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Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE.

Fellner M, Huizenga KG, Hausinger RP, Hu J.

Sci Rep. 2020 Apr 2;10(1):5830. doi: 10.1038/s41598-020-62847-6.


Glutarate L-2-hydroxylase (CsiD/GlaH) is an archetype Fe(II)/2-oxoglutarate-dependent dioxygenase.

Herr CQ, Macomber L, Kalliri E, Hausinger RP.

Adv Protein Chem Struct Biol. 2019;117:63-90. doi: 10.1016/bs.apcsb.2019.05.001. Epub 2019 Jun 10. Review.


Structural Origin of the Large Redox-Linked Reorganization in the 2-Oxoglutarate Dependent Oxygenase, TauD.

John CW, Hausinger RP, Proshlyakov DA.

J Am Chem Soc. 2019 Sep 25;141(38):15318-15326. doi: 10.1021/jacs.9b07493. Epub 2019 Sep 11.


Strongly Coupled Redox-Linked Conformational Switching at the Active Site of the Non-Heme Iron-Dependent Dioxygenase, TauD.

John CW, Swain GM, Hausinger RP, Proshlyakov DA.

J Phys Chem B. 2019 Sep 19;123(37):7785-7793. doi: 10.1021/acs.jpcb.9b05866. Epub 2019 Sep 6.


New metal cofactors and recent metallocofactor insights.

Hausinger RP.

Curr Opin Struct Biol. 2019 Dec;59:1-8. doi: 10.1016/ Epub 2019 Feb 1. Review.


A structural perspective on the PP-loop ATP pyrophosphatase family.

Fellner M, Hausinger RP, Hu J.

Crit Rev Biochem Mol Biol. 2018 Dec;53(6):607-622. doi: 10.1080/10409238.2018.1516728. Epub 2018 Oct 3. Review.


Thermodynamics of Iron(II) and Substrate Binding to the Ethylene-Forming Enzyme.

Li M, Martinez S, Hausinger RP, Emerson JP.

Biochemistry. 2018 Oct 2;57(39):5696-5705. doi: 10.1021/acs.biochem.8b00730. Epub 2018 Sep 18.


Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum.

Fellner M, Rankin JA, Desguin B, Hu J, Hausinger RP.

Biochemistry. 2018 Sep 25;57(38):5513-5523. doi: 10.1021/acs.biochem.8b00601. Epub 2018 Sep 11.


Nickel-pincer nucleotide cofactor.

Hausinger RP, Desguin B, Fellner M, Rankin JA, Hu J.

Curr Opin Chem Biol. 2018 Dec;47:18-23. doi: 10.1016/j.cbpa.2018.06.019. Epub 2018 Jul 9. Review.


The Irving-Williams series and the 2-His-1-carboxylate facial triad: a thermodynamic study of Mn2+, Fe2+, and Co2+ binding to taurine/α-ketoglutarate dioxygenase (TauD).

Li M, Henderson KL, Martinez S, Hausinger RP, Emerson JP.

J Biol Inorg Chem. 2018 Jul;23(5):785-793. doi: 10.1007/s00775-018-1574-4. Epub 2018 Jun 19.


Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase.

Desguin B, Fellner M, Riant O, Hu J, Hausinger RP, Hols P, Soumillion P.

J Biol Chem. 2018 Aug 10;293(32):12303-12317. doi: 10.1074/jbc.RA118.003741. Epub 2018 Jun 10.


Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases.

Herr CQ, Hausinger RP.

Trends Biochem Sci. 2018 Jul;43(7):517-532. doi: 10.1016/j.tibs.2018.04.002. Epub 2018 Apr 27. Review.


A Structural Model of the Urease Activation Complex Derived from Ion Mobility-Mass Spectrometry and Integrative Modeling.

Eschweiler JD, Farrugia MA, Dixit SM, Hausinger RP, Ruotolo BT.

Structure. 2018 Apr 3;26(4):599-606.e3. doi: 10.1016/j.str.2018.03.001. Epub 2018 Mar 22.


Lactate Racemase Nickel-Pincer Cofactor Operates by a Proton-Coupled Hydride Transfer Mechanism.

Rankin JA, Mauban RC, Fellner M, Desguin B, McCracken J, Hu J, Varganov SA, Hausinger RP.

Biochemistry. 2018 Jun 12;57(23):3244-3251. doi: 10.1021/acs.biochem.8b00100. Epub 2018 Mar 9.


Characterization of human AlkB homolog 1 produced in mammalian cells and demonstration of mitochondrial dysfunction in ALKBH1-deficient cells.

Müller TA, Struble SL, Meek K, Hausinger RP.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):98-103. doi: 10.1016/j.bbrc.2017.10.158. Epub 2017 Oct 31.


Unexpected complexity in the lactate racemization system of lactic acid bacteria.

