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Items: 31

1.

Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.

Williams WA, Linley JE, Jones CA, Shibata Y, Snijder A, Button J, Hatcher JP, Huang L, Taddese B, Thornton P, Schofield DJ, Thom G, Popovic B, Dosanjh B, Wilkinson T, Hughes J, Dobson CL, Groves MA, Webster CI, Billinton A, Vaughan TJ, Chessell I.

Pain. 2019 Apr 24. doi: 10.1097/j.pain.0000000000001587. [Epub ahead of print]

PMID:
31045747
2.

A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model.

Thom G, Tian MM, Hatcher JP, Rodrigo N, Burrell M, Gurrell I, Vitalis TZ, Abraham T, Jefferies WA, Webster CI, Gabathuler R.

J Cereb Blood Flow Metab. 2018 May 30:271678X18772998. doi: 10.1177/0271678X18772998. [Epub ahead of print]

PMID:
29845881
3.

Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain.

Nicol LSC, Thornton P, Hatcher JP, Glover CP, Webster CI, Burrell M, Hammett K, Jones CA, Sleeman MA, Billinton A, Chessell I.

Pain. 2018 Mar;159(3):550-559. doi: 10.1097/j.pain.0000000000001130.

4.

Artemin-GFRα3 interactions partially contribute to acute inflammatory hypersensitivity.

Thornton P, Hatcher JP, Robinson I, Sargent B, Franzén B, Martino G, Kitching L, Glover CP, Anderson D, Forsmo-Bruce H, Low CP, Cusdin F, Dosanjh B, Williams W, Steffen AC, Thompson S, Eklund M, Lloyd C, Chessell I, Hughes J.

Neurosci Lett. 2013 Jun 17;545:23-8. doi: 10.1016/j.neulet.2013.04.007. Epub 2013 Apr 19.

PMID:
23603259
5.

Use of dynamic weight bearing as a novel end-point for the assessment of Freund's Complete Adjuvant induced hypersensitivity in mice.

Robinson I, Sargent B, Hatcher JP.

Neurosci Lett. 2012 Aug 30;524(2):107-10. doi: 10.1016/j.neulet.2012.07.017. Epub 2012 Jul 20.

PMID:
22819976
6.

Biologics: the next-generation therapeutics for analgesia?

Hatcher JP, Chessell IP, Hughes JP.

Expert Rev Neurother. 2011 Nov;11(11):1653-8. doi: 10.1586/ern.11.66. Review.

PMID:
22014142
7.

Biologic drugs for analgesia: redefining the opportunity.

Hughes J, Hatcher JP, Chessell IP.

Curr Pharm Biotechnol. 2011 Oct;12(10):1660-70. Review.

PMID:
21466448
8.

Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain.

Ulmann L, Hatcher JP, Hughes JP, Chaumont S, Green PJ, Conquet F, Buell GN, Reeve AJ, Chessell IP, Rassendren F.

J Neurosci. 2008 Oct 29;28(44):11263-8. doi: 10.1523/JNEUROSCI.2308-08.2008.

9.

The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain.

Staton PC, Hatcher JP, Walker DJ, Morrison AD, Shapland EM, Hughes JP, Chong E, Mander PK, Green PJ, Billinton A, Fulleylove M, Lancaster HC, Smith JC, Bailey LT, Wise A, Brown AJ, Richardson JC, Chessell IP.

Pain. 2008 Sep 30;139(1):225-36. doi: 10.1016/j.pain.2008.04.006. Epub 2008 May 27.

PMID:
18502582
10.

Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action.

Medhurst SJ, Hatcher JP, Hille CJ, Bingham S, Clayton NM, Billinton A, Chessell IP.

J Pain. 2008 Jul;9(7):580-7. doi: 10.1016/j.jpain.2008.01.336.

PMID:
18420461
11.

The role of P2X₇ in pain and inflammation.

Hughes JP, Hatcher JP, Chessell IP.

Purinergic Signal. 2007 Mar;3(1-2):163-9. doi: 10.1007/s11302-006-9031-1. Epub 2007 Jan 3.

12.

The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.

Amaya F, Wang H, Costigan M, Allchorne AJ, Hatcher JP, Egerton J, Stean T, Morisset V, Grose D, Gunthorpe MJ, Chessell IP, Tate S, Green PJ, Woolf CJ.

J Neurosci. 2006 Dec 13;26(50):12852-60.

13.

Transgenic models of pain: a brief review.

Hatcher JP, Chessell IP.

Curr Opin Investig Drugs. 2006 Jul;7(7):647-52. Review.

PMID:
16869119
14.

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain.

Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, Grahames CB, Casula MA, Yiangou Y, Birch R, Anand P, Buell GN.

