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Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy.

Rhodius-Meester HFM, van Maurik IS, Koikkalainen J, Tolonen A, Frederiksen KS, Hasselbalch SG, Soininen H, Herukka SK, Remes AM, Teunissen CE, Barkhof F, Pijnenburg YAL, Scheltens P, Lötjönen J, van der Flier WM.

PLoS One. 2020 Jan 15;15(1):e0226784. doi: 10.1371/journal.pone.0226784. eCollection 2020.


A visual rating scale for cingulate island sign on 18F-FDG-PET to differentiate dementia with Lewy bodies and Alzheimer's disease.

Gjerum L, Frederiksen KS, Henriksen OM, Law I, Anderberg L, Andersen BB, Bjerregaard E, Hejl AM, Høgh P, Hasselbalch SG.

J Neurol Sci. 2019 Dec 24;410:116645. doi: 10.1016/j.jns.2019.116645. [Epub ahead of print]


Cerebrospinal fluid oxidative stress metabolites in patients with bipolar disorder and healthy controls: a longitudinal case-control study.

Knorr U, Simonsen AH, Roos P, Weimann A, Henriksen T, Christensen EM, Vinberg M, Mikkelsen RL, Kirkegaard T, Jensen RN, Akhøj M, Forman J, Poulsen HE, Hasselbalch SG, Kessing LV.

Transl Psychiatry. 2019 Nov 28;9(1):325. doi: 10.1038/s41398-019-0664-6.


Ageing as a risk factor for neurodegenerative disease.

Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, Bohr VA.

Nat Rev Neurol. 2019 Oct;15(10):565-581. doi: 10.1038/s41582-019-0244-7. Epub 2019 Sep 9. Review.


Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease.

Frederiksen KS, Madsen K, Andersen BB, Beyer N, Garde E, Høgh P, Waldemar G, Hasselbalch SG, Law I.

Alzheimers Dement (N Y). 2019 Jun 7;5:208-215. doi: 10.1016/j.trci.2019.04.006. eCollection 2019.


Biomarkers for Alzheimer's Disease in Saliva: A Systematic Review.

Gleerup HS, Hasselbalch SG, Simonsen AH.

Dis Markers. 2019 May 2;2019:4761054. doi: 10.1155/2019/4761054. eCollection 2019.


Hybrid FDG PET/MRI vs. FDG PET and CT in patients with suspected dementia - A comparison of diagnostic yield and propagated influence on clinical diagnosis and patient management.

Kaltoft NS, Marner L, Larsen VA, Hasselbalch SG, Law I, Henriksen OM.

PLoS One. 2019 May 2;14(5):e0216409. doi: 10.1371/journal.pone.0216409. eCollection 2019.


Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise.

Jensen CS, Simonsen AH, Siersma V, Beyer N, Frederiksen KS, Gottrup H, Hoffman K, Høgh P, Frikke-Schmidt R, Sobol NA, Waldemar G, Wermuth L, Hasselbalch SG.

Alzheimers Dement (N Y). 2019 Apr 8;5:99-106. doi: 10.1016/j.trci.2019.02.007. eCollection 2019.


Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma.

Jensen CS, Bahl JM, Østergaard LB, Høgh P, Wermuth L, Heslegrave A, Zetterberg H, Heegaard NHH, Hasselbalch SG, Simonsen AH.

Exp Gerontol. 2019 Jul 1;121:91-98. doi: 10.1016/j.exger.2019.04.003. Epub 2019 Apr 11.


Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study.

Bruun M, Frederiksen KS, Rhodius-Meester HFM, Baroni M, Gjerum L, Koikkalainen J, Urhemaa T, Tolonen A, van Gils M, Rueckert D, Dyremose N, Andersen BB, Lemstra AW, Hallikainen M, Kurl S, Herukka SK, Remes AM, Waldemar G, Soininen H, Mecocci P, van der Flier WM, Lötjönen J, Hasselbalch SG.

Alzheimers Res Ther. 2019 Mar 20;11(1):25. doi: 10.1186/s13195-019-0482-3.


