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Items: 1 to 50 of 174

1.

GI Motility Testing: Stomach, Small Bowel, and Colon.

Lee A, Baker J, Hasler WL.

J Clin Gastroenterol. 2019 Mar;53(3):159-169. doi: 10.1097/MCG.0000000000001138.

PMID:
30702487
2.

Propagation Characteristics of Fasting Duodeno-Jejunal Contractions in Healthy Controls Measured by Clustered Closely-spaced Manometric Sensors.

Baker JR, Dickens JR, Koenigsknecht M, Frances A, Lee AA, Shedden KA, Brasseur JG, Amidon GL, Sun D, Hasler WL.

J Neurogastroenterol Motil. 2019 Jan 31;25(1):100-112. doi: 10.5056/jnm18112.

3.

Validation of Diagnostic and Performance Characteristics of the Wireless Motility Capsule in Patients With Suspected Gastroparesis.

Lee AA, Rao S, Nguyen LA, Moshiree B, Sarosiek I, Schulman MI, Wo JM, Parkman HP, Wilding GE, McCallum RW, Hasler WL, Kuo B.

Clin Gastroenterol Hepatol. 2018 Dec 14. pii: S1542-3565(18)31381-8. doi: 10.1016/j.cgh.2018.11.063. [Epub ahead of print]

PMID:
30557741
4.

Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State.

Paixão P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, Frances A, Amidon GE, Yu A, Benninghoff G, Löbenberg R, Talattof A, Sun D, Amidon GL.

Mol Pharm. 2018 Nov 12. doi: 10.1021/acs.molpharmaceut.8b00736. [Epub ahead of print]

PMID:
30417648
5.

Ethnic, Racial, and Sex Differences in Etiology, Symptoms, Treatment, and Symptom Outcomes of Patients With Gastroparesis.

Parkman HP, Yamada G, Van Natta ML, Yates K, Hasler WL, Sarosiek I, Grover M, Schey R, Abell TL, Koch KL, Kuo B, Clarke J, Farrugia G, Nguyen L, Snape WJ, Miriel L, Tonascia J, Hamilton F, Pasricha PJ, McCallum RW.

Clin Gastroenterol Hepatol. 2018 Nov 4. pii: S1542-3565(18)31217-5. doi: 10.1016/j.cgh.2018.10.050. [Epub ahead of print]

PMID:
30404035
6.

Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions.

Bermejo M, Paixão P, Hens B, Tsume Y, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Löbenberg R, Lee A, Frances A, Amidon GE, Yu A, Salehi N, Talattof A, Benninghoff G, Sun D, Kuminek G, Cavanagh KL, Rodríguez-Hornedo N, Amidon GL.

Mol Pharm. 2018 Nov 12. doi: 10.1021/acs.molpharmaceut.8b00515. [Epub ahead of print]

PMID:
30372084
7.

Opioid Use and Potency Are Associated With Clinical Features, Quality of Life, and Use of Resources in Patients With Gastroparesis.

Hasler WL, Wilson LA, Nguyen LA, Snape WJ, Abell TL, Koch KL, McCallum RW, Pasricha PJ, Sarosiek I, Farrugia G, Grover M, Lee LA, Miriel L, Tonascia J, Hamilton FA, Parkman HP; Gastroparesis Clinical Research Consortium.

Clin Gastroenterol Hepatol. 2018 Oct 13. pii: S1542-3565(18)31134-0. doi: 10.1016/j.cgh.2018.10.013. [Epub ahead of print]

PMID:
30326297
8.

Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project.

Hens B, Sinko PD, Job N, Dean M, Al-Gousous J, Salehi N, Ziff RM, Tsume Y, Bermejo M, Paixão P, Brasseur JG, Yu A, Talattof A, Benninghoff G, Langguth P, Lennernäs H, Hasler WL, Marciani L, Dickens J, Shedden K, Sun D, Amidon GE, Amidon GL.

Int J Pharm. 2018 Sep 5;548(1):120-127. doi: 10.1016/j.ijpharm.2018.06.050. Epub 2018 Jun 23. Review.

PMID:
29944899
9.

Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach.

