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Items: 1 to 50 of 99

1.

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity.

Ristau J, van Hoef V, Peuget S, Zhu J, Guan BJ, Liang S, Hatzoglou M, Topisirovic I, Selivanova G, Larsson O.

Cell Death Dis. 2019 Nov 7;10(11):845. doi: 10.1038/s41419-019-2074-3.

2.

Author Correction: Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK.

Danielpour D, Gao Z, Zmina PM, Shankar E, Shultes BC, Jobava R, Welford SM, Hatzoglou M.

Sci Rep. 2019 Oct 10;9(1):14826. doi: 10.1038/s41598-019-51007-0.

3.

Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK.

Danielpour D, Gao Z, Zmina PM, Shankar E, Shultes BC, Jobava R, Welford SM, Hatzoglou M.

Sci Rep. 2019 Aug 8;9(1):11541. doi: 10.1038/s41598-019-47573-y. Erratum in: Sci Rep. 2019 Oct 10;9(1):14826.

4.

DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.

Zagore LL, Sweet TJ, Hannigan MM, Weyn-Vanhentenryck SM, Jobava R, Hatzoglou M, Zhang C, Licatalosi DD.

Cell Rep. 2018 Oct 30;25(5):1225-1240.e6. doi: 10.1016/j.celrep.2018.10.012.

5.

Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.

Krishnamoorthy J, Tenkerian C, Gupta J, Ghaddar N, Wang S, Darini C, Staschke KA, Ghosh A, Gandin V, Topisirovic I, Kristof AS, Hatzoglou M, Simos G, Koromilas AE.

Cell Death Dis. 2018 Feb 15;9(3):254. doi: 10.1038/s41419-018-0326-2.

6.

Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype.

Ko CW, Counihan D, Wu J, Hatzoglou M, Puchowicz MA, Croniger CM.

J Biol Chem. 2018 Mar 2;293(9):3399-3409. doi: 10.1074/jbc.M117.819136. Epub 2018 Jan 9.

7.

A Unique ISR Program Determines Cellular Responses to Chronic Stress.

Guan BJ, van Hoef V, Jobava R, Elroy-Stein O, Valasek LS, Cargnello M, Gao XH, Krokowski D, Merrick WC, Kimball SR, Komar AA, Koromilas AE, Wynshaw-Boris A, Topisirovic I, Larsson O, Hatzoglou M.

Mol Cell. 2017 Dec 7;68(5):885-900.e6. doi: 10.1016/j.molcel.2017.11.007.

8.

GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells.

Krokowski D, Guan BJ, Wu J, Zheng Y, Pattabiraman PP, Jobava R, Gao XH, Di XJ, Snider MD, Mu TW, Liu S, Storrie B, Pearlman E, Blumental-Perry A, Hatzoglou M.

Cell Rep. 2017 Dec 5;21(10):2895-2910. doi: 10.1016/j.celrep.2017.11.027.

9.

Hyperammonemia and proteostasis in cirrhosis.

Dasarathy S, Hatzoglou M.

Curr Opin Clin Nutr Metab Care. 2018 Jan;21(1):30-36. doi: 10.1097/MCO.0000000000000426. Review.

10.

The uL10 protein, a component of the ribosomal P-stalk, is released from the ribosome in nucleolar stress.

Deryło K, Michalec-Wawiórka B, Krokowski D, Wawiórka L, Hatzoglou M, Tchórzewski M.

Biochim Biophys Acta Mol Cell Res. 2018 Jan;1865(1):34-47. doi: 10.1016/j.bbamcr.2017.10.002. Epub 2017 Oct 3.

11.

eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.

Choi WG, Han J, Kim JH, Kim MJ, Park JW, Song B, Cha HJ, Choi HS, Chung HT, Lee IK, Park TS, Hatzoglou M, Choi HS, Yoo HJ, Kaufman RJ, Back SH.

Nutr Metab (Lond). 2017 Aug 1;14:48. doi: 10.1186/s12986-017-0202-6. eCollection 2017.

12.

Coordinated transcriptional control of adipocyte triglyceride lipase (Atgl) by transcription factors Sp1 and peroxisome proliferator-activated receptor γ (PPARγ) during adipocyte differentiation.

Roy D, Farabaugh KT, Wu J, Charrier A, Smas C, Hatzoglou M, Thirumurugan K, Buchner DA.

J Biol Chem. 2017 Sep 8;292(36):14827-14835. doi: 10.1074/jbc.M117.783043. Epub 2017 Jul 18.

