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The Rel stringent factor from Thermus thermophilus: crystallization and X-ray analysis.

Van Nerom K, Tamman H, Takada H, Hauryliuk V, Garcia-Pino A.

Acta Crystallogr F Struct Biol Commun. 2019 Aug 1;75(Pt 8):561-569. doi: 10.1107/S2053230X19010628. Epub 2019 Aug 2.


A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling.

Kasari V, Pochopien AA, Margus T, Murina V, Turnbull K, Zhou Y, Nissan T, Graf M, Nováček J, Atkinson GC, Johansson MJO, Wilson DN, Hauryliuk V.

Nucleic Acids Res. 2019 Jul 12. pii: gkz600. doi: 10.1093/nar/gkz600. [Epub ahead of print]


Reanalysis of Proteomics Results Fails To Detect MazF-Mediated Stress Proteins.

Kaldalu N, Maiväli Ü, Hauryliuk V, Tenson T.

MBio. 2019 Jun 11;10(3). pii: e00949-19. doi: 10.1128/mBio.00949-19. No abstract available.


Ribosome profiling analysis of eEF3-depleted Saccharomyces cerevisiae.

Kasari V, Margus T, Atkinson GC, Johansson MJO, Hauryliuk V.

Sci Rep. 2019 Feb 28;9(1):3037. doi: 10.1038/s41598-019-39403-y.


Elimination of Ribosome Inactivating Factors Improves the Efficiency of Bacillus subtilis and Saccharomyces cerevisiae Cell-Free Translation Systems.

Brodiazhenko T, Johansson MJO, Takada H, Nissan T, Hauryliuk V, Murina V.

Front Microbiol. 2018 Dec 18;9:3041. doi: 10.3389/fmicb.2018.03041. eCollection 2018.


ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life.

Murina V, Kasari M, Takada H, Hinnu M, Saha CK, Grimshaw JW, Seki T, Reith M, Putrinš M, Tenson T, Strahl H, Hauryliuk V, Atkinson GC.

J Mol Biol. 2018 Dec 28. pii: S0022-2836(18)31288-9. doi: 10.1016/j.jmb.2018.12.013. [Epub ahead of print]


Reply to Holden and Errington, "Type II Toxin-Antitoxin Systems and Persister Cells".

Goormaghtigh F, Fraikin N, Putrinš M, Hauryliuk V, Garcia-Pino A, Udekwu K, Tenson T, Kaldalu N, Van Melderen L.

MBio. 2018 Sep 25;9(5). pii: e01838-18. doi: 10.1128/mBio.01838-18. No abstract available.


Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR.

Crowe-McAuliffe C, Graf M, Huter P, Takada H, Abdelshahid M, Nováček J, Murina V, Atkinson GC, Hauryliuk V, Wilson DN.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8978-8983. doi: 10.1073/pnas.1808535115. Epub 2018 Aug 20.


Reassessing the Role of Type II Toxin-Antitoxin Systems in Formation of Escherichia coli Type II Persister Cells.

Goormaghtigh F, Fraikin N, Putrinš M, Hallaert T, Hauryliuk V, Garcia-Pino A, Sjödin A, Kasvandik S, Udekwu K, Tenson T, Kaldalu N, Van Melderen L.

MBio. 2018 Jun 12;9(3). pii: e00640-18. doi: 10.1128/mBio.00640-18.


Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest.

Murina V, Kasari M, Hauryliuk V, Atkinson GC.

Nucleic Acids Res. 2018 Apr 20;46(7):3753-3763. doi: 10.1093/nar/gky050.


The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA.

Kudrin P, Dzhygyr I, Ishiguro K, Beljantseva J, Maksimova E, Oliveira SRA, Varik V, Payoe R, Konevega AL, Tenson T, Suzuki T, Hauryliuk V.

Nucleic Acids Res. 2018 Feb 28;46(4):1973-1983. doi: 10.1093/nar/gky023.


Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP.

Manav MC, Beljantseva J, Bojer MS, Tenson T, Ingmer H, Hauryliuk V, Brodersen DE.

J Biol Chem. 2018 Mar 2;293(9):3254-3264. doi: 10.1074/jbc.RA117.001374. Epub 2018 Jan 11.


HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGpp.

Varik V, Oliveira SRA, Hauryliuk V, Tenson T.

Sci Rep. 2017 Sep 8;7(1):11022. doi: 10.1038/s41598-017-10988-6.


Small Alarmone Synthetases as novel bacterial RNA-binding proteins.

Hauryliuk V, Atkinson GC.

RNA Biol. 2017 Dec 2;14(12):1695-1699. doi: 10.1080/15476286.2017.1367889. Epub 2017 Oct 3. Review.


Negative allosteric regulation of Enterococcus faecalis small alarmone synthetase RelQ by single-stranded RNA.

Beljantseva J, Kudrin P, Andresen L, Shingler V, Atkinson GC, Tenson T, Hauryliuk V.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3726-3731. doi: 10.1073/pnas.1617868114. Epub 2017 Mar 20.


Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor.

Beljantseva J, Kudrin P, Jimmy S, Ehn M, Pohl R, Varik V, Tozawa Y, Shingler V, Tenson T, Rejman D, Hauryliuk V.

Sci Rep. 2017 Feb 3;7:41839. doi: 10.1038/srep41839.


Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to β-Lactams.

Kudrin P, Varik V, Oliveira SR, Beljantseva J, Del Peso Santos T, Dzhygyr I, Rejman D, Cava F, Tenson T, Hauryliuk V.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02173-16. doi: 10.1128/AAC.02173-16. Print 2017 Apr.


Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products.

Allas UL, Toom L, Selyutina A, Mäeorg U, Medina R, Merits A, Rinken A, Hauryliuk V, Kaldalu N, Tenson T.

Sci Rep. 2016 Nov 10;6:36844. doi: 10.1038/srep36844.


Cationic bactericidal peptide 1018 does not specifically target the stringent response alarmone (p)ppGpp.

Andresen L, Tenson T, Hauryliuk V.

Sci Rep. 2016 Nov 7;6:36549. doi: 10.1038/srep36549.


Auxotrophy-based High Throughput Screening assay for the identification of Bacillus subtilis stringent response inhibitors.

Andresen L, Varik V, Tozawa Y, Jimmy S, Lindberg S, Tenson T, Hauryliuk V.

Sci Rep. 2016 Oct 24;6:35824. doi: 10.1038/srep35824.


Evaluation of the characteristics of leucyl-tRNA synthetase (LeuRS) inhibitor AN3365 in combination with different antibiotic classes.

Monteferrante CG, Jirgensons A, Varik V, Hauryliuk V, Goessens WH, Hays JP.

Eur J Clin Microbiol Infect Dis. 2016 Nov;35(11):1857-1864. Epub 2016 Aug 9.


Persisters-as elusive as ever.

Kaldalu N, Hauryliuk V, Tenson T.

Appl Microbiol Biotechnol. 2016 Aug;100(15):6545-6553. doi: 10.1007/s00253-016-7648-8. Epub 2016 Jun 4. Review.


The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.

Arenz S, Abdelshahid M, Sohmen D, Payoe R, Starosta AL, Berninghausen O, Hauryliuk V, Beckmann R, Wilson DN.

Nucleic Acids Res. 2016 Jul 27;44(13):6471-81. doi: 10.1093/nar/gkw470. Epub 2016 May 25.


Composition of the outgrowth medium modulates wake-up kinetics and ampicillin sensitivity of stringent and relaxed Escherichia coli.

Varik V, Oliveira SR, Hauryliuk V, Tenson T.

Sci Rep. 2016 Feb 29;6:22308. doi: 10.1038/srep22308.


Aim-less translation: loss of Saccharomyces cerevisiae mitochondrial translation initiation factor mIF3/Aim23 leads to unbalanced protein synthesis.

Kuzmenko A, Derbikova K, Salvatori R, Tankov S, Atkinson GC, Tenson T, Ott M, Kamenski P, Hauryliuk V.

Sci Rep. 2016 Jan 5;6:18749. doi: 10.1038/srep18749.


From (p)ppGpp to (pp)pGpp: Characterization of Regulatory Effects of pGpp Synthesized by the Small Alarmone Synthetase of Enterococcus faecalis.

