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Serum Neurofilament Light Chain for Prognosis of Outcome After Cardiac Arrest.

Moseby-Knappe M, Mattsson N, Nielsen N, Zetterberg H, Blennow K, Dankiewicz J, Dragancea I, Friberg H, Lilja G, Insel PS, Rylander C, Westhall E, Kjaergaard J, Wise MP, Hassager C, Kuiper MA, Stammet P, Wanscher MCJ, Wetterslev J, Erlinge D, Horn J, Pellis T, Cronberg T.

JAMA Neurol. 2018 Oct 29. doi: 10.1001/jamaneurol.2018.3223. [Epub ahead of print]


Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia.

Scott WK, Medie FM, Ruffin F, Sharma-Kuinkel BK, Cyr DD, Guo S, Dykxhoorn DM, Skov RL, Bruun NE, Dahl A, Lerche CJ, Petersen A, Larsen AR, Lauridsen TK, Johansen HK, Ullum H, Sørensen E, Hassager C, Bundgaard H, Schønheyder HC, Torp-Pedersen C, Østergaard LB, Arpi M, Rosenvinge F, Erikstrup LT, Chehri M, Søgaard P, Andersen PS, Fowler VG Jr.

PLoS Genet. 2018 Oct 5;14(10):e1007667. doi: 10.1371/journal.pgen.1007667. eCollection 2018 Oct.


Lactate is a Prognostic Factor in Patients Admitted with Suspected ST-Elevation Myocardial Infarction.

Frydland M, Møller JE, Wiberg S, Lindholm MG, Hansen R, Henriques JPS, Møller-Helgestad OK, Bang LE, Frikke-Schmidt R, Goetze JP, Udesen NLJ, Thomsen JH, Ouweneel DM, Obling L, Ravn HB, Holmvang L, Jensen LO, Kjaergaard J, Hassager C.

Shock. 2018 Oct 3. doi: 10.1097/SHK.0000000000001191. [Epub ahead of print]


Refractory out-of-hospital cardiac arrest with ongoing cardiopulmonary resuscitation at hospital arrival - survival and neurological outcome without extracorporeal cardiopulmonary resuscitation.

Gregers E, Kjærgaard J, Lippert F, Thomsen JH, Køber L, Wanscher M, Hassager C, Søholm H.

Crit Care. 2018 Sep 29;22(1):242. doi: 10.1186/s13054-018-2176-9.


Use of renal replacement therapy after out-of-hospital cardiac arrest in Denmark 2005-2013.

Winther-Jensen M, Kjaergaard J, Lassen JF, Køber L, Torp-Pedersen C, Hansen SM, Lippert F, Kragholm K, Christensen EF, Hassager C.

Scand Cardiovasc J. 2018 Sep 5:1-6. doi: 10.1080/14017431.2018.1503707. [Epub ahead of print]


The impact of hemodialysis on mortality risk and cause of death in Staphylococcus aureus endocarditis.

Chaudry MS, Gislason GH, Kamper AL, Rix M, Dahl A, Østergaard L, Fosbøl EL, Lauridsen TK, Oestergaard LB, Hassager C, Torp-Pedersen C, Bruun NE.

BMC Nephrol. 2018 Sep 3;19(1):216. doi: 10.1186/s12882-018-1016-0.


Exercise Hemodynamics After Aortic Valve Replacement for Severe Aortic Stenosis.

Carter-Storch R, Dahl JS, Christensen NL, Søndergaard EV, Irmukhamedov A, Pecini R, Hassager C, Marcussen N, Møller JE.

J Am Soc Echocardiogr. 2018 Oct;31(10):1091-1100. doi: 10.1016/j.echo.2018.07.001. Epub 2018 Aug 22.


Carbon dioxide dynamics in relation to neurological outcome in resuscitated out-of-hospital cardiac arrest patients: an exploratory Target Temperature Management Trial substudy.

