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Chronic Nicotine Exposure Alters Metabotropic Glutamate Receptor 5: Longitudinal PET Study and Behavioural Assessment in Rats.

Müller Herde A, Mihov Y, Krämer SD, Mu L, Adamantidis A, Ametamey SM, Hasler G.

Neurotox Res. 2019 May 22. doi: 10.1007/s12640-019-00055-5. [Epub ahead of print]


Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

Karlsson Linnér R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA, Lebreton M, Tino SP, Abdellaoui A, Hammerschlag AR, Nivard MG, Okbay A, Rietveld CA, Timshel PN, Trzaskowski M, Vlaming R, Zünd CL, Bao Y, Buzdugan L, Caplin AH, Chen CY, Eibich P, Fontanillas P, Gonzalez JR, Joshi PK, Karhunen V, Kleinman A, Levin RZ, Lill CM, Meddens GA, Muntané G, Sanchez-Roige S, Rooij FJV, Taskesen E, Wu Y, Zhang F; 23and Me Research Team; eQTLgen Consortium; International Cannabis Consortium; Social Science Genetic Association Consortium, Auton A, Boardman JD, Clark DW, Conlin A, Dolan CC, Fischbacher U, Groenen PJF, Harris KM, Hasler G, Hofman A, Ikram MA, Jain S, Karlsson R, Kessler RC, Kooyman M, MacKillop J, Männikkö M, Morcillo-Suarez C, McQueen MB, Schmidt KM, Smart MC, Sutter M, Thurik AR, Uitterlinden AG, White J, Wit H, Yang J, Bertram L, Boomsma DI, Esko T, Fehr E, Hinds DA, Johannesson M, Kumari M, Laibson D, Magnusson PKE, Meyer MN, Navarro A, Palmer AA, Pers TH, Posthuma D, Schunk D, Stein MB, Svento R, Tiemeier H, Timmers PRHJ, Turley P, Ursano RJ, Wagner GG, Wilson JF, Gratten J, Lee JJ, Cesarini D, Benjamin DJ, Koellinger PD, Beauchamp JP.

Nat Genet. 2019 Feb;51(2):245-257. doi: 10.1038/s41588-018-0309-3. Epub 2019 Jan 14.


Cutaneous adverse drug reactions to psychotropic drugs and their risk factors - a case-control study.

Greil W, Zhang X, Stassen H, Grohmann R, Bridler R, Hasler G, Toto S, Bleich S, Kasper S.

Eur Neuropsychopharmacol. 2019 Jan;29(1):111-121. doi: 10.1016/j.euroneuro.2018.10.010. Epub 2018 Nov 10.


Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders.

Breit S, Kupferberg A, Rogler G, Hasler G.

Front Psychiatry. 2018 Mar 13;9:44. doi: 10.3389/fpsyt.2018.00044. eCollection 2018. Review.


Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder.

Akkus F, Mihov Y, Treyer V, Ametamey SM, Johayem A, Senn S, Rösner S, Buck A, Hasler G.

Transl Psychiatry. 2018 Jan 10;8(1):17. doi: 10.1038/s41398-017-0066-6.


Fronto-parietal coding of goal-directed actions performed by artificial agents.

Kupferberg A, Iacoboni M, Flanagin V, Huber M, Kasparbauer A, Baumgartner T, Hasler G, Schmidt F, Borst C, Glasauer S.

Hum Brain Mapp. 2018 Mar;39(3):1145-1162. doi: 10.1002/hbm.23905. Epub 2017 Dec 5.


Neural Correlates of Impaired Reward-Effort Integration in Remitted Bulimia Nervosa.

Mueller SV, Morishima Y, Schwab S, Wiest R, Federspiel A, Hasler G.

Neuropsychopharmacology. 2018 Mar;43(4):868-876. doi: 10.1038/npp.2017.277. Epub 2017 Nov 6.


Deep brain stimulation for psychiatric disorders: Is there an impact on social functioning?

Saleh C, Hasler G.

Surg Neurol Int. 2017 Jul 7;8:134. doi: 10.4103/sni.sni_15_17. eCollection 2017. Review.


Neural response to catecholamine depletion in remitted bulimia nervosa: Relation to depression and relapse.

Mueller SV, Mihov Y, Federspiel A, Wiest R, Hasler G.

Eur Neuropsychopharmacol. 2017 Jul;27(7):633-646. doi: 10.1016/j.euroneuro.2017.04.002. Epub 2017 May 11.


