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A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant.

Allen JP, Ozer EA, Minasov G, Shuvalova L, Kiryukhina O, Satchell KJF, Hauser AR.

Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6811-6821. doi: 10.1073/pnas.1919198117. Epub 2020 Mar 10.


Evaluation of Dose Fractionated Polymyxin B on Acute Kidney Injury: A Translational In Vivo Rat Model.

Liu J, Pais GM, Avedissian SN, Gilchrist A, Lee A, Rhodes NJ, Hauser AR, Scheetz MH.

Antimicrob Agents Chemother. 2020 Feb 18. pii: AAC.02300-19. doi: 10.1128/AAC.02300-19. [Epub ahead of print]


Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice.

Bachta KER, Allen JP, Cheung BH, Chiu CH, Hauser AR.

Nat Commun. 2020 Jan 28;11(1):543. doi: 10.1038/s41467-020-14363-4.


Complete Genome Sequence of Klebsiella pneumoniae Strain TK421, a Conjugative Hypervirulent Isolate.

Kochan TJ, Ozer EA, Pincus NB, Fitzpatrick MA, Hauser AR.

Microbiol Resour Announc. 2020 Jan 16;9(3). pii: e01408-19. doi: 10.1128/MRA.01408-19.


Long-term Persistence of an Extensively Drug Resistant Subclade of Globally Distributed Pseudomonas aeruginosa Clonal Complex 446 in an Academic Medical Center.

Pincus NB, Bachta KER, Ozer EA, Allen JP, Pura ON, Qi C, Rhodes NJ, Marty FM, Pandit A, Mekalanos JJ, Oliver A, Hauser AR.

Clin Infect Dis. 2019 Oct 4. pii: ciz973. doi: 10.1093/cid/ciz973. [Epub ahead of print]


Draft Genome Sequence of Pseudomonas aeruginosa Strain BWH047, a Sequence Type 235 Multidrug-Resistant Clinical Isolate Expressing High Levels of Colistin Resistance.

Bachta KER, Ozer EA, Pandit A, Marty FM, Mekalanos JJ, Hauser AR.

Microbiol Resour Announc. 2019 Jul 18;8(29). pii: e00623-19. doi: 10.1128/MRA.00623-19.


Natural Clostridioides difficile toxin immunization in colonized infants.

Kociolek LK, Espinosa RO, Gerding DN, Hauser AR, Ozer EA, Budz M, Balaji A, Chen X, Tanz RR, Yalcinkaya N, Conner ME, Savidge T, Kelly CP.

Clin Infect Dis. 2019 Jun 29. pii: ciz582. doi: 10.1093/cid/ciz582. [Epub ahead of print]


The Population Structure of Pseudomonas aeruginosa Is Characterized by Genetic Isolation of exoU+ and exoS+ Lineages.

Ozer EA, Nnah E, Didelot X, Whitaker RJ, Hauser AR.

Genome Biol Evol. 2019 Jul 1;11(1):1780-1796. doi: 10.1093/gbe/evz119.


In Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients.

Wu X, Siehnel RJ, Garudathri J, Staudinger BJ, Hisert KB, Ozer EA, Hauser AR, Eng JK, Manoil C, Singh PK, Bruce JE.

J Proteome Res. 2019 Jun 7;18(6):2601-2612. doi: 10.1021/acs.jproteome.9b00122. Epub 2019 May 22.


Diversity of Contact-Dependent Growth Inhibition Systems of Pseudomonas aeruginosa

Allen JP, Hauser AR.

J Bacteriol. 2019 Jun 21;201(14). pii: e00776-18. doi: 10.1128/JB.00776-18. Print 2019 Jul 15. Review.


A Genomic Approach To Identify Klebsiella pneumoniae and Acinetobacter baumannii Strains with Enhanced Competitive Fitness in the Lungs during Multistrain Pneumonia.

Agard MJ, Ozer EA, Morris AR, Piseaux R, Hauser AR.

Infect Immun. 2019 May 21;87(6). pii: e00871-18. doi: 10.1128/IAI.00871-18. Print 2019 Jun.


A Review of the Clinical Pharmacokinetics of Polymyxin B.

