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Items: 23

1.

Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway.

Szybowska P, Kostas M, Wesche J, Wiedlocha A, Haugsten EM.

Cells. 2019 May 29;8(6). pii: E518. doi: 10.3390/cells8060518.

2.

Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling.

Zakrzewska M, Opalinski L, Haugsten EM, Otlewski J, Wiedlocha A.

Int J Mol Sci. 2019 Apr 12;20(8). pii: E1826. doi: 10.3390/ijms20081826.

3.

Endocytosis and Transport of Growth Factor Receptors in Peripheral Axon Regeneration: Novel Lessons from Neurons Expressing Lysine-Deficient FGF Receptor Type 1 in vitro.

Hausott B, Förste A, Zach F, Mangger S, Haugsten EM, Klimaschewski L.

Anat Rec (Hoboken). 2019 Apr 5. doi: 10.1002/ar.24120. [Epub ahead of print]

PMID:
30950230
4.

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases.

Fafilek B, Balek L, Bosakova MK, Varecha M, Nita A, Gregor T, Gudernova I, Krenova J, Ghosh S, Piskacek M, Jonatova L, Cernohorsky NH, Zieba JT, Kostas M, Haugsten EM, Wesche J, Erneux C, Trantirek L, Krakow D, Krejci P.

Sci Signal. 2018 Sep 18;11(548). pii: eaap8608. doi: 10.1126/scisignal.aap8608.

PMID:
30228226
5.

Proximity Labeling by a Recombinant APEX2-FGF1 Fusion Protein Reveals Interaction of FGF1 with the Proteoglycans CD44 and CSPG4.

Zhen Y, Haugsten EM, Singh SK, Wesche J.

Biochemistry. 2018 Jul 3;57(26):3807-3816. doi: 10.1021/acs.biochem.8b00120. Epub 2018 Jun 13.

PMID:
29812912
6.

Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors.

Kostas M, Haugsten EM, Zhen Y, Sørensen V, Szybowska P, Fiorito E, Lorenz S, Jones N, de Souza GA, Wiedlocha A, Wesche J.

Mol Cell Proteomics. 2018 May;17(5):850-870. doi: 10.1074/mcp.RA117.000538. Epub 2018 Jan 25.

7.

Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport.

Haugsten EM, Sørensen V, Kunova Bosakova M, de Souza GA, Krejci P, Wiedlocha A, Wesche J.

J Proteome Res. 2016 Oct 7;15(10):3841-3855. Epub 2016 Sep 26.

PMID:
27615514
8.

PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.

Oppelt A, Haugsten EM, Zech T, Danielsen HE, Sveen A, Lobert VH, Skotheim RI, Wesche J.

Biochem J. 2014 Aug 1;461(3):383-90. doi: 10.1042/BJ20140132.

PMID:
24840251
9.

Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling.

Haugsten EM, Brech A, Liestøl K, Norman JC, Wesche J.

Traffic. 2014 Jun;15(6):665-83. doi: 10.1111/tra.12168. Epub 2014 Mar 31.

10.

Phosphatidylinositol 5-phosphate is a second messenger important for cell migration.

Haugsten EM, Oppelt A, Wesche J.

Commun Integr Biol. 2013 Sep 1;6(5):e25446. doi: 10.4161/cib.25446. Epub 2013 Jun 28.

11.

RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789.

Nadratowska-Wesolowska B, Haugsten EM, Zakrzewska M, Jakimowicz P, Zhen Y, Pajdzik D, Wesche J, Wiedlocha A.

Oncogene. 2014 Oct 2;33(40):4823-36. doi: 10.1038/onc.2013.425. Epub 2013 Oct 21.

PMID:
24141780
12.

ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling.

Zakrzewska M, Haugsten EM, Nadratowska-Wesolowska B, Oppelt A, Hausott B, Jin Y, Otlewski J, Wesche J, Wiedlocha A.

Sci Signal. 2013 Feb 12;6(262):ra11. doi: 10.1126/scisignal.2003087.

PMID:
23405013
13.

Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration.

Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J.

EMBO Rep. 2013 Jan;14(1):57-64. doi: 10.1038/embor.2012.183. Epub 2012 Nov 16.

14.

Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.

Zhen Y, Sørensen V, Skjerpen CS, Haugsten EM, Jin Y, Wälchli S, Olsnes S, Wiedlocha A.

Traffic. 2012 May;13(5):650-64. doi: 10.1111/j.1600-0854.2012.01341.x. Epub 2012 Mar 4.

15.

Leupeptin enhances cell surface localization of fibroblast growth factor receptor 1 in adult sensory neurons by increased recycling.

Hausott B, Vallant N, Hochfilzer M, Mangger S, Irschick R, Haugsten EM, Klimaschewski L.

Eur J Cell Biol. 2012 Feb;91(2):129-38. doi: 10.1016/j.ejcb.2011.09.009. Epub 2011 Dec 9.

PMID:
22169219
16.

Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling.

Haugsten EM, Zakrzewska M, Brech A, Pust S, Olsnes S, Sandvig K, Wesche J.

PLoS One. 2011;6(7):e21708. doi: 10.1371/journal.pone.0021708. Epub 2011 Jul 14.

17.

The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein.

Jin Y, Zhen Y, Haugsten EM, Wiedlocha A.

Cell Signal. 2011 Nov;23(11):1758-66. doi: 10.1016/j.cellsig.2011.06.010. Epub 2011 Jun 30.

PMID:
21745565
18.

Fibroblast growth factors and their receptors in cancer.

Wesche J, Haglund K, Haugsten EM.

Biochem J. 2011 Jul 15;437(2):199-213. doi: 10.1042/BJ20101603. Review.

PMID:
21711248
19.

Roles of fibroblast growth factor receptors in carcinogenesis.

Haugsten EM, Wiedlocha A, Olsnes S, Wesche J.

Mol Cancer Res. 2010 Nov;8(11):1439-52. doi: 10.1158/1541-7786.MCR-10-0168. Epub 2010 Oct 13. Review.

20.

Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.

Haugsten EM, Malecki J, Bjørklund SM, Olsnes S, Wesche J.

Mol Biol Cell. 2008 Aug;19(8):3390-403. doi: 10.1091/mbc.E07-12-1219. Epub 2008 May 14.

21.

Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus.

Sørensen V, Zhen Y, Zakrzewska M, Haugsten EM, Wälchli S, Nilsen T, Olsnes S, Wiedlocha A.

Mol Cell Biol. 2008 Jun;28(12):4129-41. doi: 10.1128/MCB.02117-07. Epub 2008 Apr 14.

22.

Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail.

Sørensen V, Wiedlocha A, Haugsten EM, Khnykin D, Wesche J, Olsnes S.

J Cell Sci. 2006 Oct 15;119(Pt 20):4332-41. Epub 2006 Sep 26.

23.

Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors.

Haugsten EM, Sørensen V, Brech A, Olsnes S, Wesche J.

J Cell Sci. 2005 Sep 1;118(Pt 17):3869-81. Epub 2005 Aug 9.

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