Rieder M, Hawcutt D.

Br J Clin Pharmacol. 2016 Nov;82(5):1308-1314. doi: 10.1111/bcp.13058. Epub 2016 Aug 8. Review.

26.

The Evidence for Intravenous Theophylline Levels between 10-20mg/L in Children Suffering an Acute Exacerbation of Asthma: A Systematic Review.

Cooney L, Hawcutt D, Sinha I.

PLoS One. 2016 Apr 20;11(4):e0153877. doi: 10.1371/journal.pone.0153877. eCollection 2016. Review.

27.

Adrenal responses to a low-dose short synacthen test in children with asthma.

Hawcutt DB, Jorgensen AL, Wallin N, Thompson B, Peak M, Lacy D, Newland P, Didi M, Couriel J, Blair J, Pirmohamed M, Smyth RL.

Clin Endocrinol (Oxf). 2016 May;84(5):793. doi: 10.1111/cen.13069. No abstract available.

PMID:
27043153
28.

Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by treatment.

Turner S, Francis B, Vijverberg S, Pino-Yanes M, Maitland-van der Zee AH, Basu K, Bignell L, Mukhopadhyay S, Tavendale R, Palmer C, Hawcutt D, Pirmohamed M, Burchard EG, Lipworth B; Pharmacogenomics in Childhood Asthma Consortium.

J Allergy Clin Immunol. 2016 Jul;138(1):107-113.e5. doi: 10.1016/j.jaci.2015.10.045. Epub 2016 Jan 7.

29.

Comparing paediatric intravenous phenytoin doses using physiologically based pharmacokinetic (PBPK) modelling software.

Batchelor H, Appleton R, Hawcutt DB.

Seizure. 2015 Dec;33:8-12. doi: 10.1016/j.seizure.2015.10.006. Epub 2015 Oct 17.

30.

UK service level audit of insulin pump therapy in paediatrics.

Ghatak A, Paul P, Hawcutt DB, White HD, Furlong NJ, Saunders S, Morrison G, Langridge P, Weston PJ.

Diabet Med. 2015 Dec;32(12):1652-7. doi: 10.1111/dme.12782. Epub 2015 Jul 24.

PMID:
25884635
31.

Pharmacogenetic Markers of Drug Efficacy and Toxicity.

Yip VL, Hawcutt DB, Pirmohamed M.

Clin Pharmacol Ther. 2015 Jul;98(1):61-70. doi: 10.1002/cpt.135. Epub 2015 Jun 3. Review.

PMID:
25870137
32.

When to report adverse drug reactions in children?

Barton C, Hawcutt DB.

Arch Dis Child. 2015 Jul;100(7):682-3. doi: 10.1136/archdischild-2014-307906. Epub 2015 Apr 8. No abstract available.

PMID:
25854873
33.

ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults.

Vijverberg SJ, Koster ES, Tavendale R, Leusink M, Koenderman L, Raaijmakers JA, Postma DS, Koppelman GH, Turner SW, Mukhopadhyay S, Tse SM, Tantisira KG, Hawcutt DB, Francis B, Pirmohamed M, Pino-Yanes M, Eng C, Burchard EG, Palmer CN, Maitland-van der Zee AH.

Clin Exp Allergy. 2015 Jun;45(6):1051-9. doi: 10.1111/cea.12492.

34.

Adrenal responses to a low-dose short synacthen test in children with asthma.

Hawcutt DB, Jorgensen AL, Wallin N, Thompson B, Peak M, Lacy D, Newland P, Didi M, Couriel J, Blair J, Pirmohamed M, Smyth RL.

Clin Endocrinol (Oxf). 2015 May;82(5):648-56. doi: 10.1111/cen.12655. Epub 2014 Dec 22. Erratum in: Clin Endocrinol (Oxf). 2016 May;84(5):793.

PMID:
25378183
35.

Adverse drug reactions in neonates: could we be documenting more?

Hawcutt DB, O'Connor O, Turner MA.

Expert Rev Clin Pharmacol. 2014 Nov;7(6):807-20. doi: 10.1586/17512433.2014.956090. Epub 2014 Sep 16. Review.

PMID:
25225053
36.

Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects.

Hawcutt DB, Ghani AA, Sutton L, Jorgensen A, Zhang E, Murray M, Michael H, Peart I, Smyth RL, Pirmohamed M.

Pharmacogenomics J. 2014 Dec;14(6):542-8. doi: 10.1038/tpj.2014.31. Epub 2014 Jul 8.

37.

Phenytoin dosing and serum concentrations in paediatric patients requiring 20 mg/kg intravenous loading.

