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Items: 1 to 50 of 91

1.

Absolute quantification of dystrophin protein in human muscle biopsies using parallel reaction monitoring (PRM).

Canessa EH, Goswami MV, Alayi TD, Hoffman EP, Hathout Y.

J Mass Spectrom. 2019 Sep 9. doi: 10.1002/jms.4437. [Epub ahead of print]

PMID:
31502334
2.

Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy.

Hathout Y, Liang C, Ogundele M, Xu G, Tawalbeh SM, Dang UJ, Hoffman EP, Gordish-Dressman H, Conklin LS, van den Anker JN, Clemens PR, Mah JK, Henricson E, McDonald C.

Sci Rep. 2019 Aug 21;9(1):12167. doi: 10.1038/s41598-019-48548-9.

3.

Orthogonal analysis of dystrophin protein and mRNA as a surrogate outcome for drug development.

Uaesoontrachoon K, Srinivassane S, Warford J, Mekhssian K, Montpetit H, Beauvois R, Keyhani A, Hathout Y, Yamashita T, Satou Y, Osaki H, Praest M, Moraca M, Malbasic M, Ross W, MacKinnon A, Rowsell J, Mullen A, Matyas M, Mummidivarpu S, Nagaraju K, Hoffman EP.

Biomark Med. 2019 Oct;13(14):1209-1225. doi: 10.2217/bmm-2019-0242. Epub 2019 Aug 5.

4.

Discovery of potential urine-accessible metabolite biomarkers associated with muscle disease and corticosteroid response in the mdx mouse model for Duchenne.

Thangarajh M, Zhang A, Gill K, Ressom HW, Li Z, Varghese RS, Hoffman EP, Nagaraju K, Hathout Y, Boca SM.

PLoS One. 2019 Jul 16;14(7):e0219507. doi: 10.1371/journal.pone.0219507. eCollection 2019.

5.

AMP-activated protein kinase signaling regulated expression of urea cycle enzymes in response to changes in dietary protein intake.

Heibel SK, McGuire PJ, Haskins N, Majumdar HD, Rayavarapu S, Nagaraju K, Hathout Y, Brown K, Tuchman M, Caldovic L.

J Inherit Metab Dis. 2019 Nov;42(6):1088-1096. doi: 10.1002/jimd.12133. Epub 2019 Aug 1.

PMID:
31177541
6.

Morpholino-induced exon skipping stimulates cell-mediated and humoral responses to dystrophin in mdx mice.

Vila MC, Novak JS, Benny Klimek M, Li N, Morales M, Fritz AG, Edwards K, Boehler JF, Hogarth MW, Kinder TB, Zhang A, Mazala D, Fiorillo AA, Douglas B, Chen YW, van den Anker J, Lu QL, Hathout Y, Hoffman EP, Partridge TA, Nagaraju K.

J Pathol. 2019 Jul;248(3):339-351. doi: 10.1002/path.5263. Epub 2019 Apr 16.

PMID:
30883742
7.

Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis.

Conklin LS, Merkel PA, Pachman LM, Parikh H, Tawalbeh S, Damsker JM, Cuthbertson DD, Morgan GA, Monach PA, Hathout Y, Nagaraju K, van den Anker J, McAlear CA, Hoffman EP.

Steroids. 2018 Dec;140:159-166. doi: 10.1016/j.steroids.2018.10.008. Epub 2018 Oct 21.

8.

Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug.

Conklin LS, Damsker JM, Hoffman EP, Jusko WJ, Mavroudis PD, Schwartz BD, Mengle-Gaw LJ, Smith EC, Mah JK, Guglieri M, Nevo Y, Kuntz N, McDonald CM, Tulinius M, Ryan MM, Webster R, Castro D, Finkel RS, Smith AL, Morgenroth LP, Arrieta A, Shimony M, Jaros M, Shale P, McCall JM, Hathout Y, Nagaraju K, van den Anker J, Ward LM, Ahmet A, Cornish MR, Clemens PR.