Altered Dopamine Responses to Monetary Rewards in Female Fibromyalgia Patients with and without Depression: A [11C]Raclopride Bolus-plus-Infusion PET Study.

Ledermann K, Jenewein J, Sprott H, Hasler G, Schnyder U, Warnock G, Johayem A, Kollias S, Buck A, Martin-Soelch C.

Psychother Psychosom. 2017;86(3):181-182. doi: 10.1159/000455927. Epub 2017 May 11. No abstract available.


Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study.

Rutrick D, Stein DJ, Subramanian G, Smith B, Fava M, Hasler G, Cha JH, Gasparini F, Donchev T, Ocwieja M, Johns D, Gomez-Mancilla B.

Adv Ther. 2017 Feb;34(2):524-541. doi: 10.1007/s12325-016-0468-5. Epub 2017 Jan 2.


Metabotropic glutamate receptor 5 neuroimaging in schizophrenia.

Akkus F, Treyer V, Ametamey SM, Johayem A, Buck A, Hasler G.

Schizophr Res. 2017 May;183:95-101. doi: 10.1016/j.schres.2016.11.008. Epub 2016 Nov 12.


Reply to 'Is Binge Drinking in Adolescents Related to Specific Impairments in Well-Being?' by Rafanelli et al.

Hasler G.

Psychother Psychosom. 2016;85(6):368. Epub 2016 Oct 15. No abstract available.


Altered Pain Perception and Fear-Learning Deficits in Subjects With Posttraumatic Stress Disorder.

Jenewein J, Erni J, Moergeli H, Grillon C, Schumacher S, Mueller-Pfeiffer C, Hassanpour K, Seiler A, Wittmann L, Schnyder U, Hasler G.

J Pain. 2016 Dec;17(12):1325-1333. doi: 10.1016/j.jpain.2016.09.002. Epub 2016 Sep 15.


Testing the social competition hypothesis of depression using a simple economic game.

Kupferberg A, Hager OM, Fischbacher U, Brändle LS, Haynes M, Hasler G.

BJPsych Open. 2016 Mar 24;2(2):163-169. eCollection 2016 Mar.


Well-Being: An Important Concept for Psychotherapy and Psychiatric Neuroscience.

Hasler G.

Psychother Psychosom. 2016;85(5):255-61. doi: 10.1159/000447268. Epub 2016 Aug 11. No abstract available.


Social functioning in major depressive disorder.

Kupferberg A, Bicks L, Hasler G.

Neurosci Biobehav Rev. 2016 Oct;69:313-32. doi: 10.1016/j.neubiorev.2016.07.002. Epub 2016 Jul 6. Review.


Inconsistency and social decision making in patients with Borderline Personality Disorder.

Preuss N, Brändle LS, Hager OM, Haynes M, Fischbacher U, Hasler G.

Psychiatry Res. 2016 Sep 30;243:115-22. doi: 10.1016/j.psychres.2016.06.017. Epub 2016 Jun 17.


Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.

Mihov Y, Hasler G.

Int J Neuropsychopharmacol. 2016 Jul 5;19(7). pii: pyw002. doi: 10.1093/ijnp/pyw002. Print 2016 Jul. Review.


Human Endogenous Retroviruses as Pathogenic Factors in the Development of Schizophrenia.

Slokar G, Hasler G.

Front Psychiatry. 2016 Jan 11;6:183. doi: 10.3389/fpsyt.2015.00183. eCollection 2015. Review.


Relation of dopamine receptor 2 binding to pain perception in female fibromyalgia patients with and without depression--A [¹¹C] raclopride PET-study.

Ledermann K, Jenewein J, Sprott H, Hasler G, Schnyder U, Warnock G, Johayem A, Kollias S, Buck A, Martin-Soelch C.

Eur Neuropsychopharmacol. 2016 Feb;26(2):320-330. doi: 10.1016/j.euroneuro.2015.12.007. Epub 2015 Dec 10.


[Advantages and controversies of depot antipsychotics in the treatment of patients with schizophrenia].

Breit S, Hasler G.

Nervenarzt. 2016 Jul;87(7):719-23. doi: 10.1007/s00115-015-0021-9. Review. German.


Association of Long-Term Nicotine Abstinence With Normal Metabotropic Glutamate Receptor-5 Binding.

Akkus F, Treyer V, Johayem A, Ametamey SM, Mancilla BG, Sovago J, Buck A, Hasler G.

Biol Psychiatry. 2016 Mar 15;79(6):474-80. doi: 10.1016/j.biopsych.2015.02.027. Epub 2015 Feb 27.


