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Emergent spatiotemporal dynamics of the actomyosin network in the presence of chemical gradients.

Miller CJ, LaFosse PK, Asokan SB, Haugh JM, Bear JE, Elston TC.

Integr Biol (Camb). 2019 Jun 1;11(6):280-292. doi: 10.1093/intbio/zyz023.


Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation.

Tiruthani K, Mischler A, Ahmed S, Mahinthakumar J, Haugh JM, Rao BM.

Sci Signal. 2019 Jun 4;12(584). pii: eaap7584. doi: 10.1126/scisignal.aap7584.


A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis.

Mohan K, Nosbisch JL, Elston TC, Bear JE, Haugh JM.

Biophys J. 2017 Jul 11;113(1):185-194. doi: 10.1016/j.bpj.2017.05.035.


Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation.

Rahman A, Haugh JM.

J Biol Chem. 2017 Feb 17;292(7):2866-2872. doi: 10.1074/jbc.M116.761205. Epub 2017 Jan 9.


Are Filopodia Privileged Signaling Structures in Migrating Cells?

Johnson HE, Haugh JM.

Biophys J. 2016 Nov 1;111(9):1827-1830. doi: 10.1016/j.bpj.2016.09.022. Epub 2016 Oct 3.


Quantitative analysis of B-lymphocyte migration directed by CXCL13.

Liu X, Asokan SB, Bear JE, Haugh JM.

Integr Biol (Camb). 2016 Aug 8;8(8):894-903. doi: 10.1039/c6ib00128a. Epub 2016 Aug 1.


Lamellipodia are crucial for haptotactic sensing and response.

King SJ, Asokan SB, Haynes EM, Zimmerman SP, Rotty JD, Alb JG Jr, Tagliatela A, Blake DR, Lebedeva IP, Marston D, Johnson HE, Parsons M, Sharpless NE, Kuhlman B, Haugh JM, Bear JE.

J Cell Sci. 2016 Jun 15;129(12):2329-42. doi: 10.1242/jcs.184507. Epub 2016 May 12.


GMFβ controls branched actin content and lamellipodial retraction in fibroblasts.

Haynes EM, Asokan SB, King SJ, Johnson HE, Haugh JM, Bear JE.

J Cell Biol. 2015 Jun 22;209(6):803-12. doi: 10.1083/jcb.201501094.


Linking morphodynamics and directional persistence of T lymphocyte migration.

Liu X, Welf ES, Haugh JM.

J R Soc Interface. 2015 May 6;12(106). pii: 20141412. doi: 10.1098/rsif.2014.1412.


Development of a tandem affinity phosphoproteomic method with motif selectivity and its application in analysis of signal transduction networks.

Herring LE, Grant KG, Blackburn K, Haugh JM, Goshe MB.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15;988:166-74. doi: 10.1016/j.jchromb.2015.02.017. Epub 2015 Feb 19.


F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling.

Johnson HE, King SJ, Asokan SB, Rotty JD, Bear JE, Haugh JM.

J Cell Biol. 2015 Feb 16;208(4):443-55. doi: 10.1083/jcb.201406102. Epub 2015 Feb 9.


Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.

Rotty JD, Wu C, Haynes EM, Suarez C, Winkelman JD, Johnson HE, Haugh JM, Kovar DR, Bear JE.

Dev Cell. 2015 Jan 12;32(1):54-67. doi: 10.1016/j.devcel.2014.10.026. Epub 2014 Dec 24.


Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway.

Asokan SB, Johnson HE, Rahman A, King SJ, Rotty JD, Lebedeva IP, Haugh JM, Bear JE.

Dev Cell. 2014 Dec 22;31(6):747-60. doi: 10.1016/j.devcel.2014.10.024. Epub 2014 Dec 4.


Deactivation of a negative regulator: a distinct signal transduction mechanism, pronounced in Akt signaling.

Rahman A, Haugh JM.

Biophys J. 2014 Nov 18;107(10):L29-32. doi: 10.1016/j.bpj.2014.10.003.


Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration.

Vernekar VN, Wallace CS, Wu M, Chao JT, O'Connor SK, Raleigh A, Liu X, Haugh JM, Reichert WM.

