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Items: 1 to 50 of 80

1.

Bone morphogenetic protein signaling in inflammation.

Wu DH, Hatzopoulos AK.

Exp Biol Med (Maywood). 2019 Feb;244(2):147-156. doi: 10.1177/1535370219828694. Epub 2019 Feb 7.

PMID:
30732465
2.

TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis.

Traverse JH, Henry TD, Pepine CJ, Willerson JT, Chugh A, Yang PC, Zhao DXM, Ellis SG, Forder JR, Perin EC, Penn MS, Hatzopoulos AK, Chambers JC, Baran KW, Raveendran G, Gee AP, Taylor DA, Moyé L, Ebert RF, Simari RD.

Circ Res. 2018 Feb 2;122(3):479-488. doi: 10.1161/CIRCRESAHA.117.311466. Epub 2017 Dec 5.

3.

The Vascular Wall: a Plastic Hub of Activity in Cardiovascular Homeostasis and Disease.

Awgulewitsch CP, Trinh LT, Hatzopoulos AK.

Curr Cardiol Rep. 2017 Jun;19(6):51. doi: 10.1007/s11886-017-0861-y. Review.

PMID:
28432663
4.

Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives.

Daily K, Ho Sui SJ, Schriml LM, Dexheimer PJ, Salomonis N, Schroll R, Bush S, Keddache M, Mayhew C, Lotia S, Perumal TM, Dang K, Pantano L, Pico AR, Grassman E, Nordling D, Hide W, Hatzopoulos AK, Malik P, Cancelas JA, Lutzko C, Aronow BJ, Omberg L.

Sci Data. 2017 Mar 28;4:170030. doi: 10.1038/sdata.2017.30.

5.

Instructive Role of the Microenvironment in Preventing Renal Fibrosis.

Matsumoto K, Xavier S, Chen J, Kida Y, Lipphardt M, Ikeda R, Gevertz A, Caviris M, Hatzopoulos AK, Kalajzic I, Dutton J, Ratliff BB, Zhao H, Darzynkiewicz Z, Rose-John S, Goligorsky MS.

Stem Cells Transl Med. 2017 Mar;6(3):992-1005. doi: 10.5966/sctm.2016-0095. Epub 2016 Oct 5.

6.

Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2.

Bylund JB, Trinh LT, Awgulewitsch CP, Paik DT, Jetter C, Jha R, Zhang J, Nolan K, Xu C, Thompson TB, Kamp TJ, Hatzopoulos AK.

Stem Cells Dev. 2017 May 1;26(9):678-693. doi: 10.1089/scd.2016.0226. Epub 2017 Mar 20.

7.

Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium.

Salomonis N, Dexheimer PJ, Omberg L, Schroll R, Bush S, Huo J, Schriml L, Ho Sui S, Keddache M, Mayhew C, Shanmukhappa SK, Wells J, Daily K, Hubler S, Wang Y, Zambidis E, Margolin A, Hide W, Hatzopoulos AK, Malik P, Cancelas JA, Aronow BJ, Lutzko C.

Stem Cell Reports. 2016 Jul 12;7(1):110-25. doi: 10.1016/j.stemcr.2016.05.006. Epub 2016 Jun 9.

8.

BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction.

Sanders LN, Schoenhard JA, Saleh MA, Mukherjee A, Ryzhov S, McMaster WG Jr, Nolan K, Gumina RJ, Thompson TB, Magnuson MA, Harrison DG, Hatzopoulos AK.

Circ Res. 2016 Jul 22;119(3):434-49. doi: 10.1161/CIRCRESAHA.116.308700. Epub 2016 Jun 9.

9.

Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies.

Gyöngyösi M, Wojakowski W, Navarese EP, Moye LÀ; ACCRUE Investigators.

Circ Res. 2016 Apr 15;118(8):1254-63. doi: 10.1161/CIRCRESAHA.115.307347.

10.

Differentiation of Atrial Cardiomyocytes from Pluripotent Stem Cells Using the BMP Antagonist Grem2.

Bylund JB, Hatzopoulos AK.

J Vis Exp. 2016 Mar 10;(109). doi: 10.3791/53919.

11.

Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension.

Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG.

Hypertension. 2016 Feb;67(2):461-8. doi: 10.1161/HYPERTENSIONAHA.115.06123. Epub 2015 Dec 22.

12.

Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis.

Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK.

