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Items: 33

1.

Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.

Cho S, Zammarchi F, Williams DG, Havenith CEG, Monks NR, Tyrer P, D'Hooge F, Fleming R, Vashisht K, Dimasi N, Bertelli F, Corbett S, Adams L, Reinert HW, Dissanayake S, Britten CE, King W, Dacosta K, Tammali R, Schifferli K, Strout P, Korade M 3rd, Masson Hinrichs MJ, Chivers S, Corey E, Liu H, Kim S, Bander NH, Howard PW, Hartley JA, Coats S, Tice DA, Herbst R, van Berkel PH.

Mol Cancer Ther. 2018 Oct;17(10):2176-2186. doi: 10.1158/1535-7163.MCT-17-0982. Epub 2018 Jul 31.

2.

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine.

Hartley JA, Flynn MJ, Bingham JP, Corbett S, Reinert H, Tiberghien A, Masterson LA, Antonow D, Adams L, Chowdhury S, Williams DG, Mao S, Harper J, Havenith CEG, Zammarchi F, Chivers S, van Berkel PH, Howard PW.

Sci Rep. 2018 Jul 11;8(1):10479. doi: 10.1038/s41598-018-28533-4.

3.

ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies.

Zammarchi F, Corbett S, Adams L, Tyrer PC, Kiakos K, Janghra N, Marafioti T, Britten CE, Havenith CEG, Chivers S, D'Hooge F, Williams DG, Tiberghien A, Howard PW, Hartley JA, van Berkel PH.

Blood. 2018 Mar 8;131(10):1094-1105. doi: 10.1182/blood-2017-10-813493. Epub 2018 Jan 3.

PMID:
29298756
4.

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies.

Flynn MJ, Zammarchi F, Tyrer PC, Akarca AU, Janghra N, Britten CE, Havenith CE, Levy JN, Tiberghien A, Masterson LA, Barry C, D'Hooge F, Marafioti T, Parren PW, Williams DG, Howard PW, van Berkel PH, Hartley JA.

Mol Cancer Ther. 2016 Nov;15(11):2709-2721. Epub 2016 Aug 17.

5.

A human CD4 monoclonal antibody for the treatment of T-cell lymphoma combines inhibition of T-cell signaling by a dual mechanism with potent Fc-dependent effector activity.

Rider DA, Havenith CE, de Ridder R, Schuurman J, Favre C, Cooper JC, Walker S, Baadsgaard O, Marschner S, vandeWinkel JG, Cambier J, Parren PW, Alexander DR.

Cancer Res. 2007 Oct 15;67(20):9945-53.

6.

Fc receptor but not complement binding is important in antibody protection against HIV.

Hessell AJ, Hangartner L, Hunter M, Havenith CE, Beurskens FJ, Bakker JM, Lanigan CM, Landucci G, Forthal DN, Parren PW, Marx PA, Burton DR.

Nature. 2007 Sep 6;449(7158):101-4.

PMID:
17805298
7.

Mesothelial cell transplantation in models of acute inflammation and chronic peritoneal dialysis.

Hekking LH, Harvey VS, Havenith CE, van den Born J, Beelen RH, Jackman RW, Nagy JA.

Perit Dial Int. 2003 Jul-Aug;23(4):323-30.

PMID:
12968839
8.

Rat monocyte-derived dendritic cells function and migrate in the same way as isolated tissue dendritic cells.

Richters CD, Mayen I, Havenith CE, Beelen RH, Kamperdijk EW.

J Leukoc Biol. 2002 Apr;71(4):582-7.

PMID:
11927643
9.

Better preservation of peritoneal morphologic features and defense in rats after long-term exposure to a bicarbonate/lactate-buffered solution.

Hekking LH, Zareie M, Driesprong BA, Faict D, Welten AG, de Greeuw I, Schadee-Eestermans IL, Havenith CE, van den Born J, ter Wee PM, Beelen RH.

J Am Soc Nephrol. 2001 Dec;12(12):2775-86.

10.

Recombinant Lactobacillus plantarum inhibits house dust mite-specific T-cell responses.

Kruisselbrink A, Heijne Den Bak-Glashouwer MJ, Havenith CE, Thole JE, Janssen R.

Clin Exp Immunol. 2001 Oct;126(1):2-8.

11.

Analysis of monocyte chemotactic protein-1 production in different major histocompatability complex-restricted antigen presentation systems.

Tekstra J, Tjin EP, Tuk CW, Broekhuis-Fluitsma D, Havenith CE, Beelen RH.

Clin Immunol. 2001 Oct;101(1):77-85.

PMID:
11580229
12.

Live bacterial delivery systems for development of mucosal vaccines.

Thole JE, van Dalen PJ, Havenith CE, Pouwels PH, Seegers JF, Tielen FD, van der Zee MD, Zegers ND, Shaw M.

Curr Opin Mol Ther. 2000 Feb;2(1):94-9. Review.

PMID:
11249657
13.

Effect of PD fluid instillation on the peritonitis-induced influx and bacterial clearing capacity of peritoneal cells.

Hekking LH, Huijsmans A, Van Gelderop E, Wieslander AP, Havenith CE, van den Born J, Beelen RH.

Nephrol Dial Transplant. 2001 Mar;16(3):679-82; idscussion 683-5.

PMID:
11239068
14.

Isolation of human lung dendritic cells.

van den Heuvel MM, Havenith CE, Beelen RH.