Ebner F, Harmon MBA, Aneman A, Cronberg T, Friberg H, Hassager C, Juffermans N, Kjærgaard J, Kuiper M, Mattsson N, Pelosi P, Ullén S, Undén J, Wise MP, Nielsen N.

Crit Care. 2018 Aug 18;22(1):196. doi: 10.1186/s13054-018-2119-5.


Proteomic Discovery and Validation of the Confounding Effect of Heparin Administration on the Analysis of Candidate Cardiovascular Biomarkers.

Beck HC, Jensen LO, Gils C, Ilondo AMM, Frydland M, Hassager C, Møller-Helgestad OK, Møller JE, Rasmussen LM.

Clin Chem. 2018 Oct;64(10):1474-1484. doi: 10.1373/clinchem.2017.282665. Epub 2018 Aug 16.


Cancer is not associated with higher short or long-term mortality after successful resuscitation from out-of-hospital cardiac arrest when adjusting for prognostic factors.

Winther-Jensen M, Kjaergaard J, Hassager C, Køber L, Lippert F, Søholm H.

Eur Heart J Acute Cardiovasc Care. 2018 Aug 10:2048872618794090. doi: 10.1177/2048872618794090. [Epub ahead of print]


Semi-automated estimation of left ventricular ejection fraction by two-dimensional and three-dimensional echocardiography is feasible, time-efficient, and reproducible.

Myhr KA, Pedersen FHG, Kristensen CB, Visby L, Hassager C, Mogelvang R.

Echocardiography. 2018 Nov;35(11):1795-1805. doi: 10.1111/echo.14112. Epub 2018 Aug 2.


Hemodynamic effects of short-term infusion of a vasopressin V1A/V2 receptor antagonist conivaptan in patients withchronic heart failure during submaximal exercise.

Balling L, Thomsen JH, Wolsk E, Hassager C, Boesgaard S, Goldsmith SR, Gustafsson F.

Am Heart J. 2018 Sep;203:101-104. doi: 10.1016/j.ahj.2018.05.015. Epub 2018 Jun 14. No abstract available.


Highly malignant routine EEG predicts poor prognosis after cardiac arrest in the Target Temperature Management trial.

Backman S, Cronberg T, Friberg H, Ullén S, Horn J, Kjaergaard J, Hassager C, Wanscher M, Nielsen N, Westhall E.

Resuscitation. 2018 Oct;131:24-28. doi: 10.1016/j.resuscitation.2018.07.024. Epub 2018 Jul 24.


The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest.

Gilje P, Frydland M, Bro-Jeppesen J, Dankiewicz J, Friberg H, Rundgren M, Devaux Y, Stammet P, Al-Mashat M, Jögi J, Kjaergaard J, Hassager C, Erlinge D.

Biomarkers. 2018 Aug 23:1-7. doi: 10.1080/1354750X.2018.1499804. [Epub ahead of print]


Validation and Clinical Evaluation of a Method for Double-Blinded Blood Pressure Target Investigation in Intensive Care Medicine.

Grand J, Meyer ASP, Hassager C, Schmidt H, Møller JE, Kjaergaard J.

Crit Care Med. 2018 Oct;46(10):1626-1633. doi: 10.1097/CCM.0000000000003289.


Neurological prognostication tools in out-of-hospital cardiac arrest patients in Danish intensive care units from 2005 to 2013.

Winther-Jensen M, Hassager C, Lassen JF, Køber L, Torp-Pedersen C, Hansen SM, Lippert F, Kragholm K, Christensen EF, Kjaergaard J.

Acta Anaesthesiol Scand. 2018 Nov;62(10):1412-1420. doi: 10.1111/aas.13177. Epub 2018 Jun 26.


Time to epileptiform activity and EEG background recovery are independent predictors after cardiac arrest.

Westhall E, Rosén I, Rundgren M, Bro-Jeppesen J, Kjaergaard J, Hassager C, Lindehammar H, Horn J, Ullén S, Nielsen N, Friberg H, Cronberg T.

