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Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?

Deme P, Rojas C, Slusher BS, Afghah Z, Geiger JD, Haughey NJ.

Exp Neurol. 2020 Jan 10:113181. doi: 10.1016/j.expneurol.2020.113181. [Epub ahead of print] Review.


Lipid accumulation and oxidation in glioblastoma multiforme.

Taïb B, Aboussalah AM, Moniruzzaman M, Chen S, Haughey NJ, Kim SF, Ahima RS.

Sci Rep. 2019 Dec 20;9(1):19593. doi: 10.1038/s41598-019-55985-z.


Proteome characterization of small extracellular vesicles from spared nerve injury model of neuropathic pain.

Jean-Toussaint R, Tian Y, Chaudhuri AD, Haughey NJ, Sacan A, Ajit SK.

J Proteomics. 2020 Jan 16;211:103540. doi: 10.1016/j.jprot.2019.103540. Epub 2019 Oct 24.


Lipidomic characterization of extracellular vesicles in human serum.

Chen S, Datta-Chaudhuri A, Deme P, Dickens A, Dastgheyb R, Bhargava P, Bi H, Haughey NJ.

J Circ Biomark. 2019 Sep 30;8:1849454419879848. doi: 10.1177/1849454419879848. eCollection 2019 Jan-Dec.


Stimulus-dependent modifications in astrocyte-derived extracellular vesicle cargo regulate neuronal excitability.

Datta Chaudhuri A, Dasgheyb RM, DeVine LR, Bi H, Cole RN, Haughey NJ.

Glia. 2020 Jan;68(1):128-144. doi: 10.1002/glia.23708. Epub 2019 Aug 30.


Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging.

Jha MK, Lee Y, Russell KA, Yang F, Dastgheyb RM, Deme P, Ament XH, Chen W, Liu Y, Guan Y, Polydefkis MJ, Hoke A, Haughey NJ, Rothstein JD, Morrison BM.

Glia. 2020 Jan;68(1):161-177. doi: 10.1002/glia.23710. Epub 2019 Aug 27.


Involvement of organelles and inter-organellar signaling in the pathogenesis of HIV-1 associated neurocognitive disorder and Alzheimer's disease.

Khan N, Haughey NJ, Nath A, Geiger JD.

Brain Res. 2019 Nov 1;1722:146389. doi: 10.1016/j.brainres.2019.146389. Epub 2019 Aug 16. Review.


Current Challenges and Solutions in Research and Clinical Care of Older Persons Living with HIV: Findings Presented at the 9th International Workshop on HIV and Aging.

Sundermann EE, Erlandson KM, Pope CN, Rubtsova A, Montoya J, Moore AA, Marzolini C, O'Brien KK, Pahwa S, Payne BAI, Rubin LH, Walmsley S, Haughey NJ, Montano M, Karris MY, Margolick JB, Moore DJ.

AIDS Res Hum Retroviruses. 2019 Nov/Dec;35(11-12):985-998. doi: 10.1089/AID.2019.0100. Epub 2019 Sep 10.


Acetylcholinesterase is not a generic marker of extracellular vesicles.

Liao Z, Jaular LM, Soueidi E, Jouve M, Muth DC, Schøyen TH, Seale T, Haughey NJ, Ostrowski M, Théry C, Witwer KW.

J Extracell Vesicles. 2019 Jul 3;8(1):1628592. doi: 10.1080/20013078.2019.1628592. eCollection 2019.


A novel and potent brain penetrant inhibitor of extracellular vesicle release.

Rojas C, Sala M, Thomas AG, Datta Chaudhuri A, Yoo SW, Li Z, Dash RP, Rais R, Haughey NJ, Nencka R, Slusher B.

Br J Pharmacol. 2019 Oct;176(19):3857-3870. doi: 10.1111/bph.14789. Epub 2019 Sep 4.


MEAnalyzer - a Spike Train Analysis Tool for Multi Electrode Arrays.

Dastgheyb RM, Yoo SW, Haughey NJ.

Neuroinformatics. 2020 Jan;18(1):163-179. doi: 10.1007/s12021-019-09431-0.


Cognitive Trajectory Phenotypes in Human Immunodeficiency Virus-Infected Patients.

Dastgheyb RM, Sacktor N, Franklin D, Letendre S, Marcotte T, Heaton R, Grant I, McArthur JC, Rubin LH, Haughey NJ.

