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Items: 1 to 50 of 66

1.

IL-1RA regulates immunopathogenesis during fungal-associated allergic airway inflammation.

Godwin MS, Reeder KM, Garth JM, Blackburn JP, Jones M, Yu Z, Matalon S, Hastie AT, Meyers DA, Steele C.

JCI Insight. 2019 Nov 1;4(21). pii: 129055. doi: 10.1172/jci.insight.129055.

2.

Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma.

Li X, Hastie AT, Peters MC, Hawkins GA, Phipatanakul W, Li H, Moore WC, Busse WW, Castro M, Erzurum SC, Gaston B, Israel E, Jarjour NN, Levy BD, Wenzel SE, Meyers DA, Fahy JV, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program (SARP) Networks.

J Allergy Clin Immunol. 2019 Sep 9. pii: S0091-6749(19)31173-X. doi: 10.1016/j.jaci.2019.08.031. [Epub ahead of print] No abstract available.

PMID:
31513878
3.

BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications.

Weathington N, O'Brien ME, Radder J, Whisenant TC, Bleecker ER, Busse WW, Erzurum SC, Gaston B, Hastie AT, Jarjour NN, Meyers DA, Milosevic J, Moore WC, Tedrow JR, Trudeau JB, Wong HP, Wu W, Kaminski N, Wenzel SE, Modena BD.

Am J Respir Crit Care Med. 2019 Oct 1;200(7):837-856. doi: 10.1164/rccm.201811-2221OC.

PMID:
31161938
4.

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.

Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV.

Am J Respir Crit Care Med. 2019 May 1;199(9):1076-1085. doi: 10.1164/rccm.201810-1869OC.

PMID:
30888839
5.

Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS.

Garudadri S, Woodruff PG, Han MK, Curtis JL, Barr RG, Bleecker ER, Bowler RP, Comellas A, Cooper CB, Criner G, Dransfield MT, Hansel NN, Paine R 3rd, Krishnan JA, Peters SP, Hastie AT, Martinez FJ, O'Neal WK, Couper DJ, Alexis NE, Christenson SA.

Chest. 2019 May;155(5):908-917. doi: 10.1016/j.chest.2018.12.022. Epub 2019 Jan 23.

PMID:
30684474
6.

Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma.

Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston BM, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, Phipatanakul W, Sorkness RL, Wenzel SE.

Am J Respir Crit Care Med. 2019 Jun 1;199(11):1358-1367. doi: 10.1164/rccm.201808-1543OC. Erratum in: Am J Respir Crit Care Med. 2019 Aug 1;200(3):400.

PMID:
30682261
7.

The common γ-chain cytokine IL-7 promotes immunopathogenesis during fungal asthma.

Reeder KM, Dunaway CW, Blackburn JP, Yu Z, Matalon S, Hastie AT, Ampleford EJ, Meyers DA, Steele C.

Mucosal Immunol. 2018 Sep;11(5):1352-1362. doi: 10.1038/s41385-018-0028-1. Epub 2018 Jun 15.

8.

ALX receptor ligands define a biochemical endotype for severe asthma.

Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program- Investigators.

JCI Insight. 2018 Mar 22;3(6). pii: 120932. doi: 10.1172/jci.insight.120932. No abstract available.

9.

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.

Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Wenzel SE, Fahy JV; National Heart, Lung and Blood Institute Severe Asthma Research Program 3.

J Allergy Clin Immunol. 2019 Jan;143(1):104-113.e14. doi: 10.1016/j.jaci.2017.12.1009. Epub 2018 Mar 7.

PMID:
29524537
10.

Complex association patterns for inflammatory mediators in induced sputum from subjects with asthma.

Hastie AT, Steele C, Dunaway CW, Moore WC, Rector BM, Ampleford E, Li H, Denlinger LC, Jarjour N, Meyers DA, Bleecker ER; NHLBI Severe Asthma Research Program (SARP).

Clin Exp Allergy. 2018 Jul;48(7):787-797. doi: 10.1111/cea.13129. Epub 2018 Apr 15.

11.

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.

Hastie AT, Martinez FJ, Curtis JL, Doerschuk CM, Hansel NN, Christenson S, Putcha N, Ortega VE, Li X, Barr RG, Carretta EE, Couper DJ, Cooper CB, Hoffman EA, Kanner RE, Kleerup E, O'Neal WK, Paine R 3rd, Peters SP, Alexis NE, Woodruff PG, Han MK, Meyers DA, Bleecker ER; SPIROMICS investigators.

Lancet Respir Med. 2017 Dec;5(12):956-967. doi: 10.1016/S2213-2600(17)30432-0. Epub 2017 Nov 13.

12.

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

Martinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, Barr RG, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Martinez FJ, Meyers DA, O'Neal WK, Paine R 3rd, Putcha N, Rennard SI, Woodruff PG, Zeidler M, Curtis JL, Freeman CM; SPIROMICS Investigators.