13.

Hydrogen sulfide modulates eukaryotic translation initiation factor 2α (eIF2α) phosphorylation status in the integrated stress-response pathway.

Yadav V, Gao XH, Willard B, Hatzoglou M, Banerjee R, Kabil O.

J Biol Chem. 2017 Aug 11;292(32):13143-13153. doi: 10.1074/jbc.M117.778654. Epub 2017 Jun 21.

14.

Protein Kinase R Mediates the Inflammatory Response Induced by Hyperosmotic Stress.

Farabaugh KT, Majumder M, Guan BJ, Jobava R, Wu J, Krokowski D, Gao XH, Schuster A, Longworth M, Chan ED, Bianchi M, Dey M, Koromilas AE, Ramakrishnan P, Hatzoglou M.

Mol Cell Biol. 2017 Feb 1;37(4). pii: e00521-16. doi: 10.1128/MCB.00521-16. Print 2017 Feb 15.

15.

Characterization of 5-(2- 18F-fluoroethoxy)-L-tryptophan for PET imaging of the pancreas.

Abbas A, Beamish C, McGirr R, Demarco J, Cockburn N, Krokowski D, Lee TY, Kovacs M, Hatzoglou M, Dhanvantari S.

Version 2. F1000Res. 2016 Jul 27 [revised 2016 Jan 1];5:1851. eCollection 2016.

16.

ER stress inhibitor attenuates hearing loss and hair cell death in Cdh23erl/erl mutant mice.

Hu J, Li B, Apisa L, Yu H, Entenman S, Xu M, Stepanyan R, Guan BJ, Müller U, Hatzoglou M, Zheng QY.

Cell Death Dis. 2016 Nov 24;7(11):e2485. doi: 10.1038/cddis.2016.386.

17.

Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway.

Ziosi M, Di Meo I, Kleiner G, Gao XH, Barca E, Sanchez-Quintero MJ, Tadesse S, Jiang H, Qiao C, Rodenburg RJ, Scalais E, Schuelke M, Willard B, Hatzoglou M, Tiranti V, Quinzii CM.

EMBO Mol Med. 2017 Jan;9(1):96-111. doi: 10.15252/emmm.201606356.

18.

The eIF2A knockout mouse.

Golovko A, Kojukhov A, Guan BJ, Morpurgo B, Merrick WC, Mazumder B, Hatzoglou M, Komar AA.

Cell Cycle. 2016 Nov 16;15(22):3115-3120. Epub 2016 Sep 29.

19.

Metabolic adaptation of skeletal muscle to hyperammonemia drives the beneficial effects of l-leucine in cirrhosis.

Davuluri G, Krokowski D, Guan BJ, Kumar A, Thapaliya S, Singh D, Hatzoglou M, Dasarathy S.

J Hepatol. 2016 Nov;65(5):929-937. doi: 10.1016/j.jhep.2016.06.004. Epub 2016 Jun 16.

20.

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.

Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, Conlon RA, Markowitz S, Kinzler KW, Velculescu VE, Brunengraber H, Willis JE, LaFramboise T, Hatzoglou M, Zhang GF, Vogelstein B, Wang Z.

Nat Commun. 2016 Jun 20;7:11971. doi: 10.1038/ncomms11971.

21.

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation.

Bott AJ, Peng IC, Fan Y, Faubert B, Zhao L, Li J, Neidler S, Sun Y, Jaber N, Krokowski D, Lu W, Pan JA, Powers S, Rabinowitz J, Hatzoglou M, Murphy DJ, Jones R, Wu S, Girnun G, Zong WX.

Cell Metab. 2015 Dec 1;22(6):1068-77. doi: 10.1016/j.cmet.2015.09.025. Epub 2015 Oct 23.

22.

Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response.

Gao XH, Krokowski D, Guan BJ, Bederman I, Majumder M, Parisien M, Diatchenko L, Kabil O, Willard B, Banerjee R, Wang B, Bebek G, Evans CR, Fox PL, Gerson SL, Hoppel CL, Liu M, Arvan P, Hatzoglou M.

Elife. 2015 Nov 23;4:e10067. doi: 10.7554/eLife.10067.

23.

Exploring Internal Ribosome Entry Sites as Therapeutic Targets.

Komar AA, Hatzoglou M.

Front Oncol. 2015 Oct 20;5:233. doi: 10.3389/fonc.2015.00233. eCollection 2015. Review.

24.