The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction: combining preclinical evidence with human Positron Emission Tomography (PET) studies.

Terbeck S, Akkus F, Chesterman LP, Hasler G.

Front Neurosci. 2015 Mar 18;9:86. doi: 10.3389/fnins.2015.00086. eCollection 2015. Review.


Serotonin versus catecholamine deficiency: behavioral and neural effects of experimental depletion in remitted depression.

Homan P, Neumeister A, Nugent AC, Charney DS, Drevets WC, Hasler G.

Transl Psychiatry. 2015 Mar 17;5:e532. doi: 10.1038/tp.2015.25.


Role of calcium, glutamate and NMDA in major depression and therapeutic application.

Deutschenbaur L, Beck J, Kiyhankhadiv A, Mühlhauser M, Borgwardt S, Walter M, Hasler G, Sollberger D, Lang UE.

Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jan 4;64:325-33. doi: 10.1016/j.pnpbp.2015.02.015. Epub 2015 Mar 4. Review.


Toward stratified treatments for bipolar disorders.

Hasler G, Wolf A.

Eur Neuropsychopharmacol. 2015 Mar;25(3):283-94. doi: 10.1016/j.euroneuro.2014.12.006. Epub 2015 Jan 2. Review.


Report of the WPA section of pharmacopsychiatry on the relationship of antiepileptic drugs with suicidality in epilepsy.

Fountoulakis KN, Gonda X, Baghai TC, Baldwin DS, Bauer M, Blier P, Gattaz W, Hasler G, Möller HJ, Tandon R, Vieta E, Kasper S.

Int J Psychiatry Clin Pract. 2015;19(3):158-67. doi: 10.3109/13651501.2014.1000930. Epub 2015 Apr 23. Review.


The role of BDNF, leptin, and catecholamines in reward learning in bulimia nervosa.

Homan P, Grob S, Milos G, Schnyder U, Eckert A, Lang U, Hasler G.

Int J Neuropsychopharmacol. 2014 Dec 7;18(5). pii: pyu092. doi: 10.1093/ijnp/pyu092.


Prefrontal GABA and glutathione imbalance in posttraumatic stress disorder: preliminary findings.

Michels L, Schulte-Vels T, Schick M, O'Gorman RL, Zeffiro T, Hasler G, Mueller-Pfeiffer C.

Psychiatry Res. 2014 Dec 30;224(3):288-95. doi: 10.1016/j.pscychresns.2014.09.007. Epub 2014 Sep 28.


Patient-reported outcomes in borderline personality disorder.

Hasler G, Hopwood CJ, Jacob GA, Brändle LS, Schulte-Vels T.

Dialogues Clin Neurosci. 2014 Jun;16(2):255-66. Review.


The role of learning-related dopamine signals in addiction vulnerability.

Huys QJ, Tobler PN, Hasler G, Flagel SB.

Prog Brain Res. 2014;211:31-77. doi: 10.1016/B978-0-444-63425-2.00003-9. Review.


Metabotropic glutamate receptor 5 binding in patients with obsessive-compulsive disorder.

Akkus F, Terbeck S, Ametamey SM, Rufer M, Treyer V, Burger C, Johayem A, Mancilla BG, Sovago J, Buck A, Hasler G.

Int J Neuropsychopharmacol. 2014 Dec;17(12):1915-22. doi: 10.1017/S1461145714000716. Epub 2014 May 15.


The missing link between clinical states and biomarkers in mental disorders.

Fava GA, Guidi J, Grandi S, Hasler G.

Psychother Psychosom. 2014;83(3):136-41. doi: 10.1159/000360348. Epub 2014 Apr 12.


The effects of catecholamine depletion on the neural response to fearful faces in remitted depression.

Homan P, Drevets WC, Hasler G.

Int J Neuropsychopharmacol. 2014 Sep;17(9):1419-28. doi: 10.1017/S1461145714000339. Epub 2014 Apr 14.


Purchase decision-making is modulated by vestibular stimulation.

Preuss N, Mast FW, Hasler G.

Front Behav Neurosci. 2014 Feb 19;8:51. doi: 10.3389/fnbeh.2014.00051. eCollection 2014.


Atypical visual processing in posttraumatic stress disorder.

Mueller-Pfeiffer C, Schick M, Schulte-Vels T, O'Gorman R, Michels L, Martin-Soelch C, Blair JR, Rufer M, Schnyder U, Zeffiro T, Hasler G.

Neuroimage Clin. 2013 Aug 29;3:531-8. doi: 10.1016/j.nicl.2013.08.009. eCollection 2013.