J Allergy Clin Immunol. 2018 Jan;141(1):429-432. doi: 10.1016/j.jaci.2017.07.039. Epub 2017 Sep 12. No abstract available.

13.

Airway Mucin Concentration as a Marker of Chronic Bronchitis.

Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez F, Paine R 3rd, Woodruff PG, O'Neal WK, Boucher RC.

N Engl J Med. 2017 Sep 7;377(10):911-922. doi: 10.1056/NEJMoa1701632.

14.

Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age.

Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN.

J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):545-554.e4. doi: 10.1016/j.jaip.2017.05.032. Epub 2017 Aug 31.

15.

Natural killer cell-mediated inflammation resolution is disabled in severe asthma.

Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.

Sci Immunol. 2017 Mar 10;2(9). pii: eaam5446. doi: 10.1126/sciimmunol.aam5446.

16.

ALX receptor ligands define a biochemical endotype for severe asthma.

Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators.

JCI Insight. 2017 Jul 20;2(14). pii: 93534. doi: 10.1172/jci.insight.93534. eCollection 2017 Jul 20. Erratum in: JCI Insight. 2018 Mar 22;3(6):.

17.

Effects of bronchoscopy on lung function in asthmatics.

Bellinger C, Bleecker ER, Peters S, Pascual R, Krings J, Smith R, Hastie AT, Moore WC.

J Asthma. 2017 Oct;54(8):866-871. doi: 10.1080/02770903.2016.1276587. Epub 2017 Jan 5.

PMID:
28055281
18.

Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma.

Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E; Severe Asthma Research Program.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1439-1448. doi: 10.1164/rccm.201607-1453OC. Erratum in: Am J Respir Crit Care Med. 2018 Apr 1;197(7):970-971.

19.

Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.

Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.

Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-313. doi: 10.1164/rccm.201602-0419OC. Erratum in: Am J Respir Crit Care Med. 2018 Apr 1;197(7):971.

20.

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts.

Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV; National Heart, Lung, and Blood Institute Severe Asthma Research Program.

Lancet Respir Med. 2016 Jul;4(7):574-584. doi: 10.1016/S2213-2600(16)30048-0. Epub 2016 Jun 6. Erratum in: Lancet Respir Med. 2018 Mar;6(3):e10.

21.

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort.

Li X, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA.

J Asthma. 2016 Oct;53(8):775-82. doi: 10.3109/02770903.2016.1158268. Epub 2016 Apr 6.

22.

eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes.

Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.

Allergy. 2015 Oct;70(10):1309-18. doi: 10.1111/all.12683. Epub 2015 Jul 24.

23.

IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle.

Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER, Hawkins GA.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L129-38. doi: 10.1152/ajplung.00288.2014. Epub 2015 May 22.

24.

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).

Freeman CM, Crudgington S, Stolberg VR, Brown JP, Sonstein J, Alexis NE, Doerschuk CM, Basta PV, Carretta EE, Couper DJ, Hastie AT, Kaner RJ, O'Neal WK, Paine R 3rd, Rennard SI, Shimbo D, Woodruff PG, Zeidler M, Curtis JL.

J Transl Med. 2015 Jan 27;13:19. doi: 10.1186/s12967-014-0374-z.

25.

Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic study.

Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D, Erzurum SC, Israel E, Montealegre F, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.

Lancet Respir Med. 2014 Mar;2(3):204-13. doi: 10.1016/S2213-2600(13)70289-3. Epub 2014 Jan 27.

26.

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis.

Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program.

J Allergy Clin Immunol. 2014 Jun;133(6):1557-63.e5. doi: 10.1016/j.jaci.2013.10.011. Epub 2013 Dec 9.

27.

Clinical heterogeneity in the severe asthma research program.

Moore WC, Fitzpatrick AM, Li X, Hastie AT, Li H, Meyers DA, Bleecker ER.

Ann Am Thorac Soc. 2013 Dec;10 Suppl:S118-24. doi: 10.1513/AnnalsATS.201309-307AW.

28.

Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects.

Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program.

J Allergy Clin Immunol. 2013 Jul;132(1):72-80. doi: 10.1016/j.jaci.2013.03.044. Epub 2013 May 21.

29.

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.

Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.

J Allergy Clin Immunol. 2013 Aug;132(2):313-20.e15. doi: 10.1016/j.jaci.2013.01.051. Epub 2013 Mar 28.

30.

The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma.

Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER; National Heart, Lung, and Blood Institute–sponsored Severe Asthma Research Program (SARP).

J Allergy Clin Immunol. 2012 Aug;130(2):510-5.e1. doi: 10.1016/j.jaci.2012.03.018. Epub 2012 May 1.

31.

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes.

Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER; National Heart, Lung, and Blood Institute Severe Asthma Research Program.

