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Items: 1 to 50 of 189

1.

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1.

Wallroth A, Koch PA, Marat AL, Krause E, Haucke V.

Nat Cell Biol. 2019 Sep;21(9):1093-1101. doi: 10.1038/s41556-019-0377-3. Epub 2019 Aug 26.

PMID:
31451768
2.

Phosphoinositides in the control of lysosome function and homeostasis.

Ebner M, Koch PA, Haucke V.

Biochem Soc Trans. 2019 Aug 30;47(4):1173-1185. doi: 10.1042/BST20190158. Epub 2019 Aug 5. Review.

PMID:
31383818
3.

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S.

Cell Rep. 2019 Jun 4;27(10):3049-3061.e6. doi: 10.1016/j.celrep.2019.05.017.

4.

A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy.

Helbig I, Lopez-Hernandez T, Shor O, Galer P, Ganesan S, Pendziwiat M, Rademacher A, Ellis CA, Hümpfer N, Schwarz N, Seiffert S, Peeden J, Shen J, Štěrbová K, Hammer TB, Møller RS, Shinde DN, Tang S, Smith L, Poduri A, Krause R, Benninger F, Helbig KL, Haucke V, Weber YG; EuroEPINOMICS-RES Consortium; GRIN Consortium.

Am J Hum Genet. 2019 Jun 6;104(6):1060-1072. doi: 10.1016/j.ajhg.2019.04.001. Epub 2019 May 16.

PMID:
31104773
5.

The cell adhesion protein CAR is a negative regulator of synaptic transmission.

Wrackmeyer U, Kaldrack J, Jüttner R, Pannasch U, Gimber N, Freiberg F, Purfürst B, Kainmueller D, Schmitz D, Haucke V, Rathjen FG, Gotthardt M.

Sci Rep. 2019 May 1;9(1):6768. doi: 10.1038/s41598-019-43150-5.

6.

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction.

Tiosano D, Baris HN, Chen A, Hitzert MM, Schueler M, Gulluni F, Wiesener A, Bergua A, Mory A, Copeland B, Gleeson JG, Rump P, van Meer H, Sival DA, Haucke V, Kriwinsky J, Knaup KX, Reis A, Hauer NN, Hirsch E, Roepman R, Pfundt R, Thiel CT, Wiesener MS, Aslanyan MG, Buchner DA.

PLoS Genet. 2019 Apr 29;15(4):e1008088. doi: 10.1371/journal.pgen.1008088. eCollection 2019 Apr.

7.

Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.

Gerth F, Jäpel M, Sticht J, Kuropka B, Schmitt XJ, Driller JH, Loll B, Wahl MC, Pagel K, Haucke V, Freund C.

Structure. 2019 Jun 4;27(6):977-987.e5. doi: 10.1016/j.str.2019.03.020. Epub 2019 Apr 25.

PMID:
31031201
8.

Phosphoinositide switches in endocytosis and in the endolysosomal system.

Wang H, Lo WT, Haucke V.

Curr Opin Cell Biol. 2019 Aug;59:50-57. doi: 10.1016/j.ceb.2019.03.011. Epub 2019 Apr 28. Review.

PMID:
31029845
9.

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function.

Dejonghe W, Sharma I, Denoo B, De Munck S, Lu Q, Mishev K, Bulut H, Mylle E, De Rycke R, Vasileva M, Savatin DV, Nerinckx W, Staes A, Drozdzecki A, Audenaert D, Yperman K, Madder A, Friml J, Van Damme D, Gevaert K, Haucke V, Savvides SN, Winne J, Russinova E.

Nat Chem Biol. 2019 Jun;15(6):641-649. doi: 10.1038/s41589-019-0262-1. Epub 2019 Apr 22.

PMID:
31011214
10.

Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression.

Buntz A, Killian T, Schmid D, Seul H, Brinkmann U, Ravn J, Lindholm M, Knoetgen H, Haucke V, Mundigl O.

Nucleic Acids Res. 2019 Jan 25;47(2):953-969. doi: 10.1093/nar/gky1158.

11.

Tamoxifen therapy in a murine model of myotubular myopathy.

Maani N, Sabha N, Rezai K, Ramani A, Groom L, Eltayeb N, Mavandadnejad F, Pang A, Russo G, Brudno M, Haucke V, Dirksen RT, Dowling JJ.

