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Items: 1 to 50 of 372

1.

Apolipoprotein C-I plays a role in the pathogenesis of glomerulosclerosis.

Bus P, Pierneef L, Bor R, Wolterbeek R, van Es LA, Rensen PC, de Heer E, Havekes LM, Bruijn JA, Berbée JF, Baelde HJ.

J Pathol. 2017 Apr;241(5):589-599. doi: 10.1002/path.4859. Epub 2017 Feb 2.

PMID:
27976371
2.

HDL functionality in South Asians as compared to white Caucasians.

Bakker LE, Boon MR, Annema W, Dikkers A, van Eyk HJ, Verhoeven A, Mayboroda OA, Jukema JW, Havekes LM, Meinders AE, Willems van Dijk K, Jazet IM, Tietge UJ, Rensen PC.

Nutr Metab Cardiovasc Dis. 2016 Aug;26(8):697-705. doi: 10.1016/j.numecd.2016.02.010. Epub 2016 Feb 19.

PMID:
27052926
3.

Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9.

van der Tuin SJ, Kühnast S, Berbée JF, Verschuren L, Pieterman EJ, Havekes LM, van der Hoorn JW, Rensen PC, Jukema JW, Princen HM, Willems van Dijk K, Wang Y.

J Lipid Res. 2015 Nov;56(11):2085-93. doi: 10.1194/jlr.M057794. Epub 2015 Sep 4.

4.

Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes.

Liang W, Verschuren L, Mulder P, van der Hoorn JW, Verheij J, van Dam AD, Boon MR, Princen HM, Havekes LM, Kleemann R, van den Hoek AM.

Br J Pharmacol. 2015 Nov;172(22):5293-305. doi: 10.1111/bph.13315. Epub 2015 Oct 22.

5.

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells.

Wang Y, van der Tuin S, Tjeerdema N, van Dam AD, Rensen SS, Hendrikx T, Berbée JF, Atanasovska B, Fu J, Hoekstra M, Bekkering S, Riksen NP, Buurman WA, Greve JW, Hofker MH, Shiri-Sverdlov R, Meijer OC, Smit JW, Havekes LM, van Dijk KW, Rensen PC.

Hepatology. 2015 Dec;62(6):1710-22. doi: 10.1002/hep.27985. Epub 2015 Aug 28.

PMID:
26174697
6.

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.

Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC.

Nat Commun. 2015 Mar 10;6:6356. doi: 10.1038/ncomms7356.

7.

Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology.

Liang W, Menke AL, Driessen A, Koek GH, Lindeman JH, Stoop R, Havekes LM, Kleemann R, van den Hoek AM.

PLoS One. 2014 Dec 23;9(12):e115922. doi: 10.1371/journal.pone.0115922. eCollection 2014.

8.

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis.

Khedoe PP, Hoeke G, Kooijman S, Dijk W, Buijs JT, Kersten S, Havekes LM, Hiemstra PS, Berbée JF, Boon MR, Rensen PC.

J Lipid Res. 2015 Jan;56(1):51-9. doi: 10.1194/jlr.M052746. Epub 2014 Oct 28.

9.

Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis.

Kooijman S, Meurs I, van der Stoep M, Habets KL, Lammers B, Berbée JF, Havekes LM, van Eck M, Romijn JA, Korporaal SJ, Rensen PC.

J Thromb Haemost. 2015 Jan;13(1):126-35. doi: 10.1111/jth.12765. Epub 2014 Nov 13.

10.

Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.

Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbée JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombès M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC.

FASEB J. 2014 Dec;28(12):5361-75. doi: 10.1096/fj.13-247643. Epub 2014 Aug 25.

PMID:
25154875
11.

Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin.

Kühnast S, van der Tuin SJ, van der Hoorn JW, van Klinken JB, Simic B, Pieterman E, Havekes LM, Landmesser U, Lüscher TF, Willems van Dijk K, Rensen PC, Jukema JW, Princen HM.