Avedissian SN, Liu J, Rhodes NJ, Lee A, Pais GM, Hauser AR, Scheetz MH.

Antibiotics (Basel). 2019 Mar 22;8(1). pii: E31. doi: 10.3390/antibiotics8010031. Review.


Multidimensional Assessment of the Host Response in Mechanically Ventilated Patients with Suspected Pneumonia.

Walter JM, Ren Z, Yacoub T, Reyfman PA, Shah RD, Abdala-Valencia H, Nam K, Morgan VK, Anekalla KR, Joshi N, McQuattie-Pimentel AC, Chen CI, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Aillon RP, Watanabe S, Williams KJN, Lu Z, Paonessa J, Hountras P, Breganio M, Borkowski N, Donnelly HK, Allen JP, Amaral LA, Bharat A, Misharin AV, Bagheri N, Hauser AR, Budinger GRS, Wunderink RG.

Am J Respir Crit Care Med. 2019 May 15;199(10):1225-1237. doi: 10.1164/rccm.201804-0650OC.


ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa.

Hughes AJ, Knoten CA, Morris AR, Hauser AR.

J Med Microbiol. 2018 Aug;67(8):1168-1180. doi: 10.1099/jmm.0.000782. Epub 2018 Jun 29.


Case Report of an Extensively Drug-Resistant Klebsiella pneumoniae Infection With Genomic Characterization of the Strain and Review of Similar Cases in the United States.

Krapp F, Ozer EA, Qi C, Hauser AR.

Open Forum Infect Dis. 2018 Apr 6;5(5):ofy074. doi: 10.1093/ofid/ofy074. eCollection 2018 May.


Environmental reservoirs for exoS+ and exoU+ strains of Pseudomonas aeruginosa.

Rutherford V, Yom K, Ozer EA, Pura O, Hughes A, Murphy KR, Cudzilo L, Mitchell D, Hauser AR.

Environ Microbiol Rep. 2018 Aug;10(4):485-492. doi: 10.1111/1758-2229.12653.


Resistance Trends and Treatment Options in Gram-Negative Ventilator-Associated Pneumonia.

Rhodes NJ, Cruce CE, O'Donnell JN, Wunderink RG, Hauser AR.

Curr Infect Dis Rep. 2018 Mar 6;20(2):3. doi: 10.1007/s11908-018-0609-x. Review.


Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital.

Kociolek LK, Ozer EA, Gerding DN, Hecht DW, Patel SJ, Hauser AR.

J Antimicrob Chemother. 2018 May 1;73(5):1222-1229. doi: 10.1093/jac/dkx523.


Virulence Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Strains from Patients with Necrotizing Skin and Soft Tissue Infections.

Krapp F, Morris AR, Ozer EA, Hauser AR.

Sci Rep. 2017 Oct 19;7(1):13533. doi: 10.1038/s41598-017-13524-8.


Phosphatidylinositol 4,5-Bisphosphate-Dependent Oligomerization of the Pseudomonas aeruginosa Cytotoxin ExoU.

Zhang A, Veesenmeyer JL, Hauser AR.

Infect Immun. 2017 Dec 19;86(1). pii: e00402-17. doi: 10.1128/IAI.00402-17. Print 2018 Jan.


Complete Genome Sequence of Clostridioides difficile Epidemic Strain DH/NAP11/106/ST-42, Isolated from Stool from a Pediatric Patient with Diarrhea.

Ozer EA, Hauser AR, Gerding DN, Espinosa RO, Hecht DW, Kociolek LK.

Genome Announc. 2017 Sep 21;5(38). pii: e00923-17. doi: 10.1128/genomeA.00923-17.


Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of Pseudomonas aeruginosa Infection.

Berube BJ, Murphy KR, Torhan MC, Bowlin NO, Williams JD, Bowlin TL, Moir DT, Hauser AR.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01202-17. doi: 10.1128/AAC.01202-17. Print 2017 Nov.


Generation and Validation of the iKp1289 Metabolic Model for Klebsiella pneumoniae KPPR1.

Henry CS, Rotman E, Lathem WW, Tyo KE, Hauser AR, Mandel MJ.

J Infect Dis. 2017 Feb 15;215(suppl_1):S37-S43. doi: 10.1093/infdis/jiw465.


Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene.

Prickett MH, Hauser AR, McColley SA, Cullina J, Potter E, Powers C, Jain M.

Thorax. 2017 Jan;72(1):40-47. doi: 10.1136/thoraxjnl-2015-208027. Epub 2016 Jun 20.


Draft Genome Sequence of a Multidrug-Resistant Klebsiella quasipneumoniae subsp. similipneumoniae Isolate from a Clinical Source.

Ozer EA, Morris AR, Krapp F, Henry CS, Tyo KE, Lathem WW, Hauser AR.

Genome Announc. 2016 May 26;4(3). pii: e00422-16. doi: 10.1128/genomeA.00422-16.


Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections.

Hauser AR, Mecsas J, Moir DT.

Clin Infect Dis. 2016 Jul 1;63(1):89-95. doi: 10.1093/cid/ciw200. Epub 2016 Mar 29.


Utility of Whole-Genome Sequencing in Characterizing Acinetobacter Epidemiology and Analyzing Hospital Outbreaks.

Fitzpatrick MA, Ozer EA, Hauser AR.

J Clin Microbiol. 2016 Mar;54(3):593-612. doi: 10.1128/JCM.01818-15. Epub 2015 Dec 23.


Pseudomonas aeruginosa: breaking down barriers.

Berube BJ, Rangel SM, Hauser AR.

Curr Genet. 2016 Feb;62(1):109-13. doi: 10.1007/s00294-015-0522-x. Epub 2015 Sep 25. Review.


Correction: The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia.

Rangel SM, Diaz MH, Knoten CA, Zhang A, Hauser AR.

PLoS Pathog. 2015 Sep 17;11(9):e1005163. doi: 10.1371/journal.ppat.1005163. eCollection 2015 Sep. No abstract available.


The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia.

Rangel SM, Diaz MH, Knoten CA, Zhang A, Hauser AR.

PLoS Pathog. 2015 Jun 19;11(6):e1004945. doi: 10.1371/journal.ppat.1004945. eCollection 2015 Jun. Erratum in: PLoS Pathog. 2015 Sep;11(9):e1005163.


The great escape: Pseudomonas breaks out of the lung.

Zhang A, Rangel SM, Hauser AR.

Microb Cell. 2015;2(10):409-411.


A novel phosphatidylinositol 4,5-bisphosphate binding domain mediates plasma membrane localization of ExoU and other patatin-like phospholipases.

Tyson GH, Halavaty AS, Kim H, Geissler B, Agard M, Satchell KJ, Cho W, Anderson WF, Hauser AR.

J Biol Chem. 2015 Jan 30;290(5):2919-37. doi: 10.1074/jbc.M114.611251. Epub 2014 Dec 10.


The Pseudomonas aeruginosa type III translocon is required for biofilm formation at the epithelial barrier.

Tran CS, Rangel SM, Almblad H, Kierbel A, Givskov M, Tolker-Nielsen T, Hauser AR, Engel JN.

PLoS Pathog. 2014 Nov 6;10(11):e1004479. doi: 10.1371/journal.ppat.1004479. eCollection 2014 Nov.


Influence of ACB complex genospecies on clinical outcomes in a U.S. hospital with high rates of multidrug resistance.

Fitzpatrick MA, Ozer E, Bolon MK, Hauser AR.

J Infect. 2015 Feb;70(2):144-52. doi: 10.1016/j.jinf.2014.09.004. Epub 2014 Sep 19.


Draft Genome Sequence of Acinetobacter baumannii Strain ABBL099, a Multidrug-Resistant Clinical Outbreak Isolate with a Novel Multilocus Sequence Type.

Ozer EA, Fitzpatrick MA, Hauser AR.

Genome Announc. 2014 Sep 11;2(5). pii: e00738-14. doi: 10.1128/genomeA.00738-14.


Characterization of the core and accessory genomes of Pseudomonas aeruginosa using bioinformatic tools Spine and AGEnt.

Ozer EA, Allen JP, Hauser AR.

BMC Genomics. 2014 Aug 29;15:737. doi: 10.1186/1471-2164-15-737.