Pharmacol Res. 2018 Oct;136:140-150. doi: 10.1016/j.phrs.2018.09.007. Epub 2018 Sep 13.

9.

Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle.

Novak JS, Hogarth MW, Boehler JF, Nearing M, Vila MC, Heredia R, Fiorillo AA, Zhang A, Hathout Y, Hoffman EP, Jaiswal JK, Nagaraju K, Cirak S, Partridge TA.

Nat Commun. 2018 Mar 23;9(1):1256. doi: 10.1038/s41467-018-03709-8.

10.

Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle.

Novak JS, Hogarth MW, Boehler JF, Nearing M, Vila MC, Heredia R, Fiorillo AA, Zhang A, Hathout Y, Hoffman EP, Jaiswal JK, Nagaraju K, Cirak S, Partridge TA.

Nat Commun. 2018 Jan 15;9(1):208. doi: 10.1038/s41467-017-02206-8.

11.

Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle.

Novak JS, Hogarth MW, Boehler JF, Nearing M, Vila MC, Heredia R, Fiorillo AA, Zhang A, Hathout Y, Hoffman EP, Jaiswal JK, Nagaraju K, Cirak S, Partridge TA.

Nat Commun. 2017 Oct 16;8(1):941. doi: 10.1038/s41467-017-00924-7. Erratum in: Nat Commun. 2018 Jan 15;9(1):208. Nat Commun. 2018 Mar 23;9(1):1256.

12.

Interleukin 1 Receptor-Like 1 Protein (ST2) is a Potential Biomarker for Cardiomyopathy in Duchenne Muscular Dystrophy.

Anderson J, Seol H, Gordish-Dressman H, Hathout Y, Spurney CF; CINRG Investigators.

Pediatr Cardiol. 2017 Dec;38(8):1606-1612. doi: 10.1007/s00246-017-1703-9. Epub 2017 Aug 18.

13.

Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy.

Vila MC, Rayavarapu S, Hogarth MW, Van der Meulen JH, Horn A, Defour A, Takeda S, Brown KJ, Hathout Y, Nagaraju K, Jaiswal JK.

Cell Death Differ. 2017 Feb;24(2):330-342. doi: 10.1038/cdd.2016.127. Epub 2016 Nov 11.

14.

PARP1 Differentially Interacts with Promoter region of DUX4 Gene in FSHD Myoblasts.

Sharma V, Pandey SN, Khawaja H, Brown KJ, Hathout Y, Chen YW.

J Genet Syndr Gene Ther. 2016 Aug;7(4). pii: 303. Epub 2016 Aug 8.

15.

Identification of Pathway-Specific Serum Biomarkers of Response to Glucocorticoid and Infliximab Treatment in Children with Inflammatory Bowel Disease.

Heier CR, Fiorillo AA, Chaisson E, Gordish-Dressman H, Hathout Y, Damsker JM, Hoffman EP, Conklin LS.

Clin Transl Gastroenterol. 2016 Sep 15;7(9):e192. doi: 10.1038/ctg.2016.49.

16.

Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children.

Hathout Y, Conklin LS, Seol H, Gordish-Dressman H, Brown KJ, Morgenroth LP, Nagaraju K, Heier CR, Damsker JM, van den Anker JN, Henricson E, Clemens PR, Mah JK, McDonald C, Hoffman EP.

Sci Rep. 2016 Aug 17;6:31727. doi: 10.1038/srep31727.

17.

Correction: Discovery of Metabolic Biomarkers for Duchenne Muscular Dystrophy within a Natural History Study.

Boca SM, Nishida M, Harris M, Rao S, Cheema AK, Gill K, Wang D, An L, Gauba R, Seol H, Morgenroth LP, Henricson E, McDonald C, Mah JK, Clemens PR, Hoffman EP, Hathout Y, Madhavan S.

PLoS One. 2016 Jul 19;11(7):e0159895. doi: 10.1371/journal.pone.0159895. eCollection 2016.

18.

Discovery of Metabolic Biomarkers for Duchenne Muscular Dystrophy within a Natural History Study.