Circ Res. 2015 Oct 9;117(9):804-16. doi: 10.1161/CIRCRESAHA.115.306886. Epub 2015 Sep 3.

13.

Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis.

Fioret BA, Heimfeld JD, Paik DT, Hatzopoulos AK.

Cell Rep. 2014 Jul 10;8(1):229-41. doi: 10.1016/j.celrep.2014.06.004. Epub 2014 Jul 4.

14.

Endothelial progenitor cells augment collateralization and hemodynamic rescue in a model of chronic cerebral ischemia.

Hecht N, Schneider UC, Czabanka M, Vinci M, Hatzopoulos AK, Vajkoczy P, Woitzik J.

J Cereb Blood Flow Metab. 2014 Aug;34(8):1297-305. doi: 10.1038/jcbfm.2014.78. Epub 2014 Apr 30.

15.

Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway.

Tanwar V, Bylund JB, Hu J, Yan J, Walthall JM, Mukherjee A, Heaton WH, Wang WD, Potet F, Rai M, Kupershmidt S, Knapik EW, Hatzopoulos AK.

Stem Cells. 2014 Jul;32(7):1774-88. doi: 10.1002/stem.1703.

16.

SDF-1 fused to a fractalkine stalk and a GPI anchor enables functional neovascularization.

Stachel G, Trenkwalder T, Götz F, El Aouni C, Muenchmeier N, Pfosser A, Nussbaum C, Sperandio M, Hatzopoulos AK, Hinkel R, Nelson PJ, Kupatt C.

Stem Cells. 2013 Sep;31(9):1795-805. doi: 10.1002/stem.1439.

17.

Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm.

Müller II, Melville DB, Tanwar V, Rybski WM, Mukherjee A, Shoemaker MB, Wang WD, Schoenhard JA, Roden DM, Darbar D, Knapik EW, Hatzopoulos AK.

Dis Model Mech. 2013 Mar;6(2):332-41. doi: 10.1242/dmm.010488. Epub 2012 Dec 7.

18.

Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial.

Traverse JH, Henry TD, Pepine CJ, Willerson JT, Zhao DX, Ellis SG, Forder JR, Anderson RD, Hatzopoulos AK, Penn MS, Perin EC, Chambers J, Baran KW, Raveendran G, Lambert C, Lerman A, Simon DI, Vaughan DE, Lai D, Gee AP, Taylor DA, Cogle CR, Thomas JD, Olson RE, Bowman S, Francescon J, Geither C, Handberg E, Kappenman C, Westbrook L, Piller LB, Simpson LM, Baraniuk S, Loghin C, Aguilar D, Richman S, Zierold C, Spoon DB, Bettencourt J, Sayre SL, Vojvodic RW, Skarlatos SI, Gordon DJ, Ebert RF, Kwak M, Moyé LA, Simari RD; Cardiovascular Cell Therapy Research Network (CCTRN).

JAMA. 2012 Dec 12;308(22):2380-9. Erratum in: JAMA. 2013 Jan 23;309(4):343. JAMA. 2015 Jul 7;314(1):86.

19.

Recent Progress on Chemical Biology of Pluripotent Stem Cell Self-renewal, Reprogramming and Cardiomyogenesis.

Hao J, Sawyer DB, Hatzopoulos AK, Hong CC.

Recent Pat Regen Med. 2011 Sep;1(3):263-274.

20.

Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element.

Keilani S, Chandwani S, Dolios G, Bogush A, Beck H, Hatzopoulos AK, Rao GN, Thomas EA, Wang R, Ehrlich ME.

J Neurosci. 2012 May 16;32(20):6808-18. doi: 10.1523/JNEUROSCI.5448-11.2012.

21.

Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: the FOCUS-CCTRN trial.

Perin EC, Willerson JT, Pepine CJ, Henry TD, Ellis SG, Zhao DX, Silva GV, Lai D, Thomas JD, Kronenberg MW, Martin AD, Anderson RD, Traverse JH, Penn MS, Anwaruddin S, Hatzopoulos AK, Gee AP, Taylor DA, Cogle CR, Smith D, Westbrook L, Chen J, Handberg E, Olson RE, Geither C, Bowman S, Francescon J, Baraniuk S, Piller LB, Simpson LM, Loghin C, Aguilar D, Richman S, Zierold C, Bettencourt J, Sayre SL, Vojvodic RW, Skarlatos SI, Gordon DJ, Ebert RF, Kwak M, Moyé LA, Simari RD; Cardiovascular Cell Therapy Research Network (CCTRN).