Methods Mol Med. 2001;64:163-73. doi: 10.1385/1-59259-150-7:163.

PMID:
21374258
15.

Engineering the microflora to vaccinate the mucosa: serum immunoglobulin G responses and activated draining cervical lymph nodes following mucosal application of tetanus toxin fragment C-expressing lactobacilli.

Shaw DM, Gaerthé B, Leer RJ, Van Der Stap JG, Smittenaar C, Heijne Den Bak-Glashouwer M, Thole JE, Tielen FJ, Pouwels PH, Havenith CE.

Immunology. 2000 Aug;100(4):510-8.

16.

Laparoscopic surgery preserves monocyte-mediated tumor cell killing in contrast to the conventional approach.

Sietses C, Havenith CE, Eijsbouts QA, van Leeuwen PA, Meijer S, Beelen RH, Cuesta MA.

Surg Endosc. 2000 May;14(5):456-60.

PMID:
10858471
17.

Effect of peritoneal dialysis fluid measured in vivo in a rat-model of continuous peritoneal dialysis.

Hekking LH, Aalders MC, Van Gelderop E, Zweers MM, Struijk DG, Havenith CE, Beelen RH.

Adv Perit Dial. 1998;14:14-8.

PMID:
10649683
18.

Talc-induced inflammation in the pleural cavity.

van den Heuvel MM, Smit HJ, Barbierato SB, Havenith CE, Beelen RH, Postmus PE.

Eur Respir J. 1998 Dec;12(6):1419-23.

19.

Experimental models in peritoneal dialysis: a European experience.

Lameire N, Van Biesen W, Van Landschoot M, Wang T, Heimbürger O, Bergström J, Lindholm B, Hekking LP, Havenith CE, Beelen RH.

Kidney Int. 1998 Dec;54(6):2194-206. Review.

20.
21.

Heterogeneity of mouse brain macrophages in alloantigen presentation to naive CD8+ T cells as revealed by a panel of microglial cell lines.

Askew D, Havenith CE, Walker WS.

Immunobiology. 1996 Oct;195(4-5):417-30. Review. No abstract available.

PMID:
8933148
22.
23.

Methods for studying immuno-effector functions and antigen presenting activity of human macrophages.

Betjes MG, Havenith CE, van de Loosdrecht AA, Beelen RH.

J Immunol Methods. 1994 Sep 14;174(1-2):215-22.

PMID:
8083525
24.

Dendritic cells and their precursors isolated from human bronchoalveolar lavage: immunocytologic and functional properties.

van Haarst JM, Hoogsteden HC, de Wit HJ, Verhoeven GT, Havenith CE, Drexhage HA.

Am J Respir Cell Mol Biol. 1994 Sep;11(3):344-50.

PMID:
8086170
25.

Enrichment and characterization of dendritic cells from human bronchoalveolar lavages.

Havenith CE, van Haarst JM, Breedijk AJ, Betjes MG, Hoogsteden HC, Beelen RH, Hoefsmit EC.

Clin Exp Immunol. 1994 May;96(2):339-43.

26.

Migration of dendritic cells into the draining lymph nodes of the lung after intratracheal instillation.

Havenith CE, van Miert PP, Breedijk AJ, Beelen RH, Hoefsmit EC.

Am J Respir Cell Mol Biol. 1993 Nov;9(5):484-8.

PMID:
8217188
27.

Separation of alveolar macrophages and dendritic cells via autofluorescence: phenotypical and functional characterization.

Havenith CE, Breedijk AJ, van Miert PP, Blijleven N, Calame W, Beelen RH, Hoefsmit EC.

J Leukoc Biol. 1993 May;53(5):504-10.

PMID:
8501394
28.

T cell priming in situ by intratracheally instilled antigen-pulsed dendritic cells.

Havenith CE, Breedijk AJ, Betjes MG, Calame W, Beelen RH, Hoefsmit EC.

Am J Respir Cell Mol Biol. 1993 Mar;8(3):319-24.

PMID:
8448020
29.

Antigen specific T cell priming in vivo by intratracheal injection of antigen presenting cells.

Havenith CE, Breedijk AJ, Calame W, Beelen RH, Hoefsmit EC.

Adv Exp Med Biol. 1993;329:571-5. No abstract available.

PMID:
8379426
30.

Heterogeneity of dendritic cells and nomenclature.

Hoefsmit EC, Arkema JM, Betjes MG, Havenith CE, van Vugt E, Beelen RH, Kamperdijk EW.

Adv Exp Med Biol. 1993;329:481-6. Review. No abstract available.

PMID:
8379414
31.

Dendritic cells isolated from rat and human non-lymphoid tissue are very potent accessory cells.

Beelen RH, van Vugt E, Steenbergen JJ, Betjes MG, Havenith CE, Kamperdijk EW.

Adv Exp Med Biol. 1993;329:123-7. No abstract available.

PMID:
8379362
32.

An improved and rapid method for the isolation of rat lymph node or spleen T lymphocytes for T cell proliferation assays.

Havenith CE, Breedijk AJ, Verdaasdonk MA, Kamperdijk EW, Beelen RH.

J Immunol Methods. 1992 Aug 30;153(1-2):73-9.

PMID:
1517604
33.

Effect of Bacillus Calmette-Guérin inoculation on numbers of dendritic cells in bronchoalveolar lavages of rats.

Havenith CE, Breedijk AJ, Hoefsmit EC.

Immunobiology. 1992 Apr;184(4-5):336-47.

PMID:
1592426

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