Physical Activity as a Moderator of Alzheimer Pathology: A Systematic Review of Observational Studies.

Frederiksen KS, Gjerum L, Waldemar G, Hasselbalch SG.

Curr Alzheimer Res. 2019;16(4):362-378. doi: 10.2174/1567205016666190315095151.


Automatically computed rating scales from MRI for patients with cognitive disorders.

Koikkalainen JR, Rhodius-Meester HFM, Frederiksen KS, Bruun M, Hasselbalch SG, Baroni M, Mecocci P, Vanninen R, Remes A, Soininen H, van Gils M, van der Flier WM, Scheltens P, Barkhof F, Erkinjuntti T, Lötjönen JMP; Alzheimer’s Disease Neuroimaging Initiative.

Eur Radiol. 2019 Sep;29(9):4937-4947. doi: 10.1007/s00330-019-06067-1. Epub 2019 Feb 22.


Detecting frontotemporal dementia syndromes using MRI biomarkers.

Bruun M, Koikkalainen J, Rhodius-Meester HFM, Baroni M, Gjerum L, van Gils M, Soininen H, Remes AM, Hartikainen P, Waldemar G, Mecocci P, Barkhof F, Pijnenburg Y, van der Flier WM, Hasselbalch SG, Lötjönen J, Frederiksen KS.

Neuroimage Clin. 2019;22:101711. doi: 10.1016/j.nicl.2019.101711. Epub 2019 Feb 4.


Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus versus Alzheimer's Disease and Subcortical Ischemic Vascular Disease: A Systematic Review.

Manniche C, Hejl AM, Hasselbalch SG, Simonsen AH.

J Alzheimers Dis. 2019;68(1):267-279. doi: 10.3233/JAD-180816.


Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study.

Schjønning Nielsen M, Simonsen AH, Siersma V, Engedal K, Jelic V, Andersen BB, Naik M, Hasselbalch SG, Høgh P.

Dement Geriatr Cogn Dis Extra. 2018 Nov 27;8(3):426-438. doi: 10.1159/000490788. eCollection 2018 Sep-Dec.


Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study.

Bruun M, Frederiksen KS, Rhodius-Meester HFM, Baroni M, Gjerum L, Koikkalainen J, Urhemaa T, Tolonen A, van Gils M, Tong T, Guerrero R, Rueckert D, Dyremose N, Andersen BB, Simonsen AH, Lemstra A, Hallikainen M, Kurl S, Herukka SK, Remes AM, Waldemar G, Soininen H, Mecocci P, van der Flier WM, Lötjönen J, Hasselbalch SG.

Curr Alzheimer Res. 2019;16(2):91-101. doi: 10.2174/1567205016666190103152425.


Evaluating combinations of diagnostic tests to discriminate different dementia types.

Bruun M, Rhodius-Meester HFM, Koikkalainen J, Baroni M, Gjerum L, Lemstra AW, Barkhof F, Remes AM, Urhemaa T, Tolonen A, Rueckert D, van Gils M, Frederiksen KS, Waldemar G, Scheltens P, Mecocci P, Soininen H, Lötjönen J, Hasselbalch SG, van der Flier WM.

Alzheimers Dement (Amst). 2018 Aug 17;10:509-518. doi: 10.1016/j.dadm.2018.07.003. eCollection 2018.


A 16-Week Aerobic Exercise Intervention Does Not Affect Hippocampal Volume and Cortical Thickness in Mild to Moderate Alzheimer's Disease.

Frederiksen KS, Larsen CT, Hasselbalch SG, Christensen AN, Høgh P, Wermuth L, Andersen BB, Siebner HR, Garde E.

Front Aging Neurosci. 2018 Sep 25;10:293. doi: 10.3389/fnagi.2018.00293. eCollection 2018.


[Confusion, loss of consciousness and unspecific visual hallucinations may be symptoms of dementia with Lewy bodies].

Dombernowsky NW, Law I, Hasselbalch SG.

Ugeskr Laeger. 2018 Sep 17;180(38). pii: V04180305. Danish.