Boca SM, Nishida M, Harris M, Rao S, Cheema AK, Gill K, Seol H, Morgenroth LP, Henricson E, McDonald C, Mah JK, Clemens PR, Hoffman EP, Hathout Y, Madhavan S.

PLoS One. 2016 Apr 15;11(4):e0153461. doi: 10.1371/journal.pone.0153461. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0159895.

19.

Clinical utility of serum biomarkers in Duchenne muscular dystrophy.

Hathout Y, Seol H, Han MH, Zhang A, Brown KJ, Hoffman EP.

Clin Proteomics. 2016 Apr 5;13:9. doi: 10.1186/s12014-016-9109-x. eCollection 2016. Review.

20.

Elusive sources of variability of dystrophin rescue by exon skipping.

Vila MC, Klimek MB, Novak JS, Rayavarapu S, Uaesoontrachoon K, Boehler JF, Fiorillo AA, Hogarth MW, Zhang A, Shaughnessy C, Gordish-Dressman H, Burki U, Straub V, Lu QL, Partridge TA, Brown KJ, Hathout Y, van den Anker J, Hoffman EP, Nagaraju K.

Skelet Muscle. 2015 Dec 1;5:44. doi: 10.1186/s13395-015-0070-6. eCollection 2015.

21.

The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse.

Zhang A, Uaesoontrachoon K, Shaughnessy C, Das JR, Rayavarapu S, Brown KJ, Ray PE, Nagaraju K, van den Anker JN, Hoffman EP, Hathout Y.

Toxicol Rep. 2015;2:838-849.

22.

Proteomic methods for biomarker discovery and validation. Are we there yet?

Hathout Y.

Expert Rev Proteomics. 2015 Aug;12(4):329-31. doi: 10.1586/14789450.2015.1064771.

PMID:
26186709
23.

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy.

Hathout Y, Brody E, Clemens PR, Cripe L, DeLisle RK, Furlong P, Gordish-Dressman H, Hache L, Henricson E, Hoffman EP, Kobayashi YM, Lorts A, Mah JK, McDonald C, Mehler B, Nelson S, Nikrad M, Singer B, Steele F, Sterling D, Sweeney HL, Williams S, Gold L.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7153-8. doi: 10.1073/pnas.1507719112. Epub 2015 May 26.

24.

Urinary biomarkers of kidney diseases in HIV-infected children.

Perazzo S, Soler-García ÁA, Hathout Y, Das JR, Ray PE.

Proteomics Clin Appl. 2015 Jun;9(5-6):490-500. doi: 10.1002/prca.201400193. Review.

25.

miR-184 regulates ezrin, LAMP-1 expression, affects phagocytosis in human retinal pigment epithelium and is downregulated in age-related macular degeneration.

Murad N, Kokkinaki M, Gunawardena N, Gunawan MS, Hathout Y, Janczura KJ, Theos AC, Golestaneh N.

FEBS J. 2014 Dec;281(23):5251-64. doi: 10.1111/febs.13066. Epub 2014 Oct 13.

26.

Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity.

Rowlands DS, Page RA, Sukala WR, Giri M, Ghimbovschi SD, Hayat I, Cheema BS, Lys I, Leikis M, Sheard PW, Wakefield SJ, Breier B, Hathout Y, Brown K, Marathi R, Orkunoglu-Suer FE, Devaney JM, Leiken B, Many G, Krebs J, Hopkins WG, Hoffman EP.

Physiol Genomics. 2014 Oct 15;46(20):747-65. doi: 10.1152/physiolgenomics.00024.2014. Epub 2014 Aug 19.

27.

Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients.

Hathout Y, Marathi RL, Rayavarapu S, Zhang A, Brown KJ, Seol H, Gordish-Dressman H, Cirak S, Bello L, Nagaraju K, Partridge T, Hoffman EP, Takeda S, Mah JK, Henricson E, McDonald C.

Hum Mol Genet. 2014 Dec 15;23(24):6458-69. doi: 10.1093/hmg/ddu366. Epub 2014 Jul 15.

28.

Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target.

Rayavarapu S, Coley W, Van der Meulen JH, Cakir E, Tappeta K, Kinder TB, Dillingham BC, Brown KJ, Hathout Y, Nagaraju K.

Arthritis Rheum. 2013 Dec;65(12):3248-58. doi: 10.1002/art.38180.

29.

Directional secretomes reflect polarity-specific functions in an in vitro model of human bronchial epithelium.

Pillai DK, Sankoorikal BJ, Johnson E, Seneviratne AN, Zurko J, Brown KJ, Hathout Y, Rose MC.

Am J Respir Cell Mol Biol. 2014 Feb;50(2):292-300. doi: 10.1165/rcmb.2013-0188OC.

30.

Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012.

Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüβ C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C.

Mol Cell Proteomics. 2013 Oct;12(10):2935-51. doi: 10.1074/mcp.M113.030643. Epub 2013 Jun 13.

31.

Accurate Quantitation of Dystrophin Protein in Human Skeletal Muscle Using Mass Spectrometry.

Brown KJ, Marathi R, Fiorillo AA, Ciccimaro EF, Sharma S, Rowlands DS, Rayavarapu S, Nagaraju K, Hoffman EP, Hathout Y.

J Bioanal Biomed. 2012 Dec 18;Suppl 7. pii: 001.

32.

The human secretome atlas initiative: implications in health and disease conditions.

Brown KJ, Seol H, Pillai DK, Sankoorikal BJ, Formolo CA, Mac J, Edwards NJ, Rose MC, Hathout Y.

Biochim Biophys Acta. 2013 Nov;1834(11):2454-61. doi: 10.1016/j.bbapap.2013.04.007. Epub 2013 Apr 19.

33.

Dystrophin deficiency leads to disturbance of LAMP1-vesicle-associated protein secretion.

Duguez S, Duddy W, Johnston H, Lainé J, Le Bihan MC, Brown KJ, Bigot A, Hathout Y, Butler-Browne G, Partridge T.

Cell Mol Life Sci. 2013 Jun;70(12):2159-74. doi: 10.1007/s00018-012-1248-2. Epub 2013 Jan 24.

PMID:
23344255
34.

Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse.

Rayavarapu S, Coley W, Cakir E, Jahnke V, Takeda S, Aoki Y, Grodish-Dressman H, Jaiswal JK, Hoffman EP, Brown KJ, Hathout Y, Nagaraju K.

Mol Cell Proteomics. 2013 May;12(5):1061-73. doi: 10.1074/mcp.M112.023127. Epub 2013 Jan 7.

35.

Secretome survey of human plexiform neurofibroma derived Schwann Cells reveals a secreted form of the RARRES1 protein.

Chen HL, Seol H, Brown KJ, Gordish-Dressman H, Hill A, Gallo V, Packer R, Hathout Y.

Int J Mol Sci. 2012;13(7):9380-99. doi: 10.3390/ijms13079380. Epub 2012 Jul 24.

36.

Advances in the proteomic investigation of the cell secretome.

Brown KJ, Formolo CA, Seol H, Marathi RL, Duguez S, An E, Pillai D, Nazarian J, Rood BR, Hathout Y.

Expert Rev Proteomics. 2012 Jun;9(3):337-45. doi: 10.1586/epr.12.21. Review.

37.

Use of quantitative membrane proteomics identifies a novel role of mitochondria in healing injured muscles.

Sharma N, Medikayala S, Defour A, Rayavarapu S, Brown KJ, Hathout Y, Jaiswal JK.

J Biol Chem. 2012 Aug 31;287(36):30455-67. doi: 10.1074/jbc.M112.354415. Epub 2012 Jul 9.

38.

Characterization of Transferrin Glycopeptide Structures in Human Cerebrospinal Fluid.

Brown KJ, Vanderver A, Hoffman EP, Schiffmann R, Hathout Y.

Int J Mass Spectrom. 2012 Feb 15;312:97-106.

39.

Quantitative proteomic analyses of human cytomegalovirus-induced restructuring of endoplasmic reticulum-mitochondrial contacts at late times of infection.