J Allergy Clin Immunol. 2010 May;125(5):1028-1036.e13. doi: 10.1016/j.jaci.2010.02.008. Epub 2010 Apr 15.

32.

Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and beta2-agonist use.

Hastie AT, Wu M, Foster GC, Hawkins GA, Batra V, Rybinski KA, Cirelli R, Zangrilli JG, Peters SP.

Respir Res. 2006 Feb 15;7:25.

34.

Concentration of cytokines and growth factors in BAL fluid after allergen challenge in asthmatics and their effect on alpha-smooth muscle actin and collagen III synthesis by human lung fibroblasts.

Batra V, Khurana S, Musani AI, Hastie AT, Carpenter KA, Zangrilli JG, Peters SP.

Chest. 2003 Mar;123(3 Suppl):398S-9S. Review. No abstract available.

PMID:
12629001
35.

Modulation of vasodilator-stimulated phosphoprotein in vivo in human epithelial cells by segmental allergen challenge and beta2-agonist therapy.

Hastie AT, Batra V, Khurana S, Carpenter KA, Cirelli R, Zangrilli JG, Peters SP.

Chest. 2003 Mar;123(3 Suppl):377S. Review. No abstract available.

PMID:
12628994
36.

Overlap between death receptor and non-receptor-mediated mechanisms during apoptosis in human eosinophils.

Niazi S, Robertson NM, Agrawal A, Hastie AT, Peters SP, Zangrilli J.

Chest. 2003 Mar;123(3 Suppl):345S. No abstract available.

PMID:
12628970
37.
38.
39.

Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma.

Ammit AJ, Hastie AT, Edsall LC, Hoffman RK, Amrani Y, Krymskaya VP, Kane SA, Peters SP, Penn RB, Spiegel S, Panettieri RA Jr.

FASEB J. 2001 May;15(7):1212-4. No abstract available.

PMID:
11344091
40.

Kinetics of IL-10 production after segmental antigen challenge of atopic asthmatic subjects.

Colavita AM, Hastie AT, Musani AI, Pascual RM, Reinach AJ, Lustine HT, Galati SA, Zangrilli JG, Fish JE, Peters SP.

J Allergy Clin Immunol. 2000 Nov;106(5):880-6.

PMID:
11080710
41.

HSP27 elevated in mild allergic inflammation protects airway epithelium from H2SO4 effects.

Hastie AT, Everts KB, Zangrilli J, Shaver JR, Pollice MB, Fish JE, Peters SP.

Am J Physiol. 1997 Aug;273(2 Pt 1):L401-9.

PMID:
9277453
42.

Kinetics of the development and recovery of the lung from IgE-mediated inflammation: dissociation of pulmonary eosinophilia, lung injury, and eosinophil-active cytokines.

Shaver JR, Zangrilli JG, Cho SK, Cirelli RA, Pollice M, Hastie AT, Fish JE, Peters SP.

Am J Respir Crit Care Med. 1997 Feb;155(2):442-8.

PMID:
9032176
43.

Beta 2-agonist-elevated stress response in human bronchial epithelial cells in vivo and in vitro.

Hastie AT, Everts KB, Shaver JR, Cirelli R, Zangrilli J, Pollice MB, Fish JE, Peters SP.

Lung. 1997;175(5):287-98.

PMID:
9270986
44.

IL-1 beta release from cultured bronchial epithelial cells and bronchoalveolar lavage cells from allergic and normal humans following segmental challenge with ragweed.

Hastie AT, Everts KB, Cho SK, Zangrilli J, Shaver JR, Pollice MB, Fish JE, Peters SP.

Cytokine. 1996 Sep;8(9):730-8.

PMID:
8932985
45.

Isolation of respiratory cilia.

Hastie AT.

Methods Cell Biol. 1995;47:93-8. No abstract available.

PMID:
7476553
46.

Two types of bacteria adherent to bovine respiratory tract ciliated epithelium.

Hastie AT, Evans LP, Allen AM.

Vet Pathol. 1993 Jan;30(1):12-9.

PMID:
8442323
47.

Ciliated respiratory epithelial surface changes after formaldehyde exposure.

Colizzo F, Krantz MJ, Fish JE, Hastie AT.

J Toxicol Environ Health. 1992 Apr;35(4):221-34.

PMID:
1533681
48.

Purification and characterization of dynein from pig tracheal cilia.

Hastie AT.

Methods Enzymol. 1991;196:223-34. No abstract available.

PMID:
1827865
49.

Inhibition and recovery of mammalian respiratory ciliary function after formaldehyde exposure.

Hastie AT, Patrick H, Fish JE.

Toxicol Appl Pharmacol. 1990 Feb;102(2):282-91.

PMID:
2137268
50.

Identification of surface components of mammalian respiratory tract cilia.

Hastie AT, Krantz MJ, Colizzo FP.

Cell Motil Cytoskeleton. 1990;17(4):317-28.

PMID:
2076548

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