Eur Heart J. 2015 Jan 1;36(1):39-48. doi: 10.1093/eurheartj/ehu319. Epub 2014 Aug 20.

12.

Inhibition of the central melanocortin system decreases brown adipose tissue activity.

Kooijman S, Boon MR, Parlevliet ET, Geerling JJ, van de Pol V, Romijn JA, Havekes LM, Meurs I, Rensen PC.

J Lipid Res. 2014 Oct;55(10):2022-32. doi: 10.1194/jlr.M045989. Epub 2014 Jul 12.

13.

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

Guigas B, de Leeuw van Weenen JE, van Leeuwen N, Simonis-Bik AM, van Haeften TW, Nijpels G, Houwing-Duistermaat JJ, Beekman M, Deelen J, Havekes LM, Penninx BW, Vogelzangs N, van 't Riet E, Dehghan A, Hofman A, Witteman JC, Uitterlinden AG, Grarup N, Jørgensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Hottenga J, Romijn JA, Diamant M, Kramer MH, Heine RJ, Willemsen G, Dekker JM, Eekhoff EM, Pijl H, de Geus EJ, Slagboom PE, 't Hart LM.

Diabet Med. 2014 Aug;31(8):1001-8. doi: 10.1111/dme.12464. Epub 2014 May 2.

PMID:
24724616
14.

Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study.

Bakker LE, Boon MR, van der Linden RA, Arias-Bouda LP, van Klinken JB, Smit F, Verberne HJ, Jukema JW, Tamsma JT, Havekes LM, van Marken Lichtenbelt WD, Jazet IM, Rensen PC.

Lancet Diabetes Endocrinol. 2014 Mar;2(3):210-7. doi: 10.1016/S2213-8587(13)70156-6. Epub 2013 Nov 12.

PMID:
24622751
15.

Metabolically induced liver inflammation leads to NASH and differs from LPS- or IL-1β-induced chronic inflammation.

Liang W, Lindeman JH, Menke AL, Koonen DP, Morrison M, Havekes LM, van den Hoek AM, Kleemann R.

Lab Invest. 2014 May;94(5):491-502. doi: 10.1038/labinvest.2014.11. Epub 2014 Feb 24.

16.

Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration.

Wang Y, Parlevliet ET, Geerling JJ, van der Tuin SJ, Zhang H, Bieghs V, Jawad AH, Shiri-Sverdlov R, Bot I, de Jager SC, Havekes LM, Romijn JA, Willems van Dijk K, Rensen PC.

Br J Pharmacol. 2014 Feb;171(3):723-34. doi: 10.1111/bph.12490.

17.

Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B.

Heemskerk MM, van den Berg SA, Pronk AC, van Klinken JB, Boon MR, Havekes LM, Rensen PC, van Dijk KW, van Harmelen V.

Am J Physiol Endocrinol Metab. 2014 Apr 1;306(7):E808-13. doi: 10.1152/ajpendo.00641.2013. Epub 2014 Jan 28.

18.

APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome.

van den Hoek AM, van der Hoorn JW, Maas AC, van den Hoogen RM, van Nieuwkoop A, Droog S, Offerman EH, Pieterman EJ, Havekes LM, Princen HM.

Diabetes Obes Metab. 2014 Jun;16(6):537-44. doi: 10.1111/dom.12252. Epub 2014 Jan 16.

PMID:
24373179
19.

Glucocorticoid excess induces long-lasting changes in body composition in male C57Bl/6J mice only with high-fat diet.

Auvinen HE, Coomans CP, Boon MR, Romijn JA, Biermasz NR, Meijer OC, Havekes LM, Smit JW, Rensen PC, Pereira AM.

Physiol Rep. 2013 Oct;1(5):e00103. doi: 10.1002/phy2.103. Epub 2013 Oct 11.

20.

The effect of PPE-induced emphysema and chronic LPS-induced pulmonary inflammation on atherosclerosis development in APOE*3-LEIDEN mice.

Khedoe PP, Wong MC, Wagenaar GT, Plomp JJ, van Eck M, Havekes LM, Rensen PC, Hiemstra PS, Berbée JF.

