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Items: 1 to 50 of 213

1.

Cerebral Concussion Primes the Lungs for Subsequent Neutrophil-Mediated Injury.

Humphries DC, O'Neill S, Scholefield E, Dorward DA, Mackinnon AC, Rossi AG, Haslett C, Andrews PJD, Rhodes J, Dhaliwal K.

Crit Care Med. 2018 Jun 27. doi: 10.1097/CCM.0000000000003270. [Epub ahead of print]

PMID:
29957711
2.

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation.

Felton JM, Lucas CD, Dorward DA, Duffin R, Kipari T, Vermeren S, Robb CT, MacLeod KG, Serrels B, Schwarze J, Haslett C, Dransfield I, Rossi AG.

J Allergy Clin Immunol. 2018 Feb 8. pii: S0091-6749(18)30215-X. doi: 10.1016/j.jaci.2018.01.029. [Epub ahead of print]

3.

Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis.

Gray RD, Hardisty G, Regan KH, Smith M, Robb CT, Duffin R, Mackellar A, Felton JM, Paemka L, McCullagh BN, Lucas CD, Dorward DA, McKone EF, Cooke G, Donnelly SC, Singh PK, Stoltz DA, Haslett C, McCray PB, Whyte MKB, Rossi AG, Davidson DJ.

Thorax. 2018 Feb;73(2):134-144. doi: 10.1136/thoraxjnl-2017-210134. Epub 2017 Sep 15.

4.

Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome.

Dorward DA, Lucas CD, Doherty MK, Chapman GB, Scholefield EJ, Conway Morris A, Felton JM, Kipari T, Humphries DC, Robb CT, Simpson AJ, Whitfield PD, Haslett C, Dhaliwal K, Rossi AG.

Thorax. 2017 Oct;72(10):928-936. doi: 10.1136/thoraxjnl-2017-210030. Epub 2017 May 3.

5.

The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome.

Dorward DA, Felton JM, Robb CT, Craven T, Kipari T, Walsh TS, Haslett C, Kefala K, Rossi AG, Lucas CD.

Thorax. 2017 Feb;72(2):182-185. doi: 10.1136/thoraxjnl-2016-209229. Epub 2016 Oct 24.

6.

Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo.

Hoodless LJ, Lucas CD, Duffin R, Denvir MA, Haslett C, Tucker CS, Rossi AG.

Sci Rep. 2016 Nov 11;5:36980. doi: 10.1038/srep36980.

7.

A labelled-ubiquicidin antimicrobial peptide for immediate in situ optical detection of live bacteria in human alveolar lung tissue.

Akram AR, Avlonitis N, Lilienkampf A, Perez-Lopez AM, McDonald N, Chankeshwara SV, Scholefield E, Haslett C, Bradley M, Dhaliwal K.

Chem Sci. 2015 Dec 1;6(12):6971-6979. doi: 10.1039/c5sc00960j. Epub 2015 Jun 29.

8.

The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation.

Dorward DA, Lucas CD, Chapman GB, Haslett C, Dhaliwal K, Rossi AG.

Am J Pathol. 2015 May;185(5):1172-84. doi: 10.1016/j.ajpath.2015.01.020. Epub 2015 Mar 17. Review.

9.

Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation.

Lucas CD, Dorward DA, Sharma S, Rennie J, Felton JM, Alessandri AL, Duffin R, Schwarze J, Haslett C, Rossi AG.

Am J Respir Crit Care Med. 2015 Mar 15;191(6):626-36. doi: 10.1164/rccm.201408-1565OC.

10.

Constitutive apoptosis in equine peripheral blood neutrophils in vitro.

Brazil TJ, Dixon PM, Haslett C, Murray J, McGorum BC.

Vet J. 2014 Dec;202(3):536-42. doi: 10.1016/j.tvjl.2014.08.029. Epub 2014 Aug 29.

11.

Chronic pleuropulmonary fibrosis and elastosis of aged donkeys: similarities to human pleuroparenchymal fibroelastosis.

Miele A, Dhaliwal K, Du Toit N, Murchison JT, Dhaliwal C, Brooks H, Smith SH, Hirani N, Schwarz T, Haslett C, Wallace WA, McGorum BC.

Chest. 2014 Jun;145(6):1325-1332. doi: 10.1378/chest.13-1306.

PMID:
24889435
12.

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung.

Lucas CD, Dorward DA, Tait MA, Fox S, Marwick JA, Allen KC, Robb CT, Hirani N, Haslett C, Duffin R, Rossi AG.

