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Items: 23

1.

Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor.

Harrison TJ, Bauer D, Berdichevsky A, Chen X, Duvadie R, Hoogheem B, Hatsis P, Liu Q, Mao J, Miduturu V, Rocheford E, Zecri F, Zessis R, Zheng R, Zhu Q, Streeper R, Patel SJ.

ACS Med Chem Lett. 2019 Jun 20;10(8):1128-1133. doi: 10.1021/acsmedchemlett.9b00117. eCollection 2019 Aug 8.

PMID:
31413796
2.

Immunoprecipitation middle-up LC-MS for in vivo drug-to-antibody ratio determination for antibody-drug conjugates.

Davis JA, Kagan M, Read J, Walles M, Hatsis P.

Bioanalysis. 2017 Oct;9(20):1535-1549. doi: 10.4155/bio-2017-0148. Epub 2017 Oct 26.

PMID:
29072490
3.

Integrated TK-TD modeling for drug-induced concurrent tachycardia and QT changes in beagle dogs.

Wu F, Heimbach T, Hatsis P, Tang HM, Dugyala R, Yue Q, Wang T, He H.

J Pharmacokinet Pharmacodyn. 2017 Oct;44(5):449-462. doi: 10.1007/s10928-017-9532-2. Epub 2017 Jun 22.

PMID:
28643108
4.

Implications for Metabolite Quantification by Mass Spectrometry in the Absence of Authentic Standards.

Hatsis P, Waters NJ, Argikar UA.

Drug Metab Dispos. 2017 May;45(5):492-496. doi: 10.1124/dmd.117.075259. Epub 2017 Mar 2.

PMID:
28254953
5.

Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry.

Chen X, Hatsis P, Judge J, Argikar UA, Ren X, Sarber J, Mansfield K, Liang G, Amaral A, Catoire A, Bentley A, Ramos L, Moench P, Hintermann S, Carcache D, Glick J, Flarakos J.

Anal Chem. 2016 Dec 6;88(23):11813-11820. Epub 2016 Nov 16.

PMID:
27797491
6.

A Comparison of LC-MS/MS and a Fully Integrated Autosampler/Solid-Phase Extraction System for the Analysis of Protein Binding Samples.

Amaral A, Saran C, Amin J, Hatsis P.

J Biomol Screen. 2016 Jul;21(6):620-5. doi: 10.1177/1087057116630706. Epub 2016 Feb 22.

PMID:
26903406
7.

Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression.

Rothman DM, Gao X, George E, Rasmusson T, Bhatia D, Alimov I, Wang L, Kamel A, Hatsis P, Feng Y, Tutter A, Michaud G, McDonald E 3rd, Venkatesan K, Farley D, Digan ME, Ni Y, Harbinski F, Gunduz M, Wilson CJ, Buckler A, Labow M, Tallarico J, Myer VE, Porter JA, Wang S.

Chem Biol. 2015 Sep 17;22(9):1228-37. doi: 10.1016/j.chembiol.2015.06.025. Epub 2015 Sep 10.

8.

Metabolically Stable tert-Butyl Replacement.

Barnes-Seeman D, Jain M, Bell L, Ferreira S, Cohen S, Chen XH, Amin J, Snodgrass B, Hatsis P.

ACS Med Chem Lett. 2013 Apr 22;4(6):514-6. doi: 10.1021/ml400045j. eCollection 2013 Jun 13.

9.

Investigation of dried blood spot card-induced interferences in liquid chromatography/mass spectrometry.

Chen X, Zhao H, Hatsis P, Amin J.

J Pharm Biomed Anal. 2012 Mar 5;61:30-7. doi: 10.1016/j.jpba.2011.11.015. Epub 2011 Nov 23.

PMID:
22177411
10.

High-throughput analysis of in vitro cytochrome p450 inhibition samples using mass spectrometry coupled with an integrated liquid chromatography/autosampler system.

Brown A, Bickford S, Hatsis P, Amin J, Bell L, Harriman S.

Rapid Commun Mass Spectrom. 2010 Apr 30;24(8):1207-10. doi: 10.1002/rcm.4461. No abstract available.

PMID:
20301107
11.

The relationship among tumor architecture, pharmacokinetics, pharmacodynamics, and efficacy of bortezomib in mouse xenograft models.

Williamson MJ, Silva MD, Terkelsen J, Robertson R, Yu L, Xia C, Hatsis P, Bannerman B, Babcock T, Cao Y, Kupperman E.

Mol Cancer Ther. 2009 Dec;8(12):3234-43. doi: 10.1158/1535-7163.MCT-09-0239.

12.

Online nanoelectrospray/high-field asymmetric waveform ion mobility spectrometry as a potential tool for discovery pharmaceutical bioanalysis.

Hatsis P, Valaskovic G, Wu JT.

Rapid Commun Mass Spectrom. 2009 Dec;23(23):3736-42. doi: 10.1002/rcm.4311.

PMID:
19902415
13.

Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. II. In vitro-in vivo correlation with ketoconazole.

Lu C, Hatsis P, Berg C, Lee FW, Balani SK.

Drug Metab Dispos. 2008 Jul;36(7):1255-60. doi: 10.1124/dmd.107.018796. Epub 2008 Apr 1.

PMID:
18381489
14.

A review on the application of high-field asymmetric waveform ion mobility spectrometry (FAIMS) in drug discovery.

Hatsis P, Kapron JT.

Rapid Commun Mass Spectrom. 2008;22(5):735-8. doi: 10.1002/rcm.3416. No abstract available.

PMID:
18257113
15.
16.

Impact of differential recovery in bioanalysis: the example of bortezomib in whole blood.

Brockman AH, Hatsis P, Paton M, Wu JT.

Anal Chem. 2007 Feb 15;79(4):1599-603.

PMID:
17297961
18.

Quantitative analysis of small pharmaceutical drugs using a high repetition rate laser matrix-assisted laser/desorption ionization source.

Hatsis P, Brombacher S, Corr J, Kovarik P, Volmer DA.

Rapid Commun Mass Spectrom. 2003;17(20):2303-9.

PMID:
14558130
19.

High-speed ion chromatographic separation of cations at elevated temperature.

Chong J, Hatsis P, Lucy CA.

J Chromatogr A. 2003 May 16;997(1-2):161-9.

PMID:
12830889
20.
21.

Ultra-fast HPLC separation of common anions using a monolithic stationary phase.

Hatsis P, Lucy CA.

Analyst. 2002 Apr;127(4):451-4.

PMID:
12022638
23.

Effect of temperature on retention and selectivity in ion chromatography of anions.

Hatsis P, Lucy CA.

J Chromatogr A. 2001 Jun 22;920(1-2):3-11.

PMID:
11453014

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