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Items: 1 to 50 of 329

1.

The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism.

Elliott MJ, Jerzak KJ, Cockburn JG, Safikhani Z, Gwynne WD, Hassell JA, Bane A, Silvester J, Thu KL, Haibe-Kains B, Mak TW, Cescon DW.

Sci Rep. 2018 Nov 8;8(1):16562. doi: 10.1038/s41598-018-34348-0.

2.

The Impact of Stressor Exposure and Glucocorticoids on Anxiety and Fear.

Hassell JE Jr, Nguyen KT, Gates CA, Lowry CA.

Curr Top Behav Neurosci. 2018 Oct 25. doi: 10.1007/7854_2018_63. [Epub ahead of print]

PMID:
30357573
3.

Two models of inescapable stress increase tph2 mRNA expression in the anxiety-related dorsomedial part of the dorsal raphe nucleus.

Donner NC, Kubala KH, Hassell JE Jr, Lieb MW, Nguyen KT, Heinze JD, Drugan RC, Maier SF, Lowry CA.

Neurobiol Stress. 2018 Jan 17;8:68-81. doi: 10.1016/j.ynstr.2018.01.003. eCollection 2018 Feb.

4.

Contribution of perinatal conditions to cerebral palsy in Uganda.

Hassell J, Tann C, Idro R, Robertson NJ.

Lancet Glob Health. 2018 Mar;6(3):e248-e249. doi: 10.1016/S2214-109X(18)30041-X. No abstract available.

5.

Identification of Drug Candidates to Suppress Cigarette Smoke-induced Inflammation via Connectivity Map Analyses.

Vanderstocken G, Dvorkin-Gheva A, Shen P, Brandsma CA, Obeidat M, Bossé Y, Hassell JA, Stampfli MR.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):727-735. doi: 10.1165/rcmb.2017-0202OC.

PMID:
29256623
6.

Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm.

Fox JH, Hassell JE Jr, Siebler PH, Arnold MR, Lamb AK, Smith DG, Day HEW, Smith TM, Simmerman EM, Outzen AA, Holmes KS, Brazell CJ, Lowry CA.

Brain Behav Immun. 2017 Nov;66:70-84. doi: 10.1016/j.bbi.2017.08.014. Epub 2017 Sep 6.

PMID:
28888667
7.

RNAi screen identifies essential regulators of human brain metastasis-initiating cells.

Singh M, Venugopal C, Tokar T, Brown KR, McFarlane N, Bakhshinyan D, Vijayakumar T, Manoranjan B, Mahendram S, Vora P, Qazi M, Dhillon M, Tong A, Durrer K, Murty N, Hallet R, Hassell JA, Kaplan DR, Cutz JC, Jurisica I, Moffat J, Singh SK.

Acta Neuropathol. 2017 Dec;134(6):923-940. doi: 10.1007/s00401-017-1757-z. Epub 2017 Aug 1.

PMID:
28766011
8.

Morbidity and mortality in infant mountain gorillas (Gorilla beringei beringei): A 46-year retrospective review.

Hassell JM, Zimmerman D, Cranfield MR, Gilardi K, Mudakikwa A, Ramer J, Nyirakaragire E, Lowenstine LJ.

Am J Primatol. 2017 Oct;79(10). doi: 10.1002/ajp.22686. Epub 2017 Jul 27.

PMID:
28749595
9.

Ex vivo expanded natural killer cells from breast cancer patients and healthy donors are highly cytotoxic against breast cancer cell lines and patient-derived tumours.

Shenouda MM, Gillgrass A, Nham T, Hogg R, Lee AJ, Chew MV, Shafaei M, Aarts C, Lee DA, Hassell J, Bane A, Dhesy-Thind S, Ashkar AA.

Breast Cancer Res. 2017 Jul 1;19(1):76. doi: 10.1186/s13058-017-0867-9.

10.

Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts.

Gwynne WD, Hallett RM, Girgis-Gabardo A, Bojovic B, Dvorkin-Gheva A, Aarts C, Dias K, Bane A, Hassell JA.