Quantitative Measurements of Motor Function in Alzheimer's Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study.

Jeppesen Kragh F, Bruun M, Budtz-Jørgensen E, Hjermind LE, Schubert R, Reilmann R, Nielsen JE, Hasselbalch SG.

Dement Geriatr Cogn Disord. 2018;46(3-4):168-179. doi: 10.1159/000492860. Epub 2018 Sep 26.


The effect of physical exercise on cerebral blood flow in Alzheimer's disease.

van der Kleij LA, Petersen ET, Siebner HR, Hendrikse J, Frederiksen KS, Sobol NA, Hasselbalch SG, Garde E.

Neuroimage Clin. 2018 Sep 4;20:650-654. doi: 10.1016/j.nicl.2018.09.003. eCollection 2018.


Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species.

Oliveira F, Leuzy A, Castelhano J, Chiotis K, Hasselbalch SG, Rinne J, Mendonça A, Otto M, Lleó A, Santana I, Johansson J, Anderl-Straub S, Arnim C, Beer A, Blesa R, Fortea J, Sanna-Kaisa H, Portelius E, Pannee J, Zetterberg H, Blennow K, Moreira AP, Abrunhosa A, Nordberg A, Castelo-Branco M.

Neuroimage Clin. 2018 Aug 19;20:603-610. doi: 10.1016/j.nicl.2018.08.023. eCollection 2018.


Change in Fitness and the Relation to Change in Cognition and Neuropsychiatric Symptoms After Aerobic Exercise in Patients with Mild Alzheimer's Disease.

Sobol NA, Dall CH, Høgh P, Hoffmann K, Frederiksen KS, Vogel A, Siersma V, Waldemar G, Hasselbalch SG, Beyer N.

J Alzheimers Dis. 2018;65(1):137-145. doi: 10.3233/JAD-180253.


Data-Driven Differential Diagnosis of Dementia Using Multiclass Disease State Index Classifier.

Tolonen A, Rhodius-Meester HFM, Bruun M, Koikkalainen J, Barkhof F, Lemstra AW, Koene T, Scheltens P, Teunissen CE, Tong T, Guerrero R, Schuh A, Ledig C, Baroni M, Rueckert D, Soininen H, Remes AM, Waldemar G, Hasselbalch SG, Mecocci P, van der Flier WM, Lötjönen J.

Front Aging Neurosci. 2018 Apr 25;10:111. doi: 10.3389/fnagi.2018.00111. eCollection 2018.


Biomarkers in cerebrospinal fluid of patients with bipolar disorder versus healthy individuals: A systematic review.

Knorr U, Simonsen AH, Zetterberg H, Blennow K, Hasselbalch SG, Kessing LV.

Eur Neuropsychopharmacol. 2018 Jul;28(7):783-794. doi: 10.1016/j.euroneuro.2018.04.002. Epub 2018 May 23.


The Diagnostic and Prognostic Value of a Dual-Tasking Paradigm in a Memory Clinic.

Nielsen MS, Simonsen AH, Siersma V, Hasselbalch SG, Hoegh P.

J Alzheimers Dis. 2018;61(3):1189-1199. doi: 10.3233/JAD-161310.


Progressive DNA and RNA damage from oxidation after aneurysmal subarachnoid haemorrhage in humans.

Jorgensen A, Staalsoe JM, Simonsen AH, Hasselbalch SG, Høgh P, Weimann A, Poulsen HE, Olsen NV.

Free Radic Res. 2018 Jan;52(1):51-56. doi: 10.1080/10715762.2017.1407413. Epub 2017 Dec 5.


Effects of Physical Exercise on Alzheimer's Disease Biomarkers: A Systematic Review of Intervention Studies.

Frederiksen KS, Gjerum L, Waldemar G, Hasselbalch SG.

J Alzheimers Dis. 2018;61(1):359-372. doi: 10.3233/JAD-170567. Review.


Effect of physical exercise on markers of neuronal dysfunction in cerebrospinal fluid in patients with Alzheimer's disease.