Nat Commun. 2018 Nov 19;9(1):4849. doi: 10.1038/s41467-018-07057-5.

12.

Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs.

Meyer K, Kirchner M, Uyar B, Cheng JY, Russo G, Hernandez-Miranda LR, Szymborska A, Zauber H, Rudolph IM, Willnow TE, Akalin A, Haucke V, Gerhardt H, Birchmeier C, Kühn R, Krauss M, Diecke S, Pascual JM, Selbach M.

Cell. 2018 Sep 20;175(1):239-253.e17. doi: 10.1016/j.cell.2018.08.019. Epub 2018 Sep 6.

13.

Membrane remodeling in clathrin-mediated endocytosis.

Haucke V, Kozlov MM.

J Cell Sci. 2018 Sep 3;131(17). pii: jcs216812. doi: 10.1242/jcs.216812. Review.

14.

Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles.

Vukoja A, Rey U, Petzoldt AG, Ott C, Vollweiter D, Quentin C, Puchkov D, Reynolds E, Lehmann M, Hohensee S, Rosa S, Lipowsky R, Sigrist SJ, Haucke V.

Neuron. 2018 Sep 19;99(6):1216-1232.e7. doi: 10.1016/j.neuron.2018.08.004. Epub 2018 Aug 30.

15.

Mechanical signals regulate TORC2 activity.

Ebner M, Haucke V.

Nat Cell Biol. 2018 Sep;20(9):994-995. doi: 10.1038/s41556-018-0181-5. No abstract available.

PMID:
30154561
16.

Identifying Small-Molecule Inhibitors of the Clathrin Terminal Domain.

Haucke V, Krauß M.

Methods Mol Biol. 2018;1847:51-64. doi: 10.1007/978-1-4939-8719-1_5. Erratum in: Methods Mol Biol. 2018;1847:E1.

PMID:
30129009
17.

Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module.

Wang H, Lo WT, Vujičić Žagar A, Gulluni F, Lehmann M, Scapozza L, Haucke V, Vadas O.

Mol Cell. 2018 Jul 19;71(2):343-351.e4. doi: 10.1016/j.molcel.2018.06.042.

18.

PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.

Kath C, Goni-Oliver P, Müller R, Schultz C, Haucke V, Eickholt B, Schmoranzer J.

PLoS One. 2018 Apr 4;13(4):e0193257. doi: 10.1371/journal.pone.0193257. eCollection 2018.

19.

Presynaptic endocytic factors in autophagy and neurodegeneration.

Azarnia Tehran D, Kuijpers M, Haucke V.

Curr Opin Neurobiol. 2018 Feb;48:153-159. doi: 10.1016/j.conb.2017.12.018. Epub 2018 Jan 6. Review.

PMID:
29316491
20.

Phosphoinositide conversion in endocytosis and the endolysosomal system.

Wallroth A, Haucke V.

J Biol Chem. 2018 Feb 2;293(5):1526-1535. doi: 10.1074/jbc.R117.000629. Epub 2017 Dec 27. Review.

21.

Coupling of exocytosis and endocytosis at the presynaptic active zone.

Maritzen T, Haucke V.

Neurosci Res. 2018 Feb;127:45-52. doi: 10.1016/j.neures.2017.09.013. Epub 2017 Dec 6. Review.

PMID:
29221907
22.

A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch.

Lo WT, Vujičić Žagar A, Gerth F, Lehmann M, Puchkov D, Krylova O, Freund C, Scapozza L, Vadas O, Haucke V.

Dev Cell. 2017 Nov 20;43(4):522-529.e4. doi: 10.1016/j.devcel.2017.10.019.

23.

Intersectin associates with synapsin and regulates its nanoscale localization and function.

Gerth F, Jäpel M, Pechstein A, Kochlamazashvili G, Lehmann M, Puchkov D, Onofri F, Benfenati F, Nikonenko AG, Fredrich K, Shupliakov O, Maritzen T, Freund C, Haucke V.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12057-12062. doi: 10.1073/pnas.1715341114. Epub 2017 Oct 23. Erratum in: Proc Natl Acad Sci U S A. 2017 Dec 11;:.

24.

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.