Gaca AO, Kudrin P, Colomer-Winter C, Beljantseva J, Liu K, Anderson B, Wang JD, Rejman D, Potrykus K, Cashel M, Hauryliuk V, Lemos JA.

J Bacteriol. 2015 Sep;197(18):2908-19. doi: 10.1128/JB.00324-15. Epub 2015 Jun 29.


Recent functional insights into the role of (p)ppGpp in bacterial physiology.

Hauryliuk V, Atkinson GC, Murakami KS, Tenson T, Gerdes K.

Nat Rev Microbiol. 2015 May;13(5):298-309. doi: 10.1038/nrmicro3448. Epub 2015 Apr 8. Review.


Fusidic acid targets elongation factor G in several stages of translocation on the bacterial ribosome.

Borg A, Holm M, Shiroyama I, Hauryliuk V, Pavlov M, Sanyal S, Ehrenberg M.

J Biol Chem. 2015 Feb 6;290(6):3440-54. doi: 10.1074/jbc.M114.611608. Epub 2014 Dec 1.


An evolutionary ratchet leading to loss of elongation factors in eukaryotes.

Atkinson GC, Kuzmenko A, Chicherin I, Soosaar A, Tenson T, Carr M, Kamenski P, Hauryliuk V.

BMC Evol Biol. 2014 Feb 24;14(1):35. doi: 10.1186/1471-2148-14-35.


Protein biosynthesis in mitochondria.

Kuzmenko AV, Levitskii SA, Vinogradova EN, Atkinson GC, Hauryliuk V, Zenkin N, Kamenski PA.

Biochemistry (Mosc). 2013 Aug;78(8):855-66. doi: 10.1134/S0006297913080014. Review.


Mitochondrial translation initiation machinery: conservation and diversification.

Kuzmenko A, Atkinson GC, Levitskii S, Zenkin N, Tenson T, Hauryliuk V, Kamenski P.

Biochimie. 2014 May;100:132-40. doi: 10.1016/j.biochi.2013.07.024. Epub 2013 Aug 14. Review.


Mechanism of tetracycline resistance by ribosomal protection protein Tet(O).

Li W, Atkinson GC, Thakor NS, Allas U, Lu CC, Chan KY, Tenson T, Schulten K, Wilson KS, Hauryliuk V, Frank J.

Nat Commun. 2013;4:1477. doi: 10.1038/ncomms2470.


GTPases IF2 and EF-G bind GDP and the SRL RNA in a mutually exclusive manner.

Mitkevich VA, Shyp V, Petrushanko IY, Soosaar A, Atkinson GC, Tenson T, Makarov AA, Hauryliuk V.

Sci Rep. 2012;2:843. doi: 10.1038/srep00843. Epub 2012 Nov 13.


Positive allosteric feedback regulation of the stringent response enzyme RelA by its product.

Shyp V, Tankov S, Ermakov A, Kudrin P, English BP, Ehrenberg M, Tenson T, Elf J, Hauryliuk V.

EMBO Rep. 2012 Sep;13(9):835-9. doi: 10.1038/embor.2012.106. Epub 2012 Jul 20.


Evolutionary and genetic analyses of mitochondrial translation initiation factors identify the missing mitochondrial IF3 in S. cerevisiae.

Atkinson GC, Kuzmenko A, Kamenski P, Vysokikh MY, Lakunina V, Tankov S, Smirnova E, Soosaar A, Tenson T, Hauryliuk V.

Nucleic Acids Res. 2012 Jul;40(13):6122-34. doi: 10.1093/nar/gks272. Epub 2012 Mar 28.


Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40.

Kuzmenko A, Tankov S, English BP, Tarassov I, Tenson T, Kamenski P, Elf J, Hauryliuk V.

Sci Rep. 2011;1:195. doi: 10.1038/srep00195. Epub 2011 Dec 14.


The RelA/SpoT homolog (RSH) superfamily: distribution and functional evolution of ppGpp synthetases and hydrolases across the tree of life.

Atkinson GC, Tenson T, Hauryliuk V.

