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Chronic Exposure to Low Dose Carbon Monoxide Alters Hemoglobin Mass and VO2max.

Schmidt WFJ, Hoffmeister T, Haupt S, Schwenke D, Wachsmuth NB, Byrnes WC.

Med Sci Sports Exerc. 2020 Feb 29. doi: 10.1249/MSS.0000000000002330. [Epub ahead of print]


Corrigendum to 'The long and the short of it: the MDM4 tail so far'.

Haupt S, Mejía-Hernández JO, Vijayakumaran R, Keam SP, Haupt Y.

J Mol Cell Biol. 2019 Dec 19;11(12):1104. doi: 10.1093/jmcb/mjz109. No abstract available.


Cannibalism in Breast Cancer: The Dangers of Overeating.

Haupt S, Keam SP, Haupt Y.

Trends Cancer. 2019 Dec;5(12):761-762. doi: 10.1016/j.trecan.2019.10.008. Epub 2019 Nov 6.


Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network.

Haupt S, Caramia F, Herschtal A, Soussi T, Lozano G, Chen H, Liang H, Speed TP, Haupt Y.

Nat Commun. 2019 Nov 26;10(1):5385. doi: 10.1038/s41467-019-13266-3.


E6AP Promotes a Metastatic Phenotype in Prostate Cancer.

Gamell C, Bandilovska I, Gulati T, Kogan A, Lim SC, Kovacevic Z, Takano EA, Timpone C, Agupitan AD, Litchfield C, Blandino G, Horvath LG, Fox SB, Williams SG, Russo A, Gallo E, Paul PJ, Mitchell C, Sandhu S, Keam SP, Haupt S, Richardson DR, Haupt Y.

iScience. 2019 Dec 20;22:1-15. doi: 10.1016/j.isci.2019.10.065. Epub 2019 Nov 2.


At Least Two Genes Encode Many Variants of Irak3 in Rainbow Trout, but Neither the Full-Length Factor Nor Its Variants Interfere Directly With the TLR-Mediated Stimulation of Inflammation.

Rebl A, Rebl H, Verleih M, Haupt S, Köbis JM, Goldammer T, Seyfert HM.

Front Immunol. 2019 Sep 20;10:2246. doi: 10.3389/fimmu.2019.02246. eCollection 2019.


Bimodal modulation of background activity in an identified descending interneuron.

Lepreux G, Haupt SS, Dürr V.

J Neurophysiol. 2019 Dec 1;122(6):2316-2330. doi: 10.1152/jn.00864.2018. Epub 2019 Sep 25.


Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.

AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, Brajanovski N, Smith LK, Rao AD, Lelliott EJ, Kleinschmidt M, Vergara IA, Papenfuss AT, Lau P, Ghosh P, Haupt S, Haupt Y, Sanij E, Poortinga G, Pearson RB, Falk H, Curtis DJ, Stupple P, Devlin M, Street I, Davies MA, McArthur GA, Sheppard KE.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17990-18000. doi: 10.1073/pnas.1901323116. Epub 2019 Aug 22.


Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma.

Cao L, Basudan A, Sikora MJ, Bahreini A, Tasdemir N, Levine KM, Jankowitz RC, McAuliffe PF, Dabbs D, Haupt S, Haupt Y, Lucas PC, Lee AV, Oesterreich S, Atkinson JM.

Cancer Lett. 2019 Oct 1;461:21-30. doi: 10.1016/j.canlet.2019.06.011. Epub 2019 Jun 20.


Retraction: The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.

Mansour M, Haupt S, Chan AL, Godde N, Rizzitelli A, Loi S, Caramia F, Deb S, Takano EA, Bishton M, Johnstone C, Monahan B, Levav-Cohen Y, Jiang YH, Yap AS, Fox S, Bernard O, Anderson R, Haupt Y.

Cancer Res. 2019 Jun 1;79(11):3008. doi: 10.1158/0008-5472.CAN-19-1133. No abstract available.


E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers.

Bandilovska I, Keam SP, Gamell C, Machicado C, Haupt S, Haupt Y.

Carcinogenesis. 2019 Jul 6;40(6):707-714. doi: 10.1093/carcin/bgz072.


Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.

Delbridge ARD, Kueh AJ, Ke F, Zamudio NM, El-Saafin F, Jansz N, Wang GY, Iminitoff M, Beck T, Haupt S, Hu Y, May RE, Whitehead L, Tai L, Chiang W, Herold MJ, Haupt Y, Smyth GK, Thomas T, Blewitt ME, Strasser A, Voss AK.

Cell Rep. 2019 Apr 9;27(2):442-454.e5. doi: 10.1016/j.celrep.2019.03.048.