PLoS One. 2013 Nov 26;8(11):e80196. doi: 10.1371/journal.pone.0080196. eCollection 2013.

21.

Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies.

Geerling JJ, Boon MR, Kooijman S, Parlevliet ET, Havekes LM, Romijn JA, Meurs IM, Rensen PC.

J Lipid Res. 2014 Feb;55(2):180-9. doi: 10.1194/jlr.R045013. Epub 2013 Nov 27. Review.

22.

Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice.

Geerling JJ, Boon MR, van der Zon GC, van den Berg SA, van den Hoek AM, Lombès M, Princen HM, Havekes LM, Rensen PC, Guigas B.

Diabetes. 2014 Mar;63(3):880-91. doi: 10.2337/db13-0194. Epub 2013 Nov 22.

23.

BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality.

Boon MR, van den Berg SA, Wang Y, van den Bossche J, Karkampouna S, Bauwens M, De Saint-Hubert M, van der Horst G, Vukicevic S, de Winther MP, Havekes LM, Jukema JW, Tamsma JT, van der Pluijm G, van Dijk KW, Rensen PC.

PLoS One. 2013 Sep 16;8(9):e74083. doi: 10.1371/journal.pone.0074083. eCollection 2013.

24.

The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system.

Coomans CP, Geerling JJ, van den Berg SA, van Diepen HC, Garcia-Tardón N, Thomas A, Schröder-van der Elst JP, Ouwens DM, Pijl H, Rensen PC, Havekes LM, Guigas B, Romijn JA.

Br J Pharmacol. 2013 Oct;170(4):908-18. doi: 10.1111/bph.12338.

25.

Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol.

Kühnast S, Louwe MC, Heemskerk MM, Pieterman EJ, van Klinken JB, van den Berg SA, Smit JW, Havekes LM, Rensen PC, van der Hoorn JW, Princen HM, Jukema JW.

PLoS One. 2013 Jun 19;8(6):e66467. doi: 10.1371/journal.pone.0066467. Print 2013.

26.

Both transient and continuous corticosterone excess inhibit atherosclerotic plaque formation in APOE*3-leiden.CETP mice.

Auvinen HE, Wang Y, Princen H, Romijn JA, Havekes LM, Smit JW, Meijer OC, Biermasz NR, Rensen PC, Pereira AM.

PLoS One. 2013 May 22;8(5):e63882. doi: 10.1371/journal.pone.0063882. Print 2013.

27.

Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake.

van den Berg SA, Heemskerk MM, Geerling JJ, van Klinken JB, Schaap FG, Bijland S, Berbée JF, van Harmelen VJ, Pronk AC, Schreurs M, Havekes LM, Rensen PC, van Dijk KW.

FASEB J. 2013 Aug;27(8):3354-62. doi: 10.1096/fj.12-225367. Epub 2013 May 6.

PMID:
23650188
28.

Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice.

Gautier T, de Haan W, Grober J, Ye D, Bahr MJ, Claudel T, Nijstad N, Van Berkel TJ, Havekes LM, Manns MP, Willems SM, Hogendoorn PC, Lagrost L, Kuipers F, Van Eck M, Rensen PC, Tietge UJ.

J Lipid Res. 2013 Aug;54(8):2195-205. doi: 10.1194/jlr.M038141. Epub 2013 Apr 25.

29.

Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis.

van Diepen JA, Berbée JF, Havekes LM, Rensen PC.

Atherosclerosis. 2013 Jun;228(2):306-15. doi: 10.1016/j.atherosclerosis.2013.02.028. Epub 2013 Mar 1. Review.

PMID:
23518178
30.

CD36 is important for adipocyte recruitment and affects lipolysis.

Vroegrijk IO, van Klinken JB, van Diepen JA, van den Berg SA, Febbraio M, Steinbusch LK, Glatz JF, Havekes LM, Voshol PJ, Rensen PC, van Dijk KW, van Harmelen V.

