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Items: 1 to 50 of 52

1.

Epigenetic Control of a Local Chromatin Landscape.

Chiarella AM, Lu D, Hathaway NA.

Int J Mol Sci. 2020 Jan 31;21(3). pii: E943. doi: 10.3390/ijms21030943. Review.

2.

Antimalarial drug resistance profiling of Plasmodium falciparum infections in Ghana using molecular inversion probes and next generation sequencing.

Mensah BA, Aydemir O, Myers-Hansen JL, Opoku M, Hathaway NJ, Marsh PW, Anto F, Bailey J, Abuaku B, Ghansah A.

Antimicrob Agents Chemother. 2020 Jan 13. pii: AAC.01423-19. doi: 10.1128/AAC.01423-19. [Epub ahead of print]

PMID:
31932374
3.

Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma.

Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J.

Nat Genet. 2019 Dec;51(12):1714-1722. doi: 10.1038/s41588-019-0534-4. Epub 2019 Nov 29.

PMID:
31784732
4.

Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery.

Chiarella AM, Butler KV, Gryder BE, Lu D, Wang TA, Yu X, Pomella S, Khan J, Jin J, Hathaway NA.

Nat Biotechnol. 2020 Jan;38(1):50-55. doi: 10.1038/s41587-019-0296-7. Epub 2019 Nov 11.

PMID:
31712774
5.

Efficient Transmission of Mixed Plasmodium falciparum/vivax Infections From Humans to Mosquitoes.

Balasubramanian S, Rahman RS, Lon C, Parobek C, Ubalee R, Hathaway N, Kuntawunginn W, My M, Vy D, Saxe J, Lanteri C, Lin FC, Spring M, Meshnick SR, Juliano JJ, Saunders DL, Lin JT.

J Infect Dis. 2020 Jan 14;221(3):428-437. doi: 10.1093/infdis/jiz388.

PMID:
31549156
6.

Pooled Deep Sequencing of Drug Resistance Loci from Plasmodium falciparum Parasites across Ethiopia.

Brazeau NF, Assefa A, Mohammed H, Seme H, Tsadik AG, Parr JB, Keeler C, Hathaway NJ, Meshnick SR, Bailey JA, Kassa M, Juliano JJ, Woyessa A.

Am J Trop Med Hyg. 2019 Nov;101(5):1139-1143. doi: 10.4269/ajtmh.19-0142.

PMID:
31516103
7.

Prevalence of Molecular Markers of Antimalarial Drug Resistance across Altitudinal Transmission Zones in Highland Western Uganda.

Boyce RM, Brazeau N, Fulton T, Hathaway N, Matte M, Ntaro M, Mulogo E, Juliano JJ.

Am J Trop Med Hyg. 2019 Oct;101(4):799-802. doi: 10.4269/ajtmh.19-0081.

PMID:
31436149
8.

Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription.

Madigan VJ, Yuziuk JA, Chiarella AM, Tyson TO, Meganck RM, Elmore ZC, Tse LV, Hathaway NA, Asokan A.

PLoS Pathog. 2019 Aug 6;15(8):e1007988. doi: 10.1371/journal.ppat.1007988. eCollection 2019 Aug.

9.

Contribution of promoter DNA sequence to heterochromatin formation velocity and memory of gene repression in mouse embryo fibroblasts.

Vignaux PA, Bregio C, Hathaway NA.

PLoS One. 2019 Jul 3;14(7):e0217699. doi: 10.1371/journal.pone.0217699. eCollection 2019.

10.

Chemical screen for epigenetic barriers to single allele activation of Oct4.

Headley KM, Kedziora KM, Alejo A, Lai EZ, Purvis JE, Hathaway NA.

Stem Cell Res. 2019 Jul;38:101470. doi: 10.1016/j.scr.2019.101470. Epub 2019 May 24.

11.

Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations.

MacDonald IA, Butler KV, Herring LE, Clinkscales SE, Yelagandula R, Stecher K, Bell O, Graves LM, Jin J, Hathaway NA.

SLAS Discov. 2019 Sep;24(8):802-816. doi: 10.1177/2472555219849838. Epub 2019 May 30.

PMID:
31145866
12.

Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study.

Khodaverdian V, Tapadar S, MacDonald IA, Xu Y, Ho PY, Bridges A, Rajpurohit P, Sanghani BA, Fan Y, Thangaraju M, Hathaway NA, Oyelere AK.