Colloids Surf B Biointerfaces. 2014 Nov 1;123:225-35. doi: 10.1016/j.colsurfb.2014.09.020. Epub 2014 Sep 19.


Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet.

Bear JE, Haugh JM.

Curr Opin Cell Biol. 2014 Oct;30:74-82. doi: 10.1016/ Epub 2014 Jul 5. Review.


Quantitative analysis of phosphoinositide 3-kinase (PI3K) signaling using live-cell total internal reflection fluorescence (TIRF) microscopy.

Johnson HE, Haugh JM.

Curr Protoc Cell Biol. 2013 Dec 2;61:14.14.1-14.14.24. doi: 10.1002/0471143030.cb1414s61.


Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states.

Ahmed S, Grant KG, Edwards LE, Rahman A, Cirit M, Goshe MB, Haugh JM.

Mol Syst Biol. 2014 Jan 30;10:718. doi: 10.1002/msb.134708. Print 2014.


Bidirectional coupling between integrin-mediated signaling and actomyosin mechanics explains matrix-dependent intermittency of leading-edge motility.

Welf ES, Johnson HE, Haugh JM.

Mol Biol Cell. 2013 Dec;24(24):3945-55. doi: 10.1091/mbc.E13-06-0311. Epub 2013 Oct 23.


Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein.

Ott LE, Sung EJ, Melvin AT, Sheats MK, Haugh JM, Adler KB, Jones SL.

PLoS One. 2013 Jun 19;8(6):e66512. doi: 10.1371/journal.pone.0066512. Print 2013.


Systemic perturbation of the ERK signaling pathway by the proteasome inhibitor, MG132.

Cirit M, Grant KG, Haugh JM.

PLoS One. 2012;7(11):e50975. doi: 10.1371/journal.pone.0050975. Epub 2012 Nov 30.


Live-cell fluorescence microscopy with molecular biosensors: what are we really measuring?

Haugh JM.

Biophys J. 2012 May 2;102(9):2003-11. doi: 10.1016/j.bpj.2012.03.055.


Cell regulation: a time to signal, a time to respond.

Haugh JM.

Bioessays. 2012 Jul;34(7):528-9. doi: 10.1002/bies.201200077. No abstract available.


Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics.

Welf ES, Haugh JM.

Methods Cell Biol. 2012;110:223-41. doi: 10.1016/B978-0-12-388403-9.00009-6.


Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism.

Welf ES, Ahmed S, Johnson HE, Melvin AT, Haugh JM.

J Cell Biol. 2012 Apr 2;197(1):105-14. doi: 10.1083/jcb.201108152.


Quantitative models of signal transduction networks: How detailed should they be?

Cirit M, Haugh JM.

Commun Integr Biol. 2011 May;4(3):353-6. doi: 10.4161/cib.4.3.15149.


Cells see the light to bring signaling under control.

Haugh JM.

Nat Methods. 2011 Sep 29;8(10):808-9. doi: 10.1038/nmeth.1708. No abstract available.


Guidelines for visualizing and annotating rule-based models.

Chylek LA, Hu B, Blinov ML, Emonet T, Faeder JR, Goldstein B, Gutenkunst RN, Haugh JM, Lipniacki T, Posner RG, Yang J, Hlavacek WS.

Mol Biosyst. 2011 Oct;7(10):2779-95. doi: 10.1039/c1mb05077j. Epub 2011 Jun 7.


In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling.

Melvin AT, Welf ES, Wang Y, Irvine DJ, Haugh JM.

Biophys J. 2011 Apr 20;100(8):1893-901. doi: 10.1016/j.bpj.2011.02.047.


Poly(vinylmethylsiloxane) elastomer networks as functional materials for cell adhesion and migration studies.

Ahmed S, Yang HK, Ozcam AE, Efimenko K, Weiger MC, Genzer J, Haugh JM.

Biomacromolecules. 2011 Apr 11;12(4):1265-71. doi: 10.1021/bm101549y. Epub 2011 Mar 1.


Signaling pathways that control cell migration: models and analysis.

Welf ES, Haugh JM.

Wiley Interdiscip Rev Syst Biol Med. 2011 Mar-Apr;3(2):231-40. doi: 10.1002/wsbm.110. Review.


