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Items: 42

1.

Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming.

Koutsioumpa M, Hatziapostolou M, Polytarchou C, Tolosa EJ, Almada LL, Mahurkar-Joshi S, Williams J, Tirado-Rodriguez AB, Huerta-Yepez S, Karavias D, Kourea H, Poultsides GA, Struhl K, Dawson DW, Donahue TR, Fernández-Zapico ME, Iliopoulos D.

Gut. 2019 Jul;68(7):1271-1286. doi: 10.1136/gutjnl-2017-315690. Epub 2018 Oct 18.

2.

Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration.

Lampropoulou E, Logoviti I, Koutsioumpa M, Hatziapostolou M, Polytarchou C, Skandalis SS, Hellman U, Fousteris M, Nikolaropoulos S, Choleva E, Lamprou M, Skoura A, Megalooikonomou V, Papadimitriou E.

Sci Rep. 2018 Apr 12;8(1):5893. doi: 10.1038/s41598-018-24326-x.

3.

A step-by-step microRNA guide to cancer development and metastasis.

Markopoulos GS, Roupakia E, Tokamani M, Chavdoula E, Hatziapostolou M, Polytarchou C, Marcu KB, Papavassiliou AG, Sandaltzopoulos R, Kolettas E.

Cell Oncol (Dordr). 2017 Aug;40(4):303-339. doi: 10.1007/s13402-017-0341-9. Epub 2017 Jul 26. Review.

PMID:
28748501
4.

Senescence-associated microRNAs target cell cycle regulatory genes in normal human lung fibroblasts.

Markopoulos GS, Roupakia E, Tokamani M, Vartholomatos G, Tzavaras T, Hatziapostolou M, Fackelmayer FO, Sandaltzopoulos R, Polytarchou C, Kolettas E.

Exp Gerontol. 2017 Oct 1;96:110-122. doi: 10.1016/j.exger.2017.06.017. Epub 2017 Jun 27.

PMID:
28658612
5.

A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma.

Palumbo T, Poultsides GA, Kouraklis G, Liakakos T, Drakaki A, Peros G, Hatziapostolou M, Iliopoulos D.

BMC Cancer. 2016 Jun 3;16:353. doi: 10.1186/s12885-016-2384-0.

6.

Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer.

Vorvis C, Hatziapostolou M, Mahurkar-Joshi S, Koutsioumpa M, Williams J, Donahue TR, Poultsides GA, Eibl G, Iliopoulos D.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1124-37. doi: 10.1152/ajpgi.00035.2016. Epub 2016 May 5.

7.

Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway.

Drakaki A, Hatziapostolou M, Polytarchou C, Vorvis C, Poultsides GA, Souglakos J, Georgoulias V, Iliopoulos D.

BMC Cancer. 2015 Jul 24;15:542. doi: 10.1186/s12885-015-1562-9.

8.

MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.

Polytarchou C, Hommes DW, Palumbo T, Hatziapostolou M, Koutsioumpa M, Koukos G, van der Meulen-de Jong AE, Oikonomopoulos A, van Deen WK, Vorvis C, Serebrennikova OB, Birli E, Choi J, Chang L, Anton PA, Tsichlis PN, Pothoulakis C, Verspaget HW, Iliopoulos D.

Gastroenterology. 2015 Oct;149(4):981-92.e11. doi: 10.1053/j.gastro.2015.05.057. Epub 2015 Jun 6.

9.

Pleiotrophin-induced endothelial cell migration is regulated by xanthine oxidase-mediated generation of reactive oxygen species.

Tsirmoula S, Lamprou M, Hatziapostolou M, Kieffer N, Papadimitriou E.

Microvasc Res. 2015 Mar;98:74-81. doi: 10.1016/j.mvr.2015.01.001. Epub 2015 Jan 10.

PMID:
25582077
10.
11.

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.

Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH.

Nature. 2014 Apr 3;508(7494):103-107. doi: 10.1038/nature13119. Epub 2014 Mar 23.

12.

Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN.

Mol Cell. 2014 Feb 20;53(4):577-90. doi: 10.1016/j.molcel.2013.12.018. Epub 2014 Jan 23.

13.

Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling.

He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M.

Cell. 2013 Oct 10;155(2):384-96. doi: 10.1016/j.cell.2013.09.031.

14.

Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice.

