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Items: 36


The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation.

Steven S, Oelze M, Hausding M, Roohani S, Kashani F, Kröller-Schön S, Helmstädter J, Jansen T, Baum C, Iglarz M, Schulz E, Münzel T, Daiber A.

Oxid Med Cell Longev. 2018 Dec 27;2018:7845629. doi: 10.1155/2018/7845629. eCollection 2018.


CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice.

Steven S, Dib M, Hausding M, Kashani F, Oelze M, Kröller-Schön S, Hanf A, Daub S, Roohani S, Gramlich Y, Lutgens E, Schulz E, Becker C, Lackner KJ, Kleinert H, Knosalla C, Niesler B, Wild PS, Münzel T, Daiber A.

Cardiovasc Res. 2018 Feb 1;114(2):312-323. doi: 10.1093/cvr/cvx197.


Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation, Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic Steatohepatitis and Liver Fibrosis.

Wang X, Hausding M, Weng SY, Kim YO, Steven S, Klein T, Daiber A, Schuppan D.

Antioxid Redox Signal. 2018 Jan 10;28(2):87-109. doi: 10.1089/ars.2016.6953. Epub 2017 Jul 25.


Role of Protein Kinase C and Nox2-Derived Reactive Oxygen Species Formation in the Activation and Maturation of Dendritic Cells by Phorbol Ester and Lipopolysaccharide.

Stein J, Steven S, Bros M, Sudowe S, Hausding M, Oelze M, Münzel T, Grabbe S, Reske-Kunz A, Daiber A.

Oxid Med Cell Longev. 2017;2017:4157213. doi: 10.1155/2017/4157213. Epub 2017 Mar 28.


Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats.

Jabs A, Oelze M, Mikhed Y, Stamm P, Kröller-Schön S, Welschof P, Jansen T, Hausding M, Kopp M, Steven S, Schulz E, Stasch JP, Münzel T, Daiber A.

Vascul Pharmacol. 2015 Aug;71:181-91. doi: 10.1016/j.vph.2015.03.007. Epub 2015 Apr 11.


Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia.

Steven S, Hausding M, Kröller-Schön S, Mader M, Mikhed Y, Stamm P, Zinßius E, Pfeffer A, Welschof P, Agdauletova S, Sudowe S, Li H, Oelze M, Schulz E, Klein T, Münzel T, Daiber A.

Basic Res Cardiol. 2015 Mar;110(2):6. doi: 10.1007/s00395-015-0465-x. Epub 2015 Jan 20.


The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity.

Oelze M, Kröller-Schön S, Welschof P, Jansen T, Hausding M, Mikhed Y, Stamm P, Mader M, Zinßius E, Agdauletova S, Gottschlich A, Steven S, Schulz E, Bottari SP, Mayoux E, Münzel T, Daiber A.

PLoS One. 2014 Nov 17;9(11):e112394. doi: 10.1371/journal.pone.0112394. eCollection 2014.


In vitro and in vivo characterization of a new organic nitrate hybrid drug covalently bound to pioglitazone.

Knorr M, Hausding M, Pfeffer A, Jurk K, Jansen T, Schwierczek K, Oelze M, Kröller-Schön S, Schulz E, Wenzel P, Gori T, Burgin K, Sartor D, Scherhag A, Münzel T, Daiber A.

Pharmacology. 2014;93(5-6):203-15. doi: 10.1159/000361052. Epub 2014 Jun 7.


Glutathione peroxidase-1 deficiency potentiates dysregulatory modifications of endothelial nitric oxide synthase and vascular dysfunction in aging.

Oelze M, Kröller-Schön S, Steven S, Lubos E, Doppler C, Hausding M, Tobias S, Brochhausen C, Li H, Torzewski M, Wenzel P, Bachschmid M, Lackner KJ, Schulz E, Münzel T, Daiber A.

Hypertension. 2014 Feb;63(2):390-6. doi: 10.1161/HYPERTENSIONAHA.113.01602. Epub 2013 Dec 2.


CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction.

Hausding M, Jurk K, Daub S, Kröller-Schön S, Stein J, Schwenk M, Oelze M, Mikhed Y, Kerahrodi JG, Kossmann S, Jansen T, Schulz E, Wenzel P, Reske-Kunz AB, Becker C, Münzel T, Grabbe S, Daiber A.

Basic Res Cardiol. 2013 Nov;108(6):386. doi: 10.1007/s00395-013-0386-5. Epub 2013 Sep 24.


Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species-studies in white blood cells and in animal models.

Kröller-Schön S, Steven S, Kossmann S, Scholz A, Daub S, Oelze M, Xia N, Hausding M, Mikhed Y, Zinssius E, Mader M, Stamm P, Treiber N, Scharffetter-Kochanek K, Li H, Schulz E, Wenzel P, Münzel T, Daiber A.