Sci Rep. 2019 Mar 18;9(1):4802. doi: 10.1038/s41598-019-39214-1.

13.

Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome.

Chory EJ, Calarco JP, Hathaway NA, Bell O, Neel DS, Crabtree GR.

Mol Cell. 2019 Jan 3;73(1):61-72.e3. doi: 10.1016/j.molcel.2018.10.028. Epub 2018 Nov 21.

14.

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers.

Chiarella AM, Wang TA, Butler KV, Jin J, Hathaway NA.

J Vis Exp. 2018 Sep 20;(139). doi: 10.3791/58222.

15.

Reuse of malaria rapid diagnostic tests for amplicon deep sequencing to estimate Plasmodium falciparum transmission intensity in western Uganda.

Boyce RM, Hathaway N, Fulton T, Reyes R, Matte M, Ntaro M, Mulogo E, Waltmann A, Bailey JA, Siedner MJ, Juliano JJ.

Sci Rep. 2018 Jul 5;8(1):10159. doi: 10.1038/s41598-018-28534-3.

16.

Drug-Resistance and Population Structure of Plasmodium falciparum Across the Democratic Republic of Congo Using High-Throughput Molecular Inversion Probes.

Aydemir O, Janko M, Hathaway NJ, Verity R, Mwandagalirwa MK, Tshefu AK, Tessema SK, Marsh PW, Tran A, Reimonn T, Ghani AC, Ghansah A, Juliano JJ, Greenhouse BR, Emch M, Meshnick SR, Bailey JA.

J Infect Dis. 2018 Aug 14;218(6):946-955. doi: 10.1093/infdis/jiy223.

17.

Cavitation Enhancement Increases the Efficiency and Consistency of Chromatin Fragmentation from Fixed Cells for Downstream Quantitative Applications.

Chiarella AM, Quimby AL, Mehrab-Mohseni M, Velasco B, Kasoji SK, Davis IJ, Dayton PA, Hathaway NA, Pattenden SG.

Biochemistry. 2018 May 15;57(19):2756-2761. doi: 10.1021/acs.biochem.8b00075. Epub 2018 Apr 25.

18.

Plasmodium falciparum genetic variation of var2csa in the Democratic Republic of the Congo.

Verity R, Hathaway NJ, Waltmann A, Doctor SM, Watson OJ, Patel JC, Mwandagalirwa K, Tshefu AK, Bailey JA, Ghani AC, Juliano JJ, Meshnick SR.

Malar J. 2018 Jan 24;17(1):46. doi: 10.1186/s12936-018-2193-9.

19.

Matched Placental and Circulating Plasmodium falciparum Parasites are Genetically Homologous at the var2csa ID1-DBL2X Locus by Deep Sequencing.

Waltmann A, Patel JC, Thwai KL, Hathaway NJ, Parobek CM, Massougbodji A, Fievet N, Bailey JA, Deloron P, Juliano JJ, Ndam NT, Meshnick SR.

Am J Trop Med Hyg. 2018 Jan;98(1):77-82. doi: 10.4269/ajtmh.17-0529.

20.

A deep sequencing approach to estimate Plasmodium falciparum complexity of infection (COI) and explore apical membrane antigen 1 diversity.

Miller RH, Hathaway NJ, Kharabora O, Mwandagalirwa K, Tshefu A, Meshnick SR, Taylor SM, Juliano JJ, Stewart VA, Bailey JA.

Malar J. 2017 Dec 16;16(1):490. doi: 10.1186/s12936-017-2137-9.

21.

SeekDeep: single-base resolution de novo clustering for amplicon deep sequencing.

Hathaway NJ, Parobek CM, Juliano JJ, Bailey JA.

Nucleic Acids Res. 2018 Feb 28;46(4):e21. doi: 10.1093/nar/gkx1201.

22.

Design, Implementation, and Outcomes of a Three-week Pharmacy Bridging Course.

McLaughlin JE, Khanova J, Persky A, Hathaway N, Cox W.

Am J Pharm Educ. 2017 Sep;81(7):6313. doi: 10.5688/ajpe8176313.

23.

Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity.

Butler KV, Chiarella AM, Jin J, Hathaway NA.