Mucosal Immunol. 2014 Jul;7(4):857-68. doi: 10.1038/mi.2013.102. Epub 2013 Nov 27.

13.

Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments.

Marwick JA, Dorward DA, Lucas CD, Jones KO, Sheldrake TA, Fox S, Ward C, Murray J, Brittan M, Hirani N, Duffin R, Dransfield I, Haslett C, Rossi AG.

J Leukoc Biol. 2013 Dec;94(6):1285-92. doi: 10.1189/jlb.0912462. Epub 2013 Aug 20.

14.

Combined dysfunctions of immune cells predict nosocomial infection in critically ill patients.

Conway Morris A, Anderson N, Brittan M, Wilkinson TS, McAuley DF, Antonelli J, McCulloch C, Barr LC, Dhaliwal K, Jones RO, Haslett C, Hay AW, Swann DG, Laurenson IF, Davidson DJ, Rossi AG, Walsh TS, Simpson AJ.

Br J Anaesth. 2013 Nov;111(5):778-87. doi: 10.1093/bja/aet205. Epub 2013 Jun 10.

15.

Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase.

Avlonitis N, Debunne M, Aslam T, McDonald N, Haslett C, Dhaliwal K, Bradley M.

Org Biomol Chem. 2013 Jul 14;11(26):4414-8. doi: 10.1039/c3ob40212f. Epub 2013 May 28.

PMID:
23715090
16.

Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production.

Dorward DA, Lucas CD, Alessandri AL, Marwick JA, Rossi F, Dransfield I, Haslett C, Dhaliwal K, Rossi AG.

J Leukoc Biol. 2013 Jul;94(1):193-202. doi: 10.1189/jlb.0113040. Epub 2013 May 10.

17.

Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps.

Gray RD, Lucas CD, MacKellar A, Li F, Hiersemenzel K, Haslett C, Davidson DJ, Rossi AG.

J Inflamm (Lond). 2013 Mar 21;10(1):12. doi: 10.1186/1476-9255-10-12.

18.

Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway.

Lucas CD, Allen KC, Dorward DA, Hoodless LJ, Melrose LA, Marwick JA, Tucker CS, Haslett C, Duffin R, Rossi AG.

FASEB J. 2013 Mar;27(3):1084-94. doi: 10.1096/fj.12-218990. Epub 2012 Nov 29.

19.

Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung.

Wilkinson TS, Conway Morris A, Kefala K, O'Kane CM, Moore NR, Booth NA, McAuley DF, Dhaliwal K, Walsh TS, Haslett C, Sallenave JM, Simpson AJ.

Chest. 2012 Dec;142(6):1425-1432. doi: 10.1378/chest.11-3273.

PMID:
22911225
20.

Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.

Dhaliwal K, Scholefield E, Ferenbach D, Gibbons M, Duffin R, Dorward DA, Morris AC, Humphries D, MacKinnon A, Wilkinson TS, Wallace WA, van Rooijen N, Mack M, Rossi AG, Davidson DJ, Hirani N, Hughes J, Haslett C, Simpson AJ.

Am J Respir Crit Care Med. 2012 Sep 15;186(6):514-24. doi: 10.1164/rccm.201112-2132OC. Epub 2012 Jul 19.

21.

Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration.

McHugh BJ, Murdoch A, Haslett C, Sethi T.

PLoS One. 2012;7(7):e40346. doi: 10.1371/journal.pone.0040346. Epub 2012 Jul 5.

22.

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation.

Leitch AE, Lucas CD, Marwick JA, Duffin R, Haslett C, Rossi AG.

Cell Death Differ. 2012 Dec;19(12):1950-61. doi: 10.1038/cdd.2012.80. Epub 2012 Jun 29.

23.

Imaging inflammation: molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution.

Dorward DA, Lucas CD, Rossi AG, Haslett C, Dhaliwal K.

Pharmacol Ther. 2012 Aug;135(2):182-99. doi: 10.1016/j.pharmthera.2012.05.006. Epub 2012 May 22. Review.

PMID:
22627270
24.

Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN.

Hart SP, Rossi AG, Haslett C, Dransfield I.

PLoS One. 2012;7(3):e33142. doi: 10.1371/journal.pone.0033142. Epub 2012 Mar 9.

25.

A novel subpopulation of monocyte-like cells in the human lung after lipopolysaccharide inhalation.

Brittan M, Barr L, Conway Morris A, Duffin R, Rossi F, Johnston S, Monro G, Anderson N, Rossi AG, McAuley DF, Haslett C, Hirani N, Dhaliwal K, Simpson AJ.

