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Items: 5


Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme.

Marciel MP, Rose AH, Martinez V, Horio DT, Hashimoto AS, Hoffmann FW, Bertino P, Hoffmann PR.

Cancer Med. 2018 Jan;7(1):175-183. doi: 10.1002/cam4.1260. Epub 2017 Dec 6.


Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.

Rose AH, Huang Z, Mafnas C, Hara JH, Hoffmann FW, Hashimoto AS, Bertino P, Hoffmann PR.

Inflamm Bowel Dis. 2015 Sep;21(9):2005-15. doi: 10.1097/MIB.0000000000000471.


Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis.

Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR.

J Immunol. 2013 Oct 1;191(7):3778-88. doi: 10.4049/jimmunol.1300972. Epub 2013 Aug 28.


Specific antioxidant selenoproteins are induced in the heart during hypertrophy.

Hoffmann FW, Hashimoto AS, Lee BC, Rose AH, Shohet RV, Hoffmann PR.

Arch Biochem Biophys. 2011 Aug 1;512(1):38-44. doi: 10.1016/ Epub 2011 May 20.


Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses.

Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR.

J Immunol. 2011 Feb 15;186(4):2127-37. doi: 10.4049/jimmunol.1002878. Epub 2011 Jan 10.

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