Desguin B, Soumillion P, Hausinger RP, Hols P.

FEMS Microbiol Rev. 2017 Aug 1;41(Supp_1):S71-S83. doi: 10.1093/femsre/fux021. Review.


Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.

Fellner M, Desguin B, Hausinger RP, Hu J.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9074-9079. doi: 10.1073/pnas.1704967114. Epub 2017 Aug 7.


Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist.

Martinez S, Fellner M, Herr CQ, Ritchie A, Hu J, Hausinger RP.

J Am Chem Soc. 2017 Aug 30;139(34):11980-11988. doi: 10.1021/jacs.7b06186. Epub 2017 Aug 22.


Correction to Biochemical and Spectroscopic Characterization of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme from Pseudomonas syringae pv. phaseolicola PK2.

Martinez S, Hausinger RP.

Biochemistry. 2017 Jun 20;56(24):3158. doi: 10.1021/acs.biochem.7b00502. Epub 2017 Jun 7. No abstract available.


Biochemical Characterization of AP Lyase and m6A Demethylase Activities of Human AlkB Homologue 1 (ALKBH1).

Müller TA, Tobar MA, Perian MN, Hausinger RP.

Biochemistry. 2017 Apr 4;56(13):1899-1910. doi: 10.1021/acs.biochem.7b00060. Epub 2017 Mar 21.


ALKBH7 Variant Related to Prostate Cancer Exhibits Altered Substrate Binding.

Walker AR, Silvestrov P, Müller TA, Podolsky RH, Dyson G, Hausinger RP, Cisneros GA.

PLoS Comput Biol. 2017 Feb 23;13(2):e1005345. doi: 10.1371/journal.pcbi.1005345. eCollection 2017 Feb.


Global stability of an α-ketoglutarate-dependent dioxygenase (TauD) and its related complexes.

Henderson KL, Li M, Martinez S, Lewis EA, Hausinger RP, Emerson JP.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):987-994. doi: 10.1016/j.bbagen.2017.02.018. Epub 2017 Feb 15.


Increased heterocyst frequency by patN disruption in Anabaena leads to enhanced photobiological hydrogen production at high light intensity and high cell density.

Masukawa H, Sakurai H, Hausinger RP, Inoue K.

Appl Microbiol Biotechnol. 2017 Mar;101(5):2177-2188. doi: 10.1007/s00253-016-8078-3. Epub 2017 Jan 7.


Non-thiolate ligation of nickel by nucleotide-free UreG of Klebsiella aerogenes.

Martin-Diaconescu V, Joseph CA, Boer JL, Mulrooney SB, Hausinger RP, Maroney MJ.

J Biol Inorg Chem. 2017 Jun;22(4):497-503. doi: 10.1007/s00775-016-1429-9. Epub 2016 Dec 21.


Spectroscopic analyses of 2-oxoglutarate-dependent oxygenases: TauD as a case study.

Proshlyakov DA, McCracken J, Hausinger RP.

J Biol Inorg Chem. 2017 Apr;22(2-3):367-379. doi: 10.1007/s00775-016-1406-3. Epub 2016 Nov 3. Review.


Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.

Desguin B, Soumillion P, Hols P, Hausinger RP.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5598-603. doi: 10.1073/pnas.1600486113. Epub 2016 Apr 25.


Mutational and Computational Evidence That a Nickel-Transfer Tunnel in UreD Is Used for Activation of Klebsiella aerogenes Urease.

Farrugia MA, Wang B, Feig M, Hausinger RP.

Biochemistry. 2015 Oct 20;54(41):6392-401. doi: 10.1021/acs.biochem.5b00942. Epub 2015 Oct 5.


Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases.

Martinez S, Hausinger RP.

J Biol Chem. 2015 Aug 21;290(34):20702-11. doi: 10.1074/jbc.R115.648691. Epub 2015 Jul 7. Review.


METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase.

Desguin B, Zhang T, Soumillion P, Hols P, Hu J, Hausinger RP.

Science. 2015 Jul 3;349(6243):66-9. doi: 10.1126/science.aab2272.


Calorimetric assessment of Fe(2+) binding to α-ketoglutarate/taurine dioxygenase: ironing out the energetics of metal coordination by the 2-His-1-carboxylate facial triad.

Henderson KL, Müller TA, Hausinger RP, Emerson JP.

Inorg Chem. 2015 Mar 2;54(5):2278-83. doi: 10.1021/ic502881q. Epub 2015 Feb 10.


Reduction of urease activity by interaction with the flap covering the active site.

Macomber L, Minkara MS, Hausinger RP, Merz KM Jr.

J Chem Inf Model. 2015 Feb 23;55(2):354-61. doi: 10.1021/ci500562t. Epub 2015 Jan 30.


Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1).

Silvestrov P, Müller TA, Clark KN, Hausinger RP, Cisneros GA.

