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Second Correction for Hassan et al., "CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76".

Hassan NJ, Simmonds SJ, Clarkson NG, Hanrahan S, Puklavec MJ, Bomb M, Barclay AN, Brown MH.

Mol Cell Biol. 2019 Mar 19;39(7). pii: e00054-19. doi: 10.1128/MCB.00054-19. Print 2019 Apr 1. No abstract available.


An approved in vitro approach to preclinical safety and efficacy evaluation of engineered T cell receptor anti-CD3 bispecific (ImmTAC) molecules.

Harper J, Adams KJ, Bossi G, Wright DE, Stacey AR, Bedke N, Martinez-Hague R, Blat D, Humbert L, Buchanan H, Le Provost GS, Donnellan Z, Carreira RJ, Paston SJ, Weigand LU, Canestraro M, Sanderson JP, Botta Gordon-Smith S, Lowe KL, Rygiel KA, Powlesland AS, Vuidepot A, Hassan NJ, Cameron BJ, Jakobsen BK, Dukes J.

PLoS One. 2018 Oct 15;13(10):e0205491. doi: 10.1371/journal.pone.0205491. eCollection 2018.


Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells.

Boudousquie C, Bossi G, Hurst JM, Rygiel KA, Jakobsen BK, Hassan NJ.

Immunology. 2017 Nov;152(3):425-438. doi: 10.1111/imm.12779. Epub 2017 Aug 2.


Elimination of Latently HIV-infected Cells from Antiretroviral Therapy-suppressed Subjects by Engineered Immune-mobilizing T-cell Receptors.

Yang H, Buisson S, Bossi G, Wallace Z, Hancock G, So C, Ashfield R, Vuidepot A, Mahon T, Molloy P, Oates J, Paston SJ, Aleksic M, Hassan NJ, Jakobsen BK, Dorrell L.

Mol Ther. 2016 Nov;24(11):1913-1925. doi: 10.1038/mt.2016.114. Epub 2016 Jun 6.


Case Report of a Fatal Serious Adverse Event Upon Administration of T Cells Transduced With a MART-1-specific T-cell Receptor.

van den Berg JH, Gomez-Eerland R, van de Wiel B, Hulshoff L, van den Broek D, Bins A, Tan HL, Harper JV, Hassan NJ, Jakobsen BK, Jorritsma A, Blank CU, Schumacher TN, Haanen JB.

Mol Ther. 2015 Sep;23(9):1541-50. doi: 10.1038/mt.2015.60. Epub 2015 Apr 21.


ImmTACs for targeted cancer therapy: Why, what, how, and which.

Oates J, Hassan NJ, Jakobsen BK.

Mol Immunol. 2015 Oct;67(2 Pt A):67-74. doi: 10.1016/j.molimm.2015.01.024. Epub 2015 Feb 21. Review.


ImmTAC-redirected tumour cell killing induces and potentiates antigen cross-presentation by dendritic cells.

Bossi G, Buisson S, Oates J, Jakobsen BK, Hassan NJ.

Cancer Immunol Immunother. 2014 May;63(5):437-48. doi: 10.1007/s00262-014-1525-z. Epub 2014 Feb 15.


Examining the presentation of tumor-associated antigens on peptide-pulsed T2 cells.

Bossi G, Gerry AB, Paston SJ, Sutton DH, Hassan NJ, Jakobsen BK.

Oncoimmunology. 2013 Nov 1;2(11):e26840. Epub 2013 Oct 21.


Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells.

Cameron BJ, Gerry AB, Dukes J, Harper JV, Kannan V, Bianchi FC, Grand F, Brewer JE, Gupta M, Plesa G, Bossi G, Vuidepot A, Powlesland AS, Legg A, Adams KJ, Bennett AD, Pumphrey NJ, Williams DD, Binder-Scholl G, Kulikovskaya I, Levine BL, Riley JL, Varela-Rohena A, Stadtmauer EA, Rapoport AP, Linette GP, June CH, Hassan NJ, Kalos M, Jakobsen BK.

Sci Transl Med. 2013 Aug 7;5(197):197ra103. doi: 10.1126/scitranslmed.3006034.


Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.

Linette GP, Stadtmauer EA, Maus MV, Rapoport AP, Levine BL, Emery L, Litzky L, Bagg A, Carreno BM, Cimino PJ, Binder-Scholl GK, Smethurst DP, Gerry AB, Pumphrey NJ, Bennett AD, Brewer JE, Dukes J, Harper J, Tayton-Martin HK, Jakobsen BK, Hassan NJ, Kalos M, June CH.

Blood. 2013 Aug 8;122(6):863-71. doi: 10.1182/blood-2013-03-490565. Epub 2013 Jun 14.


Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors.

McCormack E, Adams KJ, Hassan NJ, Kotian A, Lissin NM, Sami M, Mujić M, Osdal T, Gjertsen BT, Baker D, Powlesland AS, Aleksic M, Vuidepot A, Morteau O, Sutton DH, June CH, Kalos M, Ashfield R, Jakobsen BK.

Cancer Immunol Immunother. 2013 Apr;62(4):773-85. doi: 10.1007/s00262-012-1384-4. Epub 2012 Dec 22.


Strategies to generate biological reagents for kinase drug discovery.

Hassan NJ, Gul S.

Expert Opin Drug Discov. 2011 Dec;6(12):1215-25. doi: 10.1517/17460441.2011.635140. Epub 2011 Nov 9.


Monoclonal TCR-redirected tumor cell killing.

Liddy N, Bossi G, Adams KJ, Lissina A, Mahon TM, Hassan NJ, Gavarret J, Bianchi FC, Pumphrey NJ, Ladell K, Gostick E, Sewell AK, Lissin NM, Harwood NE, Molloy PE, Li Y, Cameron BJ, Sami M, Baston EE, Todorov PT, Paston SJ, Dennis RE, Harper JV, Dunn SM, Ashfield R, Johnson A, McGrath Y, Plesa G, June CH, Kalos M, Price DA, Vuidepot A, Williams DD, Sutton DH, Jakobsen BK.

Nat Med. 2012 Jun;18(6):980-7. doi: 10.1038/nm.2764.


High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay.

Singh PK, Chan PF, Hibbs MJ, Vazquez MJ, Segura DC, Thomas DA, Theobald AJ, Gallagher KT, Hassan NJ.

Protein Expr Purif. 2011 Apr;76(2):165-72. doi: 10.1016/j.pep.2010.08.001. Epub 2010 Aug 13.


Development of an insect-cell-based assay for detection of kinase inhibition using NF-kappaB-inducing kinase as a paradigm.

Hassan NJ, Gul S, Flett F, Hollingsworth E, Dunne AA, Emmons AJ, Hutchinson JP, Hibbs MJ, Dyos S, Kitson JD, Hiley E, Rüdiger M, Tew DG, Powell DJ, Morse MA.

Biochem J. 2009 Apr 1;419(1):65-73. doi: 10.1042/BJ20081646.


Baculoviruses and mammalian cell-based assays for drug screening.

Condreay JP, Ames RS, Hassan NJ, Kost TA, Merrihew RV, Mossakowska DE, Pountney DJ, Romanos MA.

Adv Virus Res. 2006;68:255-86. Review. No abstract available.


CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.

Hassan NJ, Simmonds SJ, Clarkson NG, Hanrahan S, Puklavec MJ, Bomb M, Barclay AN, Brown MH.

Mol Cell Biol. 2006 Sep;26(17):6727-38. Erratum in: Mol Cell Biol. 2009 Jun;29(12):3452. Mol Cell Biol. 2019 Mar 19;39(7):.


BacMam recombinant baculovirus in transporter expression: a study of BCRP and OATP1B1.

Hassan NJ, Pountney DJ, Ellis C, Mossakowska DE.

Protein Expr Purif. 2006 Jun;47(2):591-8. Epub 2006 Jan 30.


Frontline: Optimal T cell activation requires the engagement of CD6 and CD166.

Hassan NJ, Barclay AN, Brown MH.

Eur J Immunol. 2004 Apr;34(4):930-40.


Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.

Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL.

Eur J Biochem. 2000 Sep;267(18):5699-710.

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