Paixão P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, Frances A, Amidon GE, Yu A, Benninghoff G, Löbenberg R, Talattof A, Sun D, Amidon GL.

Eur J Pharm Biopharm. 2018 Aug;129:162-174. doi: 10.1016/j.ejpb.2018.05.033. Epub 2018 May 29.

PMID:
29857136
10.

G-POEM for Gastroparesis: Is There Pressure to Go with the Flow?

Lee AA, Hasler WL.

Dig Dis Sci. 2018 Sep;63(9):2165-2167. doi: 10.1007/s10620-018-5116-2. No abstract available.

PMID:
29855769
11.

Glucose sensor-augmented continuous subcutaneous insulin infusion in patients with diabetic gastroparesis: An open-label pilot prospective study.

Calles-Escandón J, Koch KL, Hasler WL, Van Natta ML, Pasricha PJ, Tonascia J, Parkman HP, Hamilton F, Herman WH, Basina M, Buckingham B, Earle K, Kirkeby K, Hairston K, Bright T, Rothberg AE, Kraftson AT, Siraj ES, Subauste A, Lee LA, Abell TL, McCallum RW, Sarosiek I, Nguyen L, Fass R, Snape WJ, Vaughn IA, Miriel LA, Farrugia G; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

PLoS One. 2018 Apr 13;13(4):e0194759. doi: 10.1371/journal.pone.0194759. eCollection 2018.

12.

Islet Cell Associated Autoantibodies and C-Peptide Levels in Patients with Diabetes and Symptoms of Gastroparesis.

Siraj ES, Homko C, Wilson LA, May P, Rao AD, Calles J, Farrugia G, Hasler WL, Koch KL, Nguyen L, Snape WJ, Abell TL, Sarosiek I, McCallum RW, Pasricha PJ, Clarke J, Tonascia J, Hamilton F, Parkman HP.

Front Endocrinol (Lausanne). 2018 Feb 13;9:32. doi: 10.3389/fendo.2018.00032. eCollection 2018.

13.

Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country.

Farmer AD, Wegeberg AL, Brock B, Hobson AR, Mohammed SD, Scott SM, Bruckner-Holt CE, Semler JR, Hasler WL, Hellström PM, Drewes AM, Brock C.

Aliment Pharmacol Ther. 2018 Feb;47(3):391-400. doi: 10.1111/apt.14438. Epub 2017 Dec 6.

PMID:
29210098
14.

Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis.

Gibbons SJ, Grover M, Choi KM, Wadhwa A, Zubair A, Wilson LA, Wu Y, Abell TL, Hasler WL, Koch KL, McCallum RW, Nguyen LAB, Parkman HP, Sarosiek I, Snape WJ, Tonascia J, Hamilton FA, Pasricha PJ, Farrugia G.

PLoS One. 2017 Nov 21;12(11):e0187772. doi: 10.1371/journal.pone.0187772. eCollection 2017.

15.

Aprepitant Has Mixed Effects on Nausea and Reduces Other Symptoms in Patients With Gastroparesis and Related Disorders.

Pasricha PJ, Yates KP, Sarosiek I, McCallum RW, Abell TL, Koch KL, Nguyen LAB, Snape WJ, Hasler WL, Clarke JO, Dhalla S, Stein EM, Lee LA, Miriel LA, Van Natta ML, Grover M, Farrugia G, Tonascia J, Hamilton FA, Parkman HP; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

Gastroenterology. 2018 Jan;154(1):65-76.e11. doi: 10.1053/j.gastro.2017.08.033. Epub 2017 Oct 28.

16.

Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time.

Yu A, Jackson T, Tsume Y, Koenigsknecht M, Wysocki J, Marciani L, Amidon GL, Frances A, Baker JR, Hasler W, Wen B, Pai A, Sun D.

AAPS J. 2017 Nov;19(6):1682-1690. doi: 10.1208/s12248-017-0145-x. Epub 2017 Oct 4.

PMID:
28980204
17.

Intragastric Meal Distribution During Gastric Emptying Scintigraphy for Assessment of Fundic Accommodation: Correlation with Symptoms of Gastroparesis.

