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Flexibility in nucleic acid binding is central to APOBEC3H antiviral activity.

Bohn JA, DaSilva J, Kharytonchyk S, Mercedes M, Vosters J, Telesnitsky A, Hatziioannou T, Smith JL.

J Virol. 2019 Oct 2. pii: JVI.01275-19. doi: 10.1128/JVI.01275-19. [Epub ahead of print]


Derivation of simian tropic HIV-1 infectious clone reveals virus adaptation to a new host.

Schmidt F, Keele BF, Del Prete GQ, Voronin D, Fennessey CM, Soll S, Kane M, Raymond A, Gifford RJ, KewalRamani V, Lifson JD, Bieniasz PD, Hatziioannou T.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10504-10509. doi: 10.1073/pnas.1818059116. Epub 2019 May 2.


Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes.

O'Brien SP, Swanstrom AE, Pegu A, Ko SY, Immonen TT, Del Prete GQ, Fennessey CM, Gorman J, Foulds KE, Schmidt SD, Doria-Rose N, Williamson C, Hatziioannou T, Bieniasz PD, Li H, Shaw GM, Mascola JR, Koup RA, Kwong PD, Lifson JD, Roederer M, Keele BF.

PLoS Pathog. 2019 Apr 3;15(4):e1007632. doi: 10.1371/journal.ppat.1007632. eCollection 2019 Apr.


Short Communication: Ultrasensitive Immunoassay for Assessing Residual Simian-Tropic HIV in Nonhuman Primate Models of AIDS.

Swanstrom AE, Jacques A, Del Prete GQ, Bieniasz P, Hatziioannou T, Gorelick R, Lifson JD.

AIDS Res Hum Retroviruses. 2019 May;35(5):473-476. doi: 10.1089/AID.2018.0278. Epub 2019 Feb 13.


APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA.

Bohn JA, Thummar K, York A, Raymond A, Brown WC, Bieniasz PD, Hatziioannou T, Smith JL.

Nat Commun. 2017 Oct 18;8(1):1021. doi: 10.1038/s41467-017-01309-6.


A single gp120 residue can affect HIV-1 tropism in macaques.

Del Prete GQ, Keele BF, Fode J, Thummar K, Swanstrom AE, Rodriguez A, Raymond A, Estes JD, LaBranche CC, Montefiori DC, KewalRamani VN, Lifson JD, Bieniasz PD, Hatziioannou T.

PLoS Pathog. 2017 Sep 25;13(9):e1006572. doi: 10.1371/journal.ppat.1006572. eCollection 2017 Sep.


Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo.

Saito A, Henning MS, Serrao E, Dubose BN, Teng S, Huang J, Li X, Saito N, Roy SP, Siddiqui MA, Ahn J, Tsuji M, Hatziioannou T, Engelman AN, Yamashita M.

J Virol. 2016 Jul 11;90(15):6918-6935. doi: 10.1128/JVI.00019-16. Print 2016 Aug 1.


Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques.

Li H, Wang S, Kong R, Ding W, Lee FH, Parker Z, Kim E, Learn GH, Hahn P, Policicchio B, Brocca-Cofano E, Deleage C, Hao X, Chuang GY, Gorman J, Gardner M, Lewis MG, Hatziioannou T, Santra S, Apetrei C, Pandrea I, Alam SM, Liao HX, Shen X, Tomaras GD, Farzan M, Chertova E, Keele BF, Estes JD, Lifson JD, Doms RW, Montefiori DC, Haynes BF, Sodroski JG, Kwong PD, Hahn BH, Shaw GM.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3413-22. doi: 10.1073/pnas.1606636113. Epub 2016 May 31.


Correction for Bitzegeio et al., Adaptation to the Interferon-Induced Antiviral State by Human and Simian Immunodeficiency Viruses.

Bitzegeio J, Sampias M, Bieniasz PD, Hatziioannou T.

J Virol. 2015 Oct;89(19):10133. doi: 10.1128/JVI.01711-15. No abstract available.


Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins.

Del Prete GQ, Ailers B, Moldt B, Keele BF, Estes JD, Rodriguez A, Sampias M, Oswald K, Fast R, Trubey CM, Chertova E, Smedley J, LaBranche CC, Montefiori DC, Burton DR, Shaw GM, Markowitz M, Piatak M Jr, KewalRamani VN, Bieniasz PD, Lifson JD, Hatziioannou T.

Cell Host Microbe. 2014 Sep 10;16(3):412-8. doi: 10.1016/j.chom.2014.08.003.


HIV-1-induced AIDS in monkeys.