Oncotarget. 2017 May 9;8(19):32101-32116. doi: 10.18632/oncotarget.16646.

11.

Dexmedetomidine Combined with Therapeutic Hypothermia Is Associated with Cardiovascular Instability and Neurotoxicity in a Piglet Model of Perinatal Asphyxia.

Ezzati M, Kawano G, Rocha-Ferreira E, Alonso-Alconada D, Hassell JK, Broad KD, Fierens I, Fleiss B, Bainbridge A, Price DL, Kaynezhad P, Anderson B, Hristova M, Tachtsidis I, Golay X, Gressens P, Sanders RD, Robertson NJ.

Dev Neurosci. 2017;39(1-4):156-170. doi: 10.1159/000458438. Epub 2017 Apr 8.

PMID:
28391258
12.

Surgery increases cell death and induces changes in gene expression compared with anesthesia alone in the developing piglet brain.

Broad KD, Kawano G, Fierens I, Rocha-Ferreira E, Hristova M, Ezzati M, Rostami J, Alonso-Alconada D, Chaban B, Hassell J, Fleiss B, Gressens P, Sanders RD, Robertson NJ.

PLoS One. 2017 Mar 29;12(3):e0173413. doi: 10.1371/journal.pone.0173413. eCollection 2017.

13.

Activation of 5-HT1A receptors in the rat dorsomedial hypothalamus inhibits stress-induced activation of the hypothalamic-pituitary-adrenal axis.

Stamper CE, Hassell JE Jr, Kapitz AJ, Renner KJ, Orchinik M, Lowry CA.

Stress. 2017 Mar;20(2):223-230. doi: 10.1080/10253890.2017.1301426. Epub 2017 Mar 27.

PMID:
28345385
14.

Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells.

Bassey-Archibong BI, Rayner LG, Hercules SM, Aarts CW, Dvorkin-Gheva A, Bramson JL, Hassell JA, Daniel JM.

Cell Death Dis. 2017 Mar 23;8(3):e2689. doi: 10.1038/cddis.2017.92.

15.

Claudin-Low Breast Cancer; Clinical & Pathological Characteristics.

Dias K, Dvorkin-Gheva A, Hallett RM, Wu Y, Hassell J, Pond GR, Levine M, Whelan T, Bane AL.

PLoS One. 2017 Jan 3;12(1):e0168669. doi: 10.1371/journal.pone.0168669. eCollection 2017.

16.

Urbanization and Disease Emergence: Dynamics at the Wildlife-Livestock-Human Interface.

Hassell JM, Begon M, Ward MJ, Fèvre EM.

Trends Ecol Evol. 2017 Jan;32(1):55-67. doi: 10.1016/j.tree.2016.09.012. Epub 2016 Oct 28. Review.

17.

Total particulate matter concentration skews cigarette smoke's gene expression profile.

Dvorkin-Gheva A, Vanderstocken G, Yildirim AÖ, Brandsma CA, Obeidat M, Bossé Y, Hassell JA, Stampfli MR.

ERJ Open Res. 2016 Nov 9;2(4). pii: 00029-2016. eCollection 2016 Oct.

18.

Isoflurane Exposure Induces Cell Death, Microglial Activation and Modifies the Expression of Genes Supporting Neurodevelopment and Cognitive Function in the Male Newborn Piglet Brain.

Broad KD, Hassell J, Fleiss B, Kawano G, Ezzati M, Rocha-Ferreira E, Hristova M, Bennett K, Fierens I, Burnett R, Chaban B, Alonso-Alconada D, Oliver-Taylor A, Tachsidis I, Rostami J, Gressens P, Sanders RD, Robertson NJ.

PLoS One. 2016 Nov 29;11(11):e0166784. doi: 10.1371/journal.pone.0166784. eCollection 2016.

19.

CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence.

Garg N, Bakhshinyan D, Venugopal C, Mahendram S, Rosa DA, Vijayakumar T, Manoranjan B, Hallett R, McFarlane N, Delaney KH, Kwiecien JM, Arpin CC, Lai PS, Gómez-Biagi RF, Ali AM, de Araujo ED, Ajani OA, Hassell JA, Gunning PT, Singh SK.