Clin Neurophysiol. 2018 Aug;129(8):1660-1668. doi: 10.1016/j.clinph.2018.05.016. Epub 2018 Jun 9.


Lactate, lactate clearance and outcome after cardiac arrest: A post-hoc analysis of the TTM-Trial.

Düring J, Dankiewicz J, Cronberg T, Hassager C, Hovdenes J, Kjaergaard J, Kuiper M, Nielsen N, Pellis T, Stammet P, Vulto J, Wanscher M, Wise M, Åneman A, Friberg H.

Acta Anaesthesiol Scand. 2018 Nov;62(10):1436-1442. doi: 10.1111/aas.13172. Epub 2018 Jun 21.


Osborn waves following out-of-hospital cardiac arrest-Effect of level of temperature management and risk of arrhythmia and death.

Hadziselimovic E, Thomsen JH, Kjaergaard J, Køber L, Graff C, Pehrson S, Nielsen N, Erlinge D, Frydland M, Wiberg S, Hassager C.

Resuscitation. 2018 Jul;128:119-125. doi: 10.1016/j.resuscitation.2018.04.037. Epub 2018 May 1.


Two-dimensional global longitudinal strain is superior to left ventricular ejection fraction in prediction of outcome in patients with left-sided infective endocarditis.

Lauridsen TK, Alhede C, Crowley AL, Kisslo J, Sørensen LL, Hansen TF, Risum N, Larsen CT, Hassager C, Søgaard P, Dahl A, Bruun NE.

Int J Cardiol. 2018 Jun 1;260:118-123. doi: 10.1016/j.ijcard.2018.01.031.


Importance of comorbidities in comatose survivors of shockable and non-shockable out-of-hospital cardiac arrest treated with target temperature management.

Salam I, Thomsen JH, Kjaergaard J, Bro-Jeppesen J, Frydland M, Winther-Jensen M, Køber L, Wanscher M, Hassager C, Søholm H.

Scand Cardiovasc J. 2018 Jun;52(3):133-140. doi: 10.1080/14017431.2018.1450991. Epub 2018 Mar 19.


Out-of-hospital cardiac arrest: in-hospital intervention strategies.

Hassager C, Nagao K, Hildick-Smith D.

Lancet. 2018 Mar 10;391(10124):989-998. doi: 10.1016/S0140-6736(18)30315-5. Review.


Optimised care of elderly patients with acute coronary syndrome.

Leonardi S, Bueno H, Ahrens I, Hassager C, Bonnefoy E, Lettino M.

Eur Heart J Acute Cardiovasc Care. 2018 Apr;7(3):287-295. doi: 10.1177/2048872618761621. Epub 2018 Mar 5. Review. No abstract available.


Plasma Concentration of Biomarkers Reflecting Endothelial Cell- and Glycocalyx Damage are Increased in Patients With Suspected ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock.

Frydland M, Ostrowski SR, Møller JE, Hadziselimovic E, Holmvang L, Ravn HB, Jensen LO, Pettersson AS, Kjaergaard J, Lindholm MG, Johansson PI, Hassager C.

Shock. 2018 Nov;50(5):538-544. doi: 10.1097/SHK.0000000000001123.


The feasibility of tricuspid annular plane systolic excursion performed by transesophageal echocardiography throughout heart surgery and its interchangeability with transthoracic echocardiography.

Korshin A, Grønlykke L, Nilsson JC, Møller-Sørensen H, Ihlemann N, Kjøller M, Damgaard S, Lehnert P, Hassager C, Kjaergaard J, Ravn HB.

Int J Cardiovasc Imaging. 2018 Jul;34(7):1017-1028. doi: 10.1007/s10554-018-1306-4. Epub 2018 Jan 30.


Time to awakening after cardiac arrest and the association with target temperature management.