Jensen CS, Portelius E, Høgh P, Wermuth L, Blennow K, Zetterberg H, Hasselbalch SG, Simonsen AH.

Alzheimers Dement (N Y). 2017 Apr 17;3(2):284-290. doi: 10.1016/j.trci.2017.03.007. eCollection 2017 Jun.


A Parallel Reaction Monitoring Mass Spectrometric Method for Analysis of Potential CSF Biomarkers for Alzheimer's Disease.

Brinkmalm G, Sjödin S, Simonsen AH, Hasselbalch SG, Zetterberg H, Brinkmalm A, Blennow K.

Proteomics Clin Appl. 2018 Jan;12(1). doi: 10.1002/prca.201700131. Epub 2017 Nov 23.


Season-independent cognitive deficits in seasonal affective disorder and their relation to depressive symptoms.

Hjordt LV, Stenbæk DS, Ozenne B, Mc Mahon B, Hageman I, Hasselbalch SG, Knudsen GM.

Psychiatry Res. 2017 Nov;257:219-226. doi: 10.1016/j.psychres.2017.07.056. Epub 2017 Jul 30.


Brain serotonin 4 receptor binding is inversely associated with verbal memory recall.

Stenbæk DS, Fisher PM, Ozenne B, Andersen E, Hjordt LV, McMahon B, Hasselbalch SG, Frokjaer VG, Knudsen GM.

Brain Behav. 2017 Mar 17;7(4):e00674. doi: 10.1002/brb3.674. eCollection 2017 Apr.


[State-of-the-art work-up of dementia disorder].

Hasselbalch SG.

Ugeskr Laeger. 2017 Mar 20;179(12). pii: V09160696. Review. Danish.


State-dependent alterations in inhibitory control and emotional face identification in seasonal affective disorder.

Hjordt LV, Stenbæk DS, Madsen KS, Mc Mahon B, Jensen CG, Vestergaard M, Hageman I, Meder D, Hasselbalch SG, Knudsen GM.

J Abnorm Psychol. 2017 Apr;126(3):291-300. doi: 10.1037/abn0000251. Epub 2017 Feb 9.


Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting.

Schjønning Nielsen M, Simonsen AH, Siersma V, Hasselbalch SG, Høgh P.

Dement Geriatr Cogn Dis Extra. 2016 Oct 7;6(3):465-476. eCollection 2016 Sep-Dec.


Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study.

Leuzy A, Chiotis K, Hasselbalch SG, Rinne JO, de Mendonça A, Otto M, Lleó A, Castelo-Branco M, Santana I, Johansson J, Anderl-Straub S, von Arnim CA, Beer A, Blesa R, Fortea J, Herukka SK, Portelius E, Pannee J, Zetterberg H, Blennow K, Nordberg A.

Brain. 2016 Sep;139(Pt 9):2540-53. doi: 10.1093/brain/aww160. Epub 2016 Jul 7.


Effect of aerobic exercise on physical performance in patients with Alzheimer's disease.

Sobol NA, Hoffmann K, Frederiksen KS, Vogel A, Vestergaard K, Brændgaard H, Gottrup H, Lolk A, Wermuth L, Jakobsen S, Laugesen L, Gergelyffy R, Høgh P, Bjerregaard E, Siersma V, Andersen BB, Johannsen P, Waldemar G, Hasselbalch SG, Beyer N.

Alzheimers Dement. 2016 Dec;12(12):1207-1215. doi: 10.1016/j.jalz.2016.05.004. Epub 2016 Jun 23.


[The risk of dementia and cognitive decline can be reduced].

Jørgensen K, Hasselbalch SG, Waldemar G.

Ugeskr Laeger. 2016 Feb 15;178(7):V11150887. Review. Danish.


[Immunotherapy for Alzheimer's disease].

Falkentoft AC, Hasselbalch SG.

Ugeskr Laeger. 2016 Jan 18;178(3):V07150588. Review. Danish.


