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Items: 1 to 50 of 90

1.

Megabase Length Hypermutation Accompanies Human Structural Variation at 17p11.2.

Beck CR, Carvalho CMB, Akdemir ZC, Sedlazeck FJ, Song X, Meng Q, Hu J, Doddapaneni H, Chong Z, Chen ES, Thornton PC, Liu P, Yuan B, Withers M, Jhangiani SN, Kalra D, Walker K, English AC, Han Y, Chen K, Muzny DM, Ira G, Shaw CA, Gibbs RA, Hastings PJ, Lupski JR.

Cell. 2019 Mar 7;176(6):1310-1324.e10. doi: 10.1016/j.cell.2019.01.045. Epub 2019 Feb 28.

PMID:
30827684
2.

Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.

Xia J, Chiu LY, Nehring RB, Bravo Núñez MA, Mei Q, Perez M, Zhai Y, Fitzgerald DM, Pribis JP, Wang Y, Hu CW, Powell RT, LaBonte SA, Jalali A, Matadamas Guzmán ML, Lentzsch AM, Szafran AT, Joshi MC, Richters M, Gibson JL, Frisch RL, Hastings PJ, Bates D, Queitsch C, Hilsenbeck SG, Coarfa C, Hu JC, Siegele DA, Scott KL, Liang H, Mancini MA, Herman C, Miller KM, Rosenberg SM.

Cell. 2019 Jan 10;176(1-2):127-143.e24. doi: 10.1016/j.cell.2018.12.008.

PMID:
30633903
3.

Fluorescent fusions of the N protein of phage Mu label DNA damage in living cells.

Kotlajich MV, Xia J, Zhai Y, Lin HY, Bradley CC, Shen X, Mei Q, Wang AZ, Lynn EJ, Shee C, Chen LT, Li L, Miller KM, Herman C, Hastings PJ, Rosenberg SM.

DNA Repair (Amst). 2018 Dec;72:86-92. doi: 10.1016/j.dnarep.2018.09.005. Epub 2018 Sep 14.

4.

Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance.

Fitzgerald DM, Hastings PJ, Rosenberg SM.

Annu Rev Cancer Biol. 2017 Mar;1:119-140. doi: 10.1146/annurev-cancerbio-050216-121919.

5.

Oxygen and RNA in stress-induced mutation.

Correa R, Thornton PC, Rosenberg SM, Hastings PJ.

Curr Genet. 2018 Aug;64(4):769-776. doi: 10.1007/s00294-017-0801-9. Epub 2018 Jan 2. Review.

6.

A radical way to die.

Hastings PJ, Rosenberg SM.

Nat Microbiol. 2017 Dec;2(12):1582-1583. doi: 10.1038/s41564-017-0074-6. No abstract available.

PMID:
29176695
7.

Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli.

Moore JM, Correa R, Rosenberg SM, Hastings PJ.

PLoS Genet. 2017 Jul 20;13(7):e1006733. doi: 10.1371/journal.pgen.1006733. eCollection 2017 Jul.

8.

US immigration order strikes against biotech.

Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci WE, McArthur JG, McCann CM, McCarthy SA, McDonough CG, Mendlein J, Miller L, Miralles D, Moch KI, More B, Myers AG, Narachi MA, Nashat A, Nelson W, Newell WJ, Olle B, Osborn JE, Owens JC, Pande A, Papadopoulos S, Parker HS, Parmar KM, Patterson MR, Paul SM, Perez R, Perry M, Pfeffer CG, Powell M, Pruzanski M, Purcell DJ, Rakhit A, Ramamoorthi K, Rastetter W, Rawcliffe AA, Reid LE, Renaud RC, Rhodes JP, Rieflin WJ, Robins C, Rocklage SM, Rosenblatt M, Rosin JG, Rutter WJ, Saha S, Samuels C, Sato VL, Scangos G, Scarlett JA, Schenkein D, Schreiber SL, Schwab A, Sekhri P, Shah R, Shenk T, Siegall CB, Simon NJ, Simonian N, Stein J, Su M, Szela MT, Taglietti M, Tandon N, Termeer H, Thornberry NA, Tolar M, Ulevitch R, Vaishnaw AK, VanLent A, Varsavsky M, Vlasuk GP, Vounatsos M, Waksal SG, Warma N, Watts RJ, Werber Y, Westphal C, Wierenga W, Williams DE, Williams LR, Xanthopoulos KG, Zohar D, Zweifach SS.