Orthey P, Yu D, Van Natta ML, Ramsey FV, Diaz JR, Bennett PA, Iagaru AH, Fragomeni RS, McCallum RW, Sarosiek I, Hasler WL, Farrugia G, Grover M, Koch KL, Nguyen L, Snape WJ, Abell TL, Pasricha PJ, Tonascia J, Hamilton F, Parkman HP, Maurer AH; NIH Gastroparesis Consortium.

J Nucl Med. 2018 Apr;59(4):691-697. doi: 10.2967/jnumed.117.197053. Epub 2017 Sep 28.

18.

In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract under Fed and Fasted Conditions.

Koenigsknecht MJ, Baker JR, Wen B, Frances A, Zhang H, Yu A, Zhao T, Tsume Y, Pai MP, Bleske BE, Zhang X, Lionberger R, Lee A, Amidon GL, Hasler WL, Sun D.

Mol Pharm. 2017 Dec 4;14(12):4295-4304. doi: 10.1021/acs.molpharmaceut.7b00425. Epub 2017 Oct 5.

PMID:
28937221
19.

Diabetes and the Stomach.

Lee AA, Hasler WL.

Curr Treat Options Gastroenterol. 2017 Dec;15(4):441-459. doi: 10.1007/s11938-017-0146-y. Review.

PMID:
28879488
20.

Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis.

Hasler WL, May KP, Wilson LA, Van Natta M, Parkman HP, Pasricha PJ, Koch KL, Abell TL, McCallum RW, Nguyen LA, Snape WJ, Sarosiek I, Clarke JO, Farrugia G, Calles-Escandon J, Grover M, Tonascia J, Lee LA, Miriel L, Hamilton FA; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

Neurogastroenterol Motil. 2018 Feb;30(2). doi: 10.1111/nmo.13196. Epub 2017 Sep 5.

21.

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs.

Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Loebenberg R, Lee A, Frances A, Amidon G, Yu A, Benninghoff G, Salehi N, Talattof A, Sun D, Amidon GL.

Mol Pharm. 2017 Dec 4;14(12):4281-4294. doi: 10.1021/acs.molpharmaceut.7b00426. Epub 2017 Aug 4.

PMID:
28737409
22.

White Paper AGA: Gastroparesis: Clinical and Regulatory Insights for Clinical Trials.

Pasricha PJ, Camilleri M, Hasler WL, Parkman HP.

Clin Gastroenterol Hepatol. 2017 Aug;15(8):1184-1190. doi: 10.1016/j.cgh.2017.04.011. Epub 2017 Apr 12.

PMID:
28410896
23.

The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation.

Dahl JU, Gray MJ, Bazopoulou D, Beaufay F, Lempart J, Koenigsknecht MJ, Wang Y, Baker JR, Hasler WL, Young VB, Sun D, Jakob U.

Nat Microbiol. 2017 Jan 23;2:16267. doi: 10.1038/nmicrobiol.2016.267.

24.

Diabetic and idiopathic gastroparesis is associated with loss of CD206-positive macrophages in the gastric antrum.

Grover M, Bernard CE, Pasricha PJ, Parkman HP, Gibbons SJ, Tonascia J, Koch KL, McCallum RW, Sarosiek I, Hasler WL, Nguyen LAB, Abell TL, Snape WJ, Kendrick ML, Kellogg TA, McKenzie TJ, Hamilton FA, Farrugia G; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13018. Epub 2017 Jan 9.

25.

Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract.

Yu A, Baker JR, Fioritto AF, Wang Y, Luo R, Li S, Wen B, Bly M, Tsume Y, Koenigsknecht MJ, Zhang X, Lionberger R, Amidon GL, Hasler WL, Sun D.

Mol Pharm. 2017 Feb 6;14(2):345-358. doi: 10.1021/acs.molpharmaceut.6b00641. Epub 2016 Dec 23.

PMID:
28009518
26.

Opioids and GI Motility-Friend or Foe?

Lee AA, Hasler WL.

Curr Treat Options Gastroenterol. 2016 Dec;14(4):478-494. Review.

PMID:
27807793
27.

Early satiety and postprandial fullness in gastroparesis correlate with gastroparesis severity, gastric emptying, and water load testing.

