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Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome.

Racine Miousse I, Ewing LE, Skinner CM, Pathak R, Garg S, Kutanzi KR, Melnyk S, Hauer-Jensen M, Koturbash I.

Am J Physiol Gastrointest Liver Physiol. 2020 Jan 21. doi: 10.1152/ajpgi.00351.2019. [Epub ahead of print]


C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress.

Banerjee S, Fu Q, Shah SK, Melnyk SB, Sterneck E, Hauer-Jensen M, Pawar SA.

Sci Rep. 2019 Sep 27;9(1):13953. doi: 10.1038/s41598-019-49437-x.


Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O).

Miousse IR, Skinner CM, Sridharan V, Seawright JW, Singh P, Landes RD, Cheema AK, Hauer-Jensen M, Boerma M, Koturbash I.

Life Sci Space Res (Amst). 2019 Aug;22:8-15. doi: 10.1016/j.lssr.2019.05.003. Epub 2019 May 31.


Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation.

Binz RL, Tian E, Sadhukhan R, Zhou D, Hauer-Jensen M, Pathak R.

Sci Rep. 2019 Jul 22;9(1):10554. doi: 10.1038/s41598-019-47002-0.


Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin.

Pathak R, Kumar VP, Hauer-Jensen M, Ghosh SP.

Mil Med. 2019 Mar 1;184(Suppl 1):644-651. doi: 10.1093/milmed/usy408.


Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery.

Garg S, Sadhukhan R, Banerjee S, Savenka AV, Basnakian AG, McHargue V, Wang J, Pawar SA, Ghosh SP, Ware J, Hauer-Jensen M, Pathak R.

Antioxidants (Basel). 2019 Mar 6;8(3). pii: E57. doi: 10.3390/antiox8030057.


Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice.

Seawright JW, Sridharan V, Landes RD, Cao M, Singh P, Koturbash I, Mao XW, Miousse IR, Singh SP, Nelson GA, Hauer-Jensen M, Boerma M.

Life Sci Space Res (Amst). 2019 Feb;20:72-84. doi: 10.1016/j.lssr.2019.01.003. Epub 2019 Jan 15.


Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects.

Aykin-Burns N, Pathak R, Boerma M, Kim T, Hauer-Jensen M.

Semin Radiat Oncol. 2019 Jan;29(1):55-61. doi: 10.1016/j.semradonc.2018.10.008. Review.


NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity.

Ewing LE, Miousse IR, Pathak R, Skinner CM, Kosanke S, Boerma M, Hauer-Jensen M, Koturbash I.

Int J Radiat Biol. 2020 Jan;96(1):93-99. doi: 10.1080/09553002.2018.1547437. Epub 2019 Jan 14.


Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation.

Pathak R, Shah SK, Hauer-Jensen M.

Int J Radiat Biol. 2019 Apr;95(4):493-505. doi: 10.1080/09553002.2018.1552374. Epub 2019 Jan 8. Review.


Interval estimators of relative potency in toxicology and radiation countermeasure studies: comparing methods and experimental designs.

Landes RD, Lensing SY, Hauer-Jensen M.

J Biopharm Stat. 2019;29(2):348-358. doi: 10.1080/10543406.2018.1535500. Epub 2018 Oct 23.


Proteomic Changes in Mouse Spleen after Radiation-Induced Injury and its Modulation by Gamma-Tocotrienol.

Cheema AK, Byrum SD, Sharma NK, Altadill T, Kumar VP, Biswas S, Balgley BM, Hauer-Jensen M, Tackett AJ, Ghosh SP.

Radiat Res. 2018 Nov;190(5):449-463. doi: 10.1667/RR15008.1. Epub 2018 Aug 2.


M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion.

Luo Y, Shao L, Chang J, Feng W, Liu YL, Cottler-Fox MH, Emanuel PD, Hauer-Jensen M, Bernstein ID, Liu L, Chen X, Zhou J, Murray PJ, Zhou D.

Blood Adv. 2018 Apr 24;2(8):859-870. doi: 10.1182/bloodadvances.2018015685.


Cebpd Is Essential for Gamma-Tocotrienol Mediated Protection against Radiation-Induced Hematopoietic and Intestinal Injury.

Banerjee S, Shah SK, Melnyk SB, Pathak R, Hauer-Jensen M, Pawar SA.

Antioxidants (Basel). 2018 Apr 6;7(4). pii: E55. doi: 10.3390/antiox7040055.


Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model.

Bose C, Awasthi S, Sharma R, Beneš H, Hauer-Jensen M, Boerma M, Singh SP.

PLoS One. 2018 Mar 8;13(3):e0193918. doi: 10.1371/journal.pone.0193918. eCollection 2018.


Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice.

Wang Y, Chang J, Li X, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L.

PLoS One. 2017 Dec 12;12(12):e0189466. doi: 10.1371/journal.pone.0189466. eCollection 2017.


Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology.

Miousse IR, Pathak R, Garg S, Skinner CM, Melnyk S, Pavliv O, Hendrickson H, Landes RD, Lumen A, Tackett AJ, Deutz NEP, Hauer-Jensen M, Koturbash I.