Eur Respir J. 2012 Jul;40(1):206-14. doi: 10.1183/09031936.00113811. Epub 2012 Jan 20.

26.

Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation.

Alessandri AL, Duffin R, Leitch AE, Lucas CD, Sheldrake TA, Dorward DA, Hirani N, Pinho V, de Sousa LP, Teixeira MM, Lyons JF, Haslett C, Rossi AG.

PLoS One. 2011;6(9):e25683. doi: 10.1371/journal.pone.0025683. Epub 2011 Sep 30.

27.

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.

Gibbons MA, MacKinnon AC, Ramachandran P, Dhaliwal K, Duffin R, Phythian-Adams AT, van Rooijen N, Haslett C, Howie SE, Simpson AJ, Hirani N, Gauldie J, Iredale JP, Sethi T, Forbes SJ.

Am J Respir Crit Care Med. 2011 Sep 1;184(5):569-81. doi: 10.1164/rccm.201010-1719OC.

PMID:
21680953
28.

Multi-modal molecular imaging approaches to detect primary cells in preclinical models.

Dhaliwal K, Alexander L, Escher G, Unciti-Broceta A, Jansen M, Mcdonald N, Cardenas-Maestre JM, Sanchez-Martin R, Simpson J, Haslett C, Bradley M.

Faraday Discuss. 2011;149:107-14; discussion 137-57. Review.

PMID:
21413177
29.

C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients.

Morris AC, Brittan M, Wilkinson TS, McAuley DF, Antonelli J, McCulloch C, Barr LC, McDonald NA, Dhaliwal K, Jones RO, Mackellar A, Haslett C, Hay AW, Swann DG, Anderson N, Laurenson IF, Davidson DJ, Rossi AG, Walsh TS, Simpson AJ.

Blood. 2011 May 12;117(19):5178-88. doi: 10.1182/blood-2010-08-304667. Epub 2011 Feb 3.

30.

A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis.

Murray MP, Govan JR, Doherty CJ, Simpson AJ, Wilkinson TS, Chalmers JD, Greening AP, Haslett C, Hill AT.

Am J Respir Crit Care Med. 2011 Feb 15;183(4):491-9. doi: 10.1164/rccm.201005-0756OC. Epub 2010 Sep 24.

PMID:
20870753
31.

Targeting granulocyte apoptosis: mechanisms, models, and therapies.

Duffin R, Leitch AE, Fox S, Haslett C, Rossi AG.

Immunol Rev. 2010 Jul;236:28-40. doi: 10.1111/j.1600-065X.2010.00922.x. Review.

PMID:
20636806
32.

Neutrophil apoptosis: relevance to the innate immune response and inflammatory disease.

Fox S, Leitch AE, Duffin R, Haslett C, Rossi AG.

J Innate Immun. 2010;2(3):216-27. doi: 10.1159/000284367. Epub 2010 Feb 11. Review.

33.

The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis.

Leitch AE, Riley NA, Sheldrake TA, Festa M, Fox S, Duffin R, Haslett C, Rossi AG.

Eur J Immunol. 2010 Apr;40(4):1127-38. doi: 10.1002/eji.200939664.

34.

The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium.

Barlow PG, Beaumont PE, Cosseau C, Mackellar A, Wilkinson TS, Hancock RE, Haslett C, Govan JR, Simpson AJ, Davidson DJ.

Am J Respir Cell Mol Biol. 2010 Dec;43(6):692-702. doi: 10.1165/rcmb.2009-0250OC. Epub 2010 Jan 22.

35.

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum.

McHugh BJ, Buttery R, Lad Y, Banks S, Haslett C, Sethi T.

J Cell Sci. 2010 Jan 1;123(Pt 1):51-61. doi: 10.1242/jcs.056424.

36.

Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia.

Conway Morris A, Kefala K, Wilkinson TS, Moncayo-Nieto OL, Dhaliwal K, Farrell L, Walsh TS, Mackenzie SJ, Swann DG, Andrews PJ, Anderson N, Govan JR, Laurenson IF, Reid H, Davidson DJ, Haslett C, Sallenave JM, Simpson AJ.

Thorax. 2010 Mar;65(3):201-7. doi: 10.1136/thx.2009.122291. Epub 2009 Oct 12. Erratum in: Thorax. 2010 Sep;65(9):844.

37.

Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents.

Leitch AE, Haslett C, Rossi AG.