J Mol Graph Model. 2014 Nov;54:123-30. doi: 10.1016/j.jmgm.2014.10.013. Epub 2014 Oct 27.


Mechanism of the 6-hydroxy-3-succinoyl-pyridine 3-monooxygenase flavoprotein from Pseudomonas putida S16.

Yu H, Hausinger RP, Tang HZ, Xu P.

J Biol Chem. 2014 Oct 17;289(42):29158-70. doi: 10.1074/jbc.M114.558049. Epub 2014 Aug 29.


Nickel-dependent metalloenzymes.

Boer JL, Mulrooney SB, Hausinger RP.

Arch Biochem Biophys. 2014 Feb 15;544:142-52. doi: 10.1016/ Epub 2013 Sep 10. Review.


ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination.

Müller TA, Yu K, Hausinger RP, Meek K.

PLoS One. 2013 Jun 25;8(6):e67403. doi: 10.1371/journal.pone.0067403. Print 2013.


Analysis of a soluble (UreD:UreF:UreG)2 accessory protein complex and its interactions with Klebsiella aerogenes urease by mass spectrometry.

Farrugia MA, Han L, Zhong Y, Boer JL, Ruotolo BT, Hausinger RP.

J Am Soc Mass Spectrom. 2013 Sep;24(9):1328-37.


A covalent protein-DNA 5'-product adduct is generated following AP lyase activity of human ALKBH1 (AlkB homologue 1).

Müller TA, Andrzejak MM, Hausinger RP.

Biochem J. 2013 Jun 15;452(3):509-18. doi: 10.1042/BJ20121908.


Biosynthesis of the urease metallocenter.

Farrugia MA, Macomber L, Hausinger RP.

J Biol Chem. 2013 May 10;288(19):13178-85. doi: 10.1074/jbc.R112.446526. Epub 2013 Mar 28. Review.


Genetic engineering of cyanobacteria to enhance biohydrogen production from sunlight and water.

Masukawa H, Kitashima M, Inoue K, Sakurai H, Hausinger RP.

Ambio. 2012;41 Suppl 2:169-73. doi: 10.1007/s13280-012-0275-4.


Characterization of a Trypanosoma brucei Alkb homolog capable of repairing alkylated DNA.

Simmons JM, Koslowsky DJ, Hausinger RP.

Exp Parasitol. 2012 May;131(1):92-100. doi: 10.1016/j.exppara.2012.03.011. Epub 2012 Mar 20.


Klebsiella aerogenes UreF: identification of the UreG binding site and role in enhancing the fidelity of urease activation.

Boer JL, Hausinger RP.

Biochemistry. 2012 Mar 20;51(11):2298-308. doi: 10.1021/bi3000897. Epub 2012 Mar 6.


Apoprotein isolation and activation, and vibrational structure of the Helicobacter mustelae iron urease.

Carter EL, Proshlyakov DA, Hausinger RP.

J Inorg Biochem. 2012 Jun;111:195-202. doi: 10.1016/j.jinorgbio.2011.10.016. Epub 2011 Nov 28.


Fructose-1,6-bisphosphate aldolase (class II) is the primary site of nickel toxicity in Escherichia coli.

Macomber L, Elsey SP, Hausinger RP.

Mol Microbiol. 2011 Dec;82(5):1291-300. doi: 10.1111/j.1365-2958.2011.07891.x. Epub 2011 Nov 8.


Function of UreB in Klebsiella aerogenes urease.

Carter EL, Boer JL, Farrugia MA, Flugga N, Towns CL, Hausinger RP.

Biochemistry. 2011 Nov 1;50(43):9296-308. doi: 10.1021/bi2011064. Epub 2011 Oct 6.


Mechanisms of nickel toxicity in microorganisms.

Macomber L, Hausinger RP.

Metallomics. 2011 Nov;3(11):1153-62. doi: 10.1039/c1mt00063b. Epub 2011 Jul 28. Review.


Iron-containing urease in a pathogenic bacterium.

Carter EL, Tronrud DE, Taber SR, Karplus PA, Hausinger RP.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13095-9. doi: 10.1073/pnas.1106915108. Epub 2011 Jul 25.


The Escherichia coli alkylation response protein AidB is a redox partner of flavodoxin and binds RNA and acyl carrier protein.

Mulrooney SB, Howard MJ, Hausinger RP.

Arch Biochem Biophys. 2011 Sep 15;513(2):81-6. doi: 10.1016/ Epub 2011 Jul 18.


Site-directed mutagenesis of the Anabaena sp. strain PCC 7120 nitrogenase active site to increase photobiological hydrogen production.

Masukawa H, Inoue K, Sakurai H, Wolk CP, Hausinger RP.

Appl Environ Microbiol. 2010 Oct;76(20):6741-50. doi: 10.1128/AEM.01056-10. Epub 2010 Aug 13.

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