Antioxid Redox Signal. 2014 Jan 10;20(2):247-66. doi: 10.1089/ars.2012.4953. Epub 2013 Aug 17.


Peroxisome proliferator-activated receptor γ, coactivator 1α deletion induces angiotensin II-associated vascular dysfunction by increasing mitochondrial oxidative stress and vascular inflammation.

Kröller-Schön S, Jansen T, Schüler A, Oelze M, Wenzel P, Hausding M, Kerahrodi JG, Beisele M, Lackner KJ, Daiber A, Münzel T, Schulz E.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1928-35. doi: 10.1161/ATVBAHA.113.301717. Epub 2013 Jun 20.


Angiotensin II-induced vascular dysfunction depends on interferon-γ-driven immune cell recruitment and mutual activation of monocytes and NK-cells.

Kossmann S, Schwenk M, Hausding M, Karbach SH, Schmidgen MI, Brandt M, Knorr M, Hu H, Kröller-Schön S, Schönfelder T, Grabbe S, Oelze M, Daiber A, Münzel T, Becker C, Wenzel P.

Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1313-9. doi: 10.1161/ATVBAHA.113.301437. Epub 2013 Mar 21. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):e126.


Effects of telmisartan or amlodipine monotherapy versus telmisartan/amlodipine combination therapy on vascular dysfunction and oxidative stress in diabetic rats.

Mollnau H, Oelze M, Zinßius E, Hausding M, Wu Z, Knorr M, Ghaemi Kerahrodi J, Kröller-Schön S, Jansen T, Teutsch C, Foster C, Li H, Wenzel P, Schulz E, Münzel T, Daiber A.

Naunyn Schmiedebergs Arch Pharmacol. 2013 May;386(5):405-19. doi: 10.1007/s00210-013-0842-7. Epub 2013 Feb 27.


Characterization of new organic nitrate hybrid drugs covalently bound to valsartan and cilostazol.

Knorr M, Hausding M, Schulz E, Oelze M, Rümmler R, Schuff A, Daub S, Schreiner J, Kröller-Schön S, Wenzel P, Gori T, Burgin K, Sartor D, Scherhag A, Münzel T, Daiber A.

Pharmacology. 2012;90(3-4):193-204. doi: 10.1159/000339861. Epub 2012 Sep 13.


Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition.

Kröller-Schön S, Knorr M, Hausding M, Oelze M, Schuff A, Schell R, Sudowe S, Scholz A, Daub S, Karbach S, Kossmann S, Gori T, Wenzel P, Schulz E, Grabbe S, Klein T, Münzel T, Daiber A.

Cardiovasc Res. 2012 Oct 1;96(1):140-9. doi: 10.1093/cvr/cvs246. Epub 2012 Jul 27.


α1AMP-activated protein kinase mediates vascular protective effects of exercise.

Kröller-Schön S, Jansen T, Hauptmann F, Schüler A, Heeren T, Hausding M, Oelze M, Viollet B, Keaney JF Jr, Wenzel P, Daiber A, Münzel T, Schulz E.

Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1632-41. doi: 10.1161/ATVBAHA.111.243980. Epub 2012 Apr 26.


Hyperglycemia and oxidative stress in cultured endothelial cells--a comparison of primary endothelial cells with an immortalized endothelial cell line.

Karbach S, Jansen T, Horke S, Heeren T, Scholz A, Coldewey M, Karpi A, Hausding M, Kröller-Schön S, Oelze M, Münzel T, Daiber A.

J Diabetes Complications. 2012 May-Jun;26(3):155-62. doi: 10.1016/j.jdiacomp.2012.03.011. Epub 2012 Apr 20.


Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction.

Wenzel P, Knorr M, Kossmann S, Stratmann J, Hausding M, Schuhmacher S, Karbach SH, Schwenk M, Yogev N, Schulz E, Oelze M, Grabbe S, Jonuleit H, Becker C, Daiber A, Waisman A, Münzel T.

Circulation. 2011 Sep 20;124(12):1370-81. doi: 10.1161/CIRCULATIONAHA.111.034470. Epub 2011 Aug 29.


Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy.

Schuhmacher S, Oelze M, Bollmann F, Kleinert H, Otto C, Heeren T, Steven S, Hausding M, Knorr M, Pautz A, Reifenberg K, Schulz E, Gori T, Wenzel P, Münzel T, Daiber A.

Diabetes. 2011 Oct;60(10):2608-16. doi: 10.2337/db10-1395. Epub 2011 Aug 15.


Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-Glutathionylation of endothelial nitric oxide synthase: beneficial effects of therapy with the AT1 receptor blocker telmisartan.