ACS Synth Biol. 2018 Jan 19;7(1):38-45. doi: 10.1021/acssynbio.7b00295. Epub 2017 Nov 7.

24.

Report and Application of a Tool Compound Data Set.

Butler KV, MacDonald IA, Hathaway NA, Jin J.

J Chem Inf Model. 2017 Nov 27;57(11):2699-2706. doi: 10.1021/acs.jcim.7b00343. Epub 2017 Nov 2.

25.

International Classification of Disease Coding of Exertional Heat Illness in U.S. Army Soldiers.

DeGroot DW, Mok G, Hathaway NE.

Mil Med. 2017 Sep;182(9):e1946-e1950. doi: 10.7205/MILMED-D-16-00429.

PMID:
28885960
26.

Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade.

Patel JC, Hathaway NJ, Parobek CM, Thwai KL, Madanitsa M, Khairallah C, Kalilani-Phiri L, Mwapasa V, Massougbodji A, Fievet N, Bailey JA, Ter Kuile FO, Deloron P, Engel SM, Taylor SM, Juliano JJ, Tuikue Ndam N, Meshnick SR.

Sci Rep. 2017 Aug 11;7(1):7768. doi: 10.1038/s41598-017-04737-y.

27.

Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.

Ren J, Hathaway NA, Crabtree GR, Muegge K.

Epigenetics. 2018;13(2):173-181. doi: 10.1080/15592294.2017.1338234. Epub 2018 Feb 6.

28.

Surveillance for sulfadoxine-pyrimethamine resistant malaria parasites in the Lake and Southern Zones, Tanzania, using pooling and next-generation sequencing.

Ngondi JM, Ishengoma DS, Doctor SM, Thwai KL, Keeler C, Mkude S, Munishi OM, Willilo RA, Lalji S, Kaspar N, Kitojo C, Paxton LA, Hathaway NJ, Bailey JA, Juliano JJ, Meshnick SR, Gutman J.

Malar J. 2017 Jun 5;16(1):236. doi: 10.1186/s12936-017-1886-9.

29.

Exertional Heat Injury: Effects of Adding Cold (4°C) Intravenous Saline to Prehospital Protocol.

Mok G, DeGroot D, Hathaway NE, Bigley DP, McGuire CS.

Curr Sports Med Rep. 2017 Mar/Apr;16(2):103-108. doi: 10.1249/JSR.0000000000000345.

PMID:
28282357
30.

Longitudinal Pooled Deep Sequencing of the Plasmodium vivax K12 Kelch Gene in Cambodia Reveals a Lack of Selection by Artemisinin.

Brazeau NF, Hathaway N, Parobek CM, Lin JT, Bailey JA, Lon C, Saunders DL, Juliano JJ.

Am J Trop Med Hyg. 2016 Dec 7;95(6):1409-1412. Epub 2016 Oct 31.

31.

A deep sequencing tool for partitioning clearance rates following antimalarial treatment in polyclonal infections.

Mideo N, Bailey JA, Hathaway NJ, Ngasala B, Saunders DL, Lon C, Kharabora O, Jamnik A, Balasubramanian S, Björkman A, Mårtensson A, Meshnick SR, Read AF, Juliano JJ.

Evol Med Public Health. 2016 Jan 27;2016(1):21-36. doi: 10.1093/emph/eov036.

32.

Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice.

Burgoyne JR, Rudyk O, Cho HJ, Prysyazhna O, Hathaway N, Weeks A, Evans R, Ng T, Schröder K, Brandes RP, Shah AM, Eaton P.

Nat Commun. 2015 Aug 10;6:7920. doi: 10.1038/ncomms8920.

PMID:
26258640
33.

Variation in the Microbiota of Ixodes Ticks with Regard to Geography, Species, and Sex.

Van Treuren W, Ponnusamy L, Brinkerhoff RJ, Gonzalez A, Parobek CM, Juliano JJ, Andreadis TG, Falco RC, Ziegler LB, Hathaway N, Keeler C, Emch M, Bailey JA, Roe RM, Apperson CS, Knight R, Meshnick SR.

Appl Environ Microbiol. 2015 Sep;81(18):6200-9. doi: 10.1128/AEM.01562-15. Epub 2015 Jul 6.

34.

Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse.

Lin JT, Hathaway NJ, Saunders DL, Lon C, Balasubramanian S, Kharabora O, Gosi P, Sriwichai S, Kartchner L, Chuor CM, Satharath P, Lanteri C, Bailey JA, Juliano JJ.

