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Catalytically important damage-free structures of a copper nitrite reductase obtained by femtosecond X-ray laser and room-temperature neutron crystallography.

Halsted TP, Yamashita K, Gopalasingam CC, Shenoy RT, Hirata K, Ago H, Ueno G, Blakeley MP, Eady RR, Antonyuk SV, Yamamoto M, Hasnain SS.

IUCrJ. 2019 Jun 23;6(Pt 4):761-772. doi: 10.1107/S2052252519008285. eCollection 2019 Jul 1.


LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM.

Chiduza GN, Johnson RM, Wright GSA, Antonyuk SV, Muench SP, Hasnain SS.

Acta Crystallogr D Struct Biol. 2019 Jul 1;75(Pt 7):660-669. doi: 10.1107/S2059798319009094. Epub 2019 Jun 28.


Synchrotron science in the UK: NINA, the SRS and Diamond.

Hasnain SS, Catlow CRA.

Philos Trans A Math Phys Eng Sci. 2019 Jun 17;377(2147):20190147. doi: 10.1098/rsta.2019.0147.


The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM.

Muench SP, Antonyuk SV, Hasnain SS.

IUCrJ. 2019 Mar 1;6(Pt 2):167-177. doi: 10.1107/S2052252519002422. eCollection 2019 Mar 1. Review.


Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone-based compounds.

Panmanee J, Bradley-Clarke J, Mato JM, O'Neill PM, Antonyuk SV, Hasnain SS.

FEBS J. 2019 Jun;286(11):2135-2154. doi: 10.1111/febs.14790. Epub 2019 Mar 4.


Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS.

Sala FA, Wright GSA, Antonyuk SV, Garratt RC, Hasnain SS.

PLoS Biol. 2019 Feb 8;17(2):e3000141. doi: 10.1371/journal.pbio.3000141. eCollection 2019 Feb.


Identification of a tyrosine switch in copper-haem nitrite reductases.

Dong J, Sasaki D, Eady RR, Antonyuk SV, Hasnain SS.

IUCrJ. 2018 Jun 25;5(Pt 4):510-518. doi: 10.1107/S2052252518008242. eCollection 2018 Jul 1.


X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery.

Amporndanai K, Johnson RM, O'Neill PM, Fishwick CWG, Jamson AH, Rawson S, Muench SP, Hasnain SS, Antonyuk SV.

IUCrJ. 2018 Feb 20;5(Pt 2):200-210. doi: 10.1107/S2052252518001616. eCollection 2018 Mar 1.


Enzyme catalysis captured using multiple structures from one crystal at varying temperatures.

Horrell S, Kekilli D, Sen K, Owen RL, Dworkowski FSN, Antonyuk SV, Keal TW, Yong CW, Eady RR, Hasnain SS, Strange RW, Hough MA.

IUCrJ. 2018 Mar 16;5(Pt 3):283-292. doi: 10.1107/S205225251800386X. eCollection 2018 May 1.


The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.

Capper MJ, Wright GSA, Barbieri L, Luchinat E, Mercatelli E, McAlary L, Yerbury JJ, O'Neill PM, Antonyuk SV, Banci L, Hasnain SS.

Nat Commun. 2018 Apr 27;9(1):1693. doi: 10.1038/s41467-018-04114-x.


Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system.

Wright GSA, Saeki A, Hikima T, Nishizono Y, Hisano T, Kamaya M, Nukina K, Nishitani H, Nakamura H, Yamamoto M, Antonyuk SV, Hasnain SS, Shiro Y, Sawai H.

Sci Signal. 2018 Apr 10;11(525). pii: eaaq0825. doi: 10.1126/scisignal.aaq0825.


Characterization of the quinol-dependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme.

Gonska N, Young D, Yuki R, Okamoto T, Hisano T, Antonyuk S, Hasnain SS, Muramoto K, Shiro Y, Tosha T, Ädelroth P.

Sci Rep. 2018 Feb 26;8(1):3637. doi: 10.1038/s41598-018-21804-0.


An unprecedented dioxygen species revealed by serial femtosecond rotation crystallography in copper nitrite reductase.

Halsted TP, Yamashita K, Hirata K, Ago H, Ueno G, Tosha T, Eady RR, Antonyuk SV, Yamamoto M, Hasnain SS.

IUCrJ. 2018 Jan 1;5(Pt 1):22-31. doi: 10.1107/S2052252517016128. eCollection 2018 Jan 1.


Seventy years of publications.

Hasnain SS.

IUCrJ. 2017 Sep 1;4(Pt 5):512-513. doi: 10.1107/S205225251701168X. eCollection 2017 Sep 1.


Seventy years of publications.

Hasnain SS.

Acta Crystallogr C Struct Chem. 2017 Sep 1;73(Pt 9):652-653. doi: 10.1107/S205322961701172X. Epub 2017 Sep 1. No abstract available.


Seventy years of publications.

Hasnain SS.