Pain. 2005 Apr;114(3):386-96.

PMID:
15777864
15.

The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.

Bingham S, Beswick PJ, Bountra C, Brown T, Campbell IB, Chessell IP, Clayton N, Collins SD, Davey PT, Goodland H, Gray N, Haslam C, Hatcher JP, Hunter AJ, Lucas F, Murkitt G, Naylor A, Pickup E, Sargent B, Summerfield SG, Stevens A, Stratton SC, Wiseman J.

J Pharmacol Exp Ther. 2005 Mar;312(3):1161-9. Epub 2004 Nov 30.

PMID:
15572651
16.

The behavioural effect of middle cerebral artery occlusion on apolipoprotein-E deficient mice.

Hatcher JP, Virley D, Hadingham SJ, Roberts J, Hunter AJ, Parsons AA.

Behav Brain Res. 2002 Apr 1;131(1-2):139-49.

PMID:
11844581
17.

Development of SHIRPA to characterise the phenotype of gene-targeted mice.

Hatcher JP, Jones DN, Rogers DC, Hatcher PD, Reavill C, Hagan JJ, Hunter AJ.

Behav Brain Res. 2001 Nov 1;125(1-2):43-7. No abstract available.

PMID:
11682092
18.

Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity.

Jones DN, Gartlon J, Parker F, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Hatcher JP, Johns A, Porter RA, Hagan JJ, Hunter AJ, Upton N.

Psychopharmacology (Berl). 2001 Jan 1;153(2):210-8.

PMID:
11205421
19.

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.

Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA.

Nature. 2000 May 11;405(6783):183-7.

PMID:
10821274
20.

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DN, Smith MI, Piper DC, Hunter AJ, Porter RA, Upton N.

Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10911-6.

21.

The effects of dopamine D3/D2 receptor agonists on intracranial self stimulation in the rat.

Hatcher JP, Hagan JJ.

Psychopharmacology (Berl). 1998 Dec;140(4):405-10.

PMID:
9888614
22.

5-HT4 receptor antagonism does not affect motor and reward mechanisms in the rat.

Reavill C, Hatcher JP, Lewis VA, Sanger GJ, Hagan J.

Eur J Pharmacol. 1998 Sep 18;357(2-3):115-20.

PMID:
9797026
23.

Sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, reverses delay-induced deficits in the T-maze.

Hatcher JP, Loudon JM, Hagan JJ, Clark MS.

Psychopharmacology (Berl). 1998 Aug;138(3-4):275-82.

PMID:
9725749
24.

SB 202026: a novel muscarinic partial agonist with functional selectivity for M1 receptors.

Loudon JM, Bromidge SM, Brown F, Clark MS, Hatcher JP, Hawkins J, Riley GJ, Noy G, Orlek BS.

J Pharmacol Exp Ther. 1997 Dec;283(3):1059-68.

PMID:
9399977
25.

Revised CMS model.

Hagan JJ, Hatcher JP.

Psychopharmacology (Berl). 1997 Dec;134(4):354-6; discussion 371-7. No abstract available.

PMID:
9452173
26.

Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig.

Hagan JJ, Slade PD, Gaster L, Jeffrey P, Hatcher JP, Middlemiss DN.

Eur J Pharmacol. 1997 Jul 23;331(2-3):169-74.

PMID:
9274976
27.

Chronic mild stress-induced reductions in saccharin intake depend upon feeding status.

Hatcher JP, Bell DJ, Reed TJ, Hagan JJ.

J Psychopharmacol. 1997;11(4):331-8.

PMID:
9443521
28.

A computer-controlled apparatus for measuring and analysing myoclonic jerk activity in guinea pigs.

Lloyd PS, Slade PD, Hatcher JP, Hagan JJ.

J Neurosci Methods. 1996 Feb;64(2):253-62.

PMID:
8699888
29.

The role of 5-HT1D and 5-HT1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs.

Hagan JJ, Hatcher JP, Slade PD.

Eur J Pharmacol. 1995 Dec 29;294(2-3):743-51.

PMID:
8750741
30.

The 5 -HT3 receptor antagonists, granisetron and ondansetron, do not affect cocaine-induced shifts in intra-cranial self-stimulation thresholds.

Hatcher JP, Boyland P, Hagan JJ.

J Psychopharmacol. 1995 Jan;9(4):342-7. doi: 10.1177/026988119500900409.

PMID:
22298400
31.

5-HT 1D receptors mediate SKF 99101H-induced hypothermia in the guinea pig.

Hatcher JP, Slade PD, Roberts C, Hagan JJ.

J Psychopharmacol. 1995 Jan;9(3):234-41. doi: 10.1177/026988119500900306.

PMID:
22297763

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