J Infect Dis. 2015 Sep 15;212(6):999-1008. doi: 10.1093/infdis/jiv142. Epub 2015 Mar 6.

35.

Epigenetic roots of immunologic disease and new methods for examining chromatin regulatory pathways.

MacDonald IA, Hathaway NA.

Immunol Cell Biol. 2015 Mar;93(3):261-70. doi: 10.1038/icb.2014.105. Epub 2014 Dec 23. Review.

PMID:
25533290
36.

Differing patterns of selection and geospatial genetic diversity within two leading Plasmodium vivax candidate vaccine antigens.

Parobek CM, Bailey JA, Hathaway NJ, Socheat D, Rogers WO, Juliano JJ.

PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2796. doi: 10.1371/journal.pntd.0002796. eCollection 2014 Apr.

37.

Common sleep disorders in children.

Carter KA, Hathaway NE, Lettieri CF.

Am Fam Physician. 2014 Mar 1;89(5):368-77. Review.

38.

Dynamics and memory of heterochromatin in living cells.

Hathaway NA, Bell O, Hodges C, Miller EL, Neel DS, Crabtree GR.

Cell. 2012 Jun 22;149(7):1447-60. doi: 10.1016/j.cell.2012.03.052. Epub 2012 Jun 14.

39.

APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1.

Dimova NV, Hathaway NA, Lee BH, Kirkpatrick DS, Berkowitz ML, Gygi SP, Finley D, King RW.

Nat Cell Biol. 2012 Jan 29;14(2):168-76. doi: 10.1038/ncb2425.

40.

Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.

Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW.

Cancer Cell. 2010 Oct 19;18(4):382-95. doi: 10.1016/j.ccr.2010.08.010.

41.

Influence of chylomicron remnants on human monocyte activation in vitro.

Bentley C, Hathaway N, Widdows J, Bejta F, De Pascale C, Avella M, Wheeler-Jones CP, Botham KM, Lawson C.

Nutr Metab Cardiovasc Dis. 2011 Nov;21(11):871-8. doi: 10.1016/j.numecd.2010.02.019. Epub 2010 Jul 31.

42.

Microcornea, posterior megalolenticonus, persistent fetal vasculature, and coloboma: a new syndrome.

Ranchod TM, Quiram PA, Hathaway N, Ho LY, Glasgow BJ, Trese MT.

Ophthalmology. 2010 Sep;117(9):1843-7. doi: 10.1016/j.ophtha.2009.12.045. Epub 2010 Apr 24.

PMID:
20417569
43.

Clinical inquiries. When is it OK for children to start drinking fruit juice?

Stephens MB, Keville MP, Hathaway NE, Kendall SK.

J Fam Pract. 2009 Sep;58(9):E3. Review.

PMID:
19744411
44.

Retinal vein occlusion and papillitis in serpiginous choroidopathy.

Kotsolis AI, Karamchandani HK, Hathaway N, Williams GA, Yannuzzi LA.

Retin Cases Brief Rep. 2009 Summer;3(3):296-8. doi: 10.1097/ICB.0b013e318185ea98.

PMID:
25389589
45.

Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.

Kleijnen MF, Roelofs J, Park S, Hathaway NA, Glickman M, King RW, Finley D.

Nat Struct Mol Biol. 2007 Dec;14(12):1180-8. Epub 2007 Nov 18.

PMID:
18026118
46.

Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.

Crosas B, Hanna J, Kirkpatrick DS, Zhang DP, Tone Y, Hathaway NA, Buecker C, Leggett DS, Schmidt M, King RW, Gygi SP, Finley D.

Cell. 2006 Dec 29;127(7):1401-13.

47.

Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.

Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D.

Cell. 2006 Oct 6;127(1):99-111.

48.

Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology.

Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP.

Nat Cell Biol. 2006 Jul;8(7):700-10. Epub 2006 Jun 25. Erratum in: Nat Cell Biol. 2006 Aug;8(8):896.

PMID:
16799550
49.

Dissecting cell biology with chemical scalpels.

Hathaway NA, King RW.

Curr Opin Cell Biol. 2005 Feb;17(1):12-9. Review.

PMID:
15661514
50.

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.

Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA.

Nature. 2002 Sep 12;419(6903):162-7.

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