A quantitative model to predict pathogenicity of missense variants in the TP53 gene.

Fortuno C, Cipponi A, Ballinger ML, Tavtigian SV, Olivier M, Ruparel V, Haupt Y, Haupt S, Study ISK, Tucker K, Spurdle AB, Thomas DM, James PA.

Hum Mutat. 2019 Jun;40(6):788-800. doi: 10.1002/humu.23739. Epub 2019 Mar 18.


The long and the short of it: the MDM4 tail so far.

Haupt S, Mejía-Hernández JO, Vijayakumaran R, Keam SP, Haupt Y.

J Mol Cell Biol. 2019 Mar 1;11(3):231-244. doi: 10.1093/jmcb/mjz007. Erratum in: J Mol Cell Biol. 2019 Dec 19;11(12):1104.


Induced pluripotent stem cell-based modeling of mutant LRRK2-associated Parkinson's disease.

Weykopf B, Haupt S, Jungverdorben J, Flitsch LJ, Hebisch M, Liu GH, Suzuki K, Belmonte JCI, Peitz M, Blaess S, Till A, Brüstle O.

Eur J Neurosci. 2019 Feb;49(4):561-589. doi: 10.1111/ejn.14345. Review.


Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2.

Bray C, Wright D, Haupt S, Thomas S, Stauss H, Zamoyska R.

Front Immunol. 2018 Nov 12;9:2595. doi: 10.3389/fimmu.2018.02595. eCollection 2018.


Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells.

Gulati T, Huang C, Caramia F, Raghu D, Paul PJ, Goode RJA, Keam SP, Williams SG, Haupt S, Kleifeld O, Schittenhelm RB, Gamell C, Haupt Y.

Mol Cell Proteomics. 2018 Jun;17(6):1170-1183. doi: 10.1074/mcp.RA117.000504. Epub 2018 Feb 20.


Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice.

Jackson JT, Ng AP, Shields BJ, Haupt S, Haupt Y, McCormack MP.

Blood Adv. 2018 Feb 27;2(4):347-360. doi: 10.1182/bloodadvances.2017013243.


New insights on the regulation of INK4/ARF locus expression.

Gamell C, Ginsberg D, Haupt S, Haupt Y.

Oncotarget. 2017 Nov 1;8(63):106147-106148. doi: 10.18632/oncotarget.22258. eCollection 2017 Dec 5. No abstract available.


P53 at the start of the 21st century: lessons from elephants.

Haupt S, Haupt Y.

F1000Res. 2017 Nov 22;6:2041. doi: 10.12688/f1000research.12682.1. eCollection 2017. Review.


Uncovering a novel pathway for p16 silencing: Therapeutic implications for lung cancer.

Gamell C, Gulati T, Solomon B, Haupt S, Haupt Y.

Mol Cell Oncol. 2017 Mar 7;4(5):e1299273. doi: 10.1080/23723556.2017.1299273. eCollection 2017.


Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.

Masaldan S, Clatworthy SAS, Gamell C, Meggyesy PM, Rigopoulos AT, Haupt S, Haupt Y, Denoyer D, Adlard PA, Bush AI, Cater MA.

Redox Biol. 2018 Apr;14:100-115. doi: 10.1016/j.redox.2017.08.015. Epub 2017 Sep 1.


E6AP promotes prostate cancer by reducing p27 expression.

Raghu D, Paul PJ, Gulati T, Deb S, Khoo C, Russo A, Gallo E, Blandino G, Chan AL, Takano E, Sandhu SK, Fox SB, Williams S, Haupt S, Gamell C, Haupt Y.

Oncotarget. 2017 Jun 27;8(26):42939-42948. doi: 10.18632/oncotarget.17224.


Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation.

Liu DS, Duong CP, Haupt S, Montgomery KG, House CM, Azar WJ, Pearson HB, Fisher OM, Read M, Guerra GR, Haupt Y, Cullinane C, Wiman KG, Abrahmsen L, Phillips WA, Clemons NJ.

Nat Commun. 2017 Mar 28;8:14844. doi: 10.1038/ncomms14844.


MDM4 is a rational target for treating breast cancers with mutant p53.

Miranda PJ, Buckley D, Raghu D, Pang JB, Takano EA, Vijayakumaran R, Teunisse AF, Posner A, Procter T, Herold MJ, Gamell C, Marine JC, Fox SB, Jochemsen A, Haupt S, Haupt Y.

J Pathol. 2017 Apr;241(5):661-670. doi: 10.1002/path.4877. Epub 2017 Mar 1.


The role of MDM2 and MDM4 in breast cancer development and prevention.