A phenomenological mixture model for biosynthesis and linking of cartilage extracellular matrix in scaffolds seeded with chondrocytes.

Haider MA, Olander JE, Arnold RF, Marous DR, McLamb AJ, Thompson KC, Woodruff WR, Haugh JM.

Biomech Model Mechanobiol. 2011 Dec;10(6):915-24. doi: 10.1007/s10237-010-0282-y. Epub 2011 Jan 7.


Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase.

Buhrman G, Kumar VS, Cirit M, Haugh JM, Mattos C.

J Biol Chem. 2011 Feb 4;286(5):3323-31. doi: 10.1074/jbc.M110.193854. Epub 2010 Nov 22.


Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.

Cirit M, Wang CC, Haugh JM.

J Biol Chem. 2010 Nov 19;285(47):36736-44. doi: 10.1074/jbc.M110.148759. Epub 2010 Sep 16.


Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells.

Cirit M, Krajcovic M, Choi CK, Welf ES, Horwitz AF, Haugh JM.

PLoS Comput Biol. 2010 Feb 26;6(2):e1000688. doi: 10.1371/journal.pcbi.1000688.


Directional persistence of cell migration coincides with stability of asymmetric intracellular signaling.

Weiger MC, Ahmed S, Welf ES, Haugh JM.

Biophys J. 2010 Jan 6;98(1):67-75. doi: 10.1016/j.bpj.2009.09.051.


Analysis of reaction-diffusion systems with anomalous subdiffusion.

Haugh JM.

Biophys J. 2009 Jul 22;97(2):435-42. doi: 10.1016/j.bpj.2009.05.014.


A bipolar clamp mechanism for activation of Jak-family protein tyrosine kinases.

Barua D, Faeder JR, Haugh JM.

PLoS Comput Biol. 2009 Apr;5(4):e1000364. doi: 10.1371/journal.pcbi.1000364. Epub 2009 Apr 17.


Cell population-based model of dermal wound invasion with heterogeneous intracellular signaling properties.

Monine MI, Haugh JM.

Cell Adh Migr. 2008 Apr-May;2(2):137-46. Epub 2008 Apr 26.


PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk.

Wang CC, Cirit M, Haugh JM.

Mol Syst Biol. 2009;5:246. doi: 10.1038/msb.2009.4. Epub 2009 Feb 17. Erratum in: Mol Syst Biol. 2011;7:524.


Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts.

Weiger MC, Wang CC, Krajcovic M, Melvin AT, Rhoden JJ, Haugh JM.

J Cell Sci. 2009 Feb 1;122(Pt 3):313-23. doi: 10.1242/jcs.037564. Epub 2009 Jan 6.


Combinatorial Signal Transduction Responses Mediated by Interleukin-2 and -4 Receptors in a Helper TH2 Cell Line.

Comfort KK, Haugh JM.

Cell Mol Bioeng. 2008 Sep;1(2-3). doi: 10.1007/s12195-008-0015-9.


Signal transduction at point-blank range: analysis of a spatial coupling mechanism for pathway crosstalk.

Monine MI, Haugh JM.

Biophys J. 2008 Sep;95(5):2172-82. doi: 10.1529/biophysj.108.128892. Epub 2008 May 23.


Biophysics: cells get in shape for a crawl.

Haugh JM.

Nature. 2008 May 22;453(7194):461-2. doi: 10.1038/453461a. No abstract available.


Computational models of tandem SRC homology 2 domain interactions and application to phosphoinositide 3-kinase.

Barua D, Faeder JR, Haugh JM.

J Biol Chem. 2008 Mar 21;283(12):7338-45. doi: 10.1074/jbc.M708359200. Epub 2008 Jan 20.


Structure-based kinetic models of modular signaling protein function: focus on Shp2.

Barua D, Faeder JR, Haugh JM.

Biophys J. 2007 Apr 1;92(7):2290-300. Epub 2007 Jan 5.


Mechanisms of gradient sensing and chemotaxis: conserved pathways, diverse regulation.

Schneider IC, Haugh JM.

Cell Cycle. 2006 Jun;5(11):1130-4. Epub 2006 Jun 1. Review.


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