Parkman HP, Hallinan EK, Hasler WL, Farrugia G, Koch KL, Nguyen L, Snape WJ, Abell TL, McCallum RW, Sarosiek I, Pasricha PJ, Clarke J, Miriel L, Tonascia J, Hamilton F; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

Neurogastroenterol Motil. 2017 Apr;29(4). doi: 10.1111/nmo.12981. Epub 2016 Oct 25.

28.

Newest Drugs for Chronic Unexplained Nausea and Vomiting.

Hasler WL.

Curr Treat Options Gastroenterol. 2016 Dec;14(4):371-385. Review.

29.

Methodologic considerations for studies of chronic nausea and vomiting in adults and children.

Hasler WL, Li BU, Koch KL, Parkman HP, Kovacic K, McCallum RW.

Auton Neurosci. 2017 Jan;202:28-39. doi: 10.1016/j.autneu.2016.08.001. Epub 2016 Aug 3. Review.

PMID:
27539628
30.

Nausea and vomiting in gastroparesis: similarities and differences in idiopathic and diabetic gastroparesis.

Parkman HP, Hallinan EK, Hasler WL, Farrugia G, Koch KL, Calles J, Snape WJ, Abell TL, Sarosiek I, McCallum RW, Nguyen L, Pasricha PJ, Clarke J, Miriel L, Lee L, Tonascia J, Hamilton F; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

Neurogastroenterol Motil. 2016 Dec;28(12):1902-1914. doi: 10.1111/nmo.12893. Epub 2016 Jun 27.

31.

Endoscopic Gastric Food Retention in Relation to Scintigraphic Gastric Emptying Delays and Clinical Factors.

Coleski R, Baker JR, Hasler WL.

Dig Dis Sci. 2016 Sep;61(9):2593-601. doi: 10.1007/s10620-016-4173-7. Epub 2016 May 19.

PMID:
27193562
32.

Gastroduodenal Disorders.

Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ.

Gastroenterology. 2016 May;150(6):1380-92. doi: 10.1053/j.gastro.2016.02.011. Review.

PMID:
27147122
33.

Rome IV-Functional GI Disorders: Disorders of Gut-Brain Interaction.

Drossman DA, Hasler WL.

Gastroenterology. 2016 May;150(6):1257-61. doi: 10.1053/j.gastro.2016.03.035. No abstract available.

PMID:
27147121
34.

Baseline features and differences in 48 week clinical outcomes in patients with gastroparesis and type 1 vs type 2 diabetes.

Koch KL, Hasler WL, Yates KP, Parkman HP, Pasricha PJ, Calles-Escandon J, Snape WJ, Abell TL, McCallum RW, Nguyen LA, Sarosiek I, Farrugia G, Tonascia J, Lee L, Miriel L, Hamilton F; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

Neurogastroenterol Motil. 2016 Jul;28(7):1001-15. doi: 10.1111/nmo.12800. Epub 2016 Mar 6.

35.

Blunting of Colon Contractions in Diabetics with Gastroparesis Quantified by Wireless Motility Capsule Methods.

Coleski R, Wilding GE, Semler JR, Hasler WL.

PLoS One. 2015 Oct 28;10(10):e0141183. doi: 10.1371/journal.pone.0141183. eCollection 2015.

36.

Outcomes and Factors Associated With Reduced Symptoms in Patients With Gastroparesis.

Pasricha PJ, Yates KP, Nguyen L, Clarke J, Abell TL, Farrugia G, Hasler WL, Koch KL, Snape WJ, McCallum RW, Sarosiek I, Tonascia J, Miriel LA, Lee L, Hamilton F, Parkman HP.

Gastroenterology. 2015 Dec;149(7):1762-1774.e4. doi: 10.1053/j.gastro.2015.08.008. Epub 2015 Aug 21.

37.

Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule: influence of age, gender, study country and testing protocol.

Wang YT, Mohammed SD, Farmer AD, Wang D, Zarate N, Hobson AR, Hellström PM, Semler JR, Kuo B, Rao SS, Hasler WL, Camilleri M, Scott SM.

Aliment Pharmacol Ther. 2015 Sep;42(6):761-72. doi: 10.1111/apt.13329. Epub 2015 Jul 29.