Walter AM, Müller R, Tawfik B, Wierda KD, Pinheiro PS, Nadler A, McCarthy AW, Ziomkiewicz I, Kruse M, Reither G, Rettig J, Lehmann M, Haucke V, Hille B, Schultz C, Sørensen JB.

Elife. 2017 Oct 25;6. pii: e30203. doi: 10.7554/eLife.30203.

25.

A lipid off-switch for mTORC1.

Wallroth A, Haucke V.

Mol Cell Oncol. 2017 Aug 2;4(5):e1356899. doi: 10.1080/23723556.2017.1356899. eCollection 2017.

26.

An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling.

Mertins P, Przybylski D, Yosef N, Qiao J, Clauser K, Raychowdhury R, Eisenhaure TM, Maritzen T, Haucke V, Satoh T, Akira S, Carr SA, Regev A, Hacohen N, Chevrier N.

Cell Rep. 2017 Jun 27;19(13):2853-2866. doi: 10.1016/j.celrep.2017.06.016.

27.

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.

Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Brachs S, Varela L, Szigeti-Buck K, Yi CX, Schriever SC, Tattikota SG, Carlo AS, Moroni M, Siemens J, Heuser A, van der Weyden L, Birkenfeld AL, Niendorf T, Poulet JFA, Horvath TL, Tschöp MH, Heinig M, Trajkovski M, Haucke V, Poy MN.

Nat Neurosci. 2017 Aug;20(8):1096-1103. doi: 10.1038/nn.4590. Epub 2017 Jun 19.

28.

Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission.

Schöneberg J, Lehmann M, Ullrich A, Posor Y, Lo WT, Lichtner G, Schmoranzer J, Haucke V, Noé F.

Nat Commun. 2017 Jun 19;8:15873. doi: 10.1038/ncomms15873.

29.

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate.

Marat AL, Wallroth A, Lo WT, Müller R, Norata GD, Falasca M, Schultz C, Haucke V.

Science. 2017 Jun 2;356(6341):968-972. doi: 10.1126/science.aaf8310.

PMID:
28572395
30.

Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.

Jakob B, Kochlamazashvili G, Jäpel M, Gauhar A, Bock HH, Maritzen T, Haucke V.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5533-5538. doi: 10.1073/pnas.1704447114. Epub 2017 May 8.

31.

Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration.

Kononenko NL, Claßen GA, Kuijpers M, Puchkov D, Maritzen T, Tempes A, Malik AR, Skalecka A, Bera S, Jaworski J, Haucke V.

Nat Commun. 2017 Apr 7;8:14819. doi: 10.1038/ncomms14819.

32.

Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.

Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V.

Neuron. 2017 Feb 22;93(4):854-866.e4. doi: 10.1016/j.neuron.2017.02.011.

33.

Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.

Pappas SS, Bonifacino J, Danek A, Dauer WT, De M, De Franceschi L, DiPaolo G, Fuller R, Haucke V, Hermann A, Kornmann B, Landwehrmeyer B, Levin J, Neiman AM, Rudnicki DD, Sibon O, Velayos-Baeza A, Vonk JJ, Walker RH, Weisman LS, Albin RL.

Tremor Other Hyperkinet Mov (N Y). 2017 Feb 15;7:428. doi: 10.7916/D8XD127W. eCollection 2017.

34.

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.

Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Kuner R, Poulet JF, Schmoranzer J, Poole K, Lewin GR.

Nat Neurosci. 2017 Feb;20(2):209-218. doi: 10.1038/nn.4454. Epub 2016 Dec 12.

PMID:
27941788
35.

Autophagosome Formation by Endophilin Keeps Synapses in Shape.

Kuijpers M, Haucke V.

Neuron. 2016 Nov 23;92(4):675-677. doi: 10.1016/j.neuron.2016.11.016.

36.

5-Aryl-2-(naphtha-1-yl)sulfonamido-thiazol-4(5H)-ones as clathrin inhibitors.

Robertson MJ, Horatscheck A, Sauer S, von Kleist L, Baker JR, Stahlschmidt W, Nazaré M, Whiting A, Chau N, Robinson PJ, Haucke V, McCluskey A.

Org Biomol Chem. 2016 Nov 29;14(47):11266-11278.

PMID:
27853797
37.