The ADP-ribosyltransferase domain of the effector protein ExoS inhibits phagocytosis of Pseudomonas aeruginosa during pneumonia.

Rangel SM, Logan LK, Hauser AR.

mBio. 2014 Jun 10;5(3):e01080-14. doi: 10.1128/mBio.01080-14.


Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung.

Wang N, Ozer EA, Mandel MJ, Hauser AR.

mBio. 2014 Jun 3;5(3):e01163-14. doi: 10.1128/mBio.01163-14.


Different paths to pathogenesis.

Allen JP, Ozer EA, Hauser AR.

Trends Microbiol. 2014 Apr;22(4):168-9. doi: 10.1016/j.tim.2014.02.013. Epub 2014 Mar 12.


Mutations in the Pseudomonas aeruginosa needle protein gene pscF confer resistance to phenoxyacetamide inhibitors of the type III secretion system.

Bowlin NO, Williams JD, Knoten CA, Torhan MC, Tashjian TF, Li B, Aiello D, Mecsas J, Hauser AR, Peet NP, Bowlin TL, Moir DT.

Antimicrob Agents Chemother. 2014;58(4):2211-20. doi: 10.1128/AAC.02795-13. Epub 2014 Jan 27.


Pseudomonas aeruginosa virulence and antimicrobial resistance: two sides of the same coin?

Hauser AR.

Crit Care Med. 2014 Jan;42(1):201-2. doi: 10.1097/CCM.0b013e3182a120cd. No abstract available.


Shanghai fever: a distinct Pseudomonas aeruginosa enteric disease.

Chuang CH, Wang YH, Chang HJ, Chen HL, Huang YC, Lin TY, Ozer EA, Allen JP, Hauser AR, Chiu CH.

Gut. 2014 May;63(5):736-43. doi: 10.1136/gutjnl-2013-304786. Epub 2013 Aug 13.


Hypercapnia impairs lung neutrophil function and increases mortality in murine pseudomonas pneumonia.

Gates KL, Howell HA, Nair A, Vohwinkel CU, Welch LC, Beitel GJ, Hauser AR, Sznajder JI, Sporn PH.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):821-8. doi: 10.1165/rcmb.2012-0487OC.


Phosphatidylinositol 4,5-bisphosphate is a novel coactivator of the Pseudomonas aeruginosa cytotoxin ExoU.

Tyson GH, Hauser AR.

Infect Immun. 2013 Aug;81(8):2873-81. doi: 10.1128/IAI.00414-13. Epub 2013 May 28.


Type III secretion of ExoU is critical during early Pseudomonas aeruginosa pneumonia.

Howell HA, Logan LK, Hauser AR.

mBio. 2013 Mar 12;4(2):e00032-13. doi: 10.1128/mBio.00032-13.


Structure of the type III secretion effector protein ExoU in complex with its chaperone SpcU.

Halavaty AS, Borek D, Tyson GH, Veesenmeyer JL, Shuvalova L, Minasov G, Otwinowski Z, Hauser AR, Anderson WF.

PLoS One. 2012;7(11):e49388. doi: 10.1371/journal.pone.0049388. Epub 2012 Nov 14.


Draft genome sequence of the Pseudomonas aeruginosa bloodstream isolate PABL056.

Ozer EA, Allen JP, Hauser AR.

J Bacteriol. 2012 Nov;194(21):5999. doi: 10.1128/JB.01421-12.


Ventilator-associated pneumonia caused by Pseudomonas aeruginosa: cap your needles!

Hauser AR.

Crit Care Med. 2012 Aug;40(8):2503-4. doi: 10.1097/CCM.0b013e318258e5bb. No abstract available.


An rhs gene of Pseudomonas aeruginosa encodes a virulence protein that activates the inflammasome.

Kung VL, Khare S, Stehlik C, Bacon EM, Hughes AJ, Hauser AR.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1275-80. doi: 10.1073/pnas.1109285109. Epub 2012 Jan 9.


Clinical outcomes of type III Pseudomonas aeruginosa bacteremia.

El-Solh AA, Hattemer A, Hauser AR, Alhajhusain A, Vora H.

Crit Care Med. 2012 Apr;40(4):1157-63. doi: 10.1097/CCM.0b013e3182377906.

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