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Items: 45


A Mutation Affecting Polycystin-1 Mediated Heterotrimeric G-Protein Signaling Causes PKD.

Parnell SC, Magenheimer BS, Maser RL, Pavlov TS, Havens MA, Hastings ML, Jackson SF, Ward CJ, Peterson KR, Staruschenko A, Calvet JP.

Hum Mol Genet. 2018 Jun 20. doi: 10.1093/hmg/ddy223. [Epub ahead of print]


Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production.

Chang JL, Hinrich AJ, Roman B, Norrbom M, Rigo F, Marr RA, Norstrom EM, Hastings ML.

Mol Ther. 2018 Jun 6;26(6):1539-1551. doi: 10.1016/j.ymthe.2018.02.029. Epub 2018 Mar 6.


Antisense oligonucleotide therapy rescues disruptions in organization of exploratory movements associated with Usher syndrome type 1C in mice.

Donaldson TN, Jennings KT, Cherep LA, McNeela AM, Depreux FF, Jodelka FM, Hastings ML, Wallace DG.

Behav Brain Res. 2018 Feb 15;338:76-87. doi: 10.1016/j.bbr.2017.10.012. Epub 2017 Oct 14.


Rescue of Outer Hair Cells with Antisense Oligonucleotides in Usher Mice Is Dependent on Age of Treatment.

Ponnath A, Depreux FF, Jodelka FM, Rigo F, Farris HE, Hastings ML, Lentz JJ.

J Assoc Res Otolaryngol. 2018 Feb;19(1):1-16. doi: 10.1007/s10162-017-0640-x. Epub 2017 Oct 12.


Rescue of peripheral vestibular function in Usher syndrome mice using a splice-switching antisense oligonucleotide.

Vijayakumar S, Depreux FF, Jodelka FM, Lentz JJ, Rigo F, Jones TA, Hastings ML.

Hum Mol Genet. 2017 Sep 15;26(18):3482-3494. doi: 10.1093/hmg/ddx234.


Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.

Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS.

Nat Biotechnol. 2017 Mar;35(3):264-272. doi: 10.1038/nbt.3801. Epub 2017 Feb 6.


The effects of human milk fortification on nutrients and milk properties.

Donovan R, Kelly SG, Prazad P, Talaty PN, Lefaiver C, Hastings ML, Everly DN.

J Perinatol. 2017 Jan;37(1):42-48. doi: 10.1038/jp.2016.166. Epub 2016 Oct 6.


Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse.

Depreux FF, Wang L, Jiang H, Jodelka FM, Rosencrans RF, Rigo F, Lentz JJ, Brigande JV, Hastings ML.

Nucleic Acids Res. 2016 Nov 16;44(20):9519-9529. Epub 2016 Sep 28.


Splice-switching antisense oligonucleotides as therapeutic drugs.

Havens MA, Hastings ML.

Nucleic Acids Res. 2016 Aug 19;44(14):6549-63. doi: 10.1093/nar/gkw533. Epub 2016 Jun 10. Review.


Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis.

Geraets RD, Koh Sy, Hastings ML, Kielian T, Pearce DA, Weimer JM.

Orphanet J Rare Dis. 2016 Apr 16;11:40. doi: 10.1186/s13023-016-0414-2. Review.


Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides.

Hinrich AJ, Jodelka FM, Chang JL, Brutman D, Bruno AM, Briggs CA, James BD, Stutzmann GE, Bennett DA, Miller SA, Rigo F, Marr RA, Hastings ML.

EMBO Mol Med. 2016 Apr 1;8(4):328-45. doi: 10.15252/emmm.201505846.


A Case of a Methicillin-Resistant Staphylococcus Aureus Retropharyngeal Abscess With Mediastinal Extension in an 11-Month-Old Girl.

Shanti RM, Hastings ML, Patel S, Yeoh MS.

J Oral Maxillofac Surg. 2016 Apr;74(4):747-53. doi: 10.1016/j.joms.2015.10.005. Epub 2015 Oct 23.