Obesity (Silver Spring). 2013 Oct;21(10):2037-45. doi: 10.1002/oby.20354. Epub 2013 May 29.

31.

Znf202 affects high density lipoprotein cholesterol levels and promotes hepatosteatosis in hyperlipidemic mice.

Vrins CL, Out R, van Santbrink P, van der Zee A, Mahmoudi T, Groenendijk M, Havekes LM, van Berkel TJ, Willems van Dijk K, Biessen EA.

PLoS One. 2013;8(2):e57492. doi: 10.1371/journal.pone.0057492. Epub 2013 Feb 28.

32.

Acute central neuropeptide Y administration increases food intake but does not affect hepatic very low-density lipoprotein (VLDL) production in mice.

Geerling JJ, Wang Y, Havekes LM, Romijn JA, Rensen PC.

PLoS One. 2013;8(2):e55217. doi: 10.1371/journal.pone.0055217. Epub 2013 Feb 27.

33.

Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion.

Sugimoto-Kawabata K, Shimada H, Sakai K, Suzuki K, Kelder T, Pieterman EJ, Cohen LH, Havekes LM, Princen HM, van den Hoek AM.

J Lipid Res. 2013 May;54(5):1255-64. doi: 10.1194/jlr.M032839. Epub 2013 Feb 22.

34.

Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice.

Berbée JF, Wong MC, Wang Y, van der Hoorn JW, Khedoe PP, van Klinken JB, Mol IM, Hiemstra PS, Tsikas D, Romijn JA, Havekes LM, Princen HM, Rensen PC.

J Nutr Biochem. 2013 Aug;24(8):1423-30. doi: 10.1016/j.jnutbio.2012.11.009. Epub 2013 Jan 18.

PMID:
23337345
35.

Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity.

Coomans CP, van den Berg SA, Houben T, van Klinken JB, van den Berg R, Pronk AC, Havekes LM, Romijn JA, van Dijk KW, Biermasz NR, Meijer JH.

FASEB J. 2013 Apr;27(4):1721-32. doi: 10.1096/fj.12-210898. Epub 2013 Jan 9.

PMID:
23303208
36.

Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion.

van Diepen JA, Stienstra R, Vroegrijk IO, van den Berg SA, Salvatori D, Hooiveld GJ, Kersten S, Tack CJ, Netea MG, Smit JW, Joosten LA, Havekes LM, van Dijk KW, Rensen PC.

J Lipid Res. 2013 Feb;54(2):448-56. doi: 10.1194/jlr.M031963. Epub 2012 Nov 17.

37.

GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice.

Parlevliet ET, Wang Y, Geerling JJ, Schröder-Van der Elst JP, Picha K, O'Neil K, Stojanovic-Susulic V, Ort T, Havekes LM, Romijn JA, Pijl H, Rensen PC.

PLoS One. 2012;7(11):e49152. doi: 10.1371/journal.pone.0049152. Epub 2012 Nov 2.

38.

META060 protects against diet-induced obesity and insulin resistance in a high-fat-diet fed mouse.

Vroegrijk IO, van Diepen JA, van den Berg SA, Romijn JA, Havekes LM, van Dijk KW, Darland G, Konda V, Tripp ML, Bland JS, Voshol PJ.

Nutrition. 2013 Jan;29(1):276-83. doi: 10.1016/j.nut.2012.05.004. Epub 2012 Sep 15.

39.

Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein.

Vrins CL, Ottenhoff R, van den Oever K, de Waart DR, Kruyt JK, Zhao Y, van Berkel TJ, Havekes LM, Aerts JM, van Eck M, Rensen PC, Groen AK.

J Lipid Res. 2012 Oct;53(10):2017-23. doi: 10.1194/jlr.M022194. Epub 2012 Jul 16.

40.

The effects of high fat diet on the basal activity of the hypothalamus-pituitary-adrenal axis in mice.

Auvinen HE, Romijn JA, Biermasz NR, Pijl H, Havekes LM, Smit JW, Rensen PC, Pereira AM.