JAMA. 2012 Apr 25;307(16):1717-26. doi: 10.1001/jama.2012.418. Epub 2012 Mar 24. Erratum in: JAMA. 2015 Jul 7;314(1):86.

22.

Combinatorial polymer electrospun matrices promote physiologically-relevant cardiomyogenic stem cell differentiation.

Gupta MK, Walthall JM, Venkataraman R, Crowder SW, Jung DK, Yu SS, Feaster TK, Wang X, Giorgio TD, Hong CC, Baudenbacher FJ, Hatzopoulos AK, Sung HJ.

PLoS One. 2011;6(12):e28935. doi: 10.1371/journal.pone.0028935. Epub 2011 Dec 27.

23.

Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling.

Ni TT, Rellinger EJ, Mukherjee A, Xie S, Stephens L, Thorne CA, Kim K, Hu J, Lee E, Marnett L, Hatzopoulos AK, Zhong TP.

Chem Biol. 2011 Dec 23;18(12):1658-68. doi: 10.1016/j.chembiol.2011.09.015.

24.

Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial.

Traverse JH, Henry TD, Ellis SG, Pepine CJ, Willerson JT, Zhao DX, Forder JR, Byrne BJ, Hatzopoulos AK, Penn MS, Perin EC, Baran KW, Chambers J, Lambert C, Raveendran G, Simon DI, Vaughan DE, Simpson LM, Gee AP, Taylor DA, Cogle CR, Thomas JD, Silva GV, Jorgenson BC, Olson RE, Bowman S, Francescon J, Geither C, Handberg E, Smith DX, Baraniuk S, Piller LB, Loghin C, Aguilar D, Richman S, Zierold C, Bettencourt J, Sayre SL, Vojvodic RW, Skarlatos SI, Gordon DJ, Ebert RF, Kwak M, Moyé LA, Simari RD; Cardiovascular Cell Therapy ResearchNetwork.

JAMA. 2011 Nov 16;306(19):2110-9. doi: 10.1001/jama.2011.1670. Epub 2011 Nov 14.

25.

Programmatic change: lung disease research in the era of induced pluripotency.

Ikonomou L, Hemnes AR, Bilousova G, Hamid R, Loyd JE, Hatzopoulos AK, Kotton DN, Majka SM, Austin ED.

Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L830-5. doi: 10.1152/ajplung.00255.2011. Epub 2011 Oct 7.

26.

Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population.

Wang WD, Melville DB, Montero-Balaguer M, Hatzopoulos AK, Knapik EW.

Dev Biol. 2011 Dec 1;360(1):173-85. doi: 10.1016/j.ydbio.2011.09.019. Epub 2011 Sep 22.

27.

Continuous antagonism by Dkk1 counter activates canonical Wnt signaling and promotes cardiomyocyte differentiation of embryonic stem cells.

Rai M, Walthall JM, Hu J, Hatzopoulos AK.

Stem Cells Dev. 2012 Jan;21(1):54-66. doi: 10.1089/scd.2011.0326. Epub 2011 Oct 18.

28.

The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis.

Melville DB, Montero-Balaguer M, Levic DS, Bradley K, Smith JR, Hatzopoulos AK, Knapik EW.

Dis Model Mech. 2011 Nov;4(6):763-76. doi: 10.1242/dmm.007625. Epub 2011 Jul 4.

29.

Preconditioned endothelial progenitor cells reduce formation of melanoma metastases through SPARC-driven cell-cell interactions and endocytosis.

Defresne F, Bouzin C, Grandjean M, Dieu M, Raes M, Hatzopoulos AK, Kupatt C, Feron O.

Cancer Res. 2011 Jul 15;71(14):4748-57. doi: 10.1158/0008-5472.CAN-10-2449. Epub 2011 May 26.

30.

Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation.

Wu B, Wang Y, Lui W, Langworthy M, Tompkins KL, Hatzopoulos AK, Baldwin HS, Zhou B.

Circ Res. 2011 Jul 8;109(2):183-92. doi: 10.1161/CIRCRESAHA.111.245035. Epub 2011 May 19.

31.

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition.

Aisagbonhi O, Rai M, Ryzhov S, Atria N, Feoktistov I, Hatzopoulos AK.