A big score for RNA.

Hastings ML.

RNA. 2015 Apr;21(4):634-5. doi: 10.1261/rna.050757.115. No abstract available.


Targeting SR proteins improves SMN expression in spinal muscular atrophy cells.

Wee CD, Havens MA, Jodelka FM, Hastings ML.

PLoS One. 2014 Dec 15;9(12):e115205. doi: 10.1371/journal.pone.0115205. eCollection 2014.


Drosha promotes splicing of a pre-microRNA-like alternative exon.

Havens MA, Reich AA, Hastings ML.

PLoS Genet. 2014 May 1;10(5):e1004312. doi: 10.1371/journal.pgen.1004312. eCollection 2014 May.


Expression and purification of splicing proteins from mammalian cells.

Allemand E, Hastings ML.

Methods Mol Biol. 2014;1126:205-16. doi: 10.1007/978-1-62703-980-2_16.


SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant.

Dauber A, Golzio C, Guenot C, Jodelka FM, Kibaek M, Kjaergaard S, Leheup B, Martinet D, Nowaczyk MJ, Rosenfeld JA, Zeesman S, Zunich J, Beckmann JS, Hirschhorn JN, Hastings ML, Jacquemont S, Katsanis N.

Am J Hum Genet. 2013 Nov 7;93(5):798-811. doi: 10.1016/j.ajhg.2013.09.010. Epub 2013 Oct 17. Erratum in: Am J Hum Genet. 2013 Nov 7;93(5):994.


Targeting RNA splicing for disease therapy.

Havens MA, Duelli DM, Hastings ML.

Wiley Interdiscip Rev RNA. 2013 May-Jun;4(3):247-66. doi: 10.1002/wrna.1158. Epub 2013 Mar 19. Review.


Authors' reply.

Duelli DM, Palma J, Beaman K, Hastings ML, Kwak-Kim J, Linnstaedt S, Park JC, Kim DJ.

J Mol Diagn. 2013 Jan;15(1):138-9. No abstract available.


Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness.

Lentz JJ, Jodelka FM, Hinrich AJ, McCaffrey KE, Farris HE, Spalitta MJ, Bazan NG, Duelli DM, Rigo F, Hastings ML.

Nat Med. 2013 Mar;19(3):345-50. doi: 10.1038/nm.3106. Epub 2013 Feb 4.


Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the Drosha cleavage site.

Quarles KA, Sahu D, Havens MA, Forsyth ER, Wostenberg C, Hastings ML, Showalter SA.

Biochemistry. 2013 Feb 5;52(5):795-807. doi: 10.1021/bi301452a. Epub 2013 Jan 18.


Sensitive PCR-based quantitation of cell-free circulating microRNAs.

Hastings ML, Palma J, Duelli DM.

Methods. 2012 Oct;58(2):144-50. doi: 10.1016/j.ymeth.2012.07.026. Epub 2012 Aug 3.


MicroRNAs are exported from malignant cells in customized particles.

Palma J, Yaddanapudi SC, Pigati L, Havens MA, Jeong S, Weiner GA, Weimer KM, Stern B, Hastings ML, Duelli DM.

Nucleic Acids Res. 2012 Oct;40(18):9125-38. doi: 10.1093/nar/gks656. Epub 2012 Jul 5.


Biogenesis of mammalian microRNAs by a non-canonical processing pathway.

Havens MA, Reich AA, Duelli DM, Hastings ML.

Nucleic Acids Res. 2012 May;40(10):4626-40. doi: 10.1093/nar/gks026. Epub 2012 Jan 23.


Plasma components affect accuracy of circulating cancer-related microRNA quantitation.

Kim DJ, Linnstaedt S, Palma J, Park JC, Ntrivalas E, Kwak-Kim JY, Gilman-Sachs A, Beaman K, Hastings ML, Martin JN, Duelli DM.

J Mol Diagn. 2012 Jan;14(1):71-80. doi: 10.1016/j.jmoldx.2011.09.002. Epub 2011 Nov 30.