Behavioral responses to catecholamine depletion in unmedicated, remitted subjects with bulimia nervosa and healthy subjects.

Grob S, Stern J, Gamper L, Moergeli H, Milos G, Schnyder U, Hasler G.

Biol Psychiatry. 2015 Apr 1;77(7):661-7. doi: 10.1016/j.biopsych.2013.09.013. Epub 2013 Oct 25.


Caloric vestibular stimulation modulates affective control and mood.

Preuss N, Hasler G, Mast FW.

Brain Stimul. 2014 Jan-Feb;7(1):133-40. doi: 10.1016/j.brs.2013.09.003. Epub 2013 Oct 8.


Low single dose gabapentin does not affect prefrontal and occipital gamma-aminobutyric acid concentrations.

Preuss N, van der Veen JW, Carlson PJ, Shen J, Hasler G.

Eur Neuropsychopharmacol. 2013 Dec;23(12):1708-13. doi: 10.1016/j.euroneuro.2013.08.006. Epub 2013 Sep 8.


Dopaminergic modulation of the reward system in schizophrenia: a placebo-controlled dopamine depletion fMRI study.

da Silva Alves F, Bakker G, Schmitz N, Abeling N, Hasler G, van der Meer J, Nederveen A, de Haan L, Linszen D, van Amelsvoort T.

Eur Neuropsychopharmacol. 2013 Nov;23(11):1577-86. doi: 10.1016/j.euroneuro.2013.06.008. Epub 2013 Aug 24.


Growth hormone response to catecholamine depletion in unmedicated, remitted subjects with major depressive disorder and healthy controls.

Homan P, Drevets WC, Hasler G.

J Clin Psychopharmacol. 2013 Oct;33(5):621-6. doi: 10.1097/JCP.0b013e31829a8284.


Neural correlates of free T3 alteration after catecholamine depletion in subjects with remitted major depressive disorder and in controls.

Homan P, Drevets WC, Hasler G.

Psychopharmacology (Berl). 2014 Jan;231(2):409-17. doi: 10.1007/s00213-013-3250-2. Epub 2013 Aug 18.


Associations between prefrontal γ-aminobutyric acid concentration and the tryptophan hydroxylase isoform 2 gene, a panic disorder risk allele in women.

Preuss N, Salehi B, van der Veen JW, Shen J, Drevets WC, Hodgkinson C, Goldman D, Hasler G.

Int J Neuropsychopharmacol. 2013 Sep;16(8):1707-17. doi: 10.1017/S1461145713000254. Epub 2013 Apr 3.


Fear-learning deficits in subjects with fibromyalgia syndrome?

Jenewein J, Moergeli H, Sprott H, Honegger D, Brunner L, Ettlin D, Grillon C, Bloch K, Brügger M, Schwegler K, Schumacher S, Hasler G.

Eur J Pain. 2013 Oct;17(9):1374-84. doi: 10.1002/j.1532-2149.2013.00300.x. Epub 2013 Mar 7.


Reduction in total plasma ghrelin levels following catecholamine depletion: relation to bulimic and depressive symptoms.

Homan P, Grob S, Milos G, Schnyder U, Hasler G.

Psychoneuroendocrinology. 2013 Sep;38(9):1545-52. doi: 10.1016/j.psyneuen.2012.12.024. Epub 2013 Jan 16.


Age-modulated association between prefrontal NAA and the BDNF gene.

Salehi B, Preuss N, van der Veen JW, Shen J, Neumeister A, Drevets WC, Hodgkinson C, Goldman D, Wendland JR, Singleton A, Gibbs JR, Cookson MR, Hasler G.

Int J Neuropsychopharmacol. 2013 Jul;16(6):1185-93. doi: 10.1017/S1461145712001204. Epub 2012 Dec 20.


Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [11C]ABP688 positron emission tomography.

Akkus F, Ametamey SM, Treyer V, Burger C, Johayem A, Umbricht D, Gomez Mancilla B, Sovago J, Buck A, Hasler G.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):737-42. doi: 10.1073/pnas.1210984110. Epub 2012 Dec 17.


Serotonin transporter genotype differentially modulates neural responses to emotional words following tryptophan depletion in patients recovered from depression and healthy volunteers.

Roiser JP, Levy J, Fromm SJ, Goldman D, Hodgkinson CA, Hasler G, Sahakian BJ, Drevets WC.

J Psychopharmacol. 2012 Nov;26(11):1434-42. doi: 10.1177/0269881112442789. Epub 2012 Apr 10.

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