Dis Model Mech. 2011 Jul;4(4):469-83. doi: 10.1242/dmm.006510. Epub 2011 Feb 14.

32.

Neuregulin-1β regulation of embryonic endothelial progenitor cell survival.

Safa RN, Peng XY, Pentassuglia L, Lim CC, Lamparter M, Silverstein C, Walker J, Chen B, Geisberg C, Hatzopoulos AK, Sawyer DB.

Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1311-9. doi: 10.1152/ajpheart.01104.2009. Epub 2011 Jan 14.

33.

Time is like a clock in my heart: implications for stem cell delivery after myocardial infarction.

Schoenhard JA, Hatzopoulos AK.

Cardiology. 2010;117(2):158-60. doi: 10.1159/000321396. Epub 2010 Oct 30. No abstract available.

34.

LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2 to 3 weeks after acute myocardial infarction.

Traverse JH, Henry TD, Vaughan DE, Ellis SG, Pepine CJ, Willerson JT, Zhao DX, Simpson LM, Penn MS, Byrne BJ, Perin EC, Gee AP, Hatzopoulos AK, McKenna DH, Forder JR, Taylor DA, Cogle CR, Baraniuk S, Olson RE, Jorgenson BC, Sayre SL, Vojvodic RW, Gordon DJ, Skarlatos SI, Moyè LA, Simari RD; Cardiovascular Cell Therapy Research Network.

Tex Heart Inst J. 2010;37(4):412-20.

35.

Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases.

Hammon M, Herrmann M, Bleiziffer O, Pryymachuk G, Andreoli L, Munoz LE, Amann KU, Mondini M, Gariglio M, Airó P, Schellerer VS, Hatzopoulos AK, Horch RE, Kneser U, Stürzl M, Naschberger E.

J Cell Mol Med. 2011 Jul;15(7):1582-92. doi: 10.1111/j.1582-4934.2010.01146.x.

36.

Intramyocardial injection of autologous bone marrow mononuclear cells for patients with chronic ischemic heart disease and left ventricular dysfunction (First Mononuclear Cells injected in the US [FOCUS]): Rationale and design.

Willerson JT, Perin EC, Ellis SG, Pepine CJ, Henry TD, Zhao DX, Lai D, Penn MS, Byrne BJ, Silva G, Gee A, Traverse JH, Hatzopoulos AK, Forder JR, Martin D, Kronenberg M, Taylor DA, Cogle CR, Baraniuk S, Westbrook L, Sayre SL, Vojvodic RW, Gordon DJ, Skarlatos SI, Moyé LA, Simari RD; Cardiovascular Cell Therapy Research Network (CCTRN).

Am Heart J. 2010 Aug;160(2):215-23. doi: 10.1016/j.ahj.2010.03.029.

37.

Thymosin beta4: a key factor for protective effects of eEPCs in acute and chronic ischemia.

Hinkel R, Bock-Marquette I, Hatzopoulos AK, Kupatt C.

Ann N Y Acad Sci. 2010 Apr;1194:105-11. doi: 10.1111/j.1749-6632.2010.05489.x. Erratum in: Ann N Y Acad Sci. 2010 Sep;1205(1):284. Hazopoulos, Antonis K [corrected to Hatzopoulos, Antonis K].

38.

Endothelial progenitors encapsulated in bioartificial niches are insulated from systemic cytotoxicity and are angiogenesis competent.

Ratliff BB, Ghaly T, Brudnicki P, Yasuda K, Rajdev M, Bank M, Mares J, Hatzopoulos AK, Goligorsky MS.

Am J Physiol Renal Physiol. 2010 Jul;299(1):F178-86. doi: 10.1152/ajprenal.00102.2010. Epub 2010 Apr 21.

39.

Adriamycin nephropathy: a failure of endothelial progenitor cell-induced repair.

Yasuda K, Park HC, Ratliff B, Addabbo F, Hatzopoulos AK, Chander P, Goligorsky MS.

Am J Pathol. 2010 Apr;176(4):1685-95. doi: 10.2353/ajpath.2010.091071. Epub 2010 Feb 18.

40.

Stem cell therapy: pieces of the puzzle.

Schoenhard JA, Hatzopoulos AK.

J Cardiovasc Transl Res. 2010 Feb;3(1):49-60. doi: 10.1007/s12265-009-9148-z. Epub 2009 Nov 19. Review.

