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Items: 39


Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review.

Camicia R, Winkler HC, Hassa PO.

Mol Cancer. 2015 Dec 11;14:207. doi: 10.1186/s12943-015-0474-2. Review.


Corrigendum: The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks.

Ali AA, Timinszky G, Arribas-Bosacoma R, Kozlowski M, Hassa PO, Hassler M, Ladurner AG, Pearl LH, Oliver AW.

Nat Struct Mol Biol. 2015 Aug;22(8):645. doi: 10.1038/nsmb0815-645a. No abstract available.


DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells.

Bachmann SB, Frommel SC, Camicia R, Winkler HC, Santoro R, Hassa PO.

Mol Cancer. 2014 May 27;13:125. doi: 10.1186/1476-4598-13-125.


Characterization of recombinant human and bovine thyroid-stimulating hormone preparations by mass spectrometry and determination of their endotoxin content.

Schaefer S, Hassa PO, Sieber-Ruckstuhl NS, Piechotta M, Reusch CE, Roschitzki B, Boretti FS.

BMC Vet Res. 2013 Jul 16;9:141. doi: 10.1186/1746-6148-9-141.


BAL1/ARTD9 represses the anti-proliferative and pro-apoptotic IFNγ-STAT1-IRF1-p53 axis in diffuse large B-cell lymphoma.

Camicia R, Bachmann SB, Winkler HC, Beer M, Tinguely M, Haralambieva E, Hassa PO.

J Cell Sci. 2013 May 1;126(Pt 9):1969-80. doi: 10.1242/jcs.118174. Epub 2013 Mar 13.


Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

Rosenthal F, Feijs KL, Frugier E, Bonalli M, Forst AH, Imhof R, Winkler HC, Fischer D, Caflisch A, Hassa PO, Lüscher B, Hottiger MO.

Nat Struct Mol Biol. 2013 Apr;20(4):502-7. doi: 10.1038/nsmb.2521. Epub 2013 Mar 10.


The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks.

Ali AAE, Timinszky G, Arribas-Bosacoma R, Kozlowski M, Hassa PO, Hassler M, Ladurner AG, Pearl LH, Oliver AW.

Nat Struct Mol Biol. 2012 Jun 10;19(7):685-692. doi: 10.1038/nsmb.2335. Erratum in: Nat Struct Mol Biol. 2015 Aug;22(8):645.


Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes.

Erener S, Pétrilli V, Kassner I, Minotti R, Castillo R, Santoro R, Hassa PO, Tschopp J, Hottiger MO.

Mol Cell. 2012 Apr 27;46(2):200-11. doi: 10.1016/j.molcel.2012.02.016. Epub 2012 Mar 29.


Poly(ADP-ribose) polymerase-1 protects from oxidative stress induced endothelial dysfunction.

Gebhard C, Stähli BE, Shi Y, Camici GG, Akhmedov A, Hoegger L, Lohmann C, Matter CM, Hassa PO, Hottiger MO, Malinski T, Lüscher TF, Tanner FC.

Biochem Biophys Res Commun. 2011 Nov 4;414(4):641-6. doi: 10.1016/j.bbrc.2011.09.029. Epub 2011 Oct 1.


Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

Hottiger MO, Hassa PO, Lüscher B, Schüler H, Koch-Nolte F.

Trends Biochem Sci. 2010 Apr;35(4):208-19. doi: 10.1016/j.tibs.2009.12.003. Epub 2010 Jan 26. Review.


A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.

Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG.

Nat Struct Mol Biol. 2009 Sep;16(9):923-9. doi: 10.1038/nsmb.1664. Epub 2009 Aug 13.


Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.

Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A.

Science. 2009 Apr 24;324(5926):513-6. doi: 10.1126/science.1168120.


Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites.

Altmeyer M, Messner S, Hassa PO, Fey M, Hottiger MO.

Nucleic Acids Res. 2009 Jun;37(11):3723-38. doi: 10.1093/nar/gkp229. Epub 2009 Apr 16.


The molecular "Jekyll and Hyde" duality of PARP1 in cell death and cell survival.

Hassa PO.

Front Biosci (Landmark Ed). 2009 Jan 1;14:72-111. Review.


Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

Kleine H, Poreba E, Lesniewicz K, Hassa PO, Hottiger MO, Litchfield DW, Shilton BH, Lüscher B.

Mol Cell. 2008 Oct 10;32(1):57-69. doi: 10.1016/j.molcel.2008.08.009.


Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS.

Haenni SS, Altmeyer M, Hassa PO, Valovka T, Fey M, Hottiger MO.

BMC Cell Biol. 2008 Jul 21;9:39. doi: 10.1186/1471-2121-9-39.


Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.

Haenni SS, Hassa PO, Altmeyer M, Fey M, Imhof R, Hottiger MO.

Int J Biochem Cell Biol. 2008;40(10):2274-83. doi: 10.1016/j.biocel.2008.03.008. Epub 2008 Mar 16.


Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression.

Elser M, Borsig L, Hassa PO, Erener S, Messner S, Valovka T, Keller S, Gassmann M, Hottiger MO.