38.

Amitriptyline for Functional Dyspepsia: Importance of Symptom Profile and Making a Case for Gastric Emptying Testing.

Hasler WL, Koch KL.

Gastroenterology. 2015 Aug;149(2):270-2. doi: 10.1053/j.gastro.2015.06.017. Epub 2015 Jun 25. No abstract available.

PMID:
26116797
39.

Symptomatic management for gastroparesis: antiemetics, analgesics, and symptom modulators.

Hasler WL.

Gastroenterol Clin North Am. 2015 Mar;44(1):113-26. doi: 10.1016/j.gtc.2014.11.009. Epub 2014 Dec 26. Review.

PMID:
25667027
40.

Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis.

Bernard CE, Gibbons SJ, Mann IS, Froschauer L, Parkman HP, Harbison S, Abell TL, Snape WJ, Hasler WL, McCallum RW, Sarosiek I, Nguyen LA, Koch KL, Tonascia J, Hamilton FA, Kendrick ML, Shen KR, Pasricha PJ, Farrugia G; NIDDK Gastroparesis Clinical Research Consortium (GpCRC).

Neurogastroenterol Motil. 2014 Sep;26(9):1275-84. doi: 10.1111/nmo.12389. Epub 2014 Jul 13.

41.

The use of SmartPill for gastric monitoring.

Hasler WL.

Expert Rev Gastroenterol Hepatol. 2014 Aug;8(6):587-600. doi: 10.1586/17474124.2014.922869. Epub 2014 May 31. Review.

PMID:
24881810
42.

Emerging drugs for the treatment of gastroparesis.

Hasler WL.

Expert Opin Emerg Drugs. 2014 Jun;19(2):261-79. doi: 10.1517/14728214.2014.899353. Epub 2014 Mar 26. Review.

PMID:
24669936
43.

Challenges of managing pain in constipation-predominant IBS: clinical perspectives on antinociceptive actions of linaclotide.

Hasler WL, Owyang C.

Gastroenterology. 2013 Dec;145(6):1196-9. No abstract available.

PMID:
24409483
44.

Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial.

Parkman HP, Van Natta ML, Abell TL, McCallum RW, Sarosiek I, Nguyen L, Snape WJ, Koch KL, Hasler WL, Farrugia G, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, Pasricha PJ.

JAMA. 2013 Dec 25;310(24):2640-9. doi: 10.1001/jama.2013.282833.

45.

Pathology of emesis: its autonomic basis.

Hasler WL.

Handb Clin Neurol. 2013;117:337-52. doi: 10.1016/B978-0-444-53491-0.00027-4.

PMID:
24095137
46.

Geography lessons: scrutinizing state-by-state differences in inpatient gastroparesis care.

Hasler WL.

Dig Dis Sci. 2013 Oct;58(10):2743-5. doi: 10.1007/s10620-013-2815-6. No abstract available.

PMID:
23934413
47.

Cholecystectomy and clinical presentations of gastroparesis.

Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Calles J, Abell TL, Sarosiek I, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F.

Dig Dis Sci. 2013 Apr;58(4):1062-73. doi: 10.1007/s10620-013-2596-y. Epub 2013 Mar 2.

48.

Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting.

Hasler WL, Wilson LA, Parkman HP, Koch KL, Abell TL, Nguyen L, Pasricha PJ, Snape WJ, McCallum RW, Sarosiek I, Farrugia G, Calles J, Lee L, Tonascia J, Unalp-Arida A, Hamilton F.

Neurogastroenterol Motil. 2013 May;25(5):427-38, e300-1. doi: 10.1111/nmo.12091. Epub 2013 Feb 17.

49.

Can high-resolution anorectal manometry shed new light on defecatory disorders?

Rao SS, Hasler WL.

Gastroenterology. 2013 Feb;144(2):263-5. doi: 10.1053/j.gastro.2012.12.011. Epub 2012 Dec 20. No abstract available.

PMID:
23260494
50.

Gastroparesis.

Hasler WL.

Curr Opin Gastroenterol. 2012 Nov;28(6):621-8. doi: 10.1097/MOG.0b013e328358d619. Review.

PMID:
23041675

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