Induction of antagonistic soluble decoy receptor tyrosine kinases by intronic polyA activation.

Vorlová S, Rocco G, Lefave CV, Jodelka FM, Hess K, Hastings ML, Henke E, Cartegni L.

Mol Cell. 2011 Sep 16;43(6):927-39. doi: 10.1016/j.molcel.2011.08.009.


Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.

Bruno AM, Huang JY, Bennett DA, Marr RA, Hastings ML, Stutzmann GE.

Neurobiol Aging. 2012 May;33(5):1001.e1-6. doi: 10.1016/j.neurobiolaging.2011.03.011. Epub 2011 Apr 30.


Selective release of microRNA species from normal and malignant mammary epithelial cells.

Pigati L, Yaddanapudi SC, Iyengar R, Kim DJ, Hearn SA, Danforth D, Hastings ML, Duelli DM.

PLoS One. 2010 Oct 20;5(10):e13515. doi: 10.1371/journal.pone.0013515.


A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2.

Jodelka FM, Ebert AD, Duelli DM, Hastings ML.

Hum Mol Genet. 2010 Dec 15;19(24):4906-17. doi: 10.1093/hmg/ddq425. Epub 2010 Sep 30.


An exonic splicing enhancer within a bidirectional coding sequence regulates alternative splicing of an antisense mRNA.

Salato VK, Rediske NW, Zhang C, Hastings ML, Munroe SH.

RNA Biol. 2010 Mar-Apr;7(2):179-90. Epub 2010 Mar 8.


Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy.

Hastings ML, Berniac J, Liu YH, Abato P, Jodelka FM, Barthel L, Kumar S, Dudley C, Nelson M, Larson K, Edmonds J, Bowser T, Draper M, Higgins P, Krainer AR.

Sci Transl Med. 2009 Nov 4;1(5):5ra12. doi: 10.1126/scitranslmed.3000208.


Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP.

Martins de Araújo M, Bonnal S, Hastings ML, Krainer AR, Valcárcel J.

RNA. 2009 Apr;15(4):515-23. doi: 10.1261/rna.1273209. Epub 2009 Feb 25.


Dual-specificity splice sites function alternatively as 5' and 3' splice sites.

Zhang C, Hastings ML, Krainer AR, Zhang MQ.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15028-33. Epub 2007 Sep 11.


Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65).

Hastings ML, Allemand E, Duelli DM, Myers MP, Krainer AR.

PLoS One. 2007 Jun 20;2(6):e538.


Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1.

Allemand E, Hastings ML, Murray MV, Myers MP, Krainer AR.

Nat Struct Mol Biol. 2007 Jul;14(7):630-8. Epub 2007 Jun 17.


Comprehensive splice-site analysis using comparative genomics.

Sheth N, Roca X, Hastings ML, Roeder T, Krainer AR, Sachidanandam R.

Nucleic Acids Res. 2006;34(14):3955-67. Epub 2006 Aug 12.


Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

Cartegni L, Hastings ML, Calarco JA, de Stanchina E, Krainer AR.

Am J Hum Genet. 2006 Jan;78(1):63-77. Epub 2005 Nov 16.


An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites.

Hastings ML, Resta N, Traum D, Stella A, Guanti G, Krainer AR.

Nat Struct Mol Biol. 2005 Jan;12(1):54-9. Epub 2004 Dec 19.


Pre-mRNA splicing in the new millennium.

Hastings ML, Krainer AR.

Curr Opin Cell Biol. 2001 Jun;13(3):302-9. Review.


Effects of sex, age, reading ability, socioeconomic level, and display position on a measure of spatial relations in children.

Davol SH, Hastings ML.

Percept Mot Skills. 1967 Apr;24(2):375-87. No abstract available.


Effect of age, sex, and speed of rotation on rotary pursuit performance by young children.

Davol SH, Hastings ML, Klein DA.

Percept Mot Skills. 1965 Oct;21(2):351-7. No abstract available.


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