J Acquir Immune Defic Syndr. 2019 Sep 1;82(1):61-70. doi: 10.1097/QAI.0000000000002093.


Plasma Sphingolipids Mediate a Relationship Between Type 2 Diabetes and Memory Outcomes in Patients with Coronary Artery Disease Undertaking Exercise.

Eakin KA, Saleem M, Herrmann N, Cogo-Moreira H, Mielke MM, Oh PI, Haughey NJ, Venkata SLV, Lanctôt KL, Swardfager W.

J Alzheimers Dis. 2019;69(3):717-727. doi: 10.3233/JAD-181203.


Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice.

Kim BH, Kelschenbach J, Borjabad A, Hadas E, He H, Potash MJ, Nedelcovych MT, Rais R, Haughey NJ, McArthur JC, Slusher BS, Volsky DJ.

AIDS. 2019 May 1;33(6):973-984. doi: 10.1097/QAD.0000000000002150.


Circulating low-density lipoprotein ceramide concentrations increase in Holstein dairy cows transitioning from gestation to lactation.

Davis AN, Rico JE, Myers WA, Coleman MJ, Clapham ME, Haughey NJ, McFadden JW.

J Dairy Sci. 2019 Jun;102(6):5634-5646. doi: 10.3168/jds.2018-15850. Epub 2019 Mar 21.


Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients.

Khuder SS, Chen S, Letendre S, Marcotte T, Grant I, Franklin D, Rubin LH, Margolick JB, Jacobson LP, Sacktor N, D'Souza G, Stosor V, Lake JE, Rapocciolo G, McArthur JC, Dickens AM, Haughey NJ.

Neurology. 2019 Mar 19;92(12):e1344-e1353. doi: 10.1212/WNL.0000000000007125. Epub 2019 Feb 20.


Dimethyl fumarate treatment induces lipid metabolism alterations that are linked to immunological changes.

Bhargava P, Fitzgerald KC, Venkata SLV, Smith MD, Kornberg MD, Mowry EM, Haughey NJ, Calabresi PA.

Ann Clin Transl Neurol. 2018 Oct 30;6(1):33-45. doi: 10.1002/acn3.676. eCollection 2019 Jan.


Association between sphingolipids and cardiopulmonary fitness in coronary artery disease patients undertaking cardiac rehabilitation.

Saleem M, Herrmann N, Dinoff A, Marzolini S, Mielke MM, Andreazza A, Oh PI, Vattem Venkata SL, Haughey NJ, Lanctôt KL.

J Gerontol A Biol Sci Med Sci. 2018 Dec 8. doi: 10.1093/gerona/gly273. [Epub ahead of print]


Intravenous Triacylglycerol Infusion Promotes Ceramide Accumulation and Hepatic Steatosis in Dairy Cows.

Rico JE, Giesy SL, Haughey NJ, Boisclair YR, McFadden JW.

J Nutr. 2018 Oct 1;148(10):1529-1535. doi: 10.1093/jn/nxy155.


Ceramide Accumulation Is Associated with Declining Verbal Memory in Coronary Artery Disease Patients: An Observational Study.

Chan P, Saleem M, Herrmann N, Mielke MM, Haughey NJ, Oh PI, Kiss A, Lanctôt KL.

J Alzheimers Dis. 2018;64(4):1235-1246. doi: 10.3233/JAD-180030.


TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons.

Chaudhuri AD, Dastgheyb RM, Yoo SW, Trout A, Talbot CC Jr, Hao H, Witwer KW, Haughey NJ.

Cell Death Dis. 2018 Mar 5;9(3):363. doi: 10.1038/s41419-018-0369-4.


Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse.

Nedelcovych MT, Gadiano AJ, Wu Y, Manning AA, Thomas AG, Khuder SS, Yoo SW, Xu J, McArthur JC, Haughey NJ, Volsky DJ, Rais R, Slusher BS.

ACS Chem Neurosci. 2018 Apr 18;9(4):809-816. doi: 10.1021/acschemneuro.7b00434. Epub 2018 Jan 4.


Plasma sphingolipids and depressive symptoms in coronary artery disease.

Dinoff A, Saleem M, Herrmann N, Mielke MM, Oh PI, Venkata SLV, Haughey NJ, Lanctôt KL.

Brain Behav. 2017 Sep 26;7(11):e00836. doi: 10.1002/brb3.836. eCollection 2017 Nov.