PLoS One. 2011;6(8):e23479. doi: 10.1371/journal.pone.0023479. Epub 2011 Aug 9.


Single-molecule investigations of the stringent response machinery in living bacterial cells.

English BP, Hauryliuk V, Sanamrad A, Tankov S, Dekker NH, Elf J.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):E365-73. doi: 10.1073/pnas.1102255108. Epub 2011 Jul 5.


An ancient family of SelB elongation factor-like proteins with a broad but disjunct distribution across archaea.

Atkinson GC, Hauryliuk V, Tenson T.

BMC Evol Biol. 2011 Jan 21;11:22. doi: 10.1186/1471-2148-11-22.


Structure of the Dom34-Hbs1 complex and implications for no-go decay.

Chen L, Muhlrad D, Hauryliuk V, Cheng Z, Lim MK, Shyp V, Parker R, Song H.

Nat Struct Mol Biol. 2010 Oct;17(10):1233-40. doi: 10.1038/nsmb.1922. Epub 2010 Oct 3.


Thermodynamic characterization of ppGpp binding to EF-G or IF2 and of initiator tRNA binding to free IF2 in the presence of GDP, GTP, or ppGpp.

Mitkevich VA, Ermakov A, Kulikova AA, Tankov S, Shyp V, Soosaar A, Tenson T, Makarov AA, Ehrenberg M, Hauryliuk V.

J Mol Biol. 2010 Oct 8;402(5):838-46. doi: 10.1016/j.jmb.2010.08.016. Epub 2010 Aug 14.


GTP-dependent structural rearrangement of the eRF1:eRF3 complex and eRF3 sequence motifs essential for PABP binding.

Kononenko AV, Mitkevich VA, Atkinson GC, Tenson T, Dubovaya VI, Frolova LY, Makarov AA, Hauryliuk V.

Nucleic Acids Res. 2010 Jan;38(2):548-58. doi: 10.1093/nar/gkp908. Epub 2009 Nov 11.


Thermodynamics of GTP and GDP binding to bacterial initiation factor 2 suggests two types of structural transitions.

Hauryliuk V, Mitkevich VA, Draycheva A, Tankov S, Shyp V, Ermakov A, Kulikova AA, Makarov AA, Ehrenberg M.

J Mol Biol. 2009 Dec 11;394(4):621-6. doi: 10.1016/j.jmb.2009.10.015. Epub 2009 Oct 22.


Does the ribosome have initiation and elongation modes of translation?

Tenson T, Hauryliuk V.

Mol Microbiol. 2009 Jun;72(6):1310-5. doi: 10.1111/j.1365-2958.2009.06741.x. Epub 2009 May 25. Review.


Evolution of nonstop, no-go and nonsense-mediated mRNA decay and their termination factor-derived components.

Atkinson GC, Baldauf SL, Hauryliuk V.

BMC Evol Biol. 2008 Oct 23;8:290. doi: 10.1186/1471-2148-8-290.


The pretranslocation ribosome is targeted by GTP-bound EF-G in partially activated form.

Hauryliuk V, Mitkevich VA, Eliseeva NA, Petrushanko IY, Ehrenberg M, Makarov AA.

Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15678-83. doi: 10.1073/pnas.0807912105. Epub 2008 Oct 3.


Cofactor dependent conformational switching of GTPases.

Hauryliuk V, Hansson S, Ehrenberg M.

Biophys J. 2008 Aug;95(4):1704-15. doi: 10.1529/biophysj.107.127290. Epub 2008 May 23.


The bacterial toxin RelE induces specific mRNA cleavage in the A site of the eukaryote ribosome.

Andreev D, Hauryliuk V, Terenin I, Dmitriev S, Ehrenberg M, Shatsky I.

RNA. 2008 Feb;14(2):233-9. Epub 2007 Dec 14.


Evolution of translational machinery: could translation termination come into being before elongation?

Hauryliuk V.

J Theor Biol. 2007 Oct 7;248(3):574-8. Epub 2007 Jun 9. No abstract available.


[GTPases of prokaryotic translational apparatus].

Hauryliuk VV.

Mol Biol (Mosk). 2006 Sep-Oct;40(5):769-83. Review. Russian.


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