Kyrmizi I, Ioannou M, Hatziapostolou M, Tsichlis PN, Boumpas DT, Tassiulas I.

J Leukoc Biol. 2013 Oct;94(4):751-7. doi: 10.1189/jlb.0113039. Epub 2013 Jul 29.

15.

miRNAs link metabolic reprogramming to oncogenesis.

Hatziapostolou M, Polytarchou C, Iliopoulos D.

Trends Endocrinol Metab. 2013 Jul;24(7):361-73. doi: 10.1016/j.tem.2013.03.002. Epub 2013 Apr 19. Review.

PMID:
23602813
16.

Therapeutically targeting microRNAs in liver cancer.

Drakaki A, Hatziapostolou M, Iliopoulos D.

Curr Pharm Des. 2013;19(7):1180-91. Review.

PMID:
23092338
17.

Implications of pleiotrophin in human PC3 prostate cancer cell growth in vivo.

Tsirmoula S, Dimas K, Hatziapostolou M, Lamprou M, Ravazoula P, Papadimitriou E.

Cancer Sci. 2012 Oct;103(10):1826-32. doi: 10.1111/j.1349-7006.2012.02383.x. Epub 2012 Aug 14.

18.

Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice.

Moon HS, Liu X, Nagel JM, Chamberland JP, Diakopoulos KN, Brinkoetter MT, Hatziapostolou M, Wu Y, Robson SC, Iliopoulos D, Mantzoros CS.

Gut. 2013 Apr;62(4):561-70. doi: 10.1136/gutjnl-2012-302092. Epub 2012 Jun 26.

PMID:
22735569
19.

Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury.

Vaporidi K, Vergadi E, Kaniaris E, Hatziapostolou M, Lagoudaki E, Georgopoulos D, Zapol WM, Bloch KD, Iliopoulos D.

Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1;303(3):L199-207. doi: 10.1152/ajplung.00370.2011. Epub 2012 Jun 1.

20.

The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY.

Ezell SA, Polytarchou C, Hatziapostolou M, Guo A, Sanidas I, Bihani T, Comb MJ, Sourvinos G, Tsichlis PN.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):E613-21. doi: 10.1073/pnas.1115029109. Epub 2012 Feb 6.

21.

An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis.

Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D.

Cell. 2011 Dec 9;147(6):1233-47. doi: 10.1016/j.cell.2011.10.043. Erratum in: Cell. 2013 Feb 28;152(5):1196.

22.

Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.

Hatziapostolou M, Koukos G, Polytarchou C, Kottakis F, Serebrennikova O, Kuliopulos A, Tsichlis PN.

Sci Signal. 2011 Aug 23;4(187):ra55. doi: 10.1126/scisignal.2002006.

23.

Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors.

Bakirtzi K, Hatziapostolou M, Karagiannides I, Polytarchou C, Jaeger S, Iliopoulos D, Pothoulakis C.

Gastroenterology. 2011 Nov;141(5):1749-61.e1. doi: 10.1053/j.gastro.2011.07.038. Epub 2011 Jul 30.

24.

Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression.

Stagakis E, Bertsias G, Verginis P, Nakou M, Hatziapostolou M, Kritikos H, Iliopoulos D, Boumpas DT.

Ann Rheum Dis. 2011 Aug;70(8):1496-506. doi: 10.1136/ard.2010.139857. Epub 2011 May 20.

PMID:
21602271
25.

Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.

Polytarchou C, Iliopoulos D, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K, Tsichlis PN.

Cancer Res. 2011 Jul 1;71(13):4720-31. doi: 10.1158/0008-5472.CAN-11-0365. Epub 2011 May 9.

26.

Epigenetic aberrations during oncogenesis.

Hatziapostolou M, Iliopoulos D.

Cell Mol Life Sci. 2011 May;68(10):1681-702. doi: 10.1007/s00018-010-0624-z. Epub 2011 Jan 20. Review.

PMID:
21249513
27.

Gene network analysis of bone marrow mononuclear cells reveals activation of multiple kinase pathways in human systemic lupus erythematosus.

Nakou M, Bertsias G, Stagakis I, Centola M, Tassiulas I, Hatziapostolou M, Kritikos I, Goulielmos G, Boumpas DT, Iliopoulos D.