41.

NF kappaB activation in embryonic endothelial progenitor cells enhances neovascularization via PSGL-1 mediated recruitment: novel role for LL37.

Pfosser A, El-Aouni C, Pfisterer I, Dietz M, Globisch F, Stachel G, Trenkwalder T, Pinkenburg O, Horstkotte J, Hinkel R, Sperandio M, Hatzopoulos AK, Boekstegers P, Bals R, Kupatt C.

Stem Cells. 2010 Feb;28(2):376-85. doi: 10.1002/stem.280.

42.

The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation.

Schulz H, Kolde R, Adler P, Aksoy I, Anastassiadis K, Bader M, Billon N, Boeuf H, Bourillot PY, Buchholz F, Dani C, Doss MX, Forrester L, Gitton M, Henrique D, Hescheler J, Himmelbauer H, Hübner N, Karantzali E, Kretsovali A, Lubitz S, Pradier L, Rai M, Reimand J, Rolletschek A, Sachinidis A, Savatier P, Stewart F, Storm MP, Trouillas M, Vilo J, Welham MJ, Winkler J, Wobus AM, Hatzopoulos AK; Functional Genomics in Embryonic Stem Cells Consortium.

PLoS One. 2009 Sep 3;4(9):e6804. doi: 10.1371/journal.pone.0006804.

43.

Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarction.

Traverse JH, Henry TD, Vaughan DE, Ellis SG, Pepine CJ, Willerson JT, Zhao DX, Piller LB, Penn MS, Byrne BJ, Perin EC, Gee AP, Hatzopoulos AK, McKenna DH, Forder JR, Taylor DA, Cogle CR, Olson RE, Jorgenson BC, Sayre SL, Vojvodic RW, Gordon DJ, Skarlatos SI, Moye' LA, Simari RD; Cardiovascular Cell Therapy Research Network (CCTRN).

Am Heart J. 2009 Sep;158(3):356-63. doi: 10.1016/j.ahj.2009.06.009. Epub 2009 Jul 23. Erratum in: Am Heart J. 2009 Dec;158(6):1045. Vaughn, Douglas E [corrected to Vaughan, Douglas E].

44.

Stem cell therapy for cardiac repair: benefits and barriers.

Joggerst SJ, Hatzopoulos AK.

Expert Rev Mol Med. 2009 Jul 8;11:e20. doi: 10.1017/S1462399409001124. Review.

45.

Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease.

Boudoulas KD, Hatzopoulos AK.

Dis Model Mech. 2009 Jul-Aug;2(7-8):344-58. doi: 10.1242/dmm.000240. Review.

46.

T17b murine embryonal endothelial progenitor cells can be induced towards both proliferation and differentiation in a fibrin matrix.

Bleiziffer O, Horch RE, Hammon M, Arkudas A, Naschberger E, Rath S, Pryymachuk G, Beier JP, Hatzopoulos AK, Stürzl M, Kneser U.

J Cell Mol Med. 2009 May;13(5):926-35. doi: 10.1111/j.1582-4934.2008.00527.x.

47.

Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.

Hao J, Daleo MA, Murphy CK, Yu PB, Ho JN, Hu J, Peterson RT, Hatzopoulos AK, Hong CC.

PLoS One. 2008 Aug 6;3(8):e2904. doi: 10.1371/journal.pone.0002904.

48.

Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke.

Beck H, Semisch M, Culmsee C, Plesnila N, Hatzopoulos AK.

Am J Pathol. 2008 Jul;173(1):77-92. doi: 10.2353/ajpath.2008.070648. Epub 2008 Jun 13.

49.

Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection.

Hinkel R, El-Aouni C, Olson T, Horstkotte J, Mayer S, Müller S, Willhauck M, Spitzweg C, Gildehaus FJ, Münzing W, Hannappel E, Bock-Marquette I, DiMaio JM, Hatzopoulos AK, Boekstegers P, Kupatt C.

Circulation. 2008 Apr 29;117(17):2232-40. doi: 10.1161/CIRCULATIONAHA.107.758904. Epub 2008 Apr 21.

50.

Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis.

Karantzali E, Schulz H, Hummel O, Hubner N, Hatzopoulos A, Kretsovali A.

Genome Biol. 2008 Apr 4;9(4):R65. doi: 10.1186/gb-2008-9-4-r65.

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