Hatziioannou T, Del Prete GQ, Keele BF, Estes JD, McNatt MW, Bitzegeio J, Raymond A, Rodriguez A, Schmidt F, Mac Trubey C, Smedley J, Piatak M Jr, KewalRamani VN, Lifson JD, Bieniasz PD.

Science. 2014 Jun 20;344(6190):1401-5. doi: 10.1126/science.1250761.


MX2 is an interferon-induced inhibitor of HIV-1 infection.

Kane M, Yadav SS, Bitzegeio J, Kutluay SB, Zang T, Wilson SJ, Schoggins JW, Rice CM, Yamashita M, Hatziioannou T, Bieniasz PD.

Nature. 2013 Oct 24;502(7472):563-6. doi: 10.1038/nature12653. Epub 2013 Oct 13.


Assisted evolution enables HIV-1 to overcome a high TRIM5α-imposed genetic barrier to rhesus macaque tropism.

Soll SJ, Wilson SJ, Kutluay SB, Hatziioannou T, Bieniasz PD.

PLoS Pathog. 2013;9(9):e1003667. doi: 10.1371/journal.ppat.1003667. Epub 2013 Sep 26.


Adaptation to the interferon-induced antiviral state by human and simian immunodeficiency viruses.

Bitzegeio J, Sampias M, Bieniasz PD, Hatziioannou T.

J Virol. 2013 Mar;87(6):3549-60. doi: 10.1128/JVI.03219-12. Epub 2013 Jan 16. Erratum in: J Virol. 2015 Oct;89(19):10133.


Animal models for HIV/AIDS research.

Hatziioannou T, Evans DT.

Nat Rev Microbiol. 2012 Dec;10(12):852-67. doi: 10.1038/nrmicro2911. Review.


Antiretroviral restriction factors.

Hatziioannou T, Bieniasz PD.

Curr Opin Virol. 2011 Dec;1(6):526-32. doi: 10.1016/j.coviro.2011.10.007. Review.


SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.

Zhang F, Landford WN, Ng M, McNatt MW, Bieniasz PD, Hatziioannou T.

PLoS Pathog. 2011 May;7(5):e1002039. doi: 10.1371/journal.ppat.1002039. Epub 2011 May 19.


Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.

Sauter D, Schindler M, Specht A, Landford WN, Münch J, Kim KA, Votteler J, Schubert U, Bibollet-Ruche F, Keele BF, Takehisa J, Ogando Y, Ochsenbauer C, Kappes JC, Ayouba A, Peeters M, Learn GH, Shaw G, Sharp PM, Bieniasz P, Hahn BH, Hatziioannou T, Kirchhoff F.

Cell Host Microbe. 2009 Nov 19;6(5):409-21. doi: 10.1016/j.chom.2009.10.004.


Nef proteins from simian immunodeficiency viruses are tetherin antagonists.

Zhang F, Wilson SJ, Landford WC, Virgen B, Gregory D, Johnson MC, Munch J, Kirchhoff F, Bieniasz PD, Hatziioannou T.

Cell Host Microbe. 2009 Jul 23;6(1):54-67. doi: 10.1016/j.chom.2009.05.008. Epub 2009 Jun 4.


A macaque model of HIV-1 infection.

Hatziioannou T, Ambrose Z, Chung NP, Piatak M Jr, Yuan F, Trubey CM, Coalter V, Kiser R, Schneider D, Smedley J, Pung R, Gathuka M, Estes JD, Veazey RS, KewalRamani VN, Lifson JD, Bieniasz PD.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4425-9. doi: 10.1073/pnas.0812587106. Epub 2009 Mar 2.


Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants.

McNatt MW, Zang T, Hatziioannou T, Bartlett M, Fofana IB, Johnson WE, Neil SJ, Bieniasz PD.

PLoS Pathog. 2009 Feb;5(2):e1000300. doi: 10.1371/journal.ppat.1000300. Epub 2009 Feb 13.


Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin.

Jouvenet N, Neil SJ, Zhadina M, Zang T, Kratovac Z, Lee Y, McNatt M, Hatziioannou T, Bieniasz PD.

J Virol. 2009 Feb;83(4):1837-44. doi: 10.1128/JVI.02211-08. Epub 2008 Nov 26.


Primate lentivirus capsid sensitivity to TRIM5 proteins.

Kratovac Z, Virgen CA, Bibollet-Ruche F, Hahn BH, Bieniasz PD, Hatziioannou T.

J Virol. 2008 Jul;82(13):6772-7. doi: 10.1128/JVI.00410-08. Epub 2008 Apr 16.


