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Items: 1 to 50 of 117


The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice.

Minis A, Rodriguez JA, Levin A, Liu K, Govek EE, Hatten ME, Steller H.

Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24639-24650. doi: 10.1073/pnas.1911921116. Epub 2019 Nov 21.


Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis.

Penas C, Maloof ME, Stathias V, Long J, Tan SK, Mier J, Fang Y, Valdes C, Rodriguez-Blanco J, Chiang CM, Robbins DJ, Liebl DJ, Lee JK, Hatten ME, Clarke J, Ayad NG.

Nat Commun. 2019 Jul 10;10(1):3028. doi: 10.1038/s41467-019-10799-5.


Tag-Team Genetics of Spinocerebellar Ataxia 6.

Govek EE, Hatten ME.

Neuron. 2019 May 22;102(4):707-709. doi: 10.1016/j.neuron.2019.04.041.


Murine astrotactins 1 and 2 have a similar membrane topology and mature via endoproteolytic cleavage catalyzed by a signal peptidase.

Lara P, Tellgren-Roth Å, Behesti H, Horn Z, Schiller N, Enquist K, Cammenberg M, Liljenström A, Hatten ME, von Heijne G, Nilsson I.

J Biol Chem. 2019 Mar 22;294(12):4538-4545. doi: 10.1074/jbc.RA118.007093. Epub 2019 Jan 29.


N-cadherin provides a cis and trans ligand for astrotactin that functions in glial-guided neuronal migration.

Horn Z, Behesti H, Hatten ME.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10556-10563. doi: 10.1073/pnas.1811100115. Epub 2018 Sep 27.


ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins.

Behesti H, Fore TR, Wu P, Horn Z, Leppert M, Hull C, Hatten ME.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9717-E9726. doi: 10.1073/pnas.1809382115. Epub 2018 Sep 21.


Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration.

Govek EE, Wu Z, Acehan D, Molina H, Rivera K, Zhu X, Fang Y, Tessier-Lavigne M, Hatten ME.

iScience. 2018 Mar 23;1:35-48. doi: 10.1016/j.isci.2018.01.004.


Differential 3' Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types.

Jereb S, Hwang HW, Van Otterloo E, Govek EE, Fak JJ, Yuan Y, Hatten ME, Darnell RB.

Elife. 2018 Mar 26;7. pii: e34042. doi: 10.7554/eLife.34042.


Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin.

Sundberg M, Tochitsky I, Buchholz DE, Winden K, Kujala V, Kapur K, Cataltepe D, Turner D, Han MJ, Woolf CJ, Hatten ME, Sahin M.

Mol Psychiatry. 2018 Nov;23(11):2167-2183. doi: 10.1038/s41380-018-0018-4. Epub 2018 Feb 15.


Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation.

Zhu X, Girardo D, Govek EE, John K, Mellén M, Tamayo P, Mesirov JP, Hatten ME.

Neuron. 2016 Jan 6;89(1):100-12. doi: 10.1016/j.neuron.2015.11.030. Epub 2015 Dec 17.


Consensus Paper: Cerebellar Development.

Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerková G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ, Hawkes R.

Cerebellum. 2016 Dec;15(6):789-828. Review.


The APC/C and CK1 in the developing brain.

Penas C, Hatten ME, Ayad NG.

Oncotarget. 2015 Jul 10;6(19):16792-3. No abstract available.


Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.

Penas C, Govek EE, Fang Y, Ramachandran V, Daniel M, Wang W, Maloof ME, Rahaim RJ, Bibian M, Kawauchi D, Finkelstein D, Han JL, Long J, Li B, Robbins DJ, Malumbres M, Roussel MF, Roush WR, Hatten ME, Ayad NG.

Cell Rep. 2015 Apr 14;11(2):249-60. doi: 10.1016/j.celrep.2015.03.016. Epub 2015 Apr 2.


WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.

Anne SL, Govek EE, Ayrault O, Kim JH, Zhu X, Murphy DA, Van Aelst L, Roussel MF, Hatten ME.

PLoS One. 2013 Nov 26;8(11):e81769. doi: 10.1371/journal.pone.0081769. eCollection 2013.


Multitasking on the run.

Hatten ME, Lisberger SG.

Elife. 2013 Mar 19;2:e00641. doi: 10.7554/eLife.00641.


The role of Rho GTPase proteins in CNS neuronal migration.

Govek EE, Hatten ME, Van Aelst L.

Dev Neurobiol. 2011 Jun;71(6):528-53. doi: 10.1002/dneu.20850. Review.


PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke.

Rousselet E, Marcinkiewicz J, Kriz J, Zhou A, Hatten ME, Prat A, Seidah NG.

J Lipid Res. 2011 Jul;52(7):1383-91. doi: 10.1194/jlr.M014118. Epub 2011 Apr 25.


Development and cancer of the cerebellum.

Hatten ME, Roussel MF.

Trends Neurosci. 2011 Mar;34(3):134-42. doi: 10.1016/j.tins.2011.01.002. Review.


Cerebellum development and medulloblastoma.

Roussel MF, Hatten ME.

Curr Top Dev Biol. 2011;94:235-82. doi: 10.1016/B978-0-12-380916-2.00008-5. Review.


Astn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration.