Short communication: Circulating fatty acylcarnitines are elevated in overweight periparturient dairy cows in association with sphingolipid biomarkers of insulin resistance.

Rico JE, Zang Y, Haughey NJ, Rius AG, McFadden JW.

J Dairy Sci. 2018 Jan;101(1):812-819. doi: 10.3168/jds.2017-13171. Epub 2017 Nov 2.


Internal grant review to increase grant funding for junior investigators.

Thomas HS, Brodsky MB, Ewen JB, Bergey GK, Lloyd TE, Haughey NJ, Marvel CL.

Ann Neurol. 2017 Oct;82(4):497-502. doi: 10.1002/ana.25040. Epub 2017 Oct 4. No abstract available.


Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging.

Dickens AM, Yoo SW, Chin AC, Xu J, Johnson TP, Trout AL, Hauser KF, Haughey NJ.

Sci Rep. 2017 Aug 10;7(1):7748. doi: 10.1038/s41598-017-07570-5.


Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study.

Mathews AT, Famodu OA, Olfert MD, Murray PJ, Cuff CF, Downes MT, Haughey NJ, Colby SE, Chantler PD, Olfert IM, McFadden JW.

Physiol Rep. 2017 Jul;5(13). pii: e13329. doi: 10.14814/phy2.13329.


A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise.

Saleem M, Herrmann N, Dinoff A, Mielke MM, Oh PI, Shammi P, Cao X, Venkata SLV, Haughey NJ, Lanctôt KL.

J Alzheimers Dis. 2017;60(3):829-841. doi: 10.3233/JAD-161292.


Modifications in acute phase and complement systems predict shifts in cognitive status of HIV-infected patients.

Ubaida-Mohien C, Lamberty B, Dickens AM, Mielke MM, Marcotte T, Sacktor N, Grant I, Letendre S, Franklin D, Cibrowski P, Tharakan R, McArthur JC, Fox H, Haughey NJ.

AIDS. 2017 Jun 19;31(10):1365-1378. doi: 10.1097/QAD.0000000000001503.


The Psychiatric Impact of HIV.

Nedelcovych MT, Manning AA, Semenova S, Gamaldo C, Haughey NJ, Slusher BS.

ACS Chem Neurosci. 2017 Jul 19;8(7):1432-1434. doi: 10.1021/acschemneuro.7b00169. Epub 2017 May 24.


Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation.

Rico JE, Saed Samii S, Mathews AT, Lovett J, Haughey NJ, McFadden JW.

PLoS One. 2017 May 9;12(5):e0176787. doi: 10.1371/journal.pone.0176787. eCollection 2017.


Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions.

Dickens AM, Tovar-Y-Romo LB, Yoo SW, Trout AL, Bae M, Kanmogne M, Megra B, Williams DW, Witwer KW, Gacias M, Tabatadze N, Cole RN, Casaccia P, Berman JW, Anthony DC, Haughey NJ.

Sci Signal. 2017 Apr 4;10(473). pii: eaai7696. doi: 10.1126/scisignal.aai7696.


Hippocampal encoding of interoceptive context during fear conditioning.

Yoo SW, Bae M, Tovar-Y-Romo LB, Haughey NJ.

Transl Psychiatry. 2017 Jan 3;7(1):e991. doi: 10.1038/tp.2016.254.


The Association Between Plasma Ceramides and Sphingomyelins and Risk of Alzheimer's Disease Differs by Sex and APOE in the Baltimore Longitudinal Study of Aging.

Mielke MM, Haughey NJ, Han D, An Y, Bandaru VVR, Lyketsos CG, Ferrucci L, Resnick SM.

J Alzheimers Dis. 2017;60(3):819-828. doi: 10.3233/JAD-160925.


HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.

Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, Gill AJ, Kolson DL, Diehl JA, Mankowski JL, Jordan-Sciutto KL.

Am J Pathol. 2017 Jan;187(1):91-109. doi: 10.1016/j.ajpath.2016.09.006.


Palmitic acid feeding increases ceramide supply in association with increased milk yield, circulating nonesterified fatty acids, and adipose tissue responsiveness to a glucose challenge.

Rico JE, Mathews AT, Lovett J, Haughey NJ, McFadden JW.

J Dairy Sci. 2016 Nov;99(11):8817-8830. doi: 10.3168/jds.2016-11296. Epub 2016 Sep 13.


Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users.