Lybeck A, Cronberg T, Aneman A, Hassager C, Horn J, Hovdenes J, Kjærgaard J, Kuiper M, Wanscher M, Stammet P, Wise MP, Nielsen N, Ullén S, Friberg H; TTM-trial investigators.

Resuscitation. 2018 May;126:166-171. doi: 10.1016/j.resuscitation.2018.01.027.


Layer-specific deformation analysis in severe aortic valve stenosis, primary mitral valve regurgitation, and healthy individuals validated against invasive hemodynamic measurements of heart function.

Bakkestrøm R, Christensen NL, Wolsk E, Banke A, Dahl JS, Andersen MJ, Gustafsson F, Hassager C, Møller JE.

Echocardiography. 2018 Feb;35(2):170-178. doi: 10.1111/echo.13747. Epub 2018 Jan 21.


Transient cardiac dysfunction but elevated cardiac and kidney biomarkers 24 h following an ultra-distance running event in Mexican Tarahumara.

Christensen DL, Espino D, Infante-Ramírez R, Cervantes-Borunda MS, Hernández-Torres RP, Rivera-Cisneros AE, Castillo D, Westgate K, Terzic D, Brage S, Hassager C, Goetze JP, Kjaergaard J.

Extrem Physiol Med. 2017 Dec 11;6:3. doi: 10.1186/s13728-017-0057-5. eCollection 2017.


Whole-genome sequencing of bloodstream Staphylococcus aureus isolates does not distinguish bacteraemia from endocarditis.

Lilje B, Rasmussen RV, Dahl A, Stegger M, Skov RL, Fowler VG, Ng KL, Kiil K, Larsen AR, Petersen A, Johansen HK, Schønheyder HC, Arpi M, Rosenvinge FS, Korup E, Høst U, Hassager C, Gill SUA, Hansen TF, Johannesen TB, Smit J, Søgaard P, Skytt Andersen P, Eske-Bruun N.

Microb Genom. 2017 Nov;3(11). doi: 10.1099/mgen.0.000138.


The Glucagon-Like Peptide-1 Analog Exenatide Increases Blood Glucose Clearance, Lactate Clearance, and Heart Rate in Comatose Patients After Out-of-Hospital Cardiac Arrest.

Wiberg S, Kjaergaard J, Schmidt H, Thomsen JH, Frydland M, Winther-Jensen M, Lindholm MG, Høfsten DE, Engstrøm T, Køber L, Møller JE, Hassager C.

Crit Care Med. 2018 Feb;46(2):e118-e125. doi: 10.1097/CCM.0000000000002814.


Association between QRS duration on prehospital ECG and mortality in patients with suspected STEMI.

Hansen R, Frydland M, Møller-Helgestad OK, Lindholm MG, Jensen LO, Holmvang L, Ravn HB, Kjærgaard J, Hassager C, Møller JE.

Int J Cardiol. 2017 Dec 15;249:55-60. doi: 10.1016/j.ijcard.2017.07.049.


[Extracorporeal cardiopulmonary resuscitation for patients with out-of-hospital refractory cardiac arrest].

Obling L, Wiberg S, Møller JE, Hassager C, Terkelsen CJ, Holmvang L, Aarøe J, Møller-Sørensen H, Fjølner J, Rudolph SS, Kjaergaard J.

Ugeskr Laeger. 2017 Oct 30;179(44). pii: V04170293. Danish.


Women have a worse prognosis and undergo fewer coronary angiographies after out-of-hospital cardiac arrest than men.

Winther-Jensen M, Hassager C, Kjaergaard J, Bro-Jeppesen J, Thomsen JH, Lippert FK, Køber L, Wanscher M, Søholm H.

Eur Heart J Acute Cardiovasc Care. 2018 Aug;7(5):414-422. doi: 10.1177/2048872617696368. Epub 2017 Feb 1.


The biomarkers neuron-specific enolase and S100b measured the day following admission for severe accidental hypothermia have high predictive values for poor outcome.