J Synchrotron Radiat. 2017 Sep 1;24(Pt 5):904-905. doi: 10.1107/S1600577517012292. Epub 2017 Sep 1. No abstract available.


Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.

Dickens D, Chiduza GN, Wright GS, Pirmohamed M, Antonyuk SV, Hasnain SS.

Sci Rep. 2017 Mar 8;7:43580. doi: 10.1038/srep43580.


Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal.

Horrell S, Antonyuk SV, Eady RR, Hasnain SS, Hough MA, Strange RW.

IUCrJ. 2016 Jun 15;3(Pt 4):271-81. doi: 10.1107/S205225251600823X. eCollection 2016 Jul 1.


New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.

McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, Wang K, Kim TK, He Y, Santos T, Woods S, Lee P, Donkin D, Kim E, Fraczek L, Lykins J, Esaa F, Alibana-Clouser F, Dovgin S, Weiss L, Brasseur G, Wirth D, Kent M, Hood L, Meunieur B, Roberts CW, Hasnain SS, Antonyuk SV, Fishwick C, McLeod R.

Sci Rep. 2016 Jul 14;6:29179. doi: 10.1038/srep29179.


A faulty interaction between SOD1 and hCCS in neurodegenerative disease.

Wright GS, Antonyuk SV, Hasnain SS.

Sci Rep. 2016 Jun 10;6:27691. doi: 10.1038/srep27691.


Fresh insight to functioning of selected enzymes of the nitrogen cycle.

Eady RR, Antonyuk SV, Hasnain SS.

Curr Opin Chem Biol. 2016 Apr;31:103-12. doi: 10.1016/j.cbpa.2016.02.009. Epub 2016 Mar 17. Review.


Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes.

Murray B, Antonyuk SV, Marina A, Lu SC, Mato JM, Hasnain SS, Rojas AL.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2104-9. doi: 10.1073/pnas.1510959113. Epub 2016 Feb 8.


Crystallography in the 21st century.

Hasnain SS.

IUCrJ. 2015 Nov 1;2(Pt 6):602-4. doi: 10.1107/S2052252515017509. eCollection 2015 Nov 1.


Crystallography in the 21st century.

Hasnain SS.

J Synchrotron Radiat. 2015 Nov;22(6):1331-3. doi: 10.1107/S1600577515019578. Epub 2015 Oct 31. No abstract available.


Crystallography in the 21st century.

Hasnain SS.

Acta Crystallogr A Found Adv. 2015 Nov;71(Pt 6):559-61. doi: 10.1107/S2053273315019464. Epub 2015 Oct 30. No abstract available.


Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential.

Blakeley MP, Hasnain SS, Antonyuk SV.

IUCrJ. 2015 Jun 30;2(Pt 4):464-74. doi: 10.1107/S2052252515011239. eCollection 2015 Jul 1. Review.


IUCrJ celebrates its first year of publication.

Hasnain SS.

IUCrJ. 2015 Jan 1;2(Pt 1):1-2. doi: 10.1107/S205225251402750X. eCollection 2015 Jan 1.


Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1.

Capper MJ, O'Neill PM, Fisher N, Strange RW, Moss D, Ward SA, Berry NG, Lawrenson AS, Hasnain SS, Biagini GA, Antonyuk SV.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):755-60. doi: 10.1073/pnas.1416611112. Epub 2015 Jan 6.


Acta E transforms from Structure Reports Online to Crystallographic Communications.

Hasnain SS.

Acta Crystallogr Sect E Struct Rep Online. 2014 Jun 10;70(Pt 7):1-2. doi: 10.1107/S1600536814011775. eCollection 2014 Jul 1. No abstract available.


Structure and function study of the complex that synthesizes S-adenosylmethionine.

Murray B, Antonyuk SV, Marina A, Van Liempd SM, Lu SC, Mato JM, Hasnain SS, Rojas AL.

IUCrJ. 2014 Jun 12;1(Pt 4):240-9. doi: 10.1107/S2052252514012585. eCollection 2014 Jul 1.


100 years of crystallography: the IUCr launches a comprehensive open-access journal, IUCrJ.

Hasnain SS.

IUCrJ. 2013 Dec 19;1(Pt 1):1-2. doi: 10.1107/S2052252513033691. eCollection 2014 Jan 1.


Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase.

Leferink NG, Antonyuk SV, Houwman JA, Scrutton NS, Eady RR, Hasnain SS.

Nat Commun. 2014 Jul 15;5:4395. doi: 10.1038/ncomms5395.


Fingerprinting redox and ligand states in haemprotein crystal structures using resonance Raman spectroscopy.

Kekilli D, Dworkowski FS, Pompidor G, Fuchs MR, Andrew CR, Antonyuk S, Strange RW, Eady RR, Hasnain SS, Hough MA.

Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1289-96. doi: 10.1107/S1399004714004039. Epub 2014 Apr 29.


Macromolecular structures probed by combining single-shot free-electron laser diffraction with synchrotron coherent X-ray imaging.