General inattentiveness is a long-term reliable trait independently predictive of psychological health: Danish validation studies of the Mindful Attention Awareness Scale.

Jensen CG, Niclasen J, Vangkilde SA, Petersen A, Hasselbalch SG.

Psychol Assess. 2016 May;28(5):e70-87. doi: 10.1037/pas0000196. Epub 2016 Jan 11.


Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial.

Hoffmann K, Sobol NA, Frederiksen KS, Beyer N, Vogel A, Vestergaard K, Brændgaard H, Gottrup H, Lolk A, Wermuth L, Jacobsen S, Laugesen LP, Gergelyffy RG, Høgh P, Bjerregaard E, Andersen BB, Siersma V, Johannsen P, Cotman CW, Waldemar G, Hasselbalch SG.

J Alzheimers Dis. 2016;50(2):443-53. doi: 10.3233/JAD-150817.


Open and Calm--a randomized controlled trial evaluating a public stress reduction program in Denmark.

Jensen CG, Lansner J, Petersen A, Vangkilde SA, Ringkøbing SP, Frokjaer VG, Adamsen D, Knudsen GM, Denninger JW, Hasselbalch SG.

BMC Public Health. 2015 Dec 16;15:1245. doi: 10.1186/s12889-015-2588-2.


Evaluation of acute tryptophan depletion and sham depletion with a gelatin-based collagen peptide protein mixture.

Stenbæk DS, Einarsdottir HS, Goregliad-Fjaellingsdal T, Knudsen GM, Frokjaer VG, Hasselbalch SG.

Eur Neuropsychopharmacol. 2016 Jan;26(1):147-149. doi: 10.1016/j.euroneuro.2015.11.010. Epub 2015 Nov 26.


Use of amyloid-PET to determine cutpoints for CSF markers: A multicenter study.

Zwan MD, Rinne JO, Hasselbalch SG, Nordberg A, Lleó A, Herukka SK, Soininen H, Law I, Bahl JM, Carter SF, Fortea J, Blesa R, Teunissen CE, Bouwman FH, van Berckel BN, Visser PJ.

Neurology. 2016 Jan 5;86(1):50-8. doi: 10.1212/WNL.0000000000002081. Epub 2015 Oct 14. Erratum in: Neurology. 2016 May 31;86(22):2116.


Development and psychometric validation of the verbal affective memory test.

Jensen CG, Hjordt LV, Stenbæk DS, Andersen E, Back SK, Lansner J, Hageman I, Dam H, Nielsen AP, Knudsen GM, Frokjaer VG, Hasselbalch SG.

Memory. 2016 Oct;24(9):1208-23. doi: 10.1080/09658211.2015.1087573. Epub 2015 Sep 24.


Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-β Levels in Patients with Alzheimer's Disease?

Travassos M, Santana I, Baldeiras I, Tsolaki M, Gkatzima O, Sermin G, Yener GG, Simonsen A, Hasselbalch SG, Kapaki E, Mara B, Cunha RA, Agostinho P, Blennow K, Zetterberg H, Mendes VM, Manadas B, de Mendon A.

J Alzheimers Dis. 2015;47(4):1069-78. doi: 10.3233/JAD-150374.


Biochemical Markers of Physical Exercise on Mild Cognitive Impairment and Dementia: Systematic Review and Perspectives.

Jensen CS, Hasselbalch SG, Waldemar G, Simonsen AH.

Front Neurol. 2015 Aug 26;6:187. doi: 10.3389/fneur.2015.00187. eCollection 2015. Review.


[PET with amyloid ligands should not be applied routinely in early diagnostics of Alzheimer's disease].

Hasselbalch SG.

Ugeskr Laeger. 2015 Aug 3;177(32):V11140610. Danish.


Associations between physical function, dual-task performance and cognition in patients with mild Alzheimer's disease.

Sobol NA, Hoffmann K, Vogel A, Lolk A, Gottrup H, Høgh P, Hasselbalch SG, Beyer N.

Aging Ment Health. 2016 Nov;20(11):1139-1146. Epub 2015 Jul 10.


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