Knorr M, Hausding M, Kröller-Schuhmacher S, Steven S, Oelze M, Heeren T, Scholz A, Gori T, Wenzel P, Schulz E, Daiber A, Münzel T.

Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2223-31. doi: 10.1161/ATVBAHA.111.232058. Epub 2011 Jul 14.


IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease.

Koltsida O, Hausding M, Stavropoulos A, Koch S, Tzelepis G, Ubel C, Kotenko SV, Sideras P, Lehr HA, Tepe M, Klucher KM, Doyle SE, Neurath MF, Finotto S, Andreakos E.

EMBO Mol Med. 2011 Jun;3(6):348-61. doi: 10.1002/emmm.201100142. Epub 2011 May 3.


Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma.

Hausding M, Tepe M, Ubel C, Lehr HA, Röhrig B, Höhn Y, Pautz A, Eigenbrod T, Anke T, Kleinert H, Erkel G, Finotto S.

Int Immunol. 2011 Jan;23(1):1-15. doi: 10.1093/intimm/dxq451. Epub 2010 Dec 6.


Transgenic models in allergic responses.

Hausding M, Sauer K, Maxeiner JH, Finotto S.

Curr Drug Targets. 2008 Jun;9(6):503-10. Review.


Protective role of nuclear factor of activated T cells 2 in CD8+ long-lived memory T cells in an allergy model.

Karwot R, Maxeiner JH, Schmitt S, Scholtes P, Hausding M, Lehr HA, Glimcher LH, Finotto S.

J Allergy Clin Immunol. 2008 Apr;121(4):992-9.e6. doi: 10.1016/j.jaci.2007.12.1172. Epub 2008 Mar 10.


Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma.

Hausding M, Karwot R, Scholtes P, Lehr HA, Wegmann M, Renz H, Galle PR, Birkenbach M, Neurath MF, Blumberg RS, Finotto S.

Eur J Immunol. 2007 Jun;37(6):1663-77.


A method to enable the investigation of murine bronchial immune cells, their cytokines and mediators.

Maxeiner JH, Karwot R, Hausding M, Sauer KA, Scholtes P, Finotto S.

Nat Protoc. 2007;2(1):105-12.


Asthmatic changes in mice lacking T-bet are mediated by IL-13.

Finotto S, Hausding M, Doganci A, Maxeiner JH, Lehr HA, Luft C, Galle PR, Glimcher LH.

Int Immunol. 2005 Aug;17(8):993-1007. Epub 2005 Jul 6.


The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, Haddad el-B, Lehr HA, Schmitt E, Bopp T, Kallen KJ, Herz U, Schmitt S, Luft C, Hecht O, Hohlfeld JM, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Renz H, Neurath MF, Galle PR, Finotto S.

J Clin Invest. 2005 Feb;115(2):313-25. Erratum in: J Clin Invest. 2005 May;115(5):1388. Lehr, Hans A [added].


A stage-specific functional role of the leucine zipper transcription factor c-Maf in lung Th2 cell differentiation.

Hausding M, Ho IC, Lehr HA, Weigmann B, Lux C, Schipp M, Galle PR, Finotto S.

Eur J Immunol. 2004 Dec;34(12):3401-12.


Regulation of T cells in asthma: implications for genetic manipulation.

Luft C, Hausding M, Finotto S.

Curr Opin Allergy Clin Immunol. 2004 Feb;4(1):69-74. Review.


Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo.

Finotto S, Siebler J, Hausding M, Schipp M, Wirtz S, Klein S, Protschka M, Doganci A, Lehr HA, Trautwein C, Khosravi-Far R, Strand D, Lohse A, Galle PR, Blessing M, Neurath MF.

Gut. 2004 Mar;53(3):392-400. Erratum in: Gut. 2004 Jul;53(7):1058. Khosravi-Fahr R [corrected to Khosravi-Far].


Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi.

Yao Y, Hausding M, Erkel G, Anke T, Förstermann U, Kleinert H.

Mol Pharmacol. 2003 Feb;63(2):383-91.


Enhanced transcription of the s-adenosylhomocysteine hydrolase gene precedes Epstein-Barr virus lytic gene activation in ganglioside-stimulated lymphoma cells.

Schaade L, Kleines M, Krone B, Hausding M, Walter R, Ritter K.

Med Microbiol Immunol. 2000 Sep;189(1):13-8.


Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II.

Hausding M, Witteck A, Rodriguez-Pascual F, von Eichel-Streiber C, Förstermann U, Kleinert H.

Br J Pharmacol. 2000 Oct;131(3):553-61.


Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR.

Rodriguez-Pascual F, Hausding M, Ihrig-Biedert I, Furneaux H, Levy AP, Förstermann U, Kleinert H.

J Biol Chem. 2000 Aug 25;275(34):26040-9.

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