Gallagher-Jones M, Bessho Y, Kim S, Park J, Kim S, Nam D, Kim C, Kim Y, Noh do Y, Miyashita O, Tama F, Joti Y, Kameshima T, Hatsui T, Tono K, Kohmura Y, Yabashi M, Hasnain SS, Ishikawa T, Song C.

Nat Commun. 2014 May 2;5:3798. doi: 10.1038/ncomms4798.


Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life.

Austin JA, Wright GS, Watanabe S, Grossmann JG, Antonyuk SV, Yamanaka K, Hasnain SS.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4309-14. doi: 10.1073/pnas.1317317111. Epub 2014 Mar 3.


Heterologous expression, characterization and evaluation of the matrix protein from Newcastle disease virus as a target for antiviral therapies.

Iram N, Shah MS, Ismat F, Habib M, Iqbal M, Hasnain SS, Rahman M.

Appl Microbiol Biotechnol. 2014 Feb;98(4):1691-701. Epub 2013 Jun 25.


Transport of gabapentin by LAT1 (SLC7A5).

Dickens D, Webb SD, Antonyuk S, Giannoudis A, Owen A, Rädisch S, Hasnain SS, Pirmohamed M.

Biochem Pharmacol. 2013 Jun 1;85(11):1672-83. doi: 10.1016/j.bcp.2013.03.022. Epub 2013 Apr 6.


Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426.

Padmanabhan B, Nakamura Y, Antonyuk SV, Strange RW, Hasnain SS, Yokoyama S, Bessho Y.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):342-5. doi: 10.1107/S1744309113003369. Epub 2013 Mar 28.


Structures of protein-protein complexes involved in electron transfer.

Antonyuk SV, Han C, Eady RR, Hasnain SS.

Nature. 2013 Apr 4;496(7443):123-6. doi: 10.1038/nature11996. Epub 2013 Mar 27.


The application of hybrid pixel detectors for in-house SAXS instrumentation with a view to combined chromatographic operation.

Wright GS, Lee HC, Schulze-Briese C, Grossmann JG, Strange RW, Hasnain SS.

J Synchrotron Radiat. 2013 Mar;20(Pt 2):383-5. doi: 10.1107/S0909049513001866. Epub 2013 Feb 7.


X-ray crystallography and computational docking for the detection and development of protein-ligand interactions.

Kershaw NM, Wright GS, Sharma R, Antonyuk SV, Strange RW, Berry NG, O'Neill PM, Hasnain SS.

Curr Med Chem. 2013;20(4):569-75.


Frontiers and challenges of biophysical methods: from computational biology to X-ray free electron laser.

Hasnain SS, Wakatsuki S.

Curr Opin Struct Biol. 2012 Oct;22(5):591-3. doi: 10.1016/ Epub 2012 Oct 1. No abstract available.


Structural evidence for a copper-bound carbonate intermediate in the peroxidase and dismutase activities of superoxide dismutase.

Strange RW, Hough MA, Antonyuk SV, Hasnain SS.

PLoS One. 2012;7(9):e44811. doi: 10.1371/journal.pone.0044811. Epub 2012 Sep 11.


Laser-flash photolysis indicates that internal electron transfer is triggered by proton uptake by Alcaligenes xylosoxidans copper-dependent nitrite reductase.

Leferink NG, Eady RR, Hasnain SS, Scrutton NS.

FEBS J. 2012 Jun;279(12):2174-81. doi: 10.1111/j.1742-4658.2012.08601.x. Epub 2012 May 21.


Characterization of a novel copper-haem c dissimilatory nitrite reductase from Ralstonia pickettii.

Han C, Wright GS, Fisher K, Rigby SE, Eady RR, Hasnain SS.

Biochem J. 2012 Jun 1;444(2):219-26. doi: 10.1042/BJ20111623.


A distal pocket Leu residue inhibits the binding of O2 and NO at the distal heme site of cytochrome c'.

Garton EM, Pixton DA, Petersen CA, Eady RR, Hasnain SS, Andrew CR.

J Am Chem Soc. 2012 Jan 25;134(3):1461-3. doi: 10.1021/ja209770p. Epub 2012 Jan 9.


Challenges of sulfur SAD phasing as a routine method in macromolecular crystallography.

Doutch J, Hough MA, Hasnain SS, Strange RW.

J Synchrotron Radiat. 2012 Jan;19(Pt 1):19-29. doi: 10.1107/S0909049511049004. Epub 2011 Nov 29.


Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins.

Antonyuk SV, Rustage N, Petersen CA, Arnst JL, Heyes DJ, Sharma R, Berry NG, Scrutton NS, Eady RR, Andrew CR, Hasnain SS.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15780-5. doi: 10.1073/pnas.1109051108. Epub 2011 Sep 7.


Risk factors in young patients of acute myocardial infarction.

Faisal AW, Ayub M, Waseem T, Khan RS, Hasnain SS.

J Ayub Med Coll Abbottabad. 2011 Jul-Sep;23(3):10-3.


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