PLoS One. 2010 Oct 14;5(10):e13351. doi: 10.1371/journal.pone.0013351. Erratum in: PLoS One. 2013;8(4). doi:10.1371/annotation/d68d4b94-c44a-4893-83f4-55a8a626990f.

28.

MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.

Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN.

Sci Signal. 2009 Oct 13;2(92):ra62. doi: 10.1126/scisignal.2000356.

29.

Serum stimulates Pleiotrophin gene expression in an AP-1-dependent manner in human endothelial and glioblastoma cells.

Poimenidi E, Hatziapostolou M, Papadimitriou E.

Anticancer Res. 2009 Jan;29(1):349-54.

30.

Aprotinin stimulates angiogenesis and human endothelial cell migration through the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta.

Koutsioumpa M, Hatziapostolou M, Mikelis C, Koolwijk P, Papadimitriou E.

Eur J Pharmacol. 2009 Jan 14;602(2-3):245-9. doi: 10.1016/j.ejphar.2008.11.046. Epub 2008 Dec 3.

PMID:
19059395
31.

Nitric oxide stimulates migration of human endothelial and prostate cancer cells through up-regulation of pleiotrophin expression and its receptor protein tyrosine phosphatase beta/zeta.

Polytarchou C, Hatziapostolou M, Poimenidi E, Mikelis C, Papadopoulou A, Parthymou A, Papadimitriou E.

Int J Cancer. 2009 Apr 15;124(8):1785-93. doi: 10.1002/ijc.24084.

32.

The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress.

Polytarchou C, Pfau R, Hatziapostolou M, Tsichlis PN.

Mol Cell Biol. 2008 Dec;28(24):7451-64. doi: 10.1128/MCB.00688-08. Epub 2008 Oct 6.

33.

Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration.

Hatziapostolou M, Polytarchou C, Panutsopulos D, Covic L, Tsichlis PN.

Cancer Res. 2008 Mar 15;68(6):1851-61. doi: 10.1158/0008-5472.CAN-07-5793.

34.

Timing is everything: regulation of Cdk1 and aneuploidy.

Tsichlis PN, Hatziapostolou M, Hinds PW.

Dev Cell. 2007 Apr;12(4):477-9.

35.

Anticancer activity of cisplatin-loaded PLGA-mPEG nanoparticles on LNCaP prostate cancer cells.

Gryparis EC, Hatziapostolou M, Papadimitriou E, Avgoustakis K.

Eur J Pharm Biopharm. 2007 Aug;67(1):1-8. Epub 2007 Jan 12.

PMID:
17303395
36.

Heparin affin regulatory peptide/pleiotrophin mediates fibroblast growth factor 2 stimulatory effects on human prostate cancer cells.

Hatziapostolou M, Polytarchou C, Katsoris P, Courty J, Papadimitriou E.

J Biol Chem. 2006 Oct 27;281(43):32217-26. Epub 2006 Aug 29.

38.

Heparin affin regulatory peptide is a key player in prostate cancer cell growth and angiogenicity.

Hatziapostolou M, Delbe J, Katsoris P, Polytarchou C, Courty J, Papadimitriou E.

Prostate. 2005 Oct 1;65(2):151-8.

PMID:
15924335
39.

Heparin affin regulatory peptide: a new target for tumour therapy?

Papadimitriou E, Polykratis A, Hatziapostolou M, Parthymou A, Polytarchou C, Mikelis C.

Curr Cancer Drug Targets. 2004 Sep;4(6):471-82. Review.

PMID:
15379633
40.

Perillyl alcohol is an angiogenesis inhibitor.

Loutrari H, Hatziapostolou M, Skouridou V, Papadimitriou E, Roussos C, Kolisis FN, Papapetropoulos A.

J Pharmacol Exp Ther. 2004 Nov;311(2):568-75. Epub 2004 Jun 21.

PMID:
15210838
41.

Different inhibitors of plasmin differentially affect angiostatin production and angiogenesis.

Hatziapostolou M, Katsoris P, Papadimitriou E.

Eur J Pharmacol. 2003 Jan 26;460(1):1-8.

PMID:
12535853
42.

X-rays modulate extracellular matrix in vivo.

Giannopoulou E, Katsoris P, Hatziapostolou M, Kardamakis D, Kotsaki E, Polytarchou C, Parthymou A, Papaioannou S, Papadimitriou E.

Int J Cancer. 2001 Dec 1;94(5):690-8.

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