Nat Biotechnol. 2017 Mar 7;35(3):204-206. doi: 10.1038/nbt.3824. No abstract available.

PMID:
28267733
9.

Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase.

Xia J, Chen LT, Mei Q, Ma CH, Halliday JA, Lin HY, Magnan D, Pribis JP, Fitzgerald DM, Hamilton HM, Richters M, Nehring RB, Shen X, Li L, Bates D, Hastings PJ, Herman C, Jayaram M, Rosenberg SM.

Sci Adv. 2016 Nov 18;2(11):e1601605. doi: 10.1126/sciadv.1601605. eCollection 2016 Nov.

10.

An ultra-dense library resource for rapid deconvolution of mutations that cause phenotypes in Escherichia coli.

Nehring RB, Gu F, Lin HY, Gibson JL, Blythe MJ, Wilson R, Bravo Núñez MA, Hastings PJ, Louis EJ, Frisch RL, Hu JC, Rosenberg SM.

Nucleic Acids Res. 2016 Mar 18;44(5):e41. doi: 10.1093/nar/gkv1131. Epub 2015 Nov 17.

11.

Roles of Nucleoid-Associated Proteins in Stress-Induced Mutagenic Break Repair in Starving Escherichia coli.

Moore JM, Magnan D, Mojica AK, Núñez MA, Bates D, Rosenberg SM, Hastings PJ.

Genetics. 2015 Dec;201(4):1349-62. doi: 10.1534/genetics.115.178970. Epub 2015 Oct 23.

12.

Absence of heterozygosity due to template switching during replicative rearrangements.

Carvalho CM, Pfundt R, King DA, Lindsay SJ, Zuccherato LW, Macville MV, Liu P, Johnson D, Stankiewicz P, Brown CW; DDD Study, Shaw CA, Hurles ME, Ira G, Hastings PJ, Brunner HG, Lupski JR.

Am J Hum Genet. 2015 Apr 2;96(4):555-64. doi: 10.1016/j.ajhg.2015.01.021. Epub 2015 Mar 19.

13.

Engineered proteins detect spontaneous DNA breakage in human and bacterial cells.

Shee C, Cox BD, Gu F, Luengas EM, Joshi MC, Chiu LY, Magnan D, Halliday JA, Frisch RL, Gibson JL, Nehring RB, Do HG, Hernandez M, Li L, Herman C, Hastings PJ, Bates D, Harris RS, Miller KM, Rosenberg SM.

Elife. 2013 Oct 29;2:e01222. doi: 10.7554/eLife.01222.

14.

Replicative mechanisms for CNV formation are error prone.

Carvalho CM, Pehlivan D, Ramocki MB, Fang P, Alleva B, Franco LM, Belmont JW, Hastings PJ, Lupski JR.

Nat Genet. 2013 Nov;45(11):1319-26. doi: 10.1038/ng.2768. Epub 2013 Sep 22.

15.

R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli.

Wimberly H, Shee C, Thornton PC, Sivaramakrishnan P, Rosenberg SM, Hastings PJ.

Nat Commun. 2013;4:2115. doi: 10.1038/ncomms3115. Erratum in: Nat Commun. 2014;5:2762.

16.

Identity and function of a large gene network underlying mutagenic repair of DNA breaks.

Al Mamun AA, Lombardo MJ, Shee C, Lisewski AM, Gonzalez C, Lin D, Nehring RB, Saint-Ruf C, Gibson JL, Frisch RL, Lichtarge O, Hastings PJ, Rosenberg SM.

Science. 2012 Dec 7;338(6112):1344-8. doi: 10.1126/science.1226683.

17.

Gross chromosomal rearrangement mediated by DNA replication in stressed cells: evidence from Escherichia coli.

Moore JM, Wimberly H, Thornton PC, Rosenberg SM, Hastings PJ.

Ann N Y Acad Sci. 2012 Sep;1267:103-9. doi: 10.1111/j.1749-6632.2012.06587.x.

18.

Stress-induced mutation via DNA breaks in Escherichia coli: a molecular mechanism with implications for evolution and medicine.

Rosenberg SM, Shee C, Frisch RL, Hastings PJ.

Bioessays. 2012 Oct;34(10):885-92. doi: 10.1002/bies.201200050. Epub 2012 Aug 22.

19.

DNA breakage drives nuclear search.

Ira G, Hastings PJ.

Nat Cell Biol. 2012 May 2;14(5):448-50. doi: 10.1038/ncb2494.

20.