Wiberg S, Kjaergaard J, Kjærgaard B, Møller B, Nørnberg B, Sørensen AM, Hassager C, Wanscher M.

Resuscitation. 2017 Dec;121:49-53. doi: 10.1016/j.resuscitation.2017.10.006. Epub 2017 Oct 7.


Association between socioeconomic factors and ICD implantation in a publicly financed health care system: a Danish nationwide study.

Winther-Jensen M, Hassager C, Lassen JF, Køber L, Torp-Pedersen C, Hansen SM, Lippert F, Christensen EF, Kragholm K, Kjaergaard J.

Europace. 2018 Jul 1;20(7):1129-1137. doi: 10.1093/europace/eux223.


Six-minute walking test and long term prognosis in patients with asymptomatic aortic valve stenosis.

Sigvardsen PE, Larsen LH, Carstensen HG, Kühl JT, Møgelvang R, Hassager C, Køber L, Kofoed KF.

Int J Cardiol. 2017 Dec 15;249:334-339. doi: 10.1016/j.ijcard.2017.09.183. Epub 2017 Sep 27.


Serum tau and neurological outcome in cardiac arrest.

Mattsson N, Zetterberg H, Nielsen N, Blennow K, Dankiewicz J, Friberg H, Lilja G, Insel PS, Rylander C, Stammet P, Aneman A, Hassager C, Kjaergaard J, Kuiper M, Pellis T, Wetterslev J, Wise M, Cronberg T.

Ann Neurol. 2017 Nov;82(5):665-675. doi: 10.1002/ana.25067. Epub 2017 Nov 2.


Right ventricular function assessed by 2D strain analysis predicts ventricular arrhythmias and sudden cardiac death in patients after acute myocardial infarction.

Risum N, Valeur N, Søgaard P, Hassager C, Køber L, Ersbøll M.

Eur Heart J Cardiovasc Imaging. 2018 Jul 1;19(7):800-807. doi: 10.1093/ehjci/jex184.


Data on association between QRS duration on prehospital ECG and mortality in patients with confirmed STEMI.

Hansen R, Frydland M, Møller-Helgestad OK, Lindholm MG, Jensen LO, Holmvang L, Ravn HB, Kjærgaard J, Hassager C, Møller JE.

Data Brief. 2017 Sep 5;15:12-17. doi: 10.1016/j.dib.2017.08.051. eCollection 2017 Dec.


Level of systemic inflammation and endothelial injury is associated with cardiovascular dysfunction and vasopressor support in post-cardiac arrest patients.

Bro-Jeppesen J, Johansson PI, Kjaergaard J, Wanscher M, Ostrowski SR, Bjerre M, Hassager C.

Resuscitation. 2017 Dec;121:179-186. doi: 10.1016/j.resuscitation.2017.09.019. Epub 2017 Sep 23.


Age and Outcomes of Primary Prevention Implantable Cardioverter-Defibrillators in Patients With Nonischemic Systolic Heart Failure.

Elming MB, Nielsen JC, Haarbo J, Videbæk L, Korup E, Signorovitch J, Olesen LL, Hildebrandt P, Steffensen FH, Bruun NE, Eiskjær H, Brandes A, Thøgersen AM, Gustafsson F, Egstrup K, Videbæk R, Hassager C, Svendsen JH, Høfsten DE, Torp-Pedersen C, Pehrson S, Køber L, Thune JJ.

Circulation. 2017 Nov 7;136(19):1772-1780. doi: 10.1161/CIRCULATIONAHA.117.028829. Epub 2017 Sep 6.


Incremental Value of Circulating MiR-122-5p to Predict Outcome after Out of Hospital Cardiac Arrest.

Devaux Y, Salgado-Somoza A, Dankiewicz J, Boileau A, Stammet P, Schritz A, Zhang L, Vausort M, Gilje P, Erlinge D, Hassager C, Wise MP, Kuiper M, Friberg H, Nielsen N; TTM-trial investigators.