Genes Nutr. 2017 Sep 6;12:22. doi: 10.1186/s12263-017-0576-0. eCollection 2017.


Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome.

Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK.

Microbiome. 2017 Aug 18;5(1):105. doi: 10.1186/s40168-017-0325-z.


Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice.

Chang J, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L.

Int J Radiat Biol. 2017 Dec;93(12):1312-1320. doi: 10.1080/09553002.2017.1356941. Epub 2017 Aug 7.


Fibrinogen deficiency suppresses the development of early and delayed radiation enteropathy.

Wang J, Pathak R, Garg S, Hauer-Jensen M.

World J Gastroenterol. 2017 Jul 14;23(26):4701-4711. doi: 10.3748/wjg.v23.i26.4701.


Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart.

Seawright JW, Samman Y, Sridharan V, Mao XW, Cao M, Singh P, Melnyk S, Koturbash I, Nelson GA, Hauer-Jensen M, Boerma M.

PLoS One. 2017 Jul 5;12(7):e0180594. doi: 10.1371/journal.pone.0180594. eCollection 2017.


Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation.

Miousse IR, Chang J, Shao L, Pathak R, Nzabarushimana É, Kutanzi KR, Landes RD, Tackett AJ, Hauer-Jensen M, Zhou D, Koturbash I.

Int J Mol Sci. 2017 Jul 4;18(7). pii: E1430. doi: 10.3390/ijms18071430.


One-carbon metabolism and ionizing radiation: a multifaceted interaction.

Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I.

Biomol Concepts. 2017 May 24;8(2):83-92. doi: 10.1515/bmc-2017-0003. Review.


28Si total body irradiation injures bone marrow hematopoietic stem cells via induction of cellular apoptosis.

Chang J, Feng W, Wang Y, Allen AR, Turner J, Stewart B, Raber J, Hauer-Jensen M, Zhou D, Shao L.

Life Sci Space Res (Amst). 2017 May;13:39-44. doi: 10.1016/j.lssr.2017.03.003. Epub 2017 Apr 5.


Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice.

Pan J, Li D, Xu Y, Zhang J, Wang Y, Chen M, Lin S, Huang L, Chung EJ, Citrin DE, Wang Y, Hauer-Jensen M, Zhou D, Meng A.

Int J Radiat Oncol Biol Phys. 2017 Oct 1;99(2):353-361. doi: 10.1016/j.ijrobp.2017.02.216. Epub 2017 Mar 4.


Time- and radiation-dose dependent changes in the plasma proteome after total body irradiation of non-human primates: Implications for biomarker selection.

Byrum SD, Burdine MS, Orr L, Mackintosh SG, Authier S, Pouliot M, Hauer-Jensen M, Tackett AJ.

PLoS One. 2017 Mar 28;12(3):e0174771. doi: 10.1371/journal.pone.0174771. eCollection 2017.


Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System.

Miousse IR, Koturbash I, Chalbot MC, Hauer-Jensen M, Kavouras I, Pathak R.

J Vis Exp. 2016 Dec 21;(118). doi: 10.3791/54969.


Effects of ionizing radiation on the heart.

Boerma M, Sridharan V, Mao XW, Nelson GA, Cheema AK, Koturbash I, Singh SP, Tackett AJ, Hauer-Jensen M.

Mutat Res. 2016 Oct - Dec;770(Pt B):319-327. doi: 10.1016/j.mrrev.2016.07.003. Epub 2016 Jul 10. Review.


The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM).

Pathak R, Ghosh SP, Zhou D, Hauer-Jensen M.

Int J Mol Sci. 2016 Nov 18;17(11). pii: E1937.


Synthesis of (2R,8' S,3' E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol.

Liu X, Gujarathi S, Zhang X, Shao L, Boerma M, Compadre CM, Crooks PA, Hauer-Jensen M, Zhou D, Zheng G.

Tetrahedron. 2016 Jul;72(27-28):4001-4006. Epub 2016 May 12.


Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction.

Banerjee S, Aykin-Burns N, Krager KJ, Shah SK, Melnyk SB, Hauer-Jensen M, Pawar SA.

Free Radic Biol Med. 2016 Oct;99:296-307. doi: 10.1016/j.freeradbiomed.2016.08.022. Epub 2016 Aug 20.


Minipigs as models in drug discovery.

Singh VK, Thrall KD, Hauer-Jensen M.

Expert Opin Drug Discov. 2016 Dec;11(12):1131-1134. Epub 2016 Aug 22. No abstract available. Erratum in: Expert Opin Drug Discov. 2017 Jul;12 (7):755.


Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model.

Pathak R, Wang J, Garg S, Aykin-Burns N, Petersen KU, Hauer-Jensen M.

Radiat Res. 2016 Aug;186(2):112-20. doi: 10.1667/RR14408.1. Epub 2016 Jul 26.


Densely ionizing radiation affects DNA methylation of selective LINE-1 elements.