Mol Cancer Res. 2008 Feb;6(2):282-90. doi: 10.1158/1541-7786.MCR-07-0377.


Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1.

Hassa PO, Covic M, Bedford MT, Hottiger MO.

J Mol Biol. 2008 Mar 28;377(3):668-78. doi: 10.1016/j.jmb.2008.01.044. Epub 2008 Jan 26.


PARP1 is required for adhesion molecule expression in atherogenesis.

von Lukowicz T, Hassa PO, Lohmann C, Borén J, Braunersreuther V, Mach F, Odermatt B, Gersbach M, Camici GG, Stähli BE, Tanner FC, Hottiger MO, Lüscher TF, Matter CM.

Cardiovasc Res. 2008 Apr 1;78(1):158-66. Epub 2007 Dec 18.


Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins.

Möckli N, Deplazes A, Hassa PO, Zhang Z, Peter M, Hottiger MO, Stagljar I, Auerbach D.

Biotechniques. 2007 Jun;42(6):725-30.


Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen.

El-Andaloussi N, Valovka T, Toueille M, Hassa PO, Gehrig P, Covic M, Hübscher U, Hottiger MO.

FASEB J. 2007 Jan;21(1):26-34. Epub 2006 Nov 20.


Gene expression in synovial membrane cells after intraarticular delivery of plasmid-linked superparamagnetic iron oxide particles--a preliminary study in sheep.

Galuppo LD, Kamau SW, Steitz B, Hassa PO, Hilbe M, Vaughan L, Koch S, Fink-Petri A, Hofman M, Hofman H, Hottiger MO, von Rechenberg B.

J Nanosci Nanotechnol. 2006 Sep-Oct;6(9-10):2841-52.


Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?

Hassa PO, Haenni SS, Elser M, Hottiger MO.

Microbiol Mol Biol Rev. 2006 Sep;70(3):789-829. Review.


Arginine methylation regulates DNA polymerase beta.

El-Andaloussi N, Valovka T, Toueille M, Steinacher R, Focke F, Gehrig P, Covic M, Hassa PO, Schär P, Hübscher U, Hottiger MO.

Mol Cell. 2006 Apr 7;22(1):51-62.


Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field.

Kamau SW, Hassa PO, Steitz B, Petri-Fink A, Hofmann H, Hofmann-Amtenbrink M, von Rechenberg B, Hottiger MO.

Nucleic Acids Res. 2006 Mar 15;34(5):e40. Print 2006.


Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.

Hassa PO, Haenni SS, Buerki C, Meier NI, Lane WS, Owen H, Gersbach M, Imhof R, Hottiger MO.

J Biol Chem. 2005 Dec 9;280(49):40450-64. Epub 2005 Oct 4.


An epigenetic code for DNA damage repair pathways?

Hassa PO, Hottiger MO.

Biochem Cell Biol. 2005 Jun;83(3):270-85. Review.


Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression.

Covic M, Hassa PO, Saccani S, Buerki C, Meier NI, Lombardi C, Imhof R, Bedford MT, Natoli G, Hottiger MO.

EMBO J. 2005 Jan 12;24(1):85-96. Epub 2004 Dec 16.


Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice.

Pétrilli V, Herceg Z, Hassa PO, Patel NS, Di Paola R, Cortes U, Dugo L, Filipe HM, Thiemermann C, Hottiger MO, Cuzzocrea S, Wang ZQ.

J Clin Invest. 2004 Oct;114(8):1072-81.


PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.

Simbulan-Rosenthal CM, Rosenthal DS, Luo R, Samara R, Espinoza LA, Hassa PO, Hottiger MO, Smulson ME.

Oncogene. 2003 Nov 20;22(52):8460-71.


Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1.

Hassa PO, Buerki C, Lombardi C, Imhof R, Hottiger MO.

J Biol Chem. 2003 Nov 14;278(46):45145-53. Epub 2003 Sep 5.


Acetylation regulates the DNA end-trimming activity of DNA polymerase beta.

Hasan S, El-Andaloussi N, Hardeland U, Hassa PO, Bürki C, Imhof R, Schär P, Hottiger MO.

Mol Cell. 2002 Nov;10(5):1213-22.


The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders.

Hassa PO, Hottiger MO.

Cell Mol Life Sci. 2002 Sep;59(9):1534-53. Review.


The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function.

Hassa PO, Covic M, Hasan S, Imhof R, Hottiger MO.

J Biol Chem. 2001 Dec 7;276(49):45588-97. Epub 2001 Oct 4.


Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300.

Hasan S, Stucki M, Hassa PO, Imhof R, Gehrig P, Hunziker P, Hübscher U, Hottiger MO.

Mol Cell. 2001 Jun;7(6):1221-31.


Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis.

Hasan S, Hassa PO, Imhof R, Hottiger MO.

Nature. 2001 Mar 15;410(6826):387-91.


A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation.

Hassa PO, Hottiger MO.

Biol Chem. 1999 Jul-Aug;380(7-8):953-9.


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