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Items: 16

1.

Reducing the Crystallite Size of Spherulites in PEO-Based Polymer Nanocomposites Mediated by Carbon Nanodots and Ag Nanoparticles.

Abdullah RM, Aziz SB, Mamand SM, Hassan AQ, Hussein SA, Kadir MFZ.

Nanomaterials (Basel). 2019 Jun 9;9(6). pii: E874. doi: 10.3390/nano9060874.

2.

Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.

Ramurthy S, Taft BR, Aversa RJ, Barsanti PA, Burger MT, Lou Y, Nishiguchi GA, Rico A, Setti L, Smith A, Subramanian S, Tamez V, Tanner H, Wan L, Hu C, Appleton BA, Mamo M, Tandeske L, Tellew JE, Huang S, Yue Q, Chaudhary A, Tian H, Iyer R, Hassan AQ, Mathews Griner LA, La Bonte LR, Cooke VG, Van Abbema A, Merritt H, Gampa K, Feng F, Yuan J, Mishina Y, Wang Y, Haling JR, Vaziri S, Hekmat-Nejad M, Polyakov V, Zang R, Sethuraman V, Amiri P, Singh M, Sellers WR, Lees E, Shao W, Dillon MP, Stuart DD.

J Med Chem. 2019 May 16. doi: 10.1021/acs.jmedchem.9b00161. [Epub ahead of print]

PMID:
31059256
3.

Structural and Optical Characteristics of PVA:C-Dot Composites: Tuning the Absorption of Ultra Violet (UV) Region.

Aziz SB, Hassan AQ, Mohammed SJ, Karim WO, Kadir MFZ, Tajuddin HA, Chan NNMY.

Nanomaterials (Basel). 2019 Feb 6;9(2). pii: E216. doi: 10.3390/nano9020216.

4.

Solvothermal synthesis of phosphorus and nitrogen doped carbon quantum dots as a fluorescent probe for iron(III).

Omer KM, Tofiq DI, Hassan AQ.

Mikrochim Acta. 2018 Sep 18;185(10):466. doi: 10.1007/s00604-018-3002-4.

PMID:
30229316
5.

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.

Schoepfer J, Jahnke W, Berellini G, Buonamici S, Cotesta S, Cowan-Jacob SW, Dodd S, Drueckes P, Fabbro D, Gabriel T, Groell JM, Grotzfeld RM, Hassan AQ, Henry C, Iyer V, Jones D, Lombardo F, Loo A, Manley PW, Pellé X, Rummel G, Salem B, Warmuth M, Wylie AA, Zoller T, Marzinzik AL, Furet P.

J Med Chem. 2018 Sep 27;61(18):8120-8135. doi: 10.1021/acs.jmedchem.8b01040. Epub 2018 Sep 7.

PMID:
30137981
6.

The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.

Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR.

Nature. 2017 Mar 30;543(7647):733-737. doi: 10.1038/nature21702. Epub 2017 Mar 22.

PMID:
28329763
7.

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors.

Gibaja V, Shen F, Harari J, Korn J, Ruddy D, Saenz-Vash V, Zhai H, Rejtar T, Paris CG, Yu Z, Lira M, King D, Qi W, Keen N, Hassan AQ, Chan HM.

Oncogene. 2016 Feb 4;35(5):558-66. doi: 10.1038/onc.2015.114. Epub 2015 Apr 20.

8.

The novolactone natural product disrupts the allosteric regulation of Hsp70.

Hassan AQ, Kirby CA, Zhou W, Schuhmann T, Kityk R, Kipp DR, Baird J, Chen J, Chen Y, Chung F, Hoepfner D, Movva NR, Pagliarini R, Petersen F, Quinn C, Quinn D, Riedl R, Schmitt EK, Schitter A, Stams T, Studer C, Fortin PD, Mayer MP, Sadlish H.

Chem Biol. 2015 Jan 22;22(1):87-97. doi: 10.1016/j.chembiol.2014.11.007. Epub 2014 Dec 24.

9.

Allosteric inhibition of BCR-ABL.

Hassan AQ, Sharma SV, Warmuth M.

Cell Cycle. 2010 Sep 15;9(18):3710-4. doi: 10.4161/cc.9.18.13232. Epub 2010 Sep 3. Review.

PMID:
20930519
10.

Functional analysis of the Streptomyces coelicolor NrdR ATP-cone domain: role in nucleotide binding, oligomerization, and DNA interactions.

Grinberg I, Shteinberg T, Hassan AQ, Aharonowitz Y, Borovok I, Cohen G.

J Bacteriol. 2009 Feb;191(4):1169-79. doi: 10.1128/JB.01145-08. Epub 2008 Dec 1.

11.

Methodology to probe subunit interactions in ribonucleotide reductases.

Hassan AQ, Wang Y, Plate L, Stubbe J.

Biochemistry. 2008 Dec 9;47(49):13046-55. doi: 10.1021/bi8012559.

12.

Site-specific incorporation of chemical probes into proteins for NMR.

Hassan AQ.

ACS Chem Biol. 2008 Sep 19;3(9):524-6. doi: 10.1021/cb800215d.

PMID:
18803368
13.

Mapping the subunit interface of ribonucleotide reductase (RNR) using photo cross-linking.

Hassan AQ, Stubbe J.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5923-5. doi: 10.1016/j.bmcl.2008.08.048. Epub 2008 Aug 19.

14.

Selective chemical rescue of a thyroid-hormone-receptor mutant, TRbeta(H435Y), identified in pituitary carcinoma and resistance to thyroid hormone.

Hassan AQ, Koh JT.

Angew Chem Int Ed Engl. 2008;47(38):7280-3. doi: 10.1002/anie.200801742. No abstract available.

PMID:
18683837
15.

A pilot study of a weight management program with food provision in schizophrenia.

Jean-Baptiste M, Tek C, Liskov E, Chakunta UR, Nicholls S, Hassan AQ, Brownell KD, Wexler BE.

Schizophr Res. 2007 Nov;96(1-3):198-205. Epub 2007 Jul 12.

PMID:
17628437

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