Piepenbrink MS, Samuel M, Zheng B, Carter B, Fucile C, Bunce C, Kiebala M, Khan AA, Thakar J, Maggirwar SB, Morse D, Rosenberg AF, Haughey NJ, Valenti W, Keefer MC, Kobie JJ.

PLoS One. 2016 Jul 5;11(7):e0158641. doi: 10.1371/journal.pone.0158641. eCollection 2016.


Peripheral sphingolipids are associated with variation in white matter microstructure in older adults.

Gonzalez CE, Venkatraman VK, An Y, Landman BA, Davatzikos C, Ratnam Bandaru VV, Haughey NJ, Ferrucci L, Mielke MM, Resnick SM.

Neurobiol Aging. 2016 Jul;43:156-63. doi: 10.1016/j.neurobiolaging.2016.04.008. Epub 2016 Apr 21.


Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96 years from the Baltimore Longitudinal Study of Aging.

Fabbri E, Yang A, Simonsick EM, Chia CW, Zoli M, Haughey NJ, Mielke MM, Ferrucci L, Coen PM.

Aging Cell. 2016 Oct;15(5):825-31. doi: 10.1111/acel.12491. Epub 2016 May 2.


Erratum to: Interaction of Paroxetine with Mitochondrial Proteins Mediates Neuroprotection.

Steiner JP, Bachani M, Wolfson-Stofko B, Lee MH, Wang T, Li G, Li W, Strayer D, Haughey NJ, Nath A.

Neurotherapeutics. 2016 Jan;13(1):237. doi: 10.1007/s13311-015-0406-2. No abstract available.


Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactation.

Rico JE, Bandaru VV, Dorskind JM, Haughey NJ, McFadden JW.

J Dairy Sci. 2015 Nov;98(11):7757-70. doi: 10.3168/jds.2015-9519. Epub 2015 Sep 3.


Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species.

Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ.

Aging Cell. 2015 Dec;14(6):1014-23. doi: 10.1111/acel.12369. Epub 2015 Jul 20.


Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties.

Figuera-Losada M, Stathis M, Dorskind JM, Thomas AG, Bandaru VV, Yoo SW, Westwood NJ, Rogers GW, McArthur JC, Haughey NJ, Slusher BS, Rojas C.

PLoS One. 2015 May 26;10(5):e0124481. doi: 10.1371/journal.pone.0124481. eCollection 2015.


Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients.

Dickens AM, Anthony DC, Deutsch R, Mielke MM, Claridge TD, Grant I, Franklin D, Rosario D, Marcotte T, Letendre S, McArthur JC, Haughey NJ.

AIDS. 2015 Mar 13;29(5):559-69. doi: 10.1097/QAD.0000000000000580.


Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation.

McFadden JW, Aja S, Li Q, Bandaru VV, Kim EK, Haughey NJ, Kuhajda FP, Ronnett GV.

PLoS One. 2014 Dec 26;9(12):e115642. doi: 10.1371/journal.pone.0115642. eCollection 2014.


Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum.

Bandaru VV, Haughey NJ.

BMC Neurosci. 2014 Dec 24;15:137. doi: 10.1186/s12868-014-0137-z.


Interaction of paroxetine with mitochondrial proteins mediates neuroprotection.

Steiner JP, Bachani M, Wolfson-Stofko B, Lee MH, Wang T, Li G, Li W, Strayer D, Haughey NJ, Nath A.

Neurotherapeutics. 2015 Jan;12(1):200-16. doi: 10.1007/s13311-014-0315-9. Erratum in: Neurotherapeutics. 2016 Jan;13(1):237. Wang, Tonguang [Corrected to Wang, Tongguang].


Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging.

Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ.

Aging Cell. 2015 Feb;14(1):112-21. doi: 10.1111/acel.12275. Epub 2014 Oct 24.


Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection.

Bae M, Patel N, Xu H, Lee M, Tominaga-Yamanaka K, Nath A, Geiger J, Gorospe M, Mattson MP, Haughey NJ.

J Neurosci. 2014 Aug 20;34(34):11485-503. doi: 10.1523/JNEUROSCI.0210-14.2014.


Ceramide metabolism analysis in a model of binge drinking reveals both neuroprotective and toxic effects of ethanol.

Bae M, Bandaru VV, Patel N, Haughey NJ.

J Neurochem. 2014 Dec;131(5):645-54. doi: 10.1111/jnc.12834. Epub 2014 Aug 21.

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