J Endocrinol. 2012 Aug;214(2):191-7. doi: 10.1530/JOE-12-0056. Epub 2012 May 22.

41.

Estimation of activity related energy expenditure and resting metabolic rate in freely moving mice from indirect calorimetry data.

Van Klinken JB, van den Berg SA, Havekes LM, Willems Van Dijk K.

PLoS One. 2012;7(5):e36162. doi: 10.1371/journal.pone.0036162. Epub 2012 May 4.

42.

Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice.

Wei H, Hu C, Wang M, van den Hoek AM, Reijmers TH, Wopereis S, Bouwman J, Ramaker R, Korthout HA, Vennik M, Hankemeier T, Havekes LM, Witkamp RF, Verheij ER, Xu G, van der Greef J.

PLoS One. 2012;7(1):e30332. doi: 10.1371/journal.pone.0030332. Epub 2012 Jan 23.

43.

Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin.

Kühnast S, van der Hoorn JW, van den Hoek AM, Havekes LM, Liau G, Jukema JW, Princen HM.

J Hypertens. 2012 Jan;30(1):107-16. doi: 10.1097/HJH.0b013e32834ddd8e.

PMID:
22134386
44.

Effects of high fat diet on the Basal activity of the hypothalamus-pituitary-adrenal axis in mice: a systematic review.

Auvinen HE, Romijn JA, Biermasz NR, Havekes LM, Smit JW, Rensen PC, Pereira AM.

Horm Metab Res. 2011 Dec;43(13):899-906. doi: 10.1055/s-0031-1291305. Epub 2011 Nov 8. Review.

PMID:
22068812
45.

Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice.

Coomans CP, Biermasz NR, Geerling JJ, Guigas B, Rensen PC, Havekes LM, Romijn JA.

Diabetes. 2011 Dec;60(12):3132-40. doi: 10.2337/db10-1100. Epub 2011 Oct 25.

46.

Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet.

van Diepen JA, Vroegrijk IO, Berbée JF, Shoelson SE, Romijn JA, Havekes LM, Rensen PC, Voshol PJ.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1099-107. doi: 10.1152/ajpendo.00185.2011. Epub 2011 Aug 23.

47.

Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice.

Wong MC, van Diepen JA, Hu L, Guigas B, de Boer HC, van Puijvelde GH, Kuiper J, van Zonneveld AJ, Shoelson SE, Voshol PJ, Romijn JA, Havekes LM, Tamsma JT, Rensen PC, Hiemstra PS, Berbée JF.

Atherosclerosis. 2012 Feb;220(2):362-8. doi: 10.1016/j.atherosclerosis.2011.06.055. Epub 2011 Jul 12.

48.

A novel EPO receptor agonist improves glucose tolerance via glucose uptake in skeletal muscle in a mouse model of diabetes.

Scully MS, Ort TA, James IE, Bugelski PJ, Makropoulos DA, Deutsch HA, Pieterman EJ, van den Hoek AM, Havekes LM, Dubell WH, Wertheimer JD, Picha KM.

Exp Diabetes Res. 2011;2011:910159. doi: 10.1155/2011/910159. Epub 2011 Jun 30.

49.

Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-Leiden CETP mice.

Bijland S, Rensen PC, Pieterman EJ, Maas AC, van der Hoorn JW, van Erk MJ, Havekes LM, Willems van Dijk K, Chang SC, Ehresman DJ, Butenhoff JL, Princen HM.

Toxicol Sci. 2011 Sep;123(1):290-303. doi: 10.1093/toxsci/kfr142. Epub 2011 Jun 24.

PMID:
21705711
50.

Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice.

Coomans CP, Geerling JJ, Guigas B, van den Hoek AM, Parlevliet ET, Ouwens DM, Pijl H, Voshol PJ, Rensen PC, Havekes LM, Romijn JA.

J Lipid Res. 2011 Sep;52(9):1712-22. doi: 10.1194/jlr.M015396. Epub 2011 Jun 23.

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