Zhang A, Williamson CD, Wong DS, Bullough MD, Brown KJ, Hathout Y, Colberg-Poley AM.

Mol Cell Proteomics. 2011 Oct;10(10):M111.009936. doi: 10.1074/mcp.M111.009936. Epub 2011 Jul 8.

40.

SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas.

Brim H, Kumar K, Nazarian J, Hathout Y, Jafarian A, Lee E, Green W, Smoot D, Park J, Nouraie M, Ashktorab H.

PLoS One. 2011;6(6):e20216. doi: 10.1371/journal.pone.0020216. Epub 2011 Jun 8.

41.

Secretome signature of invasive glioblastoma multiforme.

Formolo CA, Williams R, Gordish-Dressman H, MacDonald TJ, Lee NH, Hathout Y.

J Proteome Res. 2011 Jul 1;10(7):3149-59. doi: 10.1021/pr200210w. Epub 2011 May 31.

42.

Evolution and comparative genomics of subcellular specializations: EST sequencing of Torpedo electric organ.

Nazarian J, Berry DL, Sanjari S, Razvi M, Brown K, Hathout Y, Vertes A, Dadgar S, Hoffman EP.

Mar Genomics. 2011 Mar;4(1):33-40. doi: 10.1016/j.margen.2010.12.004. Epub 2011 Feb 12.

43.

Proteomic profiling of cerebrospinal fluid identifies prostaglandin D2 synthase as a putative biomarker for pediatric medulloblastoma: A pediatric brain tumor consortium study.

Rajagopal MU, Hathout Y, MacDonald TJ, Kieran MW, Gururangan S, Blaney SM, Phillips P, Packer R, Gordish-Dressman H, Rood BR.

Proteomics. 2011 Mar;11(5):935-43. doi: 10.1002/pmic.201000198. Epub 2011 Jan 27.

44.

Time series proteome profiling.

Formolo CA, Mintz M, Takanohashi A, Brown KJ, Vanderver A, Halligan B, Hathout Y.

Methods Mol Biol. 2011;694:365-77. doi: 10.1007/978-1-60761-977-2_22.

45.

MUC5B Is the predominant mucin glycoprotein in chronic otitis media fluid.

Preciado D, Goyal S, Rahimi M, Watson AM, Brown KJ, Hathout Y, Rose MC.

Pediatr Res. 2010 Sep;68(3):231-6. doi: 10.1203/00006450-201011001-00451.

46.

Direct analysis of lipids and small metabolites in mouse brain tissue by AP IR-MALDI and reactive LAESI mass spectrometry.

Shrestha B, Nemes P, Nazarian J, Hathout Y, Hoffman EP, Vertes A.

Analyst. 2010 Apr;135(4):751-8.

PMID:
20349540
47.

Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome.

An E, Sen S, Park SK, Gordish-Dressman H, Hathout Y.

Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3379-86. doi: 10.1167/iovs.09-4853. Epub 2010 Mar 5.

48.

Proteomic profiling of glucocorticoid-exposed myogenic cells: Time series assessment of protein translocation and transcription of inactive mRNAs.

Reeves EK, Gordish-Dressman H, Hoffman EP, Hathout Y.

Proteome Sci. 2009 Jul 30;7:26. doi: 10.1186/1477-5956-7-26.

49.

The PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase: implications for the function of BTN1A1 in the mammary gland and other tissues.

Jeong J, Rao AU, Xu J, Ogg SL, Hathout Y, Fenselau C, Mather IH.

J Biol Chem. 2009 Aug 14;284(33):22444-56. doi: 10.1074/jbc.M109.020446. Epub 2009 Jun 15.

50.

Iron-related proteins: candidate urine biomarkers in childhood HIV-associated renal diseases.

Soler-García AA, Johnson D, Hathout Y, Ray PE.

Clin J Am Soc Nephrol. 2009 Apr;4(4):763-71. doi: 10.2215/CJN.0200608. Epub 2009 Mar 11.

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