Oncogene. 2017 Feb 2;36(5):606-617. doi: 10.1038/onc.2016.235. Epub 2016 Oct 24.

20.

Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening.

Sharma A, Jyotsana N, Lai CK, Chaturvedi A, Gabdoulline R, Görlich K, Murphy C, Blanchard JE, Ganser A, Brown E, Hassell JA, Humphries RK, Morgan M, Heuser M.

Curr Cancer Drug Targets. 2016;16(9):818-828.

PMID:
27321378
21.

The effects of lymph node status on predicting outcome in ER+ /HER2- tamoxifen treated breast cancer patients using gene signatures.

Cockburn JG, Hallett RM, Gillgrass AE, Dias KN, Whelan T, Levine MN, Hassell JA, Bane A.

BMC Cancer. 2016 Jul 28;16:555. doi: 10.1186/s12885-016-2501-0.

22.

Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer.

Hallett RM, Girgis-Gabardo A, Gwynne WD, Giacomelli AO, Bisson JN, Jensen JE, Dvorkin-Gheva A, Hassell JA.

Oncotarget. 2016 Aug 16;7(33):53137-53152. doi: 10.18632/oncotarget.10614.

23.

The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health.

Lowry CA, Smith DG, Siebler PH, Schmidt D, Stamper CE, Hassell JE Jr, Yamashita PS, Fox JH, Reber SO, Brenner LA, Hoisington AJ, Postolache TT, Kinney KA, Marciani D, Hernandez M, Hemmings SM, Malan-Muller S, Wright KP, Knight R, Raison CL, Rook GA.

Curr Environ Health Rep. 2016 Sep;3(3):270-86. doi: 10.1007/s40572-016-0100-5. Review.

24.

Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice.

Reber SO, Siebler PH, Donner NC, Morton JT, Smith DG, Kopelman JM, Lowe KR, Wheeler KJ, Fox JH, Hassell JE Jr, Greenwood BN, Jansch C, Lechner A, Schmidt D, Uschold-Schmidt N, Füchsl AM, Langgartner D, Walker FR, Hale MW, Lopez Perez G, Van Treuren W, González A, Halweg-Edwards AL, Fleshner M, Raison CL, Rook GA, Peddada SD, Knight R, Lowry CA.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):E3130-9. doi: 10.1073/pnas.1600324113. Epub 2016 May 16.

25.

Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple-negative breast cancer cells.

Bassey-Archibong BI, Kwiecien JM, Milosavljevic SB, Hallett RM, Rayner LG, Erb MJ, Crawford-Brown CJ, Stephenson KB, Bédard PA, Hassell JA, Daniel JM.

Oncogenesis. 2016 Mar 21;5:e208. doi: 10.1038/oncsis.2016.17.

26.

Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia.

Broad KD, Fierens I, Fleiss B, Rocha-Ferreira E, Ezzati M, Hassell J, Alonso-Alconada D, Bainbridge A, Kawano G, Ma D, Tachtsidis I, Gressens P, Golay X, Sanders RD, Robertson NJ.

Neurobiol Dis. 2016 Mar;87:29-38. doi: 10.1016/j.nbd.2015.12.001. Epub 2015 Dec 10.

27.

Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso.

Pierre CC, Longo J, Bassey-Archibong BI, Hallett RM, Milosavljevic S, Beatty L, Hassell JA, Daniel JM.

Biochim Biophys Acta. 2015 Dec;1849(12):1432-41. doi: 10.1016/j.bbagrm.2015.10.018. Epub 2015 Oct 26.

PMID:
26514431
28.

A novel stem cell culture model of recurrent glioblastoma.

Qazi MA, Vora P, Venugopal C, McFarlane N, Subapanditha MK, Murty NK, Hassell JA, Hallett RM, Singh SK.

J Neurooncol. 2016 Jan;126(1):57-67.

PMID:
26498281
29.

STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation.