The Many Virtues of tRNA-derived Stress-induced RNAs (tiRNAs): Discovering Novel Mechanisms of Stress Response and Effect on Human Health.

Saikia M, Hatzoglou M.

J Biol Chem. 2015 Dec 11;290(50):29761-8. doi: 10.1074/jbc.R115.694661. Epub 2015 Oct 13. Review.

25.

Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs.

Hsu KS, Guan BJ, Cheng X, Guan D, Lam M, Hatzoglou M, Kao HY.

Cell Death Differ. 2016 Mar;23(3):469-83. doi: 10.1038/cdd.2015.114. Epub 2015 Sep 18.

26.

DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer.

Merry CR, Forrest ME, Sabers JN, Beard L, Gao XH, Hatzoglou M, Jackson MW, Wang Z, Markowitz SD, Khalil AM.

Hum Mol Genet. 2015 Nov 1;24(21):6240-53. doi: 10.1093/hmg/ddv343. Epub 2015 Aug 25.

27.

L-type Calcium Channel Blockers Enhance Trafficking and Function of Epilepsy-associated α1(D219N) Subunits of GABA(A) Receptors.

Han DY, Guan BJ, Wang YJ, Hatzoglou M, Mu TW.

ACS Chem Biol. 2015 Sep 18;10(9):2135-48. doi: 10.1021/acschembio.5b00479. Epub 2015 Jul 21.

PMID:
26168288
28.

mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress.

Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, Staschke KA, Kristof AS, Wang S, Hatzoglou M, Koromilas AE.

Mol Cancer Res. 2015 Oct;13(10):1377-88. doi: 10.1158/1541-7786.MCR-15-0184-T. Epub 2015 Jun 30.

29.

Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity.

Krokowski D, Jobava R, Guan BJ, Farabaugh K, Wu J, Majumder M, Bianchi MG, Snider MD, Bussolati O, Hatzoglou M.

J Biol Chem. 2015 Jul 17;290(29):17822-37. doi: 10.1074/jbc.M114.636217. Epub 2015 Jun 3.

30.

Chromosome-associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters.

Schuster AT, Homer CR, Kemp JR, Nickerson KP, Deutschman E, Kim Y, West G, Sadler T, Stylianou E, Krokowski D, Hatzoglou M, de la Motte C, Rubin BP, Fiocchi C, McDonald C, Longworth MS.

Gastroenterology. 2015 Jun;148(7):1405-1416.e3. doi: 10.1053/j.gastro.2015.02.013. Epub 2015 Feb 18.

31.

Regulation of Interferon-Stimulated Gene BST2 by a lncRNA Transcribed from a Shared Bidirectional Promoter.

Kambara H, Gunawardane L, Zebrowski E, Kostadinova L, Jobava R, Krokowski D, Hatzoglou M, Anthony DD, Valadkhan S.

Front Immunol. 2015 Jan 30;5:676. doi: 10.3389/fimmu.2014.00676. eCollection 2014.

32.

Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human.

Majumder M, Mitchell D, Merkulov S, Wu J, Guan BJ, Snider MD, Krokowski D, Yee VC, Hatzoglou M.

Int J Biochem Cell Biol. 2015 Feb;59:135-41. doi: 10.1016/j.biocel.2014.12.004. Epub 2014 Dec 22.

33.

It's all about balance: cellular responses to nutrients and development of disease.

Hatzoglou M, Snider MD, Maruvada P.

Adv Nutr. 2014 Sep;5(5):558-60.

34.

Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression.

Balkrishna S, Bröer A, Welford SM, Hatzoglou M, Bröer S.

Cell Physiol Biochem. 2014;33(5):1591-606. doi: 10.1159/000358722. Epub 2014 May 16.

35.

Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress.

Saikia M, Jobava R, Parisien M, Putnam A, Krokowski D, Gao XH, Guan BJ, Yuan Y, Jankowsky E, Feng Z, Hu GF, Pusztai-Carey M, Gorla M, Sepuri NB, Pan T, Hatzoglou M.

Mol Cell Biol. 2014 Jul;34(13):2450-63. doi: 10.1128/MCB.00136-14. Epub 2014 Apr 21.

36.

Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.

Guan BJ, Krokowski D, Majumder M, Schmotzer CL, Kimball SR, Merrick WC, Koromilas AE, Hatzoglou M.

J Biol Chem. 2014 May 2;289(18):12593-611. doi: 10.1074/jbc.M113.543215. Epub 2014 Mar 19.