Haupt S, Vijayakumaran R, Miranda PJ, Burgess A, Lim E, Haupt Y.

J Mol Cell Biol. 2017 Feb 1;9(1):53-61. doi: 10.1093/jmcb/mjx007. Review.


Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.

Gamell C, Gulati T, Levav-Cohen Y, Young RJ, Do H, Pilling P, Takano E, Watkins N, Fox SB, Russell P, Ginsberg D, Monahan BJ, Wright G, Dobrovic A, Haupt S, Solomon B, Haupt Y.

Sci Signal. 2017 Jan 10;10(461). pii: eaaf8223. doi: 10.1126/scisignal.aaf8223.


TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D.

EMBO J. 2016 Nov 2;35(21):2350-2370. Epub 2016 Sep 12.


FRET energy transfer via Pdots improves the efficiency of photodynamic therapy and leads to rapid cell death.

Haupt S, Lazar I, Weitman H, Shav-Tal Y, Ehrenberg B.

J Photochem Photobiol B. 2016 Nov;164:123-131. doi: 10.1016/j.jphotobiol.2016.09.019. Epub 2016 Sep 14.


Ensuring the Quality of Stem Cell-Derived In Vitro Models for Toxicity Testing.

Stacey GN, Coecke S, Price AB, Healy L, Jennings P, Wilmes A, Pinset C, Ingelman-Sundberg M, Louisse J, Haupt S, Kidd D, Robitski A, Jahnke HG, Lemaitre G, Myatt G.

Adv Exp Med Biol. 2016;856:259-297. Review.


Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP.

Paul PJ, Raghu D, Chan AL, Gulati T, Lambeth L, Takano E, Herold MJ, Hagekyriakou J, Vessella RL, Fedele C, Shackleton M, Williams ED, Fox S, Williams S, Haupt S, Gamell C, Haupt Y.

Oncogene. 2016 Dec 1;35(48):6235-6245. doi: 10.1038/onc.2016.159. Epub 2016 Sep 19.


Impedimetric real-time monitoring of neural pluripotent stem cell differentiation process on microelectrode arrays.

Seidel D, Obendorf J, Englich B, Jahnke HG, Semkova V, Haupt S, Girard M, Peschanski M, Brüstle O, Robitzki AA.

Biosens Bioelectron. 2016 Dec 15;86:277-286. doi: 10.1016/j.bios.2016.06.056. Epub 2016 Jun 20.


The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.

Mansour M, Haupt S, Chan AL, Godde N, Rizzitelli A, Loi S, Caramia F, Deb S, Takano EA, Bishton M, Johnstone C, Monahan B, Levav-Cohen Y, Jiang YH, Yap AS, Fox S, Bernard O, Anderson R, Haupt Y.

Cancer Res. 2016 Jul 15;76(14):4236-48. doi: 10.1158/0008-5472.CAN-15-1553. Epub 2016 May 26. Retraction in: Cancer Res. 2019 Jun 1;79(11):3008.


Proximal tibiofibular joint dislocation associated with tibial shaft fractures - 7 Cases.

Haupt S, Frima H, Sommer C.

Injury. 2016 Apr;47(4):950-3. doi: 10.1016/j.injury.2016.01.037. Epub 2016 Feb 11.


Mutant p53 Drives Cancer by Subverting Multiple Tumor Suppression Pathways.

Haupt S, Raghu D, Haupt Y.

Front Oncol. 2016 Jan 27;6:12. doi: 10.3389/fonc.2016.00012. eCollection 2016. Review.


Clinical Overview of MDM2/X-Targeted Therapies.

Burgess A, Chia KM, Haupt S, Thomas D, Haupt Y, Lim E.

Front Oncol. 2016 Jan 27;6:7. doi: 10.3389/fonc.2016.00007. eCollection 2016. Review.


Regulation of Mutant p53 Protein Expression.

Vijayakumaran R, Tan KH, Miranda PJ, Haupt S, Haupt Y.

Front Oncol. 2015 Dec 17;5:284. doi: 10.3389/fonc.2015.00284. eCollection 2015. Review.


Methylation of an intragenic alternative promoter regulates transcription of GARP.

Haupt S, Söntgerath VS, Leipe J, Schulze-Koops H, Skapenko A.

Biochim Biophys Acta. 2016 Feb;1859(2):223-34. doi: 10.1016/j.bbagrm.2015.11.003. Epub 2015 Nov 14.


Walking patterns induced by learned odors in the honeybee, Apis mellifera L.

Yamashita T, Haupt SS, Ikeno H, Ai H.

J Exp Biol. 2016 Jan;219(Pt 1):12-6. doi: 10.1242/jeb.123356. Epub 2015 Nov 13.


APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma.

Liu DS, Read M, Cullinane C, Azar WJ, Fennell CM, Montgomery KG, Haupt S, Haupt Y, Wiman KG, Duong CP, Clemons NJ, Phillips WA.

Gut. 2015 Oct;64(10):1506-16. doi: 10.1136/gutjnl-2015-309770. Epub 2015 Jul 17.


Targeting Mdmx to treat breast cancers with wild-type p53.

Haupt S, Buckley D, Pang JM, Panimaya J, Paul PJ, Gamell C, Takano EA, Lee YY, Hiddingh S, Rogers TM, Teunisse AF, Herold MJ, Marine JC, Fox SB, Jochemsen A, Haupt Y.

Cell Death Dis. 2015 Jul 16;6:e1821. doi: 10.1038/cddis.2015.173.


Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells.

Fernandes TG, Duarte ST, Ghazvini M, Gaspar C, Santos DC, Porteira AR, Rodrigues GM, Haupt S, Rombo DM, Armstrong J, Sebastião AM, Gribnau J, Garcia-Cazorla À, Brüstle O, Henrique D, Cabral JM, Diogo MM.

Biotechnol J. 2015 Oct;10(10):1578-88. doi: 10.1002/biot.201400751. Epub 2015 Jun 30.


A reproducible and versatile system for the dynamic expansion of human pluripotent stem cells in suspension.

Elanzew A, Sommer A, Pusch-Klein A, Brüstle O, Haupt S.

Biotechnol J. 2015 Oct;10(10):1589-99. doi: 10.1002/biot.201400757. Epub 2015 Aug 11.


Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities.

Kollareddy M, Dimitrova E, Vallabhaneni KC, Chan A, Le T, Chauhan KM, Carrero ZI, Ramakrishnan G, Watabe K, Haupt Y, Haupt S, Pochampally R, Boss GR, Romero DG, Radu CG, Martinez LA.

Nat Commun. 2015 Jun 12;6:7389. doi: 10.1038/ncomms8389.


Spatial and temporal control of cell aggregation efficiently directs human pluripotent stem cells towards neural commitment.

Miranda CC, Fernandes TG, Pascoal JF, Haupt S, Brüstle O, Cabral JM, Diogo MM.

Biotechnol J. 2015 Oct;10(10):1612-24. doi: 10.1002/biot.201400846. Epub 2015 Apr 28.


Pdots, a new type of nanoparticle, bind to mTHPC via their lipid modified surface and exhibit very high FRET efficiency between the core and the sensitizer.

Haupt S, Lazar I, Weitman H, Senge MO, Ehrenberg B.

Phys Chem Chem Phys. 2015 May 7;17(17):11412-22. doi: 10.1039/c4cp05579a.


p53 Calls upon CIA (Calcium Induced Apoptosis) to Counter Stress.

Haupt S, Raghu D, Haupt Y.

Front Oncol. 2015 Mar 10;5:57. doi: 10.3389/fonc.2015.00057. eCollection 2015. No abstract available.


A direct descending pathway informing locomotor networks about tactile sensor movement.

Ache JM, Haupt SS, Dürr V.

J Neurosci. 2015 Mar 4;35(9):4081-91. doi: 10.1523/JNEUROSCI.3350-14.2015.


Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI).

Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi YM, Crook JM, de Sousa PA, Dvorak P, Freund C, Firpo M, Furue MK, Gokhale P, Ha HY, Han E, Haupt S, Healy L, Hei DJ, Hovatta O, Hunt C, Hwang SM, Inamdar MS, Isasi RM, Jaconi M, Jekerle V, Kamthorn P, Kibbey MC, Knezevic I, Knowles BB, Koo SK, Laabi Y, Leopoldo L, Liu P, Lomax GP, Loring JF, Ludwig TE, Montgomery K, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Oh S, Oh SK, Otonkoski T, Pera M, Peschanski M, Pranke P, Rajala KM, Rao M, Ruttachuk R, Reubinoff B, Ricco L, Rooke H, Sipp D, Stacey GN, Suemori H, Takahashi TA, Takada K, Talib S, Tannenbaum S, Yuan BZ, Zeng F, Zhou Q.

Regen Med. 2015;10(2 Suppl):1-44. doi: 10.2217/rme.14.93. No abstract available.


Odorant concentration differentiator for intermittent olfactory signals.

Fujiwara T, Kazawa T, Sakurai T, Fukushima R, Uchino K, Yamagata T, Namiki S, Haupt SS, Kanzaki R.

J Neurosci. 2014 Dec 10;34(50):16581-93. doi: 10.1523/JNEUROSCI.2319-14.2014.

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