Hypoxia and miscoupling between reduced energy efficiency and signaling to cell proliferation drive cancer to grow increasingly faster.

Cui J, Mao X, Olman V, Hastings PJ, Xu Y.

J Mol Cell Biol. 2012 Jun;4(3):174-6. doi: 10.1093/jmcb/mjs017. Epub 2012 Apr 20. No abstract available.

21.

Mechanisms for recurrent and complex human genomic rearrangements.

Liu P, Carvalho CM, Hastings PJ, Lupski JR.

Curr Opin Genet Dev. 2012 Jun;22(3):211-20. doi: 10.1016/j.gde.2012.02.012. Epub 2012 Mar 20. Review.

22.

Genomic rearrangement in three dimensions.

Hastings PJ, Rosenberg SM.

Nat Biotechnol. 2011 Dec 8;29(12):1096-8. doi: 10.1038/nbt.2064. No abstract available.

PMID:
22158363
23.

Frequency of nonallelic homologous recombination is correlated with length of homology: evidence that ectopic synapsis precedes ectopic crossing-over.

Liu P, Lacaria M, Zhang F, Withers M, Hastings PJ, Lupski JR.

Am J Hum Genet. 2011 Oct 7;89(4):580-8. doi: 10.1016/j.ajhg.2011.09.009.

24.

Inverted genomic segments and complex triplication rearrangements are mediated by inverted repeats in the human genome.

Carvalho CM, Ramocki MB, Pehlivan D, Franco LM, Gonzaga-Jauregui C, Fang P, McCall A, Pivnick EK, Hines-Dowell S, Seaver LH, Friehling L, Lee S, Smith R, Del Gaudio D, Withers M, Liu P, Cheung SW, Belmont JW, Zoghbi HY, Hastings PJ, Lupski JR.

Nat Genet. 2011 Oct 2;43(11):1074-81. doi: 10.1038/ng.944.

25.

Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements.

Liu P, Erez A, Nagamani SC, Dhar SU, Kołodziejska KE, Dharmadhikari AV, Cooper ML, Wiszniewska J, Zhang F, Withers MA, Bacino CA, Campos-Acevedo LD, Delgado MR, Freedenberg D, Garnica A, Grebe TA, Hernández-Almaguer D, Immken L, Lalani SR, McLean SD, Northrup H, Scaglia F, Strathearn L, Trapane P, Kang SH, Patel A, Cheung SW, Hastings PJ, Stankiewicz P, Lupski JR, Bi W.

Cell. 2011 Sep 16;146(6):889-903. doi: 10.1016/j.cell.2011.07.042.

26.

Global chromosomal structural instability in a subpopulation of starving Escherichia coli cells.

Lin D, Gibson IB, Moore JM, Thornton PC, Leal SM, Hastings PJ.

PLoS Genet. 2011 Aug;7(8):e1002223. doi: 10.1371/journal.pgen.1002223. Epub 2011 Aug 25.

27.

Pathways of resistance to thymineless death in Escherichia coli and the function of UvrD.

Fonville NC, Vaksman Z, DeNapoli J, Hastings PJ, Rosenberg SM.

Genetics. 2011 Sep;189(1):23-36. doi: 10.1534/genetics.111.130161. Epub 2011 Jul 29.

28.

Mechanisms of ectopic gene conversion.

Hastings PJ.

Genes (Basel). 2010 Nov 29;1(3):427-39. doi: 10.3390/genes1030427.

29.

Separate DNA Pol II- and Pol IV-dependent pathways of stress-induced mutation during double-strand-break repair in Escherichia coli are controlled by RpoS.

Frisch RL, Su Y, Thornton PC, Gibson JL, Rosenberg SM, Hastings PJ.

J Bacteriol. 2010 Sep;192(18):4694-700. doi: 10.1128/JB.00570-10. Epub 2010 Jul 16.

30.

Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells.

Hastings PJ, Hersh MN, Thornton PC, Fonville NC, Slack A, Frisch RL, Ray MP, Harris RS, Leal SM, Rosenberg SM.

PLoS One. 2010 May 27;5(5):e10862. doi: 10.1371/journal.pone.0010862.

31.

The sigma(E) stress response is required for stress-induced mutation and amplification in Escherichia coli.

Gibson JL, Lombardo MJ, Thornton PC, Hu KH, Galhardo RS, Beadle B, Habib A, Magner DB, Frost LS, Herman C, Hastings PJ, Rosenberg SM.