Br J Pharmacol. 2009 Oct;158(4):1004-16. doi: 10.1111/j.1476-5381.2009.00402.x. Epub 2009 Sep 23. Review.

38.

The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1.

Duffin R, Leitch AE, Sheldrake TA, Hallett JM, Meyer C, Fox S, Alessandri AL, Martin MC, Brady HJ, Teixeira MM, Dransfield I, Haslett C, Rossi AG.

FEBS Lett. 2009 Aug 6;583(15):2540-6. doi: 10.1016/j.febslet.2009.07.017. Epub 2009 Jul 18.

39.

Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages.

McColl A, Bournazos S, Franz S, Perretti M, Morgan BP, Haslett C, Dransfield I.

J Immunol. 2009 Aug 1;183(3):2167-75. doi: 10.4049/jimmunol.0803503. Epub 2009 Jul 13.

40.

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages.

Li HN, Barlow PG, Bylund J, Mackellar A, Björstad A, Conlon J, Hiemstra PS, Haslett C, Gray M, Simpson AJ, Rossi AG, Davidson DJ.

J Leukoc Biol. 2009 Oct;86(4):891-902. doi: 10.1189/jlb.0209050. Epub 2009 Jul 6.

41.

C5a mediates peripheral blood neutrophil dysfunction in critically ill patients.

Conway Morris A, Kefala K, Wilkinson TS, Dhaliwal K, Farrell L, Walsh T, Mackenzie SJ, Reid H, Davidson DJ, Haslett C, Rossi AG, Sallenave JM, Simpson AJ.

Am J Respir Crit Care Med. 2009 Jul 1;180(1):19-28. doi: 10.1164/rccm.200812-1928OC. Epub 2009 Mar 26.

42.

Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment.

Wilkinson TS, Dhaliwal K, Hamilton TW, Lipka AF, Farrell L, Davidson DJ, Duffin R, Morris AC, Haslett C, Govan JR, Gregory CD, Sallenave JM, Simpson AJ.

Am J Pathol. 2009 Apr;174(4):1338-46. doi: 10.2353/ajpath.2009.080746. Epub 2009 Mar 5.

43.

Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies.

MacKinnon AC, Tufail-Hanif U, Wheatley M, Rossi AG, Haslett C, Seckl M, Sethi T.

Br J Pharmacol. 2009 Jan;156(1):36-47. doi: 10.1111/j.1476-5381.2008.00003.x.

44.

Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa.

Leitch AE, Duffin R, Haslett C, Rossi AG.

Mucosal Immunol. 2008 Sep;1(5):350-63. doi: 10.1038/mi.2008.31. Epub 2008 Jul 2. Review.

PMID:
19079199
45.

Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation.

Hallett JM, Leitch AE, Riley NA, Duffin R, Haslett C, Rossi AG.

Trends Pharmacol Sci. 2008 May;29(5):250-7. doi: 10.1016/j.tips.2008.03.002. Epub 2008 Apr 11. Review.

PMID:
18407359
46.

Regulation of alternative macrophage activation by galectin-3.

MacKinnon AC, Farnworth SL, Hodkinson PS, Henderson NC, Atkinson KM, Leffler H, Nilsson UJ, Haslett C, Forbes SJ, Sethi T.

J Immunol. 2008 Feb 15;180(4):2650-8.

47.

Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function.

Farnworth SL, Henderson NC, Mackinnon AC, Atkinson KM, Wilkinson T, Dhaliwal K, Hayashi K, Simpson AJ, Rossi AG, Haslett C, Sethi T.

Am J Pathol. 2008 Feb;172(2):395-405. doi: 10.2353/ajpath.2008.070870. Epub 2008 Jan 17.

48.

Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis.

Henderson NC, Mackinnon AC, Farnworth SL, Kipari T, Haslett C, Iredale JP, Liu FT, Hughes J, Sethi T.

Am J Pathol. 2008 Feb;172(2):288-98. doi: 10.2353/ajpath.2008.070726. Epub 2008 Jan 17.

49.

Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.

Hodkinson PS, Elliott PA, Lad Y, McHugh BJ, MacKinnon AC, Haslett C, Sethi T.

J Biol Chem. 2007 Sep 28;282(39):28991-9001. Epub 2007 Jul 30.

50.

Modulation of granulocyte apoptosis can influence the resolution of inflammation.

Rossi AG, Hallett JM, Sawatzky DA, Teixeira MM, Haslett C.

Biochem Soc Trans. 2007 Apr;35(Pt 2):288-91.

PMID:
17371262

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