No effect of endogenous TRIM5alpha on HIV-1 production.

Zhang F, Perez-Caballero D, Hatziioannou T, Bieniasz PD.

Nat Med. 2008 Mar;14(3):235-6; author reply 236-8. doi: 10.1038/nm0308-235. No abstract available.


Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species.

Virgen CA, Kratovac Z, Bieniasz PD, Hatziioannou T.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3563-8. doi: 10.1073/pnas.0709258105. Epub 2008 Feb 19.


Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteins.

Virgen CA, Hatziioannou T.

J Virol. 2007 Dec;81(24):13932-7. Epub 2007 Oct 17.


HIV/AIDS: in search of an animal model.

Ambrose Z, KewalRamani VN, Bieniasz PD, Hatziioannou T.

Trends Biotechnol. 2007 Aug;25(8):333-7. Epub 2007 Jun 18. Review.


Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.

Evans MJ, von Hahn T, Tscherne DM, Syder AJ, Panis M, Wölk B, Hatziioannou T, McKeating JA, Bieniasz PD, Rice CM.

Nature. 2007 Apr 12;446(7137):801-5. Epub 2007 Feb 25. Erratum in: Nature. 2007 Apr 12;446(7137):1 p following 805.


Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells.

Naghavi MH, Valente S, Hatziioannou T, de Los Santos K, Wen Y, Mott C, Gundersen GG, Goff SP.

EMBO J. 2007 Jan 10;26(1):41-52. Epub 2006 Dec 14.


Generation of simian-tropic HIV-1 by restriction factor evasion.

Hatziioannou T, Princiotta M, Piatak M Jr, Yuan F, Zhang F, Lifson JD, Bieniasz PD.

Science. 2006 Oct 6;314(5796):95.


Antiretroviral potential of human tripartite motif-5 and related proteins.

Zhang F, Hatziioannou T, Perez-Caballero D, Derse D, Bieniasz PD.

Virology. 2006 Sep 30;353(2):396-409. Epub 2006 Jul 10.


Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity.

Perez-Caballero D, Hatziioannou T, Yang A, Cowan S, Bieniasz PD.

J Virol. 2005 Jul;79(14):8969-78.


Human immunodeficiency virus type 1 matrix inhibits and confers cooperativity on gag precursor-membrane interactions.

Perez-Caballero D, Hatziioannou T, Martin-Serrano J, Bieniasz PD.

J Virol. 2004 Sep;78(17):9560-3.


Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha.

Hatziioannou T, Perez-Caballero D, Yang A, Cowan S, Bieniasz PD.

Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10774-9. Epub 2004 Jul 12.


Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid.

Hatziioannou T, Cowan S, Von Schwedler UK, Sundquist WI, Bieniasz PD.

J Virol. 2004 Jun;78(11):6005-12.


Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors.

Towers GJ, Hatziioannou T, Cowan S, Goff SP, Luban J, Bieniasz PD.

Nat Med. 2003 Sep;9(9):1138-43. Epub 2003 Aug 3.


Restriction of multiple divergent retroviruses by Lv1 and Ref1.

Hatziioannou T, Cowan S, Goff SP, Bieniasz PD, Towers GJ.

EMBO J. 2003 Feb 3;22(3):385-94.


Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism.

Cowan S, Hatziioannou T, Cunningham T, Muesing MA, Gottlinger HG, Bieniasz PD.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11914-9. Epub 2002 Aug 1.


Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection.

Zhang YJ, Hatziioannou T, Zang T, Braaten D, Luban J, Goff SP, Bieniasz PD.

J Virol. 2002 Jun;76(12):6332-43.


Infection of nondividing cells by Rous sarcoma virus.

Hatziioannou T, Goff SP.

J Virol. 2001 Oct;75(19):9526-31.


Retroviral display of functional binding domains fused to the amino terminus of influenza hemagglutinin.

Hatziioannou T, Delahaye E, Martin F, Russell SJ, Cosset FL.

Hum Gene Ther. 1999 Jun 10;10(9):1533-44.


Receptor co-operation in retrovirus entry: recruitment of an auxiliary entry mechanism after retargeted binding.

Valsesia-Wittmann S, Morling FJ, Hatziioannou T, Russell SJ, Cosset FL.

EMBO J. 1997 Mar 17;16(6):1214-23. Erratum in: EMBO J 1997 Jul 1;16(13):4153.


Kaposi's-sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma.

Boshoff C, Whitby D, Hatziioannou T, Fisher C, van der Walt J, Hatzakis A, Weiss R, Schulz T.

Lancet. 1995 Apr 22;345(8956):1043-4. No abstract available.


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