Singh M, Garg N, Venugopal C, Hallett R, Tokar T, McFarlane N, Mahendram S, Bakhshinyan D, Manoranjan B, Vora P, Qazi M, Arpin CC, Page B, Haftchenary S, Rosa DA, Lai PS, Gómez-Biagi RF, Ali AM, Lewis A, Geletu M, Murty NK, Hassell JA, Jurisica I, Gunning PT, Singh SK.

Oncotarget. 2015 Sep 29;6(29):27461-77. doi: 10.18632/oncotarget.4742.

30.

Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury.

Avetisyan M, Wang H, Schill EM, Bery S, Grider JR, Hassell JA, Stappenbeck T, Heuckeroth RO.

J Neurosci. 2015 Aug 19;35(33):11543-58. doi: 10.1523/JNEUROSCI.5267-14.2015.

31.

Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells.

Venugopal C, Hallett R, Vora P, Manoranjan B, Mahendram S, Qazi MA, McFarlane N, Subapanditha M, Nolte SM, Singh M, Bakhshinyan D, Garg N, Vijayakumar T, Lach B, Provias JP, Reddy K, Murty NK, Doble BW, Bhatia M, Hassell JA, Singh SK.

Clin Cancer Res. 2015 Dec 1;21(23):5324-37. doi: 10.1158/1078-0432.CCR-14-3147. Epub 2015 Jul 7.

32.

Increased dopamine transporter function as a mechanism for dopamine hypoactivity in the adult infralimbic medial prefrontal cortex following adolescent social stress.

Novick AM, Forster GL, Hassell JE, Davies DR, Scholl JL, Renner KJ, Watt MJ.

Neuropharmacology. 2015 Oct;97:194-200. doi: 10.1016/j.neuropharm.2015.05.032. Epub 2015 Jun 6.

33.

Identification and evaluation of network modules for the prognosis of basal-like breast cancer.

Hallett RM, Cockburn JG, Li B, Dvorkin-Gheva A, Hassell JA, Bane A.

Oncotarget. 2015 Jul 10;6(19):17713-24.

34.

Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy.

Hallett RM, Huang C, Motazedian A, Auf der Mauer S, Pond GR, Hassell JA, Nordon RE, Draper JS.

Oncotarget. 2015 Mar 30;6(9):7040-52.

35.

A randomised controlled trial of a self-management programme for low vision implemented in low vision rehabilitation services.

Rees G, Xie J, Chiang PP, Larizza MF, Marella M, Hassell JB, Keeffe JE, Lamoureux EL.

Patient Educ Couns. 2015 Feb;98(2):174-81. doi: 10.1016/j.pec.2014.11.008. Epub 2014 Nov 20.

PMID:
25481576
36.

Brain cell death is reduced with cooling by 3.5°C to 5°C but increased with cooling by 8.5°C in a piglet asphyxia model.

Alonso-Alconada D, Broad KD, Bainbridge A, Chandrasekaran M, Faulkner SD, Kerenyi Á, Hassell J, Rocha-Ferreira E, Hristova M, Fleiss B, Bennett K, Kelen D, Cady E, Gressens P, Golay X, Robertson NJ.

Stroke. 2015 Jan;46(1):275-8. doi: 10.1161/STROKEAHA.114.007330. Epub 2014 Nov 25.

37.

Estrogen independent gene expression defines clinically relevant subgroups of estrogen receptor positive breast cancer.

Hallett RM, Hassell JA.

BMC Cancer. 2014 Nov 24;14:871. doi: 10.1186/1471-2407-14-871.

38.

Serotonergic responses to stress are enhanced in the central amygdala and inhibited in the ventral hippocampus during amphetamine withdrawal.

Li H, Scholl JL, Tu W, Hassell JE, Watt MJ, Forster GL, Renner KJ.

Eur J Neurosci. 2014 Dec;40(11):3684-92. doi: 10.1111/ejn.12735. Epub 2014 Sep 19.

39.

A program to identify prognostic and predictive gene signatures.

Chorlton SD, Hallett RM, Hassell JA.

BMC Res Notes. 2014 Aug 18;7:546. doi: 10.1186/1756-0500-7-546.

40.

Identification of a novel luminal molecular subtype of breast cancer.

Dvorkin-Gheva A, Hassell JA.