Theranostics. 2017 Jun 25;7(10):2555-2564. doi: 10.7150/thno.19851. eCollection 2017.


Editor's Choice - Acute Cardiovascular Care Association Position Paper on Intensive Cardiovascular Care Units: An update on their definition, structure, organisation and function.

Bonnefoy-Cudraz E, Bueno H, Casella G, De Maria E, Fitzsimons D, Halvorsen S, Hassager C, Iakobishvili Z, Magdy A, Marandi T, Mimoso J, Parkhomenko A, Price S, Rokyta R, Roubille F, Serpytis P, Shimony A, Stepinska J, Tint D, Trendafilova E, Tubaro M, Vrints C, Walker D, Zahger D, Zima E, Zukermann R, Lettino M.

Eur Heart J Acute Cardiovasc Care. 2018 Feb;7(1):80-95. doi: 10.1177/2048872617724269. Epub 2017 Aug 17.


[Post-resuscitation care after out-of-hospital cardiac arrest].

Grand J, Hassager C, Kjærgaard J.

Ugeskr Laeger. 2017 Jul 24;179(30). pii: V03170221. Danish.


Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.

Kirkegaard H, Søreide E, de Haas I, Pettilä V, Taccone FS, Arus U, Storm C, Hassager C, Nielsen JF, Sørensen CA, Ilkjær S, Jeppesen AN, Grejs AM, Duez CHV, Hjort J, Larsen AI, Toome V, Tiainen M, Hästbacka J, Laitio T, Skrifvars MB.

JAMA. 2017 Jul 25;318(4):341-350. doi: 10.1001/jama.2017.8978.


Does temperature management improve outcome in patients resuscitated from a non-shockable rhythm?

Thomsen JH, Hassager C, Kjaergaard J.

J Thorac Dis. 2017 Jun;9(6):1400-1402. doi: 10.21037/jtd.2017.05.37. No abstract available.


Dysglycemia, Glycemic Variability, and Outcome After Cardiac Arrest and Temperature Management at 33°C and 36°C.

Borgquist O, Wise MP, Nielsen N, Al-Subaie N, Cranshaw J, Cronberg T, Glover G, Hassager C, Kjaergaard J, Kuiper M, Smid O, Walden A, Friberg H; TTM-Trial Investigators.

Crit Care Med. 2017 Aug;45(8):1337-1343. doi: 10.1097/CCM.0000000000002367.


Digoxin Use and Subsequent Clinical Outcomes in Patients With Atrial Fibrillation With or Without Heart Failure in the ENGAGE AF-TIMI 48 Trial.

Eisen A, Ruff CT, Braunwald E, Hamershock RA, Lewis BS, Hassager C, Chao TF, Le Heuzey JY, Mercuri M, Rutman H, Antman EM, Giugliano RP.

J Am Heart Assoc. 2017 Jun 30;6(7). pii: e006035. doi: 10.1161/JAHA.117.006035.


Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C.

Stammet P, Dankiewicz J, Nielsen N, Fays F, Collignon O, Hassager C, Wanscher M, Undèn J, Wetterslev J, Pellis T, Aneman A, Hovdenes J, Wise MP, Gilson G, Erlinge D, Horn J, Cronberg T, Kuiper M, Kjaergaard J, Gasche Y, Devaux Y, Friberg H; Target Temperature Management after Out-of-Hospital Cardiac Arrest (TTM) trial investigators.

Crit Care. 2017 Jun 20;21(1):153. doi: 10.1186/s13054-017-1729-7.


Response by Wiberg et al to Letter Regarding Article, "Neuroprotective Effects of the Glucagon-Like Peptide-1 Analog Exenatide After Out-of-Hospital Cardiac Arrest: A Randomized Controlled Trial".

Wiberg S, Hassager C, Kjaergaard J.

Circulation. 2017 May 16;135(20):e1044-e1045. doi: 10.1161/CIRCULATIONAHA.117.027774. No abstract available.


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