Wilson PM, Fryer RH, Fang Y, Hatten ME.

J Neurosci. 2010 Jun 23;30(25):8529-40. doi: 10.1523/JNEUROSCI.0032-10.2010.


Lrp12/Mig13a reveals changing patterns of preplate neuronal polarity during corticogenesis that are absent in reeler mutant mice.

Schneider S, Gulacsi A, Hatten ME.

Cereb Cortex. 2011 Jan;21(1):134-44. doi: 10.1093/cercor/bhq070. Epub 2010 May 3.


Myosin II motors and F-actin dynamics drive the coordinated movement of the centrosome and soma during CNS glial-guided neuronal migration.

Solecki DJ, Trivedi N, Govek EE, Kerekes RA, Gleason SS, Hatten ME.

Neuron. 2009 Jul 16;63(1):63-80. doi: 10.1016/j.neuron.2009.05.028.


Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs.

Gong S, Doughty M, Harbaugh CR, Cummins A, Hatten ME, Heintz N, Gerfen CR.

J Neurosci. 2007 Sep 12;27(37):9817-23. No abstract available.


Differentiation of ES cells into cerebellar neurons.

Salero E, Hatten ME.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2997-3002. Epub 2007 Feb 9.


Molecular markers of neuronal progenitors in the embryonic cerebellar anlage.

Morales D, Hatten ME.

J Neurosci. 2006 Nov 22;26(47):12226-36.


mPar6 alpha controls neuronal migration.

Solecki DJ, Govek EE, Hatten ME.

J Neurosci. 2006 Oct 18;26(42):10624-5. Review.


Neuronal polarity in CNS development.

Solecki DJ, Govek EE, Tomoda T, Hatten ME.

Genes Dev. 2006 Oct 1;20(19):2639-47. Review.


A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.

Kamiya A, Kubo K, Tomoda T, Takaki M, Youn R, Ozeki Y, Sawamura N, Park U, Kudo C, Okawa M, Ross CA, Hatten ME, Nakajima K, Sawa A.

Nat Cell Biol. 2005 Dec;7(12):1167-78. Epub 2005 Nov 20. Erratum in: Nat Cell Biol. 2006 Jan;8(1):100.


The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.

Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF.

Genes Dev. 2005 Nov 15;19(22):2656-67. Epub 2005 Oct 31.


LIS-less neurons don't even make it to the starting gate.

Hatten ME.

J Cell Biol. 2005 Sep 12;170(6):867-71. Review.


Large-scale genomic approaches to brain development and circuitry.

Hatten ME, Heintz N.

Annu Rev Neurosci. 2005;28:89-108. Review.


Par6alpha signaling controls glial-guided neuronal migration.

Solecki DJ, Model L, Gaetz J, Kapoor TM, Hatten ME.

Nat Neurosci. 2004 Nov;7(11):1195-203. Epub 2004 Oct 10.


Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse.

Millen KJ, Millonig JH, Hatten ME.

Dev Biol. 2004 Jun 15;270(2):382-92.


Role of Unc51.1 and its binding partners in CNS axon outgrowth.

Tomoda T, Kim JH, Zhan C, Hatten ME.

Genes Dev. 2004 Mar 1;18(5):541-58. Epub 2004 Mar 10.


A gene expression atlas of the central nervous system based on bacterial artificial chromosomes.

Gong S, Zheng C, Doughty ML, Losos K, Didkovsky N, Schambra UB, Nowak NJ, Joyner A, Leblanc G, Hatten ME, Heintz N.

Nature. 2003 Oct 30;425(6961):917-25.


Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.

Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten ME, Snyder SH, Ross CA, Sawa A.

Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):289-94. Epub 2002 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13969.


New directions in neuronal migration.

Hatten ME.

Science. 2002 Sep 6;297(5587):1660-3. Review.


Mice that lack astrotactin have slowed neuronal migration.

Adams NC, Tomoda T, Cooper M, Dietz G, Hatten ME.

Development. 2002 Feb;129(4):965-72.


Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons.

Bhatt RS, Tomoda T, Fang Y, Hatten ME.

Genes Dev. 2000 Sep 1;14(17):2216-28.


The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS.

Millonig JH, Millen KJ, Hatten ME.

Nature. 2000 Feb 17;403(6771):764-9.


The role of the rhombic lip in avian cerebellum development.

Wingate RJ, Hatten ME.

Development. 1999 Oct;126(20):4395-404.


Neurogenetics of the cerebellar system.

Millen KJ, Millonig JH, Wingate RJ, Alder J, Hatten ME.

J Child Neurol. 1999 Sep;14(9):574-81; discussion 581-2. Review.


Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor cells.

Alder J, Lee KJ, Jessell TM, Hatten ME.

Nat Neurosci. 1999 Jun;2(6):535-40.


Central nervous system neuronal migration.

Hatten ME.

Annu Rev Neurosci. 1999;22:511-39. Review.


Expansion of CNS precursor pools: a new role for Sonic Hedgehog.

Hatten ME.

Neuron. 1999 Jan;22(1):2-3. No abstract available.


New directions for neuronal migration.

Pearlman AL, Faust PL, Hatten ME, Brunstrom JE.

Curr Opin Neurobiol. 1998 Feb;8(1):45-54. Review.


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