PLoS One. 2014 Jul 30;9(7):e103514. doi: 10.1371/journal.pone.0103514. eCollection 2014.

41.

Mammary glands exhibit molecular laterality and undergo left-right asymmetric ductal epithelial growth in MMTV-cNeu mice.

Robichaux JP, Hallett RM, Fuseler JW, Hassell JA, Ramsdell AF.

Oncogene. 2015 Apr 9;34(15):2003-10. doi: 10.1038/onc.2014.149. Epub 2014 Jun 9.

42.

Investigation of cerebral autoregulation in the newborn piglet during anaesthesia and surgery.

Bale G, Oliver-Taylor A, Fierens I, Broad K, Hassell J, Kawano G, Rostami J, Raivich G, Sanders R, Robertson N, Tachtsidis I.

Adv Exp Med Biol. 2014;812:165-171. doi: 10.1007/978-1-4939-0620-8_22.

43.

Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model.

Ezzati M, Broad K, Kawano G, Faulkner S, Hassell J, Fleiss B, Gressens P, Fierens I, Rostami J, Maze M, Sleigh JW, Anderson B, Sanders RD, Robertson NJ.

Acta Anaesthesiol Scand. 2014 Jul;58(6):733-42. doi: 10.1111/aas.12318. Epub 2014 Apr 13.

44.

Occurrence and molecular analysis of Balantidium coli in mountain gorilla (Gorilla beringei beringei) in the Volcanoes National Park, Rwanda.

Hassell JM, Blake DP, Cranfield MR, Ramer J, Hogan JN, Noheli JB, Waters M, Hermosilla C.

J Wildl Dis. 2013 Oct;49(4):1063-5. doi: 10.7589/2013-02-041.

PMID:
24502743
45.

Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala.

Arendt DH, Hassell J, Li H, Achua JK, Guarnieri DJ, Dileone RJ, Ronan PJ, Summers CH.

Psychoneuroendocrinology. 2014 Feb;40:17-26. doi: 10.1016/j.psyneuen.2013.10.010. Epub 2013 Oct 30.

46.

Immunotherapy-induced CD8+ T cells instigate immune suppression in the tumor.

McGray AJ, Hallett R, Bernard D, Swift SL, Zhu Z, Teoderascu F, Vanseggelen H, Hassell JA, Hurwitz AA, Wan Y, Bramson JL.

Mol Ther. 2014 Jan;22(1):206-18. doi: 10.1038/mt.2013.255. Epub 2013 Oct 23.

47.

Giardia in mountain gorillas (Gorilla beringei beringei), forest buffalo (Syncerus caffer), and domestic cattle in Volcanoes National Park, Rwanda.

Hogan JN, Miller WA, Cranfield MR, Ramer J, Hassell J, Noheri JB, Conrad PA, Gilardi KV.

J Wildl Dis. 2014 Jan;50(1):21-30. doi: 10.7589/2012-09-229. Epub 2013 Oct 25.

PMID:
24171566
48.

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1).

Reipas KM, Law JH, Couto N, Islam S, Li Y, Li H, Cherkasov A, Jung K, Cheema AS, Jones SJ, Hassell JA, Dunn SE.

Oncotarget. 2013 Feb;4(2):329-45.

49.

FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells.

Manoranjan B, Wang X, Hallett RM, Venugopal C, Mack SC, McFarlane N, Nolte SM, Scheinemann K, Gunnarsson T, Hassell JA, Taylor MD, Lee C, Triscott J, Foster CM, Dunham C, Hawkins C, Dunn SE, Singh SK.

Stem Cells. 2013 Jul;31(7):1266-77. doi: 10.1002/stem.1401.

50.

Single unpurified breast tumor-initiating cells from multiple mouse models efficiently elicit tumors in immune-competent hosts.

Kurpios NA, Girgis-Gabardo A, Hallett RM, Rogers S, Gludish DW, Kockeritz L, Woodgett J, Cardiff R, Hassell JA.

PLoS One. 2013;8(3):e58151. doi: 10.1371/journal.pone.0058151. Epub 2013 Mar 26.

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