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, Rost BR, Eickholt BJ, Haucke V, Schmitz D, Sigrist SJ, Rosenmund C.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620. Epub 2016 Sep 26.

38.

The progressive ankylosis protein ANK facilitates clathrin- and adaptor-mediated membrane traffic at the trans-Golgi network-to-endosome interface.

Seifert W, Posor Y, Schu P, Stenbeck G, Mundlos S, Klaassen S, Nürnberg P, Haucke V, Kornak U, Kühnisch J.

Hum Mol Genet. 2016 Sep 1;25(17):3836-3848. doi: 10.1093/hmg/ddw230. Epub 2016 Jul 27.

PMID:
27466194
39.

Cell biology: Membrane kiss mediates hormone secretion.

Soykan T, Haucke V.

Nature. 2016 Jun 23;534(7608):479-80. doi: 10.1038/nature18446. Epub 2016 Jun 15. No abstract available.

PMID:
27309811
40.

Lysosomal Dysfunction Caused by Cellular Accumulation of Silica Nanoparticles.

Schütz I, Lopez-Hernandez T, Gao Q, Puchkov D, Jabs S, Nordmeyer D, Schmudde M, Rühl E, Graf CM, Haucke V.

J Biol Chem. 2016 Jul 1;291(27):14170-84. doi: 10.1074/jbc.M115.710947. Epub 2016 May 11.

41.

Directing lipid transport at membrane contact sites.

Krauβ M, Haucke V.

Nat Cell Biol. 2016 Apr 27;18(5):461-3. doi: 10.1038/ncb3345.

PMID:
27117329
42.

Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells.

Lopes da Silva M, O'Connor MN, Kriston-Vizi J, White IJ, Al-Shawi R, Simons JP, Mössinger J, Haucke V, Cutler DF.

J Cell Sci. 2016 May 15;129(10):2096-105. doi: 10.1242/jcs.187864. Epub 2016 Apr 11.

43.

Modes and mechanisms of synaptic vesicle recycling.

Soykan T, Maritzen T, Haucke V.

Curr Opin Neurobiol. 2016 Aug;39:17-23. doi: 10.1016/j.conb.2016.03.005. Epub 2016 Mar 24. Review.

PMID:
27016897
44.

Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.

Marat AL, Haucke V.

EMBO J. 2016 Mar 15;35(6):561-79. doi: 10.15252/embj.201593564. Epub 2016 Feb 17. Review.

45.

A phosphoinositide conversion mechanism for exit from endosomes.

Ketel K, Krauss M, Nicot AS, Puchkov D, Wieffer M, Müller R, Subramanian D, Schultz C, Laporte J, Haucke V.

Nature. 2016 Jan 21;529(7586):408-12. doi: 10.1038/nature16516. Epub 2016 Jan 13.

PMID:
26760201
46.

Gottfried Schatz (1936-2015)-mitochondrial pioneer and ambassador for science.

Haucke V, Glick BS.

EMBO J. 2015 Nov 12;34(22):2725-6. doi: 10.15252/embj.201593299. Epub 2015 Oct 26. No abstract available.

47.

Hopping Pits Catch Fusing Granules.

Haucke V.

Dev Cell. 2015 Oct 12;35(1):10-1. doi: 10.1016/j.devcel.2015.09.026.

48.

Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.

Jung S, Maritzen T, Wichmann C, Jing Z, Neef A, Revelo NH, Al-Moyed H, Meese S, Wojcik SM, Panou I, Bulut H, Schu P, Ficner R, Reisinger E, Rizzoli SO, Neef J, Strenzke N, Haucke V, Moser T.

EMBO J. 2015 Nov 3;34(21):2686-702. doi: 10.15252/embj.201591885. Epub 2015 Oct 7.

49.

Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.

Koo SJ, Kochlamazashvili G, Rost B, Puchkov D, Gimber N, Lehmann M, Tadeus G, Schmoranzer J, Rosenmund C, Haucke V, Maritzen T.

Neuron. 2015 Oct 21;88(2):330-44. doi: 10.1016/j.neuron.2015.08.034. Epub 2015 Sep 24.

50.

Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins.

Gimber N, Tadeus G, Maritzen T, Schmoranzer J, Haucke V.

Nat Commun. 2015 Sep 24;6:8392. doi: 10.1038/ncomms9392.

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