37.

A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.

Krokowski D, Han J, Saikia M, Majumder M, Yuan CL, Guan BJ, Bevilacqua E, Bussolati O, Bröer S, Arvan P, Tchórzewski M, Snider MD, Puchowicz M, Croniger CM, Kimball SR, Pan T, Koromilas AE, Kaufman RJ, Hatzoglou M.

J Biol Chem. 2013 Jun 14;288(24):17202-13. doi: 10.1074/jbc.M113.466920. Epub 2013 May 3.

38.

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, Kaufman RJ.

Nat Cell Biol. 2013 May;15(5):481-90. doi: 10.1038/ncb2738. Epub 2013 Apr 28.

39.

HuR controls mitochondrial morphology through the regulation of BclxL translation.

Durie D, Hatzoglou M, Chakraborty P, Holcik M.

Translation (Austin). 2013 Apr 1;1(1). pii: e23980.

40.

Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress.

Saikia M, Krokowski D, Guan BJ, Ivanov P, Parisien M, Hu GF, Anderson P, Pan T, Hatzoglou M.

J Biol Chem. 2012 Dec 14;287(51):42708-25. doi: 10.1074/jbc.M112.371799. Epub 2012 Oct 19.

41.

Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response.

Dey S, Savant S, Teske BF, Hatzoglou M, Calkhoven CF, Wek RC.

J Biol Chem. 2012 Jun 22;287(26):21936-49. doi: 10.1074/jbc.M112.351783. Epub 2012 May 3.

42.

A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation.

Majumder M, Huang C, Snider MD, Komar AA, Tanaka J, Kaufman RJ, Krokowski D, Hatzoglou M.

Mol Cell Biol. 2012 Mar;32(5):992-1003. doi: 10.1128/MCB.06665-11. Epub 2012 Jan 3.

43.

Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway.

Mounir Z, Krishnamoorthy JL, Wang S, Papadopoulou B, Campbell S, Muller WJ, Hatzoglou M, Koromilas AE.

Sci Signal. 2011 Sep 27;4(192):ra62. doi: 10.1126/scisignal.2001630.

44.

Requirement of rRNA methylation for 80S ribosome assembly on a cohort of cellular internal ribosome entry sites.

Basu A, Das P, Chaudhuri S, Bevilacqua E, Andrews J, Barik S, Hatzoglou M, Komar AA, Mazumder B.

Mol Cell Biol. 2011 Nov;31(22):4482-99. doi: 10.1128/MCB.05804-11. Epub 2011 Sep 19.

45.

Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans.

Yuan Y, Cao P, Smith MA, Kramp K, Huang Y, Hisamoto N, Matsumoto K, Hatzoglou M, Jin H, Feng Z.

PLoS One. 2011;6(8):e22354. doi: 10.1371/journal.pone.0022354. Epub 2011 Aug 3.

46.

Characterization of hibernating ribosomes in mammalian cells.

Krokowski D, Gaccioli F, Majumder M, Mullins MR, Yuan CL, Papadopoulou B, Merrick WC, Komar AA, Taylor D, Hatzoglou M.

Cell Cycle. 2011 Aug 15;10(16):2691-702. Epub 2011 Aug 15.

47.

Function of phosphoenolpyruvate carboxykinase in mammary gland epithelial cells.

Hsieh CW, Huang C, Bederman I, Yang J, Beidelschies M, Hatzoglou M, Puchowicz M, Croniger CM.

J Lipid Res. 2011 Jul;52(7):1352-62. doi: 10.1194/jlr.M012666. Epub 2011 Apr 19.

48.

Cellular IRES-mediated translation: the war of ITAFs in pathophysiological states.

Komar AA, Hatzoglou M.

Cell Cycle. 2011 Jan 15;10(2):229-40. Epub 2011 Jan 15. Review.

49.

Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, Scheuner D, Kaufman RJ, Hatzoglou M, Koromilas AE.

Mol Biol Cell. 2010 Sep 15;21(18):3220-31. doi: 10.1091/mbc.E10-01-0023. Epub 2010 Jul 21.

50.

CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.

Zentner GE, Hurd EA, Schnetz MP, Handoko L, Wang C, Wang Z, Wei C, Tesar PJ, Hatzoglou M, Martin DM, Scacheri PC.

Hum Mol Genet. 2010 Sep 15;19(18):3491-501. doi: 10.1093/hmg/ddq265. Epub 2010 Jun 29.

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