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Items: 20


Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma.

Lin W, Yip YL, Jia L, Deng W, Zheng H, Dai W, Ko JMY, Lo KW, Chung GTY, Yip KY, Lee SD, Kwan JS, Zhang J, Liu T, Chan JY, Kwong DL, Lee VH, Nicholls JM, Busson P, Liu X, Chiang AKS, Hui KF, Kwok H, Cheung ST, Cheung YC, Chan CK, Li B, Cheung AL, Hau PM, Zhou Y, Tsang CM, Middeldorp J, Chen H, Lung ML, Tsao SW.

Nat Commun. 2018 Nov 7;9(1):4663. doi: 10.1038/s41467-018-06889-5.


EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma.

Lung RW, Hau PM, Yu KH, Yip KY, Tong JH, Chak WP, Chan AW, Lam KH, Lo AK, Tin EK, Chau SL, Pang JC, Kwan JS, Busson P, Young LS, Yap LF, Tsao SW, To KF, Lo KW.

J Pathol. 2018 Apr;244(4):394-407. doi: 10.1002/path.5018. Epub 2018 Feb 16.


Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle.

Hau PM, Tsao SW.

Viruses. 2017 Nov 16;9(11). pii: E341. doi: 10.3390/v9110341. Review.


Loss of ΔNp63α promotes mitotic exit in epithelial cells.

Hau PM, Yip YL, Huen MSY, Tsao SW.

FEBS Lett. 2017 Jun;591(11):1624. doi: 10.1002/1873-3468.12674. No abstract available.


Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations.

Li YY, Chung GT, Lui VW, To KF, Ma BB, Chow C, Woo JK, Yip KY, Seo J, Hui EP, Mak MK, Rusan M, Chau NG, Or YY, Law MH, Law PP, Liu ZW, Ngan HL, Hau PM, Verhoeft KR, Poon PH, Yoo SK, Shin JY, Lee SD, Lun SW, Jia L, Chan AW, Chan JY, Lai PB, Fung CY, Hung ST, Wang L, Chang AM, Chiosea SI, Hedberg ML, Tsao SW, van Hasselt AC, Chan AT, Grandis JR, Hammerman PS, Lo KW.

Nat Commun. 2017 Jan 18;8:14121. doi: 10.1038/ncomms14121.


Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells.

Lo AK, Dawson CW, Young LS, Ko CW, Hau PM, Lo KW.

J Pathol. 2015 Oct;237(2):238-48. doi: 10.1002/path.4575. Epub 2015 Aug 3.


Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage.

Yang J, Deng W, Hau PM, Liu J, Lau VM, Cheung AL, Huen MS, Tsao SW.

Lab Invest. 2015 Aug;95(8):937-50. doi: 10.1038/labinvest.2015.69. Epub 2015 Jun 1.


Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells.

Hau PM, Deng W, Jia L, Yang J, Tsurumi T, Chiang AK, Huen MS, Tsao SW.

J Virol. 2015 Jan;89(1):652-68. doi: 10.1128/JVI.01437-14. Epub 2014 Oct 29.


p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells.

Deng W, Zhou Y, Tiwari AF, Su H, Yang J, Zhu D, Lau VM, Hau PM, Yip YL, Cheung AL, Guan XY, Tsao SW.

Int J Cancer. 2015 Mar 15;136(6):1361-70. doi: 10.1002/ijc.29114. Epub 2014 Aug 7.


Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study.

Yip YL, Pang PS, Deng W, Tsang CM, Zeng M, Hau PM, Man C, Jin Y, Yuen AP, Tsao SW.

PLoS One. 2013 Oct 22;8(10):e78395. doi: 10.1371/journal.pone.0078395. eCollection 2013.


Enhanced IL-6/IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells.

Zhang G, Tsang CM, Deng W, Yip YL, Lui VW, Wong SC, Cheung AL, Hau PM, Zeng M, Lung ML, Chen H, Lo KW, Takada K, Tsao SW.

PLoS One. 2013 May 1;8(5):e62284. doi: 10.1371/journal.pone.0062284. Print 2013.


Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells.

Tsang CM, Yip YL, Lo KW, Deng W, To KF, Hau PM, Lau VM, Takada K, Lui VW, Lung ML, Chen H, Zeng M, Middeldorp JM, Cheung AL, Tsao SW.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):E3473-82. doi: 10.1073/pnas.1202637109. Epub 2012 Nov 16.


Epstein-Barr virus-encoded latent membrane protein 1 impairs G2 checkpoint in human nasopharyngeal epithelial cells through defective Chk1 activation.

Deng W, Pang PS, Tsang CM, Hau PM, Yip YL, Cheung AL, Tsao SW.

PLoS One. 2012;7(6):e39095. doi: 10.1371/journal.pone.0039095. Epub 2012 Jun 25.


Loss of ΔNp63α promotes mitotic exit in epithelial cells.

Hau PM, Yip YL, Huen MS, Tsao SW.

FEBS Lett. 2011 Sep 2;585(17):2720-6. doi: 10.1016/j.febslet.2011.07.030. Epub 2011 Aug 3. Erratum in: FEBS Lett. 2017 Jun;591(11):1624.


Id1 interacts and stabilizes the Epstein-Barr virus latent membrane protein 1 (LMP1) in nasopharyngeal epithelial cells.

Hau PM, Tsang CM, Yip YL, Huen MS, Tsao SW.

PLoS One. 2011;6(6):e21176. doi: 10.1371/journal.pone.0021176. Epub 2011 Jun 20.


The requirement of p53 for maintaining chromosomal stability during tetraploidization.

Ho CC, Hau PM, Marxer M, Poon RY.

Oncotarget. 2010 Nov;1(7):583-95.


Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: regulation of infection and phenotypic characterization.

Tsang CM, Zhang G, Seto E, Takada K, Deng W, Yip YL, Man C, Hau PM, Chen H, Cao Y, Lo KW, Middeldorp JM, Cheung AL, Tsao SW.

Int J Cancer. 2010 Oct 1;127(7):1570-83. doi: 10.1002/ijc.25173.


Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells.

Tsang CM, Lau EP, Di K, Cheung PY, Hau PM, Ching YP, Wong YC, Cheung AL, Wan TS, Tong Y, Tsao SW, Feng Y.

Int J Mol Med. 2009 Jul;24(1):131-8.


The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint.

Chan YW, On KF, Chan WM, Wong W, Siu HO, Hau PM, Poon RY.

J Biol Chem. 2008 Jun 6;283(23):15716-23. doi: 10.1074/jbc.M800629200. Epub 2008 Apr 9.


Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells.

Hau PM, Siu WY, Wong N, Lai PB, Poon RY.

FEBS Lett. 2006 Aug 21;580(19):4727-36. Epub 2006 Jul 28.

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