Prior S, Miousse IR, Nzabarushimana E, Pathak R, Skinner C, Kutanzi KR, Allen AR, Raber J, Tackett AJ, Hauer-Jensen M, Nelson GA, Koturbash I.

Environ Res. 2016 Oct;150:470-481. doi: 10.1016/j.envres.2016.06.043. Epub 2016 Jul 14.


Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice.

Chang J, Luo Y, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L.

PLoS One. 2016 Jul 1;11(7):e0158097. doi: 10.1371/journal.pone.0158097. eCollection 2016.


Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects.

Bujold K, Hauer-Jensen M, Donini O, Rumage A, Hartman D, Hendrickson HP, Stamatopoulos J, Naraghi H, Pouliot M, Ascah A, Sebastian M, Pugsley MK, Wong K, Authier S.

Radiat Res. 2016 Jul;186(1):71-8. doi: 10.1667/RR14305.1. Epub 2016 Jun 28.


The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage.

Pathak R, Bachri A, Ghosh SP, Koturbash I, Boerma M, Binz RK, Sawyer JR, Hauer-Jensen M.

Pharm Res. 2016 Sep;33(9):2117-25. doi: 10.1007/s11095-016-1950-0. Epub 2016 May 23.


γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status.

Singh VK, Hauer-Jensen M.

Int J Mol Sci. 2016 May 3;17(5). pii: E663. doi: 10.3390/ijms17050663. Review.


Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen.

Ghosh SP, Pathak R, Kumar P, Biswas S, Bhattacharyya S, Kumar VP, Hauer-Jensen M, Biswas R.

Radiat Res. 2016 May;185(5):485-95. doi: 10.1667/RR14248.1. Epub 2016 Apr 29.


Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart.

Koturbash I, Miousse IR, Sridharan V, Nzabarushimana E, Skinner CM, Melnyk SB, Pavliv O, Hauer-Jensen M, Nelson GA, Boerma M.

Mutat Res. 2016 May;787:43-53. doi: 10.1016/j.mrfmmm.2016.02.009. Epub 2016 Mar 2.


A Quantitative Proteomic Analysis of Urine from Gamma-Irradiated Non-Human Primates.

Byrum SD, Burdine MS, Orr L, Moreland L, Mackintosh SG, Authier S, Pouliot M, Hauer-Jensen M, Tackett AJ.

J Proteomics Bioinform. 2016;9(Suppl 10). pii: 005. Epub 2015 Dec 28.


A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation.

Ramadan SS, Sridharan V, Koturbash I, Miousse IR, Hauer-Jensen M, Nelson GA, Boerma M.

Life Sci Space Res (Amst). 2016 Feb;8:8-13. doi: 10.1016/j.lssr.2015.12.001. Epub 2015 Dec 14.


Radioprotective Efficacy of Gamma-Tocotrienol in Nonhuman Primates.

Singh VK, Kulkarni S, Fatanmi OO, Wise SY, Newman VL, Romaine PL, Hendrickson H, Gulani J, Ghosh SP, Kumar KS, Hauer-Jensen M.

Radiat Res. 2016 Mar;185(3):285-98. doi: 10.1667/RR14127.1. Epub 2016 Mar 1.


James William Osborne, PhD 1928-2015.

Spitz DR, Hauer-Jensen M.

Radiat Res. 2016 Feb;185(2):214-6. doi: 10.1667/RR0JWO.1. No abstract available.


Modulation of Radiation Response by the Tetrahydrobiopterin Pathway.

Pathak R, Cheema AK, Boca SM, Krager KJ, Hauer-Jensen M, Aykin-Burns N.

Antioxidants (Basel). 2015 Jan 22;4(1):68-81. doi: 10.3390/antiox4010068. Review.


Particle Beam may have Higher Effectiveness in Treating Chemo-resistant Cancers than Low-LET Photon Beam Therapy.

Pathak R, Hauer-Jensen M.

Res Rev J Pharm Pharm Sci. 2015 Apr-Jun;4(2):1-2. Epub 2015 Jun 14. No abstract available.


Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy.

Liu YL, Yan Y, Webster C, Shao L, Lensing SY, Ni H, Feng W, Colorado N, Pathak R, Xiang Z, Hauer-Jensen M, Li S, Zhou D, Emanuel PD.

Blood. 2016 Apr 14;127(15):1912-22. doi: 10.1182/blood-2015-05-646216. Epub 2016 Jan 13.


Space radiation and cardiovascular disease risk.

Boerma M, Nelson GA, Sridharan V, Mao XW, Koturbash I, Hauer-Jensen M.

World J Cardiol. 2015 Dec 26;7(12):882-8. doi: 10.4330/wjc.v7.i12.882. Review.


Segmental Differences in Radiation-Induced Alterations of Tight Junction-Related Proteins in Non-Human Primate Jejunum, Ileum and Colon.

Garg S, Zheng J, Wang J, Authier S, Pouliot M, Hauer-Jensen M.

Radiat Res. 2016 Jan;185(1):50-9. doi: 10.1667/RR14157.1. Epub 2015 Dec 31.

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