Piper JD, Hawcutt DB, Verghese GK, Spinty S, Newland P, Appleton R.

Arch Dis Child. 2014 Jun;99(6):585-6. doi: 10.1136/archdischild-2013-305093. Epub 2014 Jan 15.

PMID:
24431415
38.

Improving the quality of written information available at weekends in a paediatric hospital: the TRANSMIT sheet.

Hawcutt D, Green J, Durand C, Mehta F, Christopherson M, Sinha I.

BMJ Qual Improv Rep. 2013 Oct 24;2(2). pii: u202302.w1137. doi: 10.1136/bmjquality.u202302.w1137. eCollection 2014.

39.

The restrictions to the use of codeine and dilemmas about safe alternatives.

Carter B, Hawcutt DB, Arnott J.

J Child Health Care. 2013 Dec;17(4):335-7. doi: 10.1177/1367493513513663. No abstract available.

PMID:
24336191
40.

Early morning salivary cortisol and cortisone, and adrenal responses to a simplified low-dose short Synacthen test in children with asthma.

Blair J, Lancaster G, Titman A, Peak M, Newlands P, Collingwood C, Chesters C, Moorcroft T, Wallin N, Hawcutt D, Gardner C, Didi M, Lacy D, Couriel J.

Clin Endocrinol (Oxf). 2014 Mar;80(3):376-83. doi: 10.1111/cen.12302. Epub 2013 Sep 5.

PMID:
23895277
41.

Paediatric pharmacogenomics: an overview.

Hawcutt DB, Thompson B, Smyth RL, Pirmohamed M.

Arch Dis Child. 2013 Mar;98(3):232-7. doi: 10.1136/archdischild-2012-302852. Epub 2012 Nov 29. Review.

PMID:
23196740
42.

Decreased milk drinking causing flecainide toxicity in an older child.

Thompson B, Mangat J, Barton C, Hawcutt DB.

BMJ Case Rep. 2012 Jun 21;2012. pii: bcr0220125810. doi: 10.1136/bcr.02.2012.5810.

43.

Reported paediatric adverse drug reactions in the UK 2000-2009.

Hawcutt DB, Mainie P, Riordan A, Smyth RL, Pirmohamed M.

Br J Clin Pharmacol. 2012 Mar;73(3):437-46. doi: 10.1111/j.1365-2125.2011.04113.x. Review.

44.

Sulthiame in refractory paediatric epilepsies: an experience of an 'old' antiepileptic drug in a tertiary paediatric neurology unit.

Swiderska N, Hawcutt D, Eaton V, Stockton F, Kumar R, Kneen R, Appleton R.

Seizure. 2011 Dec;20(10):805-8. doi: 10.1016/j.seizure.2011.08.006. Epub 2011 Sep 15.

45.

Twin-twin confusion syndrome: blood chimerism in opposite sex dizygotic twins.

Hawcutt D, Hammond B, Sibbring J, Gokhale D, Ellis I, Bricker L, Subhedar N.

J Obstet Gynaecol. 2011 Jul;31(5):446-8. doi: 10.3109/01443615.2011.570813. No abstract available.

PMID:
21627435
46.

Serum phenytoin concentrations in paediatric patients following intravenous loading.

Hawcutt DB, Sampath S, Timmis A, Newland V, Newland P, Appleton R.

Arch Dis Child. 2011 Sep;96(9):883-4. doi: 10.1136/adc.2011.215269. Epub 2011 May 19.

PMID:
21596726
47.

'Lest we forget...'.

Mainie P, Hawcutt D.

Arch Dis Child. 2011 Jul;96(7):699. doi: 10.1136/adc.2010.208363. Epub 2011 Feb 1. No abstract available.

PMID:
21285228
48.

Prioritising neonatal medicines research: UK Medicines for Children Research Network scoping survey.

Turner MA, Lewis S, Hawcutt DB, Field D.

BMC Pediatr. 2009 Aug 12;9:50. doi: 10.1186/1471-2431-9-50.

49.

Properties of secondary and tertiary human enteric nervous system neurospheres.

Lindley RM, Hawcutt DB, Connell MG, Edgar DH, Kenny SE.

J Pediatr Surg. 2009 Jun;44(6):1249-55; discussion 1255-6. doi: 10.1016/j.jpedsurg.2009.02.048.

PMID:
19524749
50.

Drug development for children: how is pharma tackling an unmet need?

Hawcutt DB, Smyth RL.

IDrugs. 2008 Jul;11(7):502-7. Review.

PMID:
18600597

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