Mol Microbiol. 2010 Jul;77(2):415-30. doi: 10.1111/j.1365-2958.2010.07213.x. Epub 2010 May 19.

32.

Role of RecA and the SOS response in thymineless death in Escherichia coli.

Fonville NC, Bates D, Hastings PJ, Hanawalt PC, Rosenberg SM.

PLoS Genet. 2010 Mar 5;6(3):e1000865. doi: 10.1371/journal.pgen.1000865.

33.

Mechanisms of change in gene copy number.

Hastings PJ, Lupski JR, Rosenberg SM, Ira G.

Nat Rev Genet. 2009 Aug;10(8):551-64. doi: 10.1038/nrg2593. Review.

34.

DinB upregulation is the sole role of the SOS response in stress-induced mutagenesis in Escherichia coli.

Galhardo RS, Do R, Yamada M, Friedberg EC, Hastings PJ, Nohmi T, Rosenberg SM.

Genetics. 2009 May;182(1):55-68. doi: 10.1534/genetics.109.100735. Epub 2009 Mar 6.

35.

A microhomology-mediated break-induced replication model for the origin of human copy number variation.

Hastings PJ, Ira G, Lupski JR.

PLoS Genet. 2009 Jan;5(1):e1000327. doi: 10.1371/journal.pgen.1000327. Epub 2009 Jan 30. Review.

36.

A robust estimator of mutation rates.

Wu X, Strome ED, Meng Q, Hastings PJ, Plon SE, Kimmel M.

Mutat Res. 2009 Feb 10;661(1-2):101-9. doi: 10.1016/j.mrfmmm.2008.11.015. Epub 2008 Dec 3.

PMID:
19100753
37.

Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli.

Gonzalez C, Hadany L, Ponder RG, Price M, Hastings PJ, Rosenberg SM.

PLoS Genet. 2008 Oct 3;4(10):e1000208. doi: 10.1371/journal.pgen.1000208.

38.

Mutation as a stress response and the regulation of evolvability.

Galhardo RS, Hastings PJ, Rosenberg SM.

Crit Rev Biochem Mol Biol. 2007 Sep-Oct;42(5):399-435. Review.

39.

Adaptive amplification.

Hastings PJ.

Crit Rev Biochem Mol Biol. 2007 Jul-Aug;42(4):271-83. Review.

PMID:
17687669
40.

Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.

Mukhopadhyay SS, Leung KS, Hicks MJ, Hastings PJ, Youssoufian H, Plon SE.

J Cell Biol. 2006 Oct 23;175(2):225-35.

41.

On the mechanism of gene amplification induced under stress in Escherichia coli.

Slack A, Thornton PC, Magner DB, Rosenberg SM, Hastings PJ.

PLoS Genet. 2006 Apr;2(4):e48. Epub 2006 Apr 7.

42.

A role for topoisomerase III in a recombination pathway alternative to RuvABC.

Lopez CR, Yang S, Deibler RW, Ray SA, Pennington JM, Digate RJ, Hastings PJ, Rosenberg SM, Zechiedrich EL.

Mol Microbiol. 2005 Oct;58(1):80-101.

43.

Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms.

Hastings PJ, Slack A, Petrosino JF, Rosenberg SM.

PLoS Biol. 2004 Dec;2(12):e399. Epub 2004 Nov 23.

44.

Antibiotic-induced lateral transfer of antibiotic resistance.

Hastings PJ, Rosenberg SM, Slack A.

Trends Microbiol. 2004 Sep;12(9):401-4. Review.

PMID:
15337159
45.

Genomes: worming into genetic instability.

Rosenberg SM, Hastings PJ.

Nature. 2004 Aug 5;430(7000):625-6. No abstract available.

PMID:
15295584
46.

Rebuttal: growth under selection stimulates Lac(+) reversion (Roth and Andersson).

Rosenberg SM, Hastings PJ.

J Bacteriol. 2004 Aug;186(15):4862-3. No abstract available.

47.

Rebuttal: adaptive mutation in Escherichia coli (Foster).

Rosenberg SM, Hastings PJ.

J Bacteriol. 2004 Aug;186(15):4853. No abstract available.

48.
49.

Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress.

Hersh MN, Ponder RG, Hastings PJ, Rosenberg SM.

Res Microbiol. 2004 Jun;155(5):352-9. Review.

PMID:
15207867
50.

Microbiology and evolution. Modulating mutation rates in the wild.

Rosenberg SM, Hastings PJ.

Science. 2003 